Synthesis and structure-activity relationships of dual histamine H2 and gastrin receptor antagonists with modified benzodiazepine skeletons

Bioorganic and Medicinal Chemistry

Volumn 5, Issue 7, 1997, Pages 1411-1423

  Kawanishi, Yasuyuki ^a   Ishihara, Shoichi ^a   Tsushima, Tadahiko ^a   Seno, Kaoru ^a   Hagishita, Sanji ^a   Ishikawa, Michio ^a   Ishihara, Yasunobu ^a  

^a SHIONOGI AND CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1 (2,3 DIHYDRO 1 METHYL 2 OXO 5 PHENYL 1H 1,4 BENZODIAZEPIN 3 YL) 3 (3 METHYLPHENYL)UREA; CHOLECYSTOKININ RECEPTOR; CIMETIDINE; FAMOTIDINE; GASTRIN ANTAGONIST; GASTRIN RECEPTOR; HISTAMINE H2 RECEPTOR; HISTAMINE H2 RECEPTOR ANTAGONIST; ROXATIDINE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; CHIRALITY; CONTROLLED STUDY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SYNTHESIS; HYDROPHOBICITY; IN VITRO STUDY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; ORAL DRUG ADMINISTRATION; RAT; STOMACH ACID SECRETION; STRUCTURE ACTIVITY RELATION;

ANIMALS; BENZAZEPINES; BENZODIAZEPINES; GUINEA PIGS; HISTAMINE H2 ANTAGONISTS; MICE; OXAZEPINES; RECEPTORS, CHOLECYSTOKININ; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZEPINES;

ANIMALIA;

EID: 0030841356     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(97)00075-8     Document Type: Article

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