Copper, but not iron, enhances apoptosis-inducing activity of antioxidants

Anticancer Research

Volumn 17, Issue 4 A, 1997, Pages 2487-2490

  Satoh, Kazue ^a   Kadofuku, Tsuyoki ^a   Sakagami, Hiroshi ^a,b  

^a SHOWA UNIVERSITY   (Japan)

^b MEIKAI UNIVERSITY SCHOOL OF DENTISTRY   (Japan)

Author keywords

Antioxidants; Apoptosis; Copper; Iron; Methionine oxidation; Radical

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID; CAFFEIC ACID; COPPER CHLORIDE; FERRIC CHLORIDE; FERROUS CHLORIDE; FREE RADICAL; GALLIC ACID; METHIONINE;

APOPTOSIS; ARTICLE; CELL STRAIN HL 60; CONTROLLED STUDY; CYTOTOXICITY; DNA CLEAVAGE; HUMAN; HUMAN CELL; OXIDATION; PRIORITY JOURNAL; PROMYELOCYTIC LEUKEMIA;

ANTIOXIDANTS; APOPTOSIS; ASCORBIC ACID; CAFFEIC ACIDS; COPPER; FREE RADICALS; GALLIC ACID; HL-60 CELLS; HUMANS; IRON; METHIONINE; OXIDATION-REDUCTION;

EID: 0030792406     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (12)

1. Sakagami H, Kuribayashi N, Iida M, Hagiwara T, Takahashi H, Yoshida H, Shiota F, Ohata H, Momose K and Takeda M: The requirement for and mobilization of calcium during induction by sodium ascorbate and by hydrogen peroxide of cell death. Life Sciences 58: 1131-1138, 1996.
2. Kuribayashi N, Sakagami H, Sakagami T, Niimi E, Shiokawa D, Ikekita M, Takeda M and Tanuma S: Induction of DNA fragmentation in human myelogenous leukemic cell lines by sodium 5,6-benzylidene-L-ascorbate and its related compounds. Anticancer Res 14: 969-976, 1994.
3. Sakagami H, Kuribayashi N, Iida M, Sakagami T, Takeda M, Fukuchi K, Gomi K, Ohata H, Momose K, Kawazoe Y, Hatano T, Yoshida T and Okuda T: Induction of DNA fragmentation by tannin- and lignin-related substances. Anticancer Res 15: 2121-2128, 1995.
4. Sakagami H, Satoh K, Ohata H, Takahashi H, Yoshida H, Iida M, Kuribayashi N, Sakagami T, Momose K and Takeda M: Relationship between ascorbyl radical intensity and apoptosis-inducing activity. Anticancer Res 16: 2635-2644, 1996.
5. Sakagami H, Satoh K, Hatano T, Yoshida T and Okuda T: Possible role of radical intensity and oxidation potential for gallic acid-induced apoptosis. Anticancer Res 17: 377-380, 1997.
6. Satoh K and Sakagami H: Effect of metal ions on radical intensity and cytotoxic activity of ascorbate. Anticancer Res 17: in press, 1997.
7. Satoh K and Sakagami H: Effect of copper and iron ions on cytotoxicity induced by ascorbate, gallate and caffeate. Anticancer Res 17: in press, 1997.
8. Sakagami H and Satoh K: Prooxidant action of two antioxidants: ascorbic acid and gallic acid. Anticancer Res 17: 221-224, 1997.
9. Sakagami H, Satoh K, Fukuchi K, Gomi K and Takeda M: Effect of an iron-chelator on ascorbate-induced cytotoxicity. Free Radic Biol Med: 23 in press, 1997.
10. Sakagami H, Satoh K, Kadofuku T and Takeda M: Methionine oxidation and apoptosis induction by ascorbate, gallate and hydrogen peroxide. Anticancer Res 17: in press, 1997.
11. Sakagami H and Satoh K: Effect of ascorbate oxidase on radical intensity and cytotoxic activity of ascorbate. Anticancer Res 17: in press, 1997.
12. Satoh K and Sakagami H: Effect of cysteine, N-acetyl-L-cysteine and glutathione on cytotoxic activity of antioxidants. submitted to Anticancer Res 17: in press, 1997.