Role of UME6 in transcriptional regulation of a DNA repair gene in Saccharomyces cerevisiae

Molecular and Cellular Biology

Volumn 17, Issue 11, 1997, Pages 6223-6235

  Sweet, Douglas H ^a,b   Jang, Yeun Kyu ^a   Sancar, Gwendolyn B ^a  

^a UNIVERSITY OF NORTH CAROLINA SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYRIBODIPYRIMIDINE PHOTOLYASE; DNA; GLYCOGEN; MESSENGER RNA;

ARTICLE; BINDING AFFINITY; DNA REPAIR; ELECTROPHORETIC MOBILITY; GENE; GENE DELETION; GENE EXPRESSION; NONHUMAN; NORTHERN BLOTTING; POLYMERASE CHAIN REACTION; PRIORITY JOURNAL; SACCHAROMYCES CEREVISIAE; SOUTHERN BLOTTING; TRANSCRIPTION REGULATION;

EID: 0030868390     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.17.11.6223     Document Type: Article

References (73)

1. 6, binuclear cluster that binds the URS1 DNA sequence in a zinc-dependent manner. Protein Sci. 4:1832-1843.
2. Belazzi, T., A. Wagner, R. Wieser, M. Schanz, G. Adam, A. Hartig, and H. Ruis. 1991. Negative regulation of transcription of the Saccharomyces cerevisiae catalase T (CTT1) gene by cAMP is mediated by a positive control element. EMBO J. 10:585-592.
3. Bowdish, K. S., H. E. Yuan, and A. P. Mitchell. 1995. Positive control of yeast meiotic genes by the negative regulator UME6. Mol. Cell. Biol. 15:2955-2961.
4. Buckingham, L. E., H.-T. Wang, R. T. Elder, R. M. McCarroll, M. R. Slater, and R. E. Esposito. 1990. Nucleotide sequence and promoter analysis of SPO13, a meiosis-specific gene of Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 87:9406-9410.
5. Cameron, S., L. Levin, M. Zoller, and M. Wigler. 1988. cAMP-independent control of sporulation, glycogen metabolism, and heat shock resistance in S. cerevisiae. Cell 53:555-566.
6. Carlson, M., and D. Botstein. 1982. Two differentially regulated mRNAs with different 5′ ends encode secreted and intracellular forms of yeast invertase. Cell 28:145-154.
7. Cherry, J. M., C. Adler, C. Ball, S. Dwight, S. Chervitz, G. Juvik, G. Wang, and D. Botstein. 1996. Saccharomyces genome database. http://genome-www.stanford.edu/Saccharomyces/SacchDB9.10.96. 4.5.B12.
8. Cleary, M. A., and W. Herr. 1995. Mechanisms for flexibility in DNA sequence recognition and VP16-induced complex formation by the Oct-1 POU domain. Mol. Cell. Biol. 15:2090-2100.
9. De Rijcke, M., S. Seneca, B. Punyammalee, N. Glansdorff, and M. Crabeel. 1992. Characterization of the DNA target site for the yeast ARGR regulatory complex, a sequence able to mediate repression or induction by arginine. Mol. Cell. Biol. 12:68-81.
10. Einerhand, A. W. C., W. Kos, W. C. Smart, A. J. Kal, H. F. Tabak, and T. G. Cooper. 1995. The upstream region of the FOX3 gene encoding peroxisomal 3-oxoacyl-coenzyme A thiolase in Saccharomyces cerevisiae contains ABF1- and replication protein A-binding sites that participate in its regulation by glucose repression. Mol. Cell. Biol. 15:3405-3414.
11. Flick, J. S., and M. Johnston. 1990. Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:4757-4769.
12. Francois, J., P. Eraso, and C. Gancedo. 1987. Changes in the concentration of cAMP, fructose 2,6-bisphosphate and related metabolites and enzymes in Saccharomyces cerevisiae during growth on glucose. Eur. J. Biochem. 164: 369-373.
13. Friedberg, E. C., G. C. Walker, and W. Siede. 1995. DNA repair and mutagenesis, p. 595-631. ASM Press, Washington, D.C.
14. 6 DNA-binding domain. Nat. Struct. Biol. 2:898-905.
15. Hamil, K. G., H. G. Nam, and H. M. Fried. 1988. Constitutive transcription of yeast ribosomal protein gene TCM1 is promoted by uncommon cis- and trans-acting elements. Mol. Cell. Biol. 8:4328-4341.
16. Hardy, T. A., D. Huang, and P. J. Roach. 1996. Interactions between cAMP-dependent and SNF1 protein kinases in the control of glycogen accumulation in Saccharomyces cerevisiae. J. Biol. Chem. 269:27907-27913.
17. Harm, W., H. Harm, and C. S. Rupert. 1968. Analysis of photoenzymatic repair of UV lesions in DNA by single light flashes. II. In vivo studies with Escherichia coli and bacteriophage. Mutat. Res. 6:371-385.
18. Ho, Y., S. Mason, R. Kobayashi, M. Hoekstra, and B. Andrews. 1997. Role of the casein kinase I isoform. Hrr25, and the cell cycle-regulatory transcription factor, SBF, in the transcriptional response to DNA damage in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 94:581-586.
19. Jackson, J. C., and J. M. Lopes. 1996. The yeast UME6 gene is required for both negative and positive transcriptional regulation of phospholipid biosynthetic gene expression. Nucleic Acids Res. 24:1322-1329.
20. Jang, Y. K., Y. H. Jin, M. J. Kim, R. H. Seong, S. H. Hong, and S. D. Park. 1995. A simple and efficient method for the isolation of total RNA from the fission yeast Schizosaccharomyces pombe. Biochem. Mol. Biol. Int. 37:339-344.
21. Kadosh, D., and K. Struhl. 1997. Repression by Ume6 involves recruitment of a complex containing Sin3 corepressor and Rpd3 histone deacetylase to target promoters. Cell 89:365-371.
22. Kassir, Y., D. Granot, and G. Simchen. 1988. IME1, a positive regulator gene of meiosis in Saccharomyces cerevisiae. Cell 52:853-862.
23. Kiser, G. L., and T. A. Weinert. 1996. Distinct roles of yeast MEC and RAD checkpoint genes in transcriptional induction after DNA damage and implications for function. Mol. Biol. Cell 7:703-718.
24. Knight, J. L., and G. B. Sancar. 1997. Unpublished observations.
25. Kraus, B., and G. B. Sancar. 1997. Unpublished observations.
26. Waf1/Cip1/Sdi1 in the free and Cdk2-bound state: conformational disorder mediates binding diversity. Proc. Natl. Acad. Sci. USA 93:11504-11509.
27. Lillie, S. H., and J. R. Pringle. 1980. Reserve carbohydrate metabolism in Saccharomyces cerevisiae: responses to nutrient limitation. J. Bacteriol. 143: 1384-1394.
28. Luche, R. M., W. C. Smart, and T. G. Cooper. 1992. Purification of the heteromeric protein binding to the URS1 transcriptional repression site in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 89:7412-7416.
29. Luche, R. M., W. C. Smart, T. Marion, M. Tillman, R. Sumrada, and T. G. Cooper. 1993. Saccharomyces cerevisiae BUF protein binds to sequences participating in DNA replication in addition to those mediating transcriptional repression (URS1) and activation. Mol. Cell. Biol. 13:5749-5761.
30. Luche, R. M., R. Sumrada, and T. G. Cooper. 1990. A cis-acting element present in multiple genes serves as a repressor protein binding site for the yeast CAR1 gene. Mol. Cell. Biol. 10:3884-3895.
31. Madura, K., and S. Prakash. 1986. Nucleotide sequence, transcript mapping, and regulation of the RAD2 gene of Saccharomyces cerevisiae. J. Bacteriol. 166:914-923.
32. Marchler, G., C. Schüller, G. Adam, and H. Ruis. 1993. A Saccharomyces cerevisiae UAS element controlled by protein kinase A activates transcription in response to a variety of stress conditions. EMBO J. 12:1997-2003.
33. Marmorstein, R., M. Carey, M. Ptashne, and S. C. Harrison. 1992. DNA recognition by GAL4: structure of a protein-DNA complex. Nature 356:408-414.
34. 6 binuclear cluster. Genes Dev. 8:2504-2512.
35. Martinez-Pastor, M. T., G. Marchler, C. Schuller, A. Marchler-Bauer, H. Ruis, and F. Estruch. 1996. The Saccharomyces cerevisiae zinc finger proteins Msn2p and Msn4p are required for transcriptional induction through the stress-response element (STRE). EMBO J. 15:2227-2235.
36. Matsura, A., M. Treinin, H. Mitsuzawa, Y. Kassir, I. Uno, and G. Simchen. 1990. The adenylate cyclase/protein kinase cascade regulates entry into meiosis in Saccharomyces cerevisiae through the gene IME1. EMBO J. 9:3225-3232.
37. Miller, J. H. 1972. Experiments in molecular genetics. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, N.Y.
38. Misra, V., S. Walker, P. Yang, S. Hayes, and P. O'Hare. 1996. Conformational alteration of Oct-1 upon DNA binding dictates selectivity in differential interactions with related transcriptional coactivators. Mol. Cell. Biol. 16:4404-4413.
39. Mitchell, A. P. 1994. Control of meiotic gene expression in Saccharomyces cerevisiae. Microbiol. Rev. 58:56-70.
40. Mitchell, A. P., S. E. Driscoll, and H. E. Smith. 1990. Positive control of sporulation-specific genes by the IME1 and IME2 products in Saccharomyces cerevisiae. Mol. Cell. Biol. 10:2104-2110.
41. Navas, T. A., Y. Sanchez, and S. J. Elledge. 1996. RAD9 and DNA polymerase I form parallel sensory branches for transducing the DNA damage checkpoint signal in Saccharomyces cerevisiae. Genes Dev. 10:2632-2643.
42. Park, H.-D., R. M. Luche, and T. G. Cooper. 1992. The yeast UME6 gene product is required for transcriptional repression mediated by the CAR1 URS1 repressor binding site. Nucleic Acids Res. 20:1909-1915.
43. Perozzi, G., and S. Prakash. 1986. RAD7 gene of Saccharomyces cerevisiae: transcripts, nucleotide sequence analysis, and functional relationship between RAD7 and RAD23 gene product. Mol. Cell. Biol. 6:1497-1507.
44. Pfeifer, K., K.-S. Kim, S. Kogan, and L. Guarente. 1989. Functional dissection and sequence of yeast HAP1 activator. Cell 56:291-301.
45. 44a. Prakash, S., and H. Qiu. Personal communication.
46. Rubin-Bejerano, I., S. Mandel, K. Robzyk, and Y. Kassir. 1996. Induction of meiosis in Saccharomyces cerevisiae depends on conversion of the transcriptional repressor Ume6 to a positive regulator by its regulated association with the transcriptional activator Ime1. Mol. Cell. Biol. 16:2518-2526.
47. Sancar, G. B. 1985. Sequence of the Saccharomyces cerevisiae PHR1 gene and homology of the PHR1 photolyase to E. coli photolyase. Nucleic Acids Res. 13:8231-8246.
48. Sancar, G. B., R. Ferris, F. W. Smith, and B. Vandeberg. 1995. Promoter elements of the PHR1 gene of Saccharomyces cerevisiae and their roles in the response to DNA damage. Nucleic Acids Res. 21:4320-4328.
49. Sancar, G. B., and F. W. Smith. 1989. Interactions between yeast photolyase and nucleotide excision repair proteins in Saccharomyces cerevisiae and Escherichia coli. Mol. Cell. Biol. 9:4767-4776.
50. Schmitt, A. P., and K. McEntee. 1996. Msn2p, a zinc finger DNA-binding protein, is the transcriptional activator of the multistress response in Saccharomyces cerevisiae. Proc. Natl. Acad. Sci. USA 93:5777-5782.
51. Sebastian, J., B. Kraus, and G. B. Sancar. 1990. Expression of the yeast PHR1 gene is induced by DNA-damaging agents. Mol. Cell. Biol. 10:4630-4637.
52. Sebastian, J., and G. B. Sancar. 1991. A damage-responsive DNA binding protein regulates transcription of the yeast DNA repair gene PHR1. Proc. Natl. Acad. Sci. USA 88:11251-11255.
53. Shiozaki, K., and P. Russell. 1996. Conjugation, meiosis, and the osmotic stress response are regulated by Spc1 kinase through Atf1 transcription factor in fission yeast. Genes Dev. 10:2276-2288.
54. Siede, W., G. W. Robinson, D. Kalainov, T. Malley, and E. C. Friedberg. 1989. Regulation of the RAD2 gene of Saccharomyces cerevisiae. Mol. Microbiol. 3:1697-1707.
55. Sikorski, R. S., and P. Hieter. 1989. A system for shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122:19-27.
56. Singh, K. K., and L. Samson. 1995. Replication protein A binds to regulatory elements in yeast DNA repair and DNA metabolism genes. Proc. Natl. Acad. Sci. USA 92:4907-4911.
57. Skroch, J. M. 1992: The role of GAC1 in glycogen metabolism in the yeast Saccharomyces cerevisiae. M.S. thesis. North Carolina State University, Raleigh.
58. Steber, C. M., and R. E. Esposito. 1995. UME6 is a central component of a developmental regulatory switch controlling meiosis-specific gene development. Proc. Natl. Acad. Sci. USA 92:12409-12494.
59. Strich, R., M. R. Slater, and R. E. Esposito. 1989. Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast. Proc. Natl. Acad. Sci. USA 86:10018-10022.
60. Strich, R., R. T. Surosky, C. Steber, E. Dubois, F. Messenguy, and R E. Esposilo. 1994. UME6 is a key regulator of nitrogen repression and meiotic development. Genes Dev. 8:796-810.
61. Sun, A., D. S. Fay, and F. Marini. 1996. Spkl/Rad53 is regulated by Mec1-dependent protein phosphorylation in DNA replication and damage checkpoint pathways. Genes Dev. 10:395-406.
62. Szent-Gyorgi, C. 1995. A bipartite operator interacts with a heat shock element to mediate early meiotic induction of Saccharomyces cerevisiae HSP82. Mol. Cell. Biol. 15:6754-6769.
63. + encodes a transcription factor required for sexual development and entry into stationary phase. EMBO J. 14:6193-6208.
64. Tan, S., and T. J. Richmond. 1990. DNA binding-induced conformational change of the yeast transcriptional activator PRTF. Cell 62:367-377.
65. Thompson-Jaeger, S., J. Francois, J. P. Gaughran, and K. Tatchell. 1991. Deletion of SNF1 affects the nutrient response of yeast and resembles mutations which activate the adenylate cyclase pathway. Genetics 129:697-706.
66. Unrau, P., R. Wheatcroft, B. S. Cox, and T. Olive. 1973. The formation of pyrimidine dimers in the DNA of fungi and bacteria. Biochim. Biophys. Acta 312:626-632.
67. Vidal, M., A. M. Buckley, C. Yohn, D. J. Hoeppner, and R. F. Gaber. 1995. Identification of essential nucleotides in an upstream repressing sequence of Saccharomyces cerevisiae by selection for increased expression of TRK2. Proc. Natl. Acad. Sci. USA 92:2370-2374.
68. Werner-Washburne, M., E. Braun, G. C. Johnston, and R. A. Singer. 1993. Stationary phase in the yeast Saccharomyces cerevisiae. Microbiol. Rev. 57: 383-401.
69. Xiao, W., K. K. Singh, B. Chen, and L. Samson. 1993. A common element involved in transcriptional regulation of two DNA alkylation repair genes (MAG and MGT1) of Saccharomyces cerevisiae. Mol. Cell. Biol. 13:7213-7221.
70. Yasui, A., and W. Laskowski. 1975. Determination of the number of photoreactivating enzyme molecules per haploid Saccharomyces cell. Int. J. Radiat. Biol. 28:511-518.
71. Zhang, L., and L. Guarente. 1994. The yeast activator HAP1 - a GAL4 family member - binds DNA in a directly repeated orientation. Genes Dev. 8:2110-2119.
72. Zheng, P., D. S. Fay, J. Burton, H. Xiao, J. L. Pinkham, and D. F. Stern. 1993. SPK1 is an essential S-phase-specific gene of Saccharomyces cerevisiae that encodes a nuclear serine/threonine/tyrosine kinase. Mol. Cell. Biol. 13:5829-5842.
73. Zhou, Z., and S. J. Elledge. 1993. DUN1 encodes a protein kinase that controls the DNA damage response in yeast. Cell 75:1119-1127.