A new linker for primary amines applicable to combinatorial approaches

Bioorganic and Medicinal Chemistry Letters

Volumn 6, Issue 13, 1996, Pages 1525-1528

  Bannwarth, Willi ^a   Huebscher, Josef ^a   Barner, Richard ^a  

^a F HOFFMANN LA ROCHE LTD   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

AMINE;

ARTICLE; DRUG DEGRADATION; DRUG STABILITY; DRUG SYNTHESIS; PEPTIDE SYNTHESIS;

EID: 0030576321     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(96)00258-2     Document Type: Article

References (15)

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3. 3. Semenov, A. N.; Gordeev, K. Y. Inf. J. Peptide Protein Res. 1995, 303.
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11. 11. Caution: Hydrazine is highly toxic and carcinogenic.
12. 12. Knorr, R.; Trzeciak, A.; Bannwarth, W.; Gillessen, D. Tetrahedron Lett. 1989, 30, 1927.
13. 5 (212.20): C 56.60, H 5.70; found: C 56.34, H 5.79.
14. 14. Yan, B.; Kumaravel, G.; Anjaria, H.; Wu, A.; Petter, R. C.; Jewell, Jr., C. F.; Wareing, .J.R. J. Org. Chem. 1995, 60, 5736.
15. 15. Abbreviations: DBU: 1.8-Diazabicyclo[5.4.0]undec-7-eńe; DMAP: Dimethylaminopyridine; FT-IR: FourierTransform-Infrared-Spectroscopy; TFA: Trifluoroacetic acid; TLC: Thin layer chromatography.