A novel, chemically robust, amine releasing linker

Tetrahedron Letters

Volumn 38, Issue 39, 1997, Pages 6941-6944

  Kay, Corinne ^a   Murray, Peter John ^a   Sandow, Lisa ^a   Holmes, Andrew B ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE; POLYMER; RESIN; SULFONAMIDE;

ARTICLE; CHEMICAL BINDING; DECOMPOSITION; IMMOBILIZATION; OXIDATION; SOLID; SYNTHESIS;

EID: 0030813392     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(97)01627-4     Document Type: Article

References (28)

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24. NovaSyn BHA resin, ex NovaBiochem, loading: 0.78 mmol/g. The aminocaproic acid spacer was incorporated to improve the efficiency of coupling the sulfonamide linker to the polymeric support; both amide couplings gave a negative Kaiser test.
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26. 2 (4 × 2 ml), and ether (2 × 2 ml) and then dried in vacuo to give the resin bound sulfonamide 7f.
27. 18 reverse phase column (Dynamax 60A, 250 mm, 4.6 mm φ with 10 to 95 % solvent B gradient (1 ml/min) as the mobile phase. [Solvent A: 1% TFA in water; Solvent B; 0.5% TFA in MeCN:water (10 : 1), 15 min gradient time].
28. 22NO: 256.1701; found: 256.1705.