The molecular basis of nonmelanoma skin cancer: New understanding

Archives of Dermatology

Volumn 133, Issue 10, 1997, Pages 1263-1270

  Grossman, Douglas ^a   Leffell, David J ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENINE; ANTIGEN; CARBON; CYCLOBUTANE; CYTOSINE; DNA; DNA POLYMERASE; ENDONUCLEASE; ENZYME; GAMMA INTERFERON; GAP JUNCTION PROTEIN; GROWTH FACTOR RECEPTOR; GUANINE NUCLEOTIDE BINDING PROTEIN; GUANOSINE TRIPHOSPHATE; IMMUNOGLOBULIN G2; INTEGRIN; INTERLEUKIN 10; INTERLEUKIN 12; INTERLEUKIN 2; INTERLEUKIN 4; KERATIN; NITROGEN; PROTEIN P53; PYRIMIDINE; PYRIMIDINONE DERIVATIVE; THYMINE; TRANSFORMING GROWTH FACTOR; TUMOR NECROSIS FACTOR ALPHA; UNINDEXED DRUG; UROCANIC ACID;

ANTIGEN PRESENTATION; APOPTOSIS; BASAL CELL NEVUS SYNDROME; CANCER PREVENTION; COCKAYNE SYNDROME; DNA REPAIR; DNA REPLICATION; GENE MUTATION; GENE THERAPY; HUMAN; IMMUNE DEFICIENCY; IMMUNE SYSTEM; NONHUMAN; PRIORITY JOURNAL; PROTO ONCOGENE; REVIEW; SKIN BIOPSY; SKIN CANCER; SKIN CARCINOGENESIS; TRICHOTHIODYSTROPHY; ULTRAVIOLET RADIATION; XERODERMA PIGMENTOSUM;

EID: 0030838767     PISSN: 0003987X     EISSN: None     Source Type: Journal    
DOI: 10.1001/archderm.133.10.1263     Document Type: Review

References (50)

1. Sutherland BM, Delihas NC, Oliver RP, Sutherland JC. Action spectra for ultraviolet-induced transformation of human cells to anchorage-independent growth. Cancer Res. 1981;41:2211-2214.
2. Livneh Z, Cohen-Fix O, Skaliter R, Elizur T. Replication of damaged DNA and the molecular mechanism of ultraviolet light mutagenesis. Crit Rev Biochem MoIl Biol. 1993;28:465-513.
3. Mitchell DL, Nairn RS. The biology of the (6-4) photoproduct. Photochem Photobiol. 1989;49:805-819.
4. Hart RW, Setlow RB, Woodhead AD. Evidence that pyrimidine dimers in DNA can give rise to tumors. Proc Natl Acad Sci U S A. 1977;75:5574-5578.
5. Strauss BS. The 'A rule' of mutagen specificity: a consequence of DNA polymerase bypass of noninstructional lesions? Bioessays. 1991;13:79-84.
6. Setlow RB, Grist E, Thompson K, Woodhead AD. Wavelengths effective in induction of malignant melanoma. Proc Natl Acad Sci U S A. 1993;90:6666-6670.
7. Drobetsky EA, Turcotte J, Chateauneuf A. A role for ultraviolet A in solar mutagenesis. Proc Natl Acad Sci U S A. 1995;92:2350-2354.
8. Setlow RB, Swenson PA, Carrier WL. Thymine dimers and inhibition of DNA synthesis by ultraviolet irradiation of cells. Science. 1963;142:1464-1466.
9. Yarosh D, Alas LG, Yee V, et al. Pyrimidine dimer removal enhanced by DNA repair liposomes reduces the incidence of UV skin cancer in mice. Cancer Res. 1992;52:4227-4231.
10. Alcalay J, Freeman SE, Goldberg LH, Wolf JE. Excision repair of pyrimidine dimers induced by simulated solar radiation in the skin of patients with basal cell carcinoma. J Invest Dermatol. 1990;95:506-509.
11. Wei Q, Matanoski GM, Farmer ER, Hedayati MA, Grossman L. DNA repair and aging in basal cell carcinoma: a molecular epidemiology study. Proc Natl Acad Sci U S A. 1993;90:1614-1618.
12. Kraemer KH, Levy DD, Parris CN, et al. Xeroderma pigmentosum and related disorders: examining the linkage between defective DNA repair and cancer. J Invest Dermatol. 1994;103:96-101.
13. Venema J, Mullenders LH, Natarajan AT, van Zeeland AA, Mayne LV. The genetic defect in Cockayne syndrome is associated with a defect in repair of UV-induced DNA damage in transcriptionally active DNA. Proc Natl Acad Sci U S A. 1990;87:4707-4711.
14. Parris CN, Kraemer KH. Ultraviolet-induced mutations in Cockayne syndrome are primarily caused by cyclobutane dimer photoproducts while repair of other photoproducts is normal. Proc Natl Acad Sci U S A. 1993;90:7260-7264.
15. Yuspa SH, Dlugosz AA, Cheng CK, et al. Role of oncogenes and tumor suppressor genes in multistage carcinogenesis. J Invest Dermatol. 1994;103(suppl): 90S-95S.
16. Slaga TJ, Budunova IV, Gimenez-Conti IB, Aldaz CM. The mouse skin carcinogenesis model. J Invest Dermatol Symp Proc. 1996;1:151-156.
17. Greenhalgh DA, Rothnagel JA, Quintanilla MI, et al. Induction of epidermal hyperplasia, hyperkeratosis, and papillomas in transgenic mice by a targeted v-Ha-ras oncogene. Mol Carcinog. 1993;7:99-110.
18. Van der Schroeff JG, Evers LM, Boot AJM, Bos JL. Ras oncogene point mutations in basal cell carcinomas and squamous cell carcinomas of the human skin. J Invest Dermatol. 1990;94:423-425.
19. Greenhalgh DA, Wang X-J, Roop DR. Multistage epidermal carcinogenesis in transgenic mice: cooperativity and paradox. J Invest Dermatol Symp Proc. 1996; 1:162-176.
20. Ha induces autonomous papillomas in transgenic epidermis but not malignant conversion. Cancer Res. 1993;53:5071-5075.
21. Lowe SW, Schmitt EM, Smith SW, Osborne BA, Jacks T. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature. 1993;362:847-849.
22. Brash DE, Rudolph JA, Simon JA, et al. A role for sunlight in skin cancer: UV-induced p53 mutations in squamous cell carcinoma. Proc Natl Acad Sci U S A. 1991;88:10124-10128.
23. Ziegler A, Leffell DJ, Kunala S, et al. Mutation hotspots due to sunlight in the p53 gene of nonmelanoma skin cancers. Proc Natl Acad Sci U S A. 1993;90: 4216-4220.
24. Basset-Seguin N, Moles JP, Mils V, Dereure O, Guilhou JJ. TP53 tumor suppressor gene and skin carcinogenesis. J Invest Dermatol. 1994;103(suppl): 102S-106S.
25. Ziegler A, Jonason AS, Leffell DJ, et al. Sunburn and p53 in the onset of skin cancer. Nature. 1994;372:773-776.
26. Brash DE, Ziegler A, Jonason AS, Simon JA, Kunala S, Leffell DJ. Sunlight and sunburn in human skin cancer: p53, apoptosis, and tumor promotion. J Invest Dermatol Symp Proc. 1996;1:136-142.
27. Hahn H, Wicking C, Zaphiropoulous PG, et al. Mutations of the human homolog of Drosophila patched in the nevoid basal cell carcinoma syndrome. Cell. 1996;85:841-851.
28. Johnson RL, Rothman AL, Xie J, et al. Human homolog of patched, a candidate gene for the basal cell nevus syndrome. Science. 1996;272:1668-1671.
29. Kripke ML. Immunologic mechanisms in UV radiation carcinogenesis. Adv Cancer Res. 1981;34:89-106.
30. Daynes RA, Bernhard EJ, Gurish MF, Lynch DH. Experimental photoimmunology: immunologic ramifications of UV-induced carcinogenesis. J Invest Dermatol. 1981;77:77-85.
31. Yoshikawa T, Rae V, Bruins-Slot W, Van den Berg JW, Taylor JR, Streilein JW. Susceptibility to effects of UVB radiation on induction of contact hypersensitivity as a risk factor for skin cancer in humans. J Invest Dermatol. 1990;95: 530-536.
32. + epidermal macrophage induction, and Langerhans cell depletion. Proc Natl Acad Sci U S A. 1992;89:8497-8501.
33. Streilein JW, Taylor JR, Vincek V, et al. Immune surveillance and sunlight-induced skin cancer. Immunol Today. 1994;5:174-179.
34. Weimar VM, Ceilley RI, Goeken JA. Cell-mediated immunity in patients with basal and squamous cell skin cancer. J Am Acad Dermatol. 1980;2:143-147
35. Elmets CA, Mukhtar H. Ultraviolet radiation and skin cancer: progress in pathophysiologic mechanisms. Prog Dermatol (Dermatol Found). 1996;30.
36. Ullrich SE. Modulation of immunity by ultraviolet radiation: key effects on antigen presentation. J Invest Dermatol. 1995;105(suppl):30S-36S.
37. Toews GB, Bergstresser PR, Streilein JW. Epidermal Langerhans cell density determines whether contact hypersensitivity or unresponsiveness follows skin painting with DNFB. J Immunol. 1980;124:445-449.
38. Cooper KD, Duraiswamy N, Hammerberg C, et al. Neutrophils, differentiated macrophages, and monocyte/macrophage antigen-presenting cells infiltrate murine epidermis after UV injury. J Invest Dermatol. 1993;101:155-163.
39. + monocytic/macrophagic cells. J Invest Dermatol. 1996;107:755-763.
40. Vermeer M, Streilein JW. Ultraviolet B light-induced alterations in epidermal Langerhans cells are mediated in part by tumor necrosis factor-alpha. Photodermatol Photoimmunol Photomed. 1990;7:258-265.
41. Kondo S, Wang B, Fujisawa H, et al. Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced suppression. J Immunol. 1995;155:3801-3805.
42. Noonan FP, De Fabo EC. Immunosuppression by ultraviolet B radiation: initiation by urocanic acid. Immunol Today. 1992;13:250-257.
43. Kurimoto I, Streilein JW. Cis-urocanic acid suppression of contact hypersensitivity induction is mediated via tumor necrosis factor-α. J Immunol. 1992; 148:3072-3078.
44. Beissert S, Hosoi J, Grabbe S, Asahina A, Granstein RD. IL-10 inhibits tumor antigen presentation by epidermal antigen-presenting cells. J Immunol. 1995; 154:1280-1286.
45. Ullrich SE. Mechanism involved in the systemic suppression of antigen-presenting cell function by UV radiation: keratinocyte-derived IL-10 modulates antigen-presenting cell function of splenic adherent cells. J Immunol. 1994; 152:3410-3416.
46. Ding L, Linsley PS, Huang L-Y, Germain RN, Shevach EM. IL-10 inhibits macrophage costimulatory activity by selectively inhibiting the up-regulation of B7 expression. J Immunol. 1993;151:1224-1234.
47. + T cells. Immunol Rev. 1991;123:209-229.
48. Fisher MS, Kripke ML. Suppressor T lymphocytes control the development of primary skin cancers in ultraviolet-irradiated mice. Science. 1982;216:1133-1134.
49. Schwarz A, Grabbe S, Aragane Y, et al. Interleukin-12 prevents ultraviolet B-induced local immunosuppression and overcomes UVB-induced tolerance. J Invest Dermatol. 1996;106:1187-1191.
50. + cells of the T helper 2 subset. J Immunol. 1990;145:2087-2091.