Downregulation of telomerase activity in HL60 cells by differentiating agents is accompanied by increased expression of telomerase-associated protein

Journal of Cellular Biochemistry

Volumn 67, Issue 1, 1997, Pages 13-23

  Reichman, Trevor W ^a   Albanell, Juan ^b,c   Wang, Xuening ^a   Moore, Malcolm A S ^b   Studzinski, George P ^a  

^a RUTGERS NEW JERSEY MEDICAL SCHOOL   (United States)

^b MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

^c HOSPITAL UNIVERSITARI VALL D HEBRON   (Spain)

Author keywords

Differentiation therapy; HL60 cells; Leukemia; Telomerase; TP1

Indexed keywords

CALCITRIOL; DIMETHYL SULFOXIDE; PHORBOL 13 ACETATE 12 MYRISTATE; RETINOIC ACID; TELOMERASE;

ARTICLE; CELL CYCLE PHASE; CELL DIFFERENTIATION; CELL DIVISION; CONTROLLED STUDY; ENZYME REGULATION; HUMAN; HUMAN CELL; PHENOTYPE; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA; PROTEIN EXPRESSION;

CALCITRIOL; CARRIER PROTEINS; CELL DIFFERENTIATION; DIMETHYL SULFOXIDE; DRUG RESISTANCE, NEOPLASM; GENE EXPRESSION REGULATION, DEVELOPMENTAL; GENE EXPRESSION REGULATION, NEOPLASTIC; HL-60 CELLS; HUMANS; MACROPHAGE-1 ANTIGEN; RNA, MESSENGER; TELOMERASE; TETRADECANOYLPHORBOL ACETATE; TRETINOIN;

ATRA;

EID: 0030884040     PISSN: 07302312     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1097-4644(19971001)67:1<13::AID-JCB2>3.0.CO;2-Z     Document Type: Article

References (25)

1. Albanell J, Han W, Mellado B, Gunawardane R, Scher HI, Dmitrovsky E, Moore MAS (1996): Telomerase activity is repressed during differentiation of maturation-sensitive but not resistant human tumor cell lines. Cancer Res 56:1503-1508.
2. Bestilny LJ, Brown CB, Miura Y, Robertson LD, Riabowol KT (1996): Selective inhibition of telomerase activity during terminal differentiation of immortal cell lines. Cancer Res 56:3796-3802.
3. Buchkovich KJ, Greider CW (1996): Telomerase regulation during entry into the cell cycle in normal human T cells. Mol Biol Cell 7:1443-1454.
4. Castalgne S, Chomienne C, Daniel MT, Berger R, Miclea JM, Ballerini P, Degos L (1990): Retinoic acids in the treatment of acute promyelocytic leukemia. Nouv Rev Fr Hematol 32:36-38.
5. Counter CM, Avilion AA, LeFeuvre CE, Stewart NG, Greider CW, Harley CB, Bacchetti S (1992): Telomere shortening associated with chromosome instability is arrested in immortal cells which express telomerase activity. EMBO J 11:1921-1929.
6. Greider CW, Blackburn EH (1987): The telomere terminal transferase of Tetrahymena is a ribonucleoprotein enzyme with two kinds of primer specificity. Cell 51:887-898.
7. Harrington L, McPhail T, Mar V, Zhou W, Oulton R, Program AEST, Bass MB, Arruda I, Robinson MO (1997): A mammalian telomerase associated protein. Science 275: 973-977.
8. Holt SE, Wright WE, Shay JW (1996): Regulation of telomerase activity in immortal cell lines. Mol Cell Biol 16: 2932-2939.
9. Huang ME, Ye YC, Chen SR, Chai JR, Lu JX, Zhoa L, Gu LJ, Wang ZY (1988): Use of all-trans retinoic acid in the treatment of acute promyelocytic leukemia. Blood, 72: 567-572.
10. Kim NW, Piatyszek MA, Prowse KR, Harley CB, West MD, Ho PLC, Coviello GM, Wright WE, Weinrich SL, Shay JW (1994): Specific association of human telomerase activity with immortal cells and cancer. Science 266:2011-2015.
11. Kim NW, Wu F (1997): Advances in quantification and characterization of telomerase activity by the telomeric repeat amplification protocol (TRAP). Nucleic Acids Research 25:2595-2597.
12. Kruk PA, Orren DK, Bohr VA (1997): Telomerase activity is elevated in early S phase in hamster cells. Biochem Biophys Res Commun 233:717-722.
13. Lingner J, Cooper JP, Cech TR (1995): Telomerase and DNA end replication: No longer a lagging strand problem? Science 269:1533-1534.
14. Lingner J, Hughes TR, Shevchenko A, Mann M, Lundblad V, Cech T (1997): Reverse transcriptase motifs in the catalytic subunit of telomerase. Science 276:561-567.
15. Lundblad V, Wright WE (1996): Telomeres and telomerase: A simple picture becomes complex. Cell 87:369-375.
16. Mantell LL, Greider CW (1994): Telomerase activity in germline and embryonic cell of Xenopus. EMBO J 13: 3211-3217.
17. Nakayama J, Saito M, Nakamura H, Matsuura A, Ishikawa F (1997): TLP1: A gene encoding a protein component of mammalian telomerase is a novel member of WD repeats family. Cell 88:875-884.
18. Sharma HW, Sokoloski JA, Perez JR, Maltese JY, Sartorelli AC, Stein CA, Nichols G, Khaled Z, Telang NT, Narayanan R (1995): Differentiation of immortal cells inhibits telomerase activity. Proc Natl Acad Sci USA 92:12343-12346.
19. Studzinski GP, Gierthy JF, Cholon JJ (1973): An autoradiographic screening test for mycoplasmal contamination of mammalian cell cultures. In Vitro 8:466-472.
20. 3 resistant HL60 cells is preceded by reduced growth factor dependence and constitutive up-regulation of Sp1 and AP-1 transcription factors. Cancer Res 56:5513-5521.
21. Studzinski GP, Rathod B, Wang QM, Rao J, Zhang F (1997): Uncoupling of cell cycle arrest from the expression of monocytic differentiation markers in HL60 cell variants. Exp Cell Res 232:376-387.
22. 3. Exp Cell Res 224:312-322.
23. Warrell RP, Frankel SR, Miller WH Jr, Scheinberg DA, Itri LM, Hittelman WN, Vyas R, Andreeff M, Tafuri A, Jakubowski A, Gabrilove J, Gordon MS, Dmitrovsky E (1991): Differentiation therapy of acute promyelocytic leukemia with tretinoin (all-trans retinoic acid). N Engl J Med 324:1385-1393.
24. Wright WE, Shay JW, Piatyszek MW (1995): Modifications of a telomeric repeat amplification protocol (TRAP) result in increased reliability, linearity and sensitivity. Nucleic Acids Res 23:3794-3795.
25. Zhu X, Kumar R, Mandal M, Sharma N, Sharma HW, Dhingra U, Sokoloski JA, Hsiao R, Narayanan R (1996): Cell cycle-dependent modulation of telomerase activity in tumor cells. Proc Natl Acad Sci U S A 93:6091-6095.