Comparison and in vivo relevance of two different in vitro head space metabolic systems: Liver S9 and liver slices

Pharmacology and Toxicology

Volumn 81, Issue 1, 1997, Pages 35-41

  Mortensen, Bjarte ^a   Løkken, Torbjørn ^b   Zahlsen, Kolbjørn ^a,b   Nilsen, Odd G ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b Bioanalytica   (Norway)

Author keywords

[No Author keywords available]

Indexed keywords

ACETONE; CYTOCHROME P450; DIETHYLDITHIOCARBAMIC ACID; HEXANE; PHENOBARBITAL; TOLUENE; VOLATILE AGENT;

ANIMAL TISSUE; ARTICLE; COMPARATIVE STUDY; LIVER CELL; LIVER MICROSOME METABOLISM; LIVER SLICE; MALE; METHODOLOGY; NONHUMAN; PREDICTION; PRIORITY JOURNAL; RAT; TOXICOKINETICS;

ANIMALIA;

EID: 0030756922     PISSN: 09019928     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1600-0773.1997.tb00028.x     Document Type: Article

References (43)

1. Andersen, M. E.: Physiological modelling of organic compounds. Ann. Occup. Hvg. 1991, 3, 309-321.
2. Andersen, M. E., H. J. Clewell III, D. A. Mahle & J. M. Gearhart: Gas uptake studies of deuterium isotope effects on dichloromethane metabolism in female B6C3F1 mice in vivo. Toxicol. Appl. Pharmacol. 1996, 128, 158-165.
3. Bach, P. H., A. E. M. Vickers, R. Fisher, A. Baumann, E. Brittebo, D. J. Carlile, H. J. Koster, B. G. Lake, F. Salmon, T. W. Sawyer & G. Skibinski: The use of tissue slices for pharmacotoxicology studies. ATLA 1996, 24, 893-919.
4. Battershill, J. M., H. P. A. Illing, R. O. Shillaker & A. M. Smith: Toxicity Review 18, n-Hexane. Health and Safety Executive, London, HMSO 1987.
5. Bayliss, M. K., J. A. Bell, K. Wilson & G. R. Park: 7-ethoxycoumarin O-deethylase kinetics in isolated rat, dog and human hepatocyte suspensions. Xenobiotics 1994, 3, 231-241.
6. Bell, G. M., J. M. Battershill & R. O. Shillaker: Toxicity Review 20. Toluene. Health and Safety Executive, London, HMSO, 1989.
7. Bisgaard, H. C. & H. R. Lam: In vitro and in vivo studies on the metabolism of 1,3-diaminobenzene: comparison of metabolite formed by the perfused rat liver, primary rat hepatocyte cultures, hepatic rat microsomes and the whole rat. Toxic. in Vitro 1989, 3, 167-174.
8. Brady, J. F., F. Xiao, M.-H. Wang, Y. Li, S. M. Ning, J. M. Gapac & C. S. Yang: Effects of disulfiram on hepatic P450IIE1, other microsomal enzymes and hepatotoxicity in rats. Toxicol. Appl. Pharmacol. 1991, 108, 366-373.
9. Carfagna, M. A. & G. L. Kedderis: Isolated hepatocytes as in vitro models for the biotransformation and toxicity of chemicals in vivo. CIIT Act. 1992, 12, 1-6.
10. 14C]toluene by human and rat liver microsomal fractions and liver slices. Drug. Metab. Dispos. 1990, 6, 929-936.
11. Chua, S. C., B. L. Lee, L. S. Liau & C. N. Ong: Determination of mandelic acid and phenylglyoxic acid in the urine and its use in monitoring of styrene exposure. J. Anal. Toxicol. 1993, 17, 120-132.
12. Dale, O., T. Holten & T. Nørkov: Rat liver slices: Metabolic changes during short time incubation in glucose-free buffer. Pharmacology & Toxicology 1990, 67, 88-90.
13. DeJongh, J. & B. J. Blaauboer: Simulation of toluene kinetics in the rat by a physiologically based pharmacokinetic model with application of biotransformation parameters derived independently in vitro and in vivo. Fund. Appl. Toxicol. 1996, 32, 260-268.
14. Fedtke, N. & H. M. Bolt: Methodological investigations on the determination of n-hexane metabolites in the urine. Int. Arch. Occup. Environm. Health 1986, 57, 149-158.
15. Filser, J. G.: The closed chamber technique-uptake, endogenous production, excretion, steady-state kinetics and rates of metabolism of gases and vapors. Arch. Toxicol. 1992, 66, 1-10.
16. Gargas, M. L., R. J. Burgess, D. E. Voisard, G. H. Cason & M. E. Andersen: Partition coefficients of low-molecular weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 1989, 98, 87-99.
17. Gargas, M. L.: Chemical-specific constants for physiologically-based pharmacokinetic models. CIIT Act. 1991, 3, 1-9.
18. Guengerich, F. P., D.-H. Kim & M. Iwasaki: Role of human cytochrome P-450 IIE1 in the oxidation of many low molecular weight cancer suspects. Chem. Res. Toxicol. 1991, 4, 168-179.
19. Guengerich, F. P., L. C. Bell & O. Okazaki; Interpretations of cytochrome P450 mechanisms from kinetic studies. Biochimie 1995, 77, 573-580.
20. Halpert, J. R., F. P. Guengerich, J. R. Bend & M. A. Correia: Selective inhibitors of cytochrome P450. Toxicol. Appl. Pharmacol. 1994, 125, 163-175.
21. Hilderbrand, R. L. & M. E. Andersen: In vivo kinetic constants for the metabolism of inhaled hydrocarbon toxicants as determined by gas uptake methods. Toxicologist 1981, 1, 86-87.
22. Hilderbrand, R. L., M. E. Andersen & L. J. Jr. Jenkins: Prediction of in vivo kinetic constants for metabolism of inhaled vapours from kinetic constants measured in vitro. Fund. Appl. Toxicol. 1981, 1, 403-409.
23. Kaneko, T., P.-Y. Wang, H. Tsukada & A. Sato: m-Xylene toxicokinetics in phenobarbital-treated rats: comparison among inhalation exposure, oral administration, and intraperitoneal administration. Toxicol. Appl. Pharmacol. 1995, 131, 13-20.
24. Kedderis, G. L., M. A. Carfagna, S. D. Held, R. Batra, J. E. Murphy & M. L. Gargas: Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro. Toxicol. Appl. Pharmacol. 1993, 123, 274-282.
25. Kedderis, G. I. & S. D. Held: Prediction of furan pharmacokinetics from hepatocyte studies: comparison of bioactivation and hepatic dosimetry in rats, mice, and humans. Toxicol. Appl. Pharmacol. 1996, 140, 124-130.
26. Kim, C., R. O. Manning, R. P. Brown & J. V. Bruckner: Use of the vial equilibration technique for determination of metabolic rate constants for dichloromethane. Toxicol. Appl. Pharmacol. 1996, 139, 243-251.
27. Koop, D. R.: Oxidative and reductive metabolism of cytochrome P450 2E1. FASEB J. 1992, 2, 724-730.
28. Krishnan, K., M. L. Gargas & M. E. Andersen: In vitro toxicology and risk assessment. Altern. Meth. Toxicol. 1993, 9, 185-203.
29. Krishnan, K. & M. E. Andersen: Physiologically based pharmacokinetic modeling in toxicology. In: Principles and methods in toxicology, 3rd ed. Ed: A. Wallace Hayes. Raven Press Ltd., New York, 1994, 149-188.
30. Lowry O. H., N. J. Rosebrough, A. L. Farr & R. J. Randall: Protein measurement with the Folin phenol reagent. J. Biol. Chem. 1951, 193, 262-75.
31. Medinsky, M. A., T. L. Leavens, G. A. Csanády, M. L. Gargas & J. A. Bond: In vivo metabolism of butadiene by mice and rats: a comparison of physiological model predictions and experimental data. Carcinogenesis 1994, 7, 1329-1340.
32. Mràz, J., P. Jheeta, A. Gecher, R. Hyland, K. Thummel & M. D. Threadgill: Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1. Chem. Res. Toxicol. 1993, 6, 197-207.
33. Nakajima, T., R.-S. Wang & N. Murayama: Immunochemical assessment of the influence of nutritional, physiological and environmental factors on the elimination of toluene. Int. Arch. Occup. Environ. Health. 1993, 65, 127-130.
34. Omura, T. & R. Sato: The carbon monoxide-binding pigment of liver microsomes. I. Evidence for its hemoprotein nature. J. Biol. Chem. 1964, 239, 2370-2378.
35. Perbellini, L., G. Pezzoli, F. Brugnone & M. Canesi: Biochemical and physiological aspects of 2,5-hexanedione: endogenous or exogenous product? Int. Arch. Occup. Environ. Health. 1993, 65, 49-52.
36. Purcell, K. J., G. H. Cason, M. L. Gargas, M. E. Andersen & C. C. Travis: In vivo metabolic interactions of benzene and toluene. Toxicol. Lett. 1990, 52, 141-152.
37. Reitz, R. H., A. L. Mendrala & F.P. Guengerich: In vitro metabolism of methylene chloride in human and animal tissues: use in physiologically based pharmacokinetics. Toxicol. Appl. Pharmacol. 1989, 97, 230-246.
38. Sato, A. & T. Nakajima: Dose-dependent metabolic interaction between benzene and toluene in vivo and in vitro. Toxicol. Appl. Pharmacol. 1979, 48, 249-256.
39. Sato, A. & T. Nakajima: Pharmacokinetics of organic solvent vapours in relation to their toxicity. Scand. J. Work Environ. Health 1987, 13, 81-93.
40. Smith, P. F., R. McKee, A. J. Gandolfi, C. L. Krumdieck, R. Fisher & K. Brendel: Precision cut liver slices: a new in vitro tool in toxicology. In: In vitro models in toxicology. Ed.: C. A. McQueen. Telford Press, New Jersey, 1989, 93-130.
41. Toftgård, R., T. Haaparanta, L. Eng & J. Halpert: Rat lung and liver microsomal cytochrome P-45 isozymes involved in the hydroxylation of n-hexane. Biochem. Pharmacol. 1986, 21, 3733-38.
42. Worboys, P. D., A. Bradbury & B. J. Houston: Kinetics of drug metabolism in rat liver slices. II. Comparison of clearance by liver slices and freshly isolated hepatocytes. Drug Metab. Dispos. 1996, 24, 676-681.
43. Zbinden, G.: Alternatives to animal experimentation; developing in vitro methods and changing legislation. Trends Pharmacol. Sci. 1990, 11, 104-107.