Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with noncyclic gastrin receptor antagonistic moieties

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 7, 1997, Pages 1425-1431

  Kawanishi, Yasuyuki ^a   Ishihara, Shoichi ^a   Kiyama, Ryuichi ^a   Hagishita, Sanji ^a   Tsushima, Tadahiko ^a   Ishikawa, Michio ^a   Ishihara, Yasunobu ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ RECEPTOR; FAMOTIDINE; GASTRIN ANTAGONIST; GASTRIN RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H2 RECEPTOR ANTAGONIST; ROXATIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BINDING AFFINITY; BRAIN CORTEX; CONTROLLED STUDY; DOG; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; HYDROPHILICITY; IN VITRO STUDY; MOLECULAR MODEL; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; PANCREAS; RAT; STOMACH; STOMACH ACID SECRETION; STRUCTURE ACTIVITY RELATION;

ABSORPTION; ADMINISTRATION, ORAL; ANIMALS; ANTACIDS; BENZODIAZEPINES; DOGS; GASTRIC ACID; GASTRIC MUCOSA; GUINEA PIGS; HISTAMINE H2 ANTAGONISTS; MOLECULAR CONFORMATION; RATS; RECEPTOR, CHOLECYSTOKININ A; RECEPTORS, CHOLECYSTOKININ; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CANIS FAMILIARIS; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030879002     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00076-X     Document Type: Article

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