FK-506 and rapamycin but not cyclosporin inhibit aldosterone-stimulated sodium transport in A6 cells

American Journal of Physiology - Cell Physiology

Volumn 271, Issue 1 40-1, 1996, Pages

  Rokaw, Michael D ^a,b   West, Michael E ^a   Palevsky, Paul M ^a   Johnson, John P ^a  

^a UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^b Laboratory of Epithelial Cell Biology   (United States)

Author keywords

56 kilodalton heat shock protein; immunophilin; steroid

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ALDOSTERONE; CALCINEURIN; CYCLOSPORIN A; GLUCOCORTICOID RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; HEAT SHOCK PROTEIN; IMMUNOSUPPRESSIVE AGENT; NYSTATIN; RAPAMYCIN; SODIUM ION; TACROLIMUS;

ANIMAL CELL; ARTICLE; CELL LINE; CELL STIMULATION; CONTROLLED STUDY; DRUG PROTEIN BINDING; ENZYME ACTIVITY; ENZYME INHIBITION; IMMUNOBLOTTING; IMMUNOPRECIPITATION; INHIBITION KINETICS; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; SODIUM TRANSPORT; TRANSPORT KINETICS;

EID: 0029775021     PISSN: 03636143     EISSN: None     Source Type: Journal    
DOI: 10.1152/ajpcell.1996.271.1.c194     Document Type: Article

References (33)

1. Alessiani, M., U. Cillo, J. J. Fung, W. Irish, K. Abu-Elmagd, A. Jain, S. Takaya, D. Van-Thiel, and T. E. Starzl. Adverse effects of FK506 overdoseage after liver transplantation. Transplant. Proc. 25: 628-634, 1993.
2. +-ATPase activity in renal tubule cells. Proc. Natl. Acad. Sci. USA 89: 7394-7397, 1992.
3. Azhderian, E. M., J. Klipaka, K. Vives, and M. I. Lorber. Nucleus associated FK506 binding proteins with potential relevance to FK506 immunosuppression. Transplant. Proc. 25: 662-664, 1993.
4. +, ATPase inhibits the activity of the enzyme. Proc. Natl. Acad. Sci. USA 86: 11359-11362, 1991.
5. Calvo, V., C. M. Crews, T. A. Vik, and B. E. Bierer. Interlerukin 2 stimulation of p70 S6 kinase is inhibited by the immunosuppresant rapamycin. Proc. Natl. Acad. Sci. USA 89: 7571-7575, 1992.
6. Collins, J. H. Sequence analysis of the ryanodine receptor: possible association with a 12 K, FK506 binding immunophilin/ protein kinase C inhibitor. Biochem. Biophys. Res. Commun. 178: 1288-1290, 1991.
7. +-ATPase in plasma membrane preperations: increasing the permeabiliuty of membrane vesicles using sodium dodecyl sulfate buffered with bovine serum albumin. Anal. Biochem. 128: 159-163, 1983.
8. Fruman, D., C. Klee, B. Brierer, and S. Bukaroff. Calcineurin phosphatase activity in T lymphocytes is inhibited by FK506 and cyclosporin A. Proc. Natl. Acad. Sci. USA 89: 3686-3690, 1992.
9. Goebel, M. G. The peptidyl-prolyl isomerase FK506-binding protein is most likely the 12 kD endogenous inhibitor 2 of protein kinase C. Cell 64: 1051-1052, 1991.
10. 1 renal cells and characterization of the porcine G alpha I-2 gene promoter. J. Biol. Chem. 268: 3964-3975, 1993.
11. 1 renal cells and isolation of porcine genomic clones encoding the gene promotor. J. Biol. Chem. 266: 1763-1771, 1991.
12. Hutchinson, K. A., L. C. Scherrer, M. J. Czar, Y. Ning, E. R. Sanchez,. L. Leach, M. R. Deibel, and W. B. Pratt. FK506 binding to the 56-kilodalton immunophilin (Hsp56) in the glucocorticoid receptor heterocomplex has no effect on receptor folding or function. Biochemistry 32: 3953-3957, 1993.
13. Johnson, J. P. Cellular mechanisms of action of mineralocorticoid hormones. Pharmacol. Ther. 53: 1-29, 1992.
14. Jordan, M., R. Shapiro, C. Vivas, V. P. Scantlebury, S. Darras, G. Carrieri, J. McCauley, A. J. Demetrius, P. Randahwa, C. Jensen, T. R. Hakala, J. J. Fung, and T. E. Starzl. Fk506 salvage of renal allografts with ongoing rejection failing cyclosporin immunosuppression. Transplant. Proc. 25: 638-640, 1993.
15. Kamel, K. S., J. H. Ethier, S. Quaggin, A. Levin, S. Albert, E. J. F. Carlisle, and M. L. Halperin. Studies to determine the basis for hyperkalemia in recipients of a renal transplant who are treated with cyclosporine. J. Am. Soc. Nephrol. 2: 1279-1284, 1991.
16. +-ATPase activity by Fk506 involves calcineurin. Kidney Int. 46: 647-652, 1994.
17. Lewis, S.A., D. C. Eaton, C. Clausen, and J. M. Diamond. Nystatin as a probe for investigating the electrical properties of a tight epithelium. J. Gen. Physiol. 70: 427-440, 1977.
18. + channels in A6 cells: a regulatory role for protein kinase C. Am. J. Physiol. 256 (Renal Fluid Electrolyte Physiol. 25): F1094-F1103, 1993.
19. Liu, J., J. D. Farmer, W. S. Lane, J. Friedman, I. Weissman, and S. L. Schreiber. Calcineurin is a common target of cyclophilin-cyclosporin A and FKBP-FK506 complexes. Cell 66: 807-815, 1991.
20. Morris, R. E. Rapamycin: Fk506's fraternal twin or distant cousin. Immunol. Today 12: 137-140, 1991.
21. Ning, Y.-M., and E. R. Sanchez. Potentiation of glucocorticoid receptor-mediated gene expression by the immunophilin ligands FK506 and rapamycin. J. Biol. Chem. 268: 6073-6076, 1993.
22. Peattie, D. A., M. W. Harding, M. A. Fleming, M. T. DeCenzo, J. A. Lipke, D. J. Livingston, and M. B. Benasutti. Expression and characterization of human FKBP52, an immunophilin that associates with the 90-kDa heat shock protein and is a component of steroid receptor complexes. Proc. Natl. Acad. Sci. USA 89: 10974-10978, 1992.
23. Pratt, W. B. The role of heat shock proteins in regulating the function, folding and trafficking of the glucocorticoid receptor. J. Biol. Chem. 268: 21455-21458, 1993.
24. Rokaw, M. D., D. J. Benos, P. M. Palevsky, S. A. Cunningham, M. E. West, and J. P. Johnson. Regulation of a sodium channel associated G-protein by aldosterone. J. Biol. Chem. 271: 4491-4496, 1996.
25. Sariban-Sohraby, S., M. Burg, W. P. Weissman, P. K. Chiang, and J. P. Johnson. Methylation increase sodium transport into A6 apical membrane vesicles: possible mode of aldosterone action. Science Wash. DC 225: 745-746, 1986.
26. + transport in A6 cells is mediated by glucocorticoid receptors. Am. J. Physiol. 264 (Cell Physiol. 33): C875-C884, 1993.
27. Schreiber, S. L. Chemistry and biology of the immunophilins and their immunosuppressive ligands. Science Wash. DC 21: 282-287, 1991.
28. Stanton, B., G. Giebisch, G. Klein-Robbenhaar, J. Wade, and R. A. DeFronzo. Effects of adrenalectomy and chronic adrenal corticosteroid replacement on potassium transport in rat kidney. J. Clin. Invest. 75: 1317-1326, 1985.
29. Steele, R. E., J. S. Handler, A. Preston, and J. P. Johnson. A device for sterile measurement of transepithelial electrical parameters of cultured cells. J. Tissue Cult. Methods 14: 259-264, 1992.
30. +-ATPase activity by cyclosporin A. Kidney Int. 43: 246-251, 1993.
31. United States Multicenter. FK506 liver study group. A comparison of Tacrolimus (FK506) and cyclosporin for immunosuppression in liver transplantation. N. Engl. J. Med. 331: 1110-1115, 1994.
32. Yanase, M., and J. S. Handler. Activators of protein kinase C inhibit sodium transport in A6 epithelia. Am. J. Physiol. 250 (Cell Physiol. 19): C517-C522, 1986.
33. Yem, A. W., A. G. Tomasseli, R. L. Heinikson, H. Zurcher-Neely, V. A. Ruff, R. A. Johnson, and M. R. Deibel. The Hsp56 component of steroid receptor complexes binds to immobilized FK506 and shows homology to FKBP-12 and FKBP-13. J. Biol. Chem. 267: 2868-2871, 1992.