IL-12 regulates T helper type 1 cytokine responses in human infectious disease

Journal of Immunology

Volumn 153, Issue 8, 1994, Pages 3639-3647

  Sieling, Peter A ^a   Wang, Xiao Hong ^a   Gately, Maurice K ^b   Oliveros, Jennifer L ^a   McHugh, Teresa ^a   Barnes, Peter F ^c   Wolf, Stanley F ^d   Golkar, Linda ^a   Yamamura, Masahiro ^a   Yogi, Yasuko ^a   Uyemura, Koichi ^a   Rea, Thomas H ^c   Modlin, Robert L ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

^b HOFFMANN LA ROCHE INC   (United States)

^c UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^d PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE;

ARTICLE; CONTROLLED STUDY; HELPER CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNE RESPONSE; IMMUNOREGULATION; LEPROMATOUS LEPROSY; PRIORITY JOURNAL; T LYMPHOCYTE; TUBERCULOID LEPROSY;

BASE SEQUENCE; CD8-POSITIVE T-LYMPHOCYTES; DNA PRIMERS; GENE EXPRESSION; HUMANS; INTERFERON TYPE II; INTERLEUKIN-10; INTERLEUKIN-12; INTERLEUKIN-4; LEPROSY; LYMPHOCYTE ACTIVATION; MOLECULAR SEQUENCE DATA; MYCOBACTERIUM LEPRAE; RNA, MESSENGER; T-LYMPHOCYTE SUBSETS; TH1 CELLS;

EID: 0028077508     PISSN: 00221767     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (29)

1. Heinzel, F. P., M. D. Sadick, B. J. Holaday, R. L. Coffman, and R. M. Locksley. 1989. Reciprocal expression of Interferon γ or interleukin 4 during the resolution or progression of murine leishmaniasis: evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 169:59.
2. Yamamura, M., K. Uyemura, R. J. Deans, K. Weinberg, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1991. Defining protective responses to pathogens: cytokine profiles in leprosy lesions. Science 254:277.
3. Gately, M. K., B. B. Desai, A. G. Wolitsky, P. M. Quinn, C. M. Dwyer, F. J. Podlaski, P. C. Familletti, F. Sinigaglia, R. Chizzonite, U. Gubler, and A. S. Stern. 1991. Regulation of human lymphocyte proliferation by a heterodimeric cytokine, IL-12 (cytotoxic lymphocyte maturation factor). J. Immunol. 147:874.
4. + T cells through IL-12 produced by Listeria-induced macrophages. Science 260:547.
5. Heinzel, F. P., D. S. Schoenhaut, R. M. Rerko, L. E. Rosser, and M. K. Gately. 1993. Recombinant interleukin 12 cures mice infected with Leishmania major. J. Exp. Med. 177:1505.
6. Sypek, J. P., C. L. Chung, S. E. H. Mayor, J. M. Subramanyam, S. J. Goldman, D. S. Sieburth, S. F. Wolf, and R. G. Schaub. 1993. Resolution of cutaneous leishmaniasis: interleukin 12 initiates a protective T helper type 1 response. J. Exp. Med. 177:1797.
7. + T cells to enhance priming for interferon-γ production and diminishes interleukin 4 inhibition of such priming. Proc. Natl. Acad. Sci. USA 90:10188.
8. D'Andrea, A., M. Rengaraju, N. M. Valiante, J. Chehimi, M. Kubin, M. Aste, S. H. Chan, M. Kobayashi, D. Young, E. Nickbarg, R. Chizzonite, S. F. Wolf, and G. Trinchieri. 1992. Production of natural killer cell stimulatory cell factor (interleukin 12) by peripheral blood mononuclear cells. J. Exp. Med. 176:1387.
9. Stern, A. S., F. J. Podlaski, J. D. Hulmes, Y. Pan, P. M. Quinn, A. G. Wolitzky. P. C. Familletti, D. L. Stremlo, T. Truitt, R. Chizzonite, and M. K. Gately. 1990. Purification to homogeneity and partial characterization of cytotoxic lymphocyte maturation factor from human B-lymphoblastoid cells. Proc. Natl. Acad. Sci. USA 87:6808.
10. Ridley, D. S., and W. H. Jopling. 1966. Classification of leprosy according to immunity: a five-group system. Int. J. Lepr. 34:255.
11. Salgame, P., J. S. Abrams, C. Clayberger, H. Goldstein, J. Convit, R. L. Modlin, and B. R. Bloom. 1991. Differing lymphokine profiles of functional subsets of human CD4 and CD8 T cell clones. Science 254:279.
12. Yamamura, M., X.-H. Wang, J. D. Ohmen, K. Uyemura, T. H. Rea, B. R. Bloom, and R. L. Modlin. 1992. Cytokine patterns of immunologically mediated tissue damage. J. Immunol. 149:1470.
13. Sieling, P. A., J. S. Abrams, M. Yamamura, P. Salgame, B. R. Bloom, T. H. Rea, and R. L. Modlin. 1993. Immunosuppressive roles for interleukin-10 and interleukin-4 in human infection: in vitro modulation of T cell responses in leprosy. J. Immunol. 150:5501.
14. Uyemura, K., R. J. Deans, H. Band, J. Ohmen, G. Panchamoorthy, C. T. Morita, T. H. Rea, and R. L. Modlin. 1991. Evidence for clonal selection of γ/δ-T cells in response to a human pathogen. J. Exp. Med. 174:683.
15. Modlin, R. L., F. M. Hofman, D. A. Horwitz, L. A. Husmann, S. Gillis, C. R. Taylor, and T. H. Rea. 1984. In situ identification of cells in human leprosy granulomas with monoclonal antibodies to interleukin 2 and its receptor. J. Immunol. 132:3085.
16. Gately, M. K., and R. Chizzonite. 1992. Measurement of human and mouse interleukin 12. In Current Protocols in Immunology. J. E. Coligan, A. M. Kruisbeek, D. H. Marqulies, E. M. Shevach, and W. Strober, eds. Greene Publishing Associates and Wiley-Interscience, New York, p. 6.16.1.
17. Desai, B. B., T. Truitt, S. Honasoge, R. Warrier, R. Chizzonite, and M. K. Gately. 1993. Expression of functional IL-12R on a human IL-2-dependent T cell line. J. Immunol. 150:207a (Abstr.).
18. Modlin, R. L., H. Kato, V. Mehra, E. E. Nelson, F. Xue-dong, T. H. Rea, P. K. Pattengale, and B. R. Bloom. 1986. Genetically restricted suppressor T-cell clones derived from lepromatous leprosy lesions. Nature 322:459.
19. Mehra, V., B. R. Bloom, V. K. Torigian, D. Mandich, M. Reichel, S. M. M. Young, P. Salgame, J. Convit, S. W. Hunter, M. McNeil, P. J. Brennan, T. H. Rea, and R. L. Modlin. 1989. Characterization of Mycobacterium leprae cell wall-associated proteins using T lymphocyte clones. J. Immunol. 142:2873.
20. D'Andrea, A., M. Aste-Amezaga, N. M. Valiante, X. Ma, M. Kubin, and G. Trinchieri. 1993. Interleukin 10 (IL-10) inhibits human lymphocyte interferon γ production by suppressing natural killer cell-stimulatory factor/IL-12 synthesis in accessory cells. J. Exp. Med. 178:1041.
21. Manetti, R., P. Parronchi, M. G. Giudizi, M. Piccinni, E. Maggi, G. Trinchieri, and S. Romagnani. 1993. Natural killer cell-stimulatory factor (interleukin 12 (IL-12)) induces T helper type 1 (Th1)-specific immune responses and inhibits the development of IL-4-producing Th cells. J. Exp. Med. 177:1199.
22. + T cells during initiation of infection. J. Exp. Med. 179:447.
23. + type 2 subsets in human leishmaniasis have distinct T cell receptor repertoires. J. Immunol. 151: 7095.
24. Germann, T., M. K. Gately, D. S. Schoenhaut, M. Lohoff, F. Mattner, S. Fischer, S. Jin, E. Schmitt, and E. Rude. 1993. Interleukin-12/T-cell stimulating factor, a cytokine with multiple effects on T helper type 1 (Th1) but not Th2 cells. Eur. J. Immunol. 23: 1762.
25. Chua, A. O., R. Chizzonite, B. B. Desai, T. P. Truitt, P. Nunes, L. J. Minetti, R. R. Warrier, D. H. Presky, J. F. Levine, M. K. Gately, and U. Gubler. 1994. Expression cloning of a human IL-12 receptor component: a new member of the cytokine receptor superfamily with strong homology to gp130. J. Immunol. 153:128.
26. Yanagida, T., T. Kato, O. Igarashi, T. Inoue, and H. Nariuchi. 1994. Second signal activity of IL-12 on the proliferation and IL-2R expression of T helper cell-1 clone. J. Immunol. 152:4919.
27. Afonso, L. C, T. M. Scharton, L. Q. Vieira, M. Wysocka, G. Trinchieri, and P. Scott. 1994. The adjuvant effect of interleukin-12 in a vaccine against Leishmania major. Science 263:235.
28. Clerici, M., D. R. Lucey, J. A. Berzofsky, L. A. Pinto, T. A. Wynn, S. P. Blatt, M. J. Dolan, C. W. Hendrix, S. F. Wolf, and G. M. Shearer. 1993. Restoration of HIV-specific cell-mediated immune responses by interleukin-12 in vitro. Science 262:1721.
29. Bloom, B. R. 1993. The power of negative thinking. J. Clin. Invest. 91:1265.