Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with decreased hydrophobicity

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 7, 1997, Pages 1401-1409

  Kawanishi, Yasuyuki ^a   Ishihara, Shoichi ^a   Tsushima, Tadahiko ^a   Hagishita, Sanji ^a   Ishikawa, Michio ^a   Ishihara, Yasunobu ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

GASTRIN ANTAGONIST; HISTAMINE H2 RECEPTOR ANTAGONIST;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOAVAILABILITY; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; GUINEA PIG; HYDROPHOBICITY; IN VITRO STUDY; INTRAGASTRIC DRUG ADMINISTRATION; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; STOMACH ACID SECRETION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZODIAZEPINES; CHEMISTRY, PHYSICAL; GASTRIC ACID; GASTRINS; GUINEA PIGS; HISTAMINE H2 ANTAGONISTS; MICE; PIPERIDINES; RATS; RECEPTORS, CHOLECYSTOKININ; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

ANIMALIA; CAVIA PORCELLUS; SUS SCROFA;

EID: 0030796216     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00074-6     Document Type: Article

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