-
1
-
-
0026724892
-
Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]- 3′-spiro-5″-[4″-amino-1″,2″-oxathiole-2″, 2″-dioxide] thymidine (TSAO-T)
-
Balzarini, J., M.-J. Pérez-Pérez, A. San-Félix, M.-J. Camarasa, I. C. Bathurst, P. J. Barr, and E. De Clercq. 1992. Kinetics of inhibition of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase by the novel HIV-1-specific nucleoside analogue [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]- 3′-spiro-5″-[4″-amino-1″,2″-oxathiole-2″, 2″-dioxide] thymidine (TSAO-T). J. Biol. Chem. 267:11831-11838.
-
(1992)
J. Biol. Chem.
, vol.267
, pp. 11831-11838
-
-
Balzarini, J.1
Pérez-Pérez, M.-J.2
San-Félix, A.3
Camarasa, M.-J.4
Bathurst, I.C.5
Barr, P.J.6
De Clercq, E.7
-
2
-
-
0027937974
-
Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720
-
Balzarini, J., A. Karlsson, C. Meichsner, A. Paessens, G. Riess, E. De Clercq, and J.-P. Kleim. 1994. Resistance pattern of human immunodeficiency virus type 1 reverse transcriptase to quinoxaline S-2720. J. Virol. 68:7986-7992.
-
(1994)
J. Virol.
, vol.68
, pp. 7986-7992
-
-
Balzarini, J.1
Karlsson, A.2
Meichsner, C.3
Paessens, A.4
Riess, G.5
De Clercq, E.6
Kleim, J.-P.7
-
3
-
-
0026771409
-
3′-spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: Synthesis and antiviral activity of [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-xylo- and -ribofuranose]-3′-spiro-5″-[4″-amino-1″,2″- oxathiole 2″,2″-dioxide] (TSAO) pyrimidine nucleosides
-
Camarasa, M.-J., M.-J. Pérez-Pérez, A. San-Félix, J. Balzarini, and E. De Clercq. 1992. 3′-spiro nucleosides, a new class of specific human immunodeficiency virus type 1 inhibitors: synthesis and antiviral activity of [2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-xylo- and -ribofuranose]-3′-spiro-5″-[4″-amino-1″,2″- oxathiole 2″,2″-dioxide] (TSAO) pyrimidine nucleosides. J. Med. Chem. 35:2721-2727.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2721-2727
-
-
Camarasa, M.-J.1
Pérez-Pérez, M.-J.2
San-Félix, A.3
Balzarini, J.4
De Clercq, E.5
-
4
-
-
0024841242
-
HIV-1 reverse transcriptase/ ribonuclease H: High level expression in Escherichia coli from a plasmid constructed using the polymerase chain reaction
-
D'Aquila, R. T., and W. C. Summers. 1989. HIV-1 reverse transcriptase/ ribonuclease H: high level expression in Escherichia coli from a plasmid constructed using the polymerase chain reaction. J. Acquired Immune Defic. Syndr. 2:579-587.
-
(1989)
J. Acquired Immune Defic. Syndr.
, vol.2
, pp. 579-587
-
-
D'Aquila, R.T.1
Summers, W.C.2
-
5
-
-
0028120730
-
HIV resistance to reverse transcriptase inhibitors
-
De Clercq, E. 1994. HIV resistance to reverse transcriptase inhibitors. Biochem. Pharmacol. 47:155-169.
-
(1994)
Biochem. Pharmacol.
, vol.47
, pp. 155-169
-
-
De Clercq, E.1
-
6
-
-
0029775166
-
What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the treatment of human immunodeficiency virus type 1 (HIV-1) infections?
-
De Clercq, E. 1996. What can be expected from non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the treatment of human immunodeficiency virus type 1 (HIV-1) infections? Rev. Med. Virol. 6:97-117.
-
(1996)
Rev. Med. Virol.
, vol.6
, pp. 97-117
-
-
De Clercq, E.1
-
7
-
-
0027231438
-
A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors
-
Dueweke, T. J., T. Pushkarskaya, S. M. Poppe, S. M. Swaney, J. Q. Zhao, I. S. Y. Chen, M. Stevenson, and W. G. Tarpley. 1993. A mutation in reverse transcriptase of bis(heteroaryl)piperazine-resistant human immunodeficiency virus type 1 that confers increased sensitivity to other nonnucleoside inhibitors. Proc. Natl. Acad. Sci. USA 90:4713-4717.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 4713-4717
-
-
Dueweke, T.J.1
Pushkarskaya, T.2
Poppe, S.M.3
Swaney, S.M.4
Zhao, J.Q.5
Chen, I.S.Y.6
Stevenson, M.7
Tarpley, W.G.8
-
8
-
-
0028924567
-
Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors
-
Esnouf, R., J. Ren, C. Ross, Y. Jones, D. Stammers, and D. Stuart. 1995. Mechanism of inhibition of HIV-1 reverse transcriptase by non-nucleoside inhibitors. Nat. Struct. Biol. 2:303-308.
-
(1995)
Nat. Struct. Biol.
, vol.2
, pp. 303-308
-
-
Esnouf, R.1
Ren, J.2
Ross, C.3
Jones, Y.4
Stammers, D.5
Stuart, D.6
-
9
-
-
0030935265
-
Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine U-90152 explain resistance mutations for this non-nucleoside inhibitor
-
Esnouf, R. M., J. Ren, A. L. Hopkins, C. K. Ross, E. Y. Jones, D. K. Stammers, and D. I. Stuart. 1997. Unique features in the structure of the complex between HIV-1 reverse transcriptase and the bis(heteroaryl)piperazine U-90152 explain resistance mutations for this non-nucleoside inhibitor. Proc. Natl. Acad. Sci. USA 94:3984-3989.
-
(1997)
Proc. Natl. Acad. Sci. USA
, vol.94
, pp. 3984-3989
-
-
Esnouf, R.M.1
Ren, J.2
Hopkins, A.L.3
Ross, C.K.4
Jones, E.Y.5
Stammers, D.K.6
Stuart, D.I.7
-
10
-
-
0030729838
-
An extensively modified version of MolScript which includes greatly enhanced colouring capabilities
-
Esnouf, R. M. 1997. An extensively modified version of MolScript which includes greatly enhanced colouring capabilities. J. Mol. Graphics 15:133-138.
-
(1997)
J. Mol. Graphics
, vol.15
, pp. 133-138
-
-
Esnouf, R.M.1
-
11
-
-
0030087537
-
Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase
-
Fletcher, R. S., G. Holleschak, E. Nagy, D. Arion, G. Borkow, Z. Gu, M. A. Wainberg, and M. A. Parniak. 1996. Single-step purification of recombinant wild-type and mutant HIV-1 reverse transcriptase. Protein Expr. Purif. 7: 27-32.
-
(1996)
Protein Expr. Purif.
, vol.7
, pp. 27-32
-
-
Fletcher, R.S.1
Holleschak, G.2
Nagy, E.3
Arion, D.4
Borkow, G.5
Gu, Z.6
Wainberg, M.A.7
Parniak, M.A.8
-
12
-
-
0026465275
-
Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxycytidine
-
Gu, Z., Q. Gao, X. Li, M. A. Parniak, and M. A. Wainberg. 1992. Novel mutation in the human immunodeficiency virus type 1 reverse transcriptase gene that encodes cross-resistance to 2′,3′-dideoxycytidine. J. Virol. 66: 7128-7135.
-
(1992)
J. Virol.
, vol.66
, pp. 7128-7135
-
-
Gu, Z.1
Gao, Q.2
Li, X.3
Parniak, M.A.4
Wainberg, M.A.5
-
13
-
-
0029976422
-
Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors
-
Hopkins, A. L., J. Ren, R. M. Esnouf, B. E. Willcox, E. Y. Jones, C. Ross, T. Miyasaka, K. T. Walker, H. Tanaka, D. K. Stammers, and D. I. Stuart. 1996. Complexes of HIV-1 reverse transcriptase with inhibitors of the HEPT series reveal conformational changes relevant to the design of potent non-nucleoside inhibitors. J. Med. Chem. 39:1589-1600.
-
(1996)
J. Med. Chem.
, vol.39
, pp. 1589-1600
-
-
Hopkins, A.L.1
Ren, J.2
Esnouf, R.M.3
Willcox, B.E.4
Jones, E.Y.5
Ross, C.6
Miyasaka, T.7
Walker, K.T.8
Tanaka, H.9
Stammers, D.K.10
Stuart, D.I.11
-
14
-
-
0027273015
-
Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication
-
Kleim, J.-P., R. Bender, U. M. Billhardt, C. Meichsner, G. Riess, M. Rösner, I. Winkler, and A. Paessens. 1993. Activity of a novel quinoxaline derivative against human immunodeficiency virus type 1 reverse transcriptase and viral replication. Antimicrob. Agents Chemother. 37:1659-1664.
-
(1993)
Antimicrob. Agents Chemother.
, vol.37
, pp. 1659-1664
-
-
Kleim, J.-P.1
Bender, R.2
Billhardt, U.M.3
Meichsner, C.4
Riess, G.5
Rösner, M.6
Winkler, I.7
Paessens, A.8
-
15
-
-
0028347888
-
Mutational analysis of residue 190 of human immunodeficiency virus type 1 reverse transcriptase
-
Kleim, J.-P., R. Bender, R. Kirsch, C. Meichsner, A. Paessens, and G. Riess. 1994. Mutational analysis of residue 190 of human immunodeficiency virus type 1 reverse transcriptase. Virology 200:696-701.
-
(1994)
Virology
, vol.200
, pp. 696-701
-
-
Kleim, J.-P.1
Bender, R.2
Kirsch, R.3
Meichsner, C.4
Paessens, A.5
Riess, G.6
-
16
-
-
0029147651
-
Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication
-
Kleim, J.-P., R. Bender, R. Kirsch, C. Meichsner, A. Paessens, M. Rösner, H. Rübsamen-Waigmann, R. Kaiser, M. Wichers, K. E. Schneweis, I. Winkler, and G. Riess. 1995. Preclinical evaluation of HBY 097, a new nonnucleoside reverse transcriptase inhibitor of human immunodeficiency virus type 1 replication. Antimicrob. Agents Chemother. 39:2253-2257.
-
(1995)
Antimicrob. Agents Chemother.
, vol.39
, pp. 2253-2257
-
-
Kleim, J.-P.1
Bender, R.2
Kirsch, R.3
Meichsner, C.4
Paessens, A.5
Rösner, M.6
Rübsamen-Waigmann, H.7
Kaiser, R.8
Wichers, M.9
Schneweis, K.E.10
Winkler, I.11
Riess, G.12
-
17
-
-
0030070683
-
Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74→Val or Ile and Val-75→Leu or Ile) HIV-1 mutants
-
Kleim, J.-P., M. Rösner, I. Winkler, A. Paessens, R. Kirsch, Y. Hsiou, E. Arnold, and G. Riess. 1996. Selective pressure of a quinoxaline nonnucleoside inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase (RT) on HIV-1 replication results in the emergence of nucleoside RT-inhibitor-specific (RT Leu-74→Val or Ile and Val-75→Leu or Ile) HIV-1 mutants. Proc. Natl. Acad. Sci. USA 93:34-38.
-
(1996)
Proc. Natl. Acad. Sci. USA
, vol.93
, pp. 34-38
-
-
Kleim, J.-P.1
Rösner, M.2
Winkler, I.3
Paessens, A.4
Kirsch, R.5
Hsiou, Y.6
Arnold, E.7
Riess, G.8
-
18
-
-
0030926748
-
In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097
-
Kleim, J.-P., I. Winkler, M. Rösner, R. Kirsch, H. Rübsamen-Waigmann, A. Paessens, and G. Riess. 1997. In vitro selection for different mutational patterns in the HIV-1 reverse transcriptase using high and low selective pressure of the nonnucleoside reverse transcriptase inhibitor HBY 097. Virology 231:112-118.
-
(1997)
Virology
, vol.231
, pp. 112-118
-
-
Kleim, J.-P.1
Winkler, I.2
Rösner, M.3
Kirsch, R.4
Rübsamen-Waigmann, H.5
Paessens, A.6
Riess, G.7
-
19
-
-
1842274532
-
-
Unpublished data
-
Kleim, J.-P., et al. Unpublished data.
-
-
-
Kleim, J.-P.1
-
20
-
-
0026244229
-
MolScript: A program to produce both detailed and schematic plots of protein structures
-
Kraulis, P. J. 1991. MolScript: a program to produce both detailed and schematic plots of protein structures. J. Appl. Crystallogr. 24:946-950.
-
(1991)
J. Appl. Crystallogr.
, vol.24
, pp. 946-950
-
-
Kraulis, P.J.1
-
21
-
-
1842352388
-
-
abstr. 92
-
Nijhuis, M., R. Schuurman, D. de Jong, P. Schipper, S. Danner, and C. Boucher. 1997. International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication, abstr. 92.
-
(1997)
International Workshop on HIV Drug Resistance, Treatment Strategies and Eradication
-
-
Nijhuis, M.1
Schuurman, R.2
De Jong, D.3
Schipper, P.4
Danner, S.5
Boucher, C.6
-
22
-
-
0026737678
-
TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]- 3′-spiro-5″-[4″-amino-1″,2″-oxathiole-2″, 2″-dioxide] pyrimidine and pyrimidine-modified nucleosides
-
Pérez-Pérez, M.-J., A. San-Félix, J. Balzarini, E. De Clercq, and M.-J. Camarasa. 1992. TSAO analogues. Stereospecific synthesis and anti-HIV-1 activity of 1-[2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]- 3′-spiro-5″-[4″-amino-1″,2″-oxathiole-2″, 2″-dioxide] pyrimidine and pyrimidine-modified nucleosides. J. Med. Chem. 35:2988-2995.
-
(1992)
J. Med. Chem.
, vol.35
, pp. 2988-2995
-
-
Pérez-Pérez, M.-J.1
San-Félix, A.2
Balzarini, J.3
De Clercq, E.4
Camarasa, M.-J.5
-
23
-
-
0026650693
-
Synthesis of {1-[2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-xylo- and β-D-ribofuranosyl]thymine}-3′-spiro-5″-[4″-amino- 1″,2″-oxathiole-2″,2″-dioxide] (TSAO): A novel type of specific anti-HIV agents
-
Pérez-Pérez, M.-J., A. San-Félix, M.-J. Camarasa, J. Balzarini, and E. De Clercq. 1992. Synthesis of {1-[2′,5′-bis-O-(tert-butyldimethylsilyl)-β-D-xylo- and β-D-ribofuranosyl]thymine}-3′-spiro-5″-[4″-amino- 1″,2″-oxathiole-2″,2″-dioxide] (TSAO): a novel type of specific anti-HIV agents. Tetrahedron Lett. 33:3029-3032.
-
(1992)
Tetrahedron Lett.
, vol.33
, pp. 3029-3032
-
-
Pérez-Pérez, M.-J.1
San-Félix, A.2
Camarasa, M.-J.3
Balzarini, J.4
De Clercq, E.5
-
24
-
-
0004136246
-
-
Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
Sambrook, J., E. F. Fritsch, and T. Maniatis. 1989. Molecular cloning: a laboratory manual, 2nd ed. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
-
(1989)
Molecular Cloning: A Laboratory Manual, 2nd Ed.
-
-
Sambrook, J.1
Fritsch, E.F.2
Maniatis, T.3
-
25
-
-
19244363136
-
Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain
-
Schmit, J.-C., J. Cogniaux, P. Hermans, C. Van Vaeck, S. Sprecher, B. Van Remoortel, M. Witvrouw, J. Balzarini, J. Desmyter, E. De Clercq, and A.-M. Vandamme. 1996. Multiple drug resistance to nucleoside analogues and nonnucleoside reverse transcriptase inhibitors in an efficiently replicating human immunodeficiency virus type 1 patient strain. J. Infect. Dis. 174:962-968.
-
(1996)
J. Infect. Dis.
, vol.174
, pp. 962-968
-
-
Schmit, J.-C.1
Cogniaux, J.2
Hermans, P.3
Van Vaeck, C.4
Sprecher, S.5
Van Remoortel, B.6
Witvrouw, M.7
Balzarini, J.8
Desmyter, J.9
De Clercq, E.10
Vandamme, A.-M.11
-
26
-
-
0030012398
-
Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538)
-
Schmit, J.-C., L. Ruiz, B. Clotet, A. Raventos, J. Tor, J. Leonard, J. Desmyter, E. De Clercq, and A.-M. Vandamme. 1996. Resistance-related mutations in the HIV-1 protease gene of patients treated for 1 year with the protease inhibitor ritonavir (ABT-538). AIDS 10:995-999.
-
(1996)
AIDS
, vol.10
, pp. 995-999
-
-
Schmit, J.-C.1
Ruiz, L.2
Clotet, B.3
Raventos, A.4
Tor, J.5
Leonard, J.6
Desmyter, J.7
De Clercq, E.8
Vandamme, A.-M.9
|