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Volumn 92, Issue 10, 1997, Pages 607-614

Inflammation and bone metabolism in rheumatoid arthritis. Pathogenetic aspects and therapeutic options;ENTZUNDUNG UND KNOCHEN-STOFFWECHSEL BEI RHEUMATOIDER ARTHRITIS

Author keywords

Bone metabolism; Inflammation; Proinflammatory cytokines; Rheumatoid arthritis

Indexed keywords

CYTOKINE; INTERLEUKIN 6; NITRIC OXIDE; VITAMIN D; AUTACOID; GLUCOCORTICOID;

EID: 0030780215     PISSN: 07235003     EISSN: None     Source Type: Journal    
DOI: 10.1007/bf03044788     Document Type: Review
Times cited : (18)

References (54)
  • 1
    • 9844238558 scopus 로고
    • The mechanoreceptor for remodeling and the influence of fluoride therapy for osteoporosis on it
    • Regling, G. (ed.): de Gruyter, Berlin - New York
    • Abendroth, K.: The mechanoreceptor for remodeling and the influence of fluoride therapy for osteoporosis on it. In: Regling, G. (ed.): Wollfs law and connective tissue regulation. de Gruyter, Berlin - New York 1992, S. 199-202.
    • (1992) Wollfs Law and Connective Tissue Regulation , pp. 199-202
    • Abendroth, K.1
  • 3
    • 0030958348 scopus 로고    scopus 로고
    • Wirkungsmechanismus der Glukokortikoide
    • Berl.
    • Bamberger, C M., H. M. Schulte: Wirkungsmechanismus der Glukokortikoide. Internist (Berl.) 38 (1997), 366-370.
    • (1997) Internist , vol.38 , pp. 366-370
    • Bamberger, C.M.1    Schulte, H.M.2
  • 4
    • 0030025735 scopus 로고    scopus 로고
    • Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells
    • Bellido, T., N. Stahl, T. J. Farruggella, V. Borba, G. D. Yancopoulos, S. C. Manolagas: Detection of receptors for interleukin-6, interleukin-11, leukemia inhibitory factor, oncostatin M, and ciliary neurotrophic factor in bone marrow stromal/osteoblastic cells. J. clin. Invest. 97 (1996), 431-437
    • (1996) J. Clin. Invest. , vol.97 , pp. 431-437
    • Bellido, T.1    Stahl, N.2    Farruggella, T.J.3    Borba, V.4    Yancopoulos, G.D.5    Manolagas, S.C.6
  • 5
    • 0028988403 scopus 로고
    • Structure-function relationships in the vitamin D endocrine system
    • Bouillon, R., W. H. Okamura, A. W. Norman: Structure-function relationships in the vitamin D endocrine system. Endocr. Rev.16 (1995) 200-257.
    • (1995) Endocr. Rev. , vol.16 , pp. 200-257
    • Bouillon, R.1    Okamura, W.H.2    Norman, A.W.3
  • 6
    • 9844230808 scopus 로고    scopus 로고
    • Bisphosphonate-induced apoptosis in J774 macrophages is associated with cell cycle arrest and decreased levels of bcl-2
    • Chilron, K. M., R. G. G. Russell, M. J. Rogers: Bisphosphonate-induced apoptosis in J774 macrophages is associated with cell cycle arrest and decreased levels of bcl-2. Bone 20, Suppl. (1997), 113S.
    • (1997) Bone , vol.20 , Issue.SUPPL.
    • Chilron, K.M.1    Russell, R.G.G.2    Rogers, M.J.3
  • 7
    • 0028809787 scopus 로고
    • The role of vitamin D metabolites in the treatment of osteoporosis
    • Civitelli, R.: The role of vitamin D metabolites in the treatment of osteoporosis. Calcif. Tiss. int. 57 (1995), 409-414.
    • (1995) Calcif. Tiss. Int. , vol.57 , pp. 409-414
    • Civitelli, R.1
  • 9
    • 0028813868 scopus 로고
    • Sex hormones, glucocorticoids and autoimmunity: Facts and hypothesis
    • Da Silva, J. A. P.: Sex hormones, glucocorticoids and autoimmunity: facts and hypothesis. Ann. rheum. Dis. 54 (1995), 6-16.
    • (1995) Ann. Rheum. Dis. , vol.54 , pp. 6-16
    • Da Silva, J.A.P.1
  • 10
    • 0029868840 scopus 로고    scopus 로고
    • Bone mass measurement and bone metabolism in rheumatoid arthritis: A review
    • Deodhar, A. A., A. D. Woolf: Bone mass measurement and bone metabolism in rheumatoid arthritis: a review. Brit. J. Rheum. 35 (1996), 309-322.
    • (1996) Brit. J. Rheum. , vol.35 , pp. 309-322
    • Deodhar, A.A.1    Woolf, A.D.2
  • 13
    • 0008069582 scopus 로고
    • Influence of inflammation and corticosteroid treatment on indices of bone turnover and parathyroid function
    • Ekenstam, E : Influence of inflammation and corticosteroid treatment on indices of bone turnover and parathyroid function. Scand. J. Rheum. 20 (1991), 220.
    • (1991) Scand. J. Rheum. , vol.20 , pp. 220
    • Ekenstam, E.1
  • 14
    • 0026554157 scopus 로고
    • The role of changes in mechanical usage set points in the pathogenesis of osteoporosis
    • Frost, H. M.: The role of changes in mechanical usage set points in the pathogenesis of osteoporosis. J. Bone Miner. Res. 7 (1992), 253-261.
    • (1992) J. Bone Miner. Res. , vol.7 , pp. 253-261
    • Frost, H.M.1
  • 15
    • 0028305241 scopus 로고
    • Generalised bone loss in patients with early rheumatoid arthritis
    • Gough, A. K., J. Lilley, S Eyre, R. L. Holder, P. Emery: Generalised bone loss in patients with early rheumatoid arthritis. Lancet 344 (1994), 23-27.
    • (1994) Lancet , vol.344 , pp. 23-27
    • Gough, A.K.1    Lilley, J.2    Eyre, S.3    Holder, R.L.4    Emery, P.5
  • 16
    • 0028147482 scopus 로고
    • Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis
    • Gough, A. K., N. F. Peel, R. Eastell, R. L. Holder, J. Lilley, P. Emery: Excretion of pyridinium crosslinks correlates with disease activity and appendicular bone loss in early rheumatoid arthritis. Ann. rheum. Dis. 53 (1994), 14-17.
    • (1994) Ann. Rheum. Dis. , vol.53 , pp. 14-17
    • Gough, A.K.1    Peel, N.F.2    Eastell, R.3    Holder, R.L.4    Lilley, J.5    Emery, P.6
  • 17
    • 0027394582 scopus 로고
    • Modulation of monocyte activation in patients with rheumatoid arthritis by leukaperesis therapy
    • Hahn, G., B. Stuhlmuller, N. Hain, J. R. Kalden, K. Pfizenmaier, G. R. Burmester: Modulation of monocyte activation in patients with rheumatoid arthritis by leukaperesis therapy. J. clin. Invest. 91 (1993), 862-870.
    • (1993) J. Clin. Invest. , vol.91 , pp. 862-870
    • Hahn, G.1    Stuhlmuller, B.2    Hain, N.3    Kalden, J.R.4    Pfizenmaier, K.5    Burmester, G.R.6
  • 18
    • 0028235096 scopus 로고
    • Vitamin D metabolism and bone mineralization in children with juvenile rheumatoid arthritis
    • Hillman, L., J T. Cassidy, L. Johnson, D. Lee, S. H. Allen Vitamin D metabolism and bone mineralization in children with juvenile rheumatoid arthritis. J. Pediat. 124 (1994), 910-916.
    • (1994) J. Pediat. , vol.124 , pp. 910-916
    • Hillman, L.1    Cassidy, J.T.2    Johnson, L.3    Lee, D.4    Allen, S.H.5
  • 19
    • 0029970622 scopus 로고    scopus 로고
    • Accelerated generation of CD14+ monocyte-lineage cells from the bone marrow of rheumatoid arthritis patients
    • Hirohata, S., T. Yanagida, K. Itoh, H. Nakamura, S. Yoshino, T. Tomita, T. Ochi: Accelerated generation of CD14+ monocyte-lineage cells from the bone marrow of rheumatoid arthritis patients. Arthr. and Rheum 39 (1996), 836-843.
    • (1996) Arthr. and Rheum , vol.39 , pp. 836-843
    • Hirohata, S.1    Yanagida, T.2    Itoh, K.3    Nakamura, H.4    Yoshino, S.5    Tomita, T.6    Ochi, T.7
  • 21
    • 0028793469 scopus 로고
    • Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity
    • Hukkanen, M., F. J. Hughes, L. D. Buttery, S. S. Gross, T. J. Evans, S. Seddon, V. Riveros-Moreno, I. Macintyre, J. M. Polak: Cytokine-stimulated expression of inducible nitric oxide synthase by mouse, rat, and human osteoblast-like cells and its functional role in osteoblast metabolic activity. Endocrinology 136 (1995), 5445-5453.
    • (1995) Endocrinology , vol.136 , pp. 5445-5453
    • Hukkanen, M.1    Hughes, F.J.2    Buttery, L.D.3    Gross, S.S.4    Evans, T.J.5    Seddon, S.6    Riveros-Moreno, V.7    Macintyre, I.8    Polak, J.M.9
  • 22
    • 9844223792 scopus 로고    scopus 로고
    • Involvement of different second messengers in PTH- and IL-1 stimulated IL-6 production in human bone marrow stromal cells
    • Kim, G . C. Choi, E. Kim, J. Park, K. U Lee: Involvement of different second messengers in PTH- and IL-1 stimulated IL-6 production in human bone marrow stromal cells. Osteoporos. int. 6, Suppl. 1 (1996), S100.
    • (1996) Osteoporos. Int. , vol.6 , Issue.1 SUPPL.
    • Kim, G..1    Choi, C.2    Kim, E.3    Park, J.4    Lee, K.U.5
  • 23
    • 0030051507 scopus 로고    scopus 로고
    • Proinflammatory cytokines downregulate platelet derived growth factor-alpha receptor gene expression in human osteoblastic cells
    • Kose, K. N., J. F Xie, D. L. Carnes, D T. Graves: Proinflammatory cytokines downregulate platelet derived growth factor-alpha receptor gene expression in human osteoblastic cells. J. cell. Physiol. 166 (1996), 188-197.
    • (1996) J. Cell. Physiol. , vol.166 , pp. 188-197
    • Kose, K.N.1    Xie, J.F.2    Carnes, D.L.3    Graves, D.T.4
  • 25
    • 0027200481 scopus 로고
    • Low serum vitamin D metabolites in women with rheumatoid arthritis
    • Kröger, H., I. M. Penttilä, E. M. Alhava: Low serum vitamin D metabolites in women with rheumatoid arthritis. Scand. J. Rheum. 22 (1993), 172-177.
    • (1993) Scand. J. Rheum. , vol.22 , pp. 172-177
    • Kröger, H.1    Penttilä, I.M.2    Alhava, E.M.3
  • 26
    • 0028355588 scopus 로고
    • Effects of cytokines on alkaline phosphatase and osteocalcin production, calcification and calcium release by human osteoblastic cells
    • Kuroki, T., M. Shingu, Y. Koshihara, M Nobunaga: Effects of cytokines on alkaline phosphatase and osteocalcin production, calcification and calcium release by human osteoblastic cells. Brit. J. Rheum. 33 (1994), 224-230.
    • (1994) Brit. J. Rheum. , vol.33 , pp. 224-230
    • Kuroki, T.1    Shingu, M.2    Koshihara, Y.3    Nobunaga, M.4
  • 27
    • 0027388832 scopus 로고
    • Bone mineral density in patients with recent onset rheumatoid arthritis. influence of disease activity and functional capacity
    • Laan, R. F. J. M., W. C. A. M. Buijs, A. L. M. Verbeek: Bone mineral density in patients with recent onset rheumatoid arthritis. influence of disease activity and functional capacity Ann. rheum. Dis. 52 (1993), 21-26.
    • (1993) Ann. Rheum. Dis. , vol.52 , pp. 21-26
    • Laan, R.F.J.M.1    Buijs, W.C.A.M.2    Verbeek, A.L.M.3
  • 29
    • 0028925088 scopus 로고
    • Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis
    • Manolagas, S. C., R. L. Jilka: Bone marrow, cytokines, and bone remodeling. Emerging insights into the pathophysiology of osteoporosis: New Engl. J. Med. 332 (1995), 305-311.
    • (1995) New Engl. J. Med. , vol.332 , pp. 305-311
    • Manolagas, S.C.1    Jilka, R.L.2
  • 30
    • 0029090688 scopus 로고
    • Sex hormone status and bone mineral density in men with rheumatoid arthritis
    • Mateo, L., J. M. Nolla, M. R. Bonnin, M. A. Navarro, D. Roig-Escofet: Sex hormone status and bone mineral density in men with rheumatoid arthritis. J. Rheum 22 (1995), 1455-1460.
    • (1995) J. Rheum , vol.22 , pp. 1455-1460
    • Mateo, L.1    Nolla, J.M.2    Bonnin, M.R.3    Navarro, M.A.4    Roig-Escofet, D.5
  • 31
    • 0027183706 scopus 로고
    • Tumor necrosis factor alpha decreases 1,25-dihydroxyvitamin D3 receptors in osteoblastic ROS 17/2.8 cells
    • Mayur, N., S. Lewis, B. D Catherwood, M. S. Nanes: Tumor necrosis factor alpha decreases 1,25-dihydroxyvitamin D3 receptors in osteoblastic ROS 17/2.8 cells. J. Bone Miner. Res. 8 (1993), 997-1003.
    • (1993) J. Bone Miner. Res. , vol.8 , pp. 997-1003
    • Mayur, N.1    Lewis, S.2    Catherwood, B.D.3    Nanes, M.S.4
  • 32
    • 0344897839 scopus 로고    scopus 로고
    • Effect of cyclical etidronate on BMD in steroid treated RA
    • McGill, P. E., H. Kerr, A. Stirling: Effect of cyclical etidronate on BMD in steroid treated RA. Bone 20, Suppl. (1997), S99.
    • (1997) Bone , vol.20 , Issue.SUPPL.
    • McGill, P.E.1    Kerr, H.2    Stirling, A.3
  • 33
    • 0025776117 scopus 로고
    • Predictors of fractures in early rheumtoid arthritis
    • Michel, B.A., D.A. Bloch, J.F. Fries: Predictors of fractures in early rheumtoid arthritis. J. Rheumatol. 18 (1991), 804-808.
    • (1991) J. Rheumatol. , vol.18 , pp. 804-808
    • Michel, B.A.1    Bloch, D.A.2    Fries, J.F.3
  • 34
    • 0027131929 scopus 로고
    • Fractures in rheumatoid arthritis. an evaluation of associated risk factors
    • Michel, B. A., D. A. Bloch, F. Wolfe, J. F. Fries: Fractures in rheumatoid arthritis. an evaluation of associated risk factors. J. Rheum. 20 (1993), 1666-1669.
    • (1993) J. Rheum. , vol.20 , pp. 1666-1669
    • Michel, B.A.1    Bloch, D.A.2    Wolfe, F.3    Fries, J.F.4
  • 35
    • 0027163599 scopus 로고
    • The effects of liposome-encapsulated and free clodronate on the growth of macropage-like cells in vitro: The role of calcium and iron
    • Mönkkönen, J., T. D. Heath: The effects of liposome-encapsulated and free clodronate on the growth of macropage-like cells in vitro: the role of calcium and iron. Calcif. Tiss. int. 53 (1995), 139-146.
    • (1995) Calcif. Tiss. Int. , vol.53 , pp. 139-146
    • Mönkkönen, J.1    Heath, T.D.2
  • 36
  • 38
    • 9844269968 scopus 로고    scopus 로고
    • Relationship between disease activity and serum levels of 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and PTH in patients with rheumatoid arthritis
    • Oelzner, P., A. Muller, T. Eidner, K Abendroth, G. Hein, G. Stein: Relationship between disease activity and serum levels of 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and PTH in patients with rheumatoid arthritis. Osteoporos. int. 6, Suppl. 1 (1996), S276.
    • (1996) Osteoporos. Int. , vol.6 , Issue.1 SUPPL.
    • Oelzner, P.1    Muller, A.2    Eidner, T.3    Abendroth, K.4    Hein, G.5    Stein, G.6
  • 39
    • 84865937753 scopus 로고    scopus 로고
    • Correlation between serum levels of calcium-regulating hormones and soluble markers of immune activation in patients with rheumatoid arthritis
    • Oelzner, P., S. Franke, A. Müller, F. Deschner, K. Abendroth, G Hein, A. Hüller, G Stein: Correlation between serum levels of calcium-regulating hormones and soluble markers of immune activation in patients with rheumatoid arthritis. Bone 20, Suppl (1997), 89S
    • (1997) Bone , vol.20 , Issue.SUPPL.
    • Oelzner, P.1    Franke, S.2    Müller, A.3    Deschner, F.4    Abendroth, K.5    Hein, G.6    Hüller, A.7    Stein, G.8
  • 40
    • 0028935929 scopus 로고
    • Cytokines and osteoclast activity
    • Pacifici, R.: Cytokines and osteoclast activity. Calcif. Tiss. int. 56, Suppl 1 (1995), S27-28.
    • (1995) Calcif. Tiss. Int. , vol.56 , Issue.1 SUPPL.
    • Pacifici, R.1
  • 41
    • 0028841832 scopus 로고
    • Risk of vertebral fracture and relationship to bone mineral density in steroid treated rheumatoid arthritis
    • Peel, N. F., D. J. Moore, N. A. Barrington, D. E. Bax, R. Eastell: Risk of vertebral fracture and relationship to bone mineral density in steroid treated rheumatoid arthritis. Ann. rheum. Dis 54 (1995). 801-806.
    • (1995) Ann. Rheum. Dis , vol.54 , pp. 801-806
    • Peel, N.F.1    Moore, D.J.2    Barrington, N.A.3    Bax, D.E.4    Eastell, R.5
  • 42
    • 4243760560 scopus 로고
    • The effect of liposome encapsulated and free bisphosphonates on IL-Iß, IL-6, TNF alpha secretion from macrophages
    • Pennanen, N., T. Nissinen, S. Lapinjoki, A. Urrti, J. Mönkkönen: The effect of liposome encapsulated and free bisphosphonates on IL-Iß, IL-6, TNF alpha secretion from macrophages. Bone Miner. Res. 25 (1994), S67.
    • (1994) Bone Miner. Res. , vol.25
    • Pennanen, N.1    Nissinen, T.2    Lapinjoki, S.3    Urrti, A.4    Mönkkönen, J.5
  • 43
    • 0029969638 scopus 로고    scopus 로고
    • Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis
    • Pepmueller, P. H., J. T. Cassidy, S. H. Allen, L. S. Hillman: Bone mineralization and bone mineral metabolism in children with juvenile rheumatoid arthritis. Arthr. and Rheum. 39 (1996), 746-757.
    • (1996) Arthr. and Rheum. , vol.39 , pp. 746-757
    • Pepmueller, P.H.1    Cassidy, J.T.2    Allen, S.H.3    Hillman, L.S.4
  • 44
    • 9844244984 scopus 로고    scopus 로고
    • Nitric oxide and bone
    • Ralston, S. H.: Nitric oxide and bone. Bone 20, Suppl. (1997), 3S.
    • (1997) Bone , vol.20 , Issue.SUPPL.
    • Ralston, S.H.1
  • 45
    • 0030140934 scopus 로고    scopus 로고
    • Generalisierte Osteoporose bei chronischer Polyarthritis - Pathomechanismen und Behandlungs-ansätze
    • Ringe, J. D.: Generalisierte Osteoporose bei chronischer Polyarthritis - Pathomechanismen und Behandlungs-ansätze. Z. Rheum. 55 (1996), 149-157.
    • (1996) Z. Rheum. , vol.55 , pp. 149-157
    • Ringe, J.D.1
  • 46
    • 15844429135 scopus 로고    scopus 로고
    • The role of gp130-mediated signals in osteoclast development: Regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures
    • Romas, E., N. Udagawa, H. Zhou, T. Tamura, M. Saito, T. Taga, D. J. Hilton, T. Suda, K. W. Ng, T. J. Martin: The role of gp130-mediated signals in osteoclast development: regulation of interleukin 11 production by osteoblasts and distribution of its receptor in bone marrow cultures. J. exp. Med. 183 (1996), 2581-2591.
    • (1996) J. Exp. Med. , vol.183 , pp. 2581-2591
    • Romas, E.1    Udagawa, N.2    Zhou, H.3    Tamura, T.4    Saito, M.5    Taga, T.6    Hilton, D.J.7    Suda, T.8    Ng, K.W.9    Martin, T.J.10
  • 48
  • 49
    • 0021969110 scopus 로고
    • Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis
    • Shimizu, S., S. Shiozawa, K. Shiozawa, S. Imura, T. Fujita: Quantitative histologic studies on the pathogenesis of periarticular osteoporosis in rheumatoid arthritis. Arthr. and Rheum. 28 (1985), 25-23.
    • (1985) Arthr. and Rheum. , vol.28 , pp. 25-123
    • Shimizu, S.1    Shiozawa, S.2    Shiozawa, K.3    Imura, S.4    Fujita, T.5
  • 50
    • 0028786577 scopus 로고
    • Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors
    • Udagawa, N., N. Takahashi, T. Katagiri, T. Tamura, S. Wada, D. M Findlay, T. J. Martin, H. Hirota, T. Taga, T. Kishimoto: Interleukin (IL)-6 induction of osteoclast differentiation depends on IL-6 receptors expressed on osteoblastic cells but not on osteoclast progenitors. J. exp. Med. 182 (1995), 1461-1468.
    • (1995) J. Exp. Med. , vol.182 , pp. 1461-1468
    • Udagawa, N.1    Takahashi, N.2    Katagiri, T.3    Tamura, T.4    Wada, S.5    Findlay, D.M.6    Martin, T.J.7    Hirota, H.8    Taga, T.9    Kishimoto, T.10
  • 51
    • 0024453739 scopus 로고
    • Prevention of postmenopausal bone loss in rheumatoid arthritis patients. A two year prospective study
    • Verstraeten, A., J. Dequeker, J. Nijs, P. Geusens: Prevention of postmenopausal bone loss in rheumatoid arthritis patients. A two year prospective study. Clin. exp. Rheum. 7 (1989), 351-358.
    • (1989) Clin. Exp. Rheum. , vol.7 , pp. 351-358
    • Verstraeten, A.1    Dequeker, J.2    Nijs, J.3    Geusens, P.4
  • 53
    • 0028224940 scopus 로고
    • Expression of monocyte chemoattractant protein 1 in human osteoblastic cells stimulated by proinflammatory mediators
    • Zhu, J. F., A J. Valente, J. A. Lorenzo, D. Carnes, D. T. Graves. Expression of monocyte chemoattractant protein 1 in human osteoblastic cells stimulated by proinflammatory mediators. J. Bone Miner. Res. 9 (1994), 1123-1130.
    • (1994) J. Bone Miner. Res. , vol.9 , pp. 1123-1130
    • Zhu, J.F.1    Valente, A.J.2    Lorenzo, J.A.3    Carnes, D.4    Graves, D.T.5
  • 54
    • 0029864560 scopus 로고    scopus 로고
    • Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. American College of Rheumatology Task Force on Osteoporosis Guidelines
    • Recommendations for the prevention and treatment of glucocorticoid-induced osteoporosis. American College of Rheumatology Task Force on Osteoporosis Guidelines. Arthr. and Rheum. 39 (1996), 1791-1801.
    • (1996) Arthr. and Rheum. , vol.39 , pp. 1791-1801


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