Simulation of toluene kinetics in the rat by a physiologically based pharmacokinetic model with application of biotransformation parameters derived independently in vitro and in vivo

Fundamental and Applied Toxicology

Volumn 32, Issue 2, 1996, Pages 260-268

  DeJongh, Joost ^a   Blaauboer, Bas J ^a  

^a Research Institute of Toxicology   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

TOLUENE;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BIOTRANSFORMATION; BRAIN TISSUE; COMPUTER SIMULATION; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG BRAIN LEVEL; DRUG UPTAKE; EXPERIMENTAL MODEL; IN VITRO STUDY; NONHUMAN; PARTITION COEFFICIENT; PHARMACOKINETICS; PREDICTION; RAT; TECHNIQUE;

ANIMALIA;

EID: 26844575255     PISSN: 02720590     EISSN: None     Source Type: Journal    
DOI: 10.1006/faat.1996.0129     Document Type: Article

References (40)

1. Andersen, M. E. (1991). Physiological modelling of organic compounds. Ann. Occup. Hyg. 35, 309-321.
2. Anderson, Y. B., Jackson, J. A., and Birnbaum, L. S. (1993). Maturational changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in Fisher 344 rats. Toxicol. Appl. Pharmacol. 119, 214-220.
3. Arms, A. D., and Travis, C. C. (1988). Reference physiological parameters in pharmacokinetic modeling. U.S. Environmental Protection Agency, EPA 600/6-88/004.
4. Bailey, J. W., Andersen, D. B., Versiegen, M. W. A., and Curtis, S. E. (1980). Relative growth rates of various fat depots in Sprague-Dawley rats. Growth 44, 220-229.
5. Banks, Y. B., Brewster, D. W., and Birnbaum, L. S. (1990). Age-related changes in dermal absorption of 2,3,7,8-tetrachlorodibenzo-p-dioxin and 2,3,4,7,8-pentachlorodibenzofuran. Fundam. Appl. Toxicol. 15, 163-173.
6. Benignus, V. A. (1981). Health effects of toluene: A review. Neurotoxicology 2, 567-588.
7. Benignus, V. A., Muller, K. E., Barton, C. N., and Bittikofer, J. A. (1981). Toluene levels in blood and brain of rats during and after respiratory exposure. Toxicol. Appl. Pharmacol. 61, 326-334.
8. Benignus, V. A., Muller, K. E., Graham, J. A., and Barton, C. N. (1984). Toluene levels in blood and brain of rats as a function of toluene level in inspired air. Environ. Res. 33, 39-46.
9. Bois, F. Y., Woodruff, T. J., and Spear, R. C. (1991). Comparison of three physiologically based pharmacokinetic models of benzene disposition. Toxicol. Appl. Pharmacol. 110, 79-89.
10. Clewell, H. J. (1993). Coupling of computer modeling with in vitro method-ologies to reduce animal usage in toxicity testing. Toxicol. Lett. 68, 101-117.
11. Clewell, H. J., and Andersen, M. E. (1986). A multiple dose physiological pharmacokinetic model for volatile chemicals using ACSL/PC. In Languages for Continuous System Simulation (F. D. Cellier, Ed.), pp. 95-101. Soc. for Computer Simulation, San Diego.
12. 14C]toluene by human and rat liver microsomal fractions and liver slices. Drug Metab. Dispos. 18, 929-936.
13. DeJongh, J., and Blaauboer, B. J. (1995). Prediction of benzene metabolism by a PB-PK model through application of biotransformation constants derived in vitro. ATLA, in press.
14. Fiserova-Bergerova, V., and Diaz, M. L. (1986). Determination and prediction of tissue-gas partition coefficients. Int. Arch. Occup. Environ. Health 58, 75-87.
15. Fornazzari, L., Wilkinson, D. A., Kapur, B. M., and Carlen, P. L. (1983). Cerebellar, cortical and functional impairment in toluene abusers. Acta Neurol. Scand. 67, 319-329.
16. Freundt, K. J., Römer, K. G., and Federsei, R. J. (1989). Decrease of inhaled toluene, ethyl benzene, m-xylene, or mesitylene in rat blood after combined exposure to ethyl acetate. Bull. Environ. Contam. Toxicol. 42, 495-498.
17. Gargas, M. L., Andersen, M. E., and Clewell, H. J. (1986). A physiologically based simulation approach for determining metabolic constants from gas uptake data. Toxicol. Appl. Pharmacol. 86, 341-352.
18. Gargas, M. L., Burgess, R. J., Voisard, D. E., Cason, G. H., and Andersen M. E. (1989). Partition coefficients of low-molecular-weight volatile chemicals in various liquids and tissues. Toxicol. Appl. Pharmacol. 98, 87-99.
19. Gearhart, J. M., Jepson, G. W., Clewell, H. J., Andersen, M. E., and Conolly, R. B. (1990). Physiologically based pharmacokinetic and pharmacodynamic model for the inhibition of acetylcholinesterase by diisopropylflu-orophosphate. Toxicol. Appl. Pharmacol. 106, 295-310.
20. Gospe, S. M., and Al-Bayati, M. A. S. (1994). Comparison of oral and inhalation exposures to toluene. J. Am. Coll. Toxicol. 13, 21-32.
21. Hildebrand, R. L., Andersen, M. E., and Jenkins, L. J. (1981). Prediction of in vivo kinetic constants from kinetic constants measured in vitro. Fundam. Appl. Toxicol. 1, 403-409.
22. Johanson, G. (1993). Use of toxicokinetics in risk assessment based on in vitro data. ATLA 21, 173-180.
23. Kedderis, G. L., Carfagna, M. A., Held, S. D., Batra, R., Murphy, J. E., and Gargas, M. L. (1993). Kinetic analysis of furan biotransformation by F-344 rats in vivo and in vitro. Toxicol. Appl. Pharmacol. 123, 274-282.
24. Kishi, R., Harabuchi, I., Ikeda, T., Yokota, H., and Miyake, H. (1988). Neurobehavioural effects and pharmacokinetics of toluene in rats and their relevance to man. Br. J. Ind. Med. 45, 396-408.
25. Krishnan, K., and Andersen, M. E. (1994). Physiologically based pharmacokinetic modeling in toxicology. In Principles and Methods of Toxicology (A. Wallace Hayes, Ed.), pp. 149-188. Raven Press, New York.
26. Leung, H. W. (1991). Development and utilization of physiologically based models for toxicological applications. J. Toxicol. Environ. Health 32, 247-267.
27. McDougal, J. N., Jepson, G. W., Clewell, H. J., Gargas, M. L., and Andersen, M. E. (1990). Dermal absorption of organic chemical vapours in rats and humans. Fundam. Appl. Toxicol. 14, 299-308.
28. Nakajima, T., and Sato, A. (1979). Enhanced activity of liver drug-metabolizing enzymes for aromatic and chlorinated hydrocarbons following food deprivation. Toxicol. Appl. Pharmacol. 50, 549-556.
29. Purcell, K. J., Cason, G. H., Gargas, M. L., Andersen, M. E., and Travis, C. C. (1990). In vivo metabolic interactions of benzene and toluene. Toxicol. Lett. 52, 141-152.
30. Ramsey, J. C., and Andersen, M. E. (1984). A physiologically based description of the inhalation pharmacokinetics of styrene in rats and humans. Toxicol. Appl. Pharmacol. 73, 159-175.
31. Rosenberg, N. L., Kleinschmide-DeMasters, B. K., and Davis, K. A. (1988). Toluene abuse causes diffuse central nervous system white matter changes. Ann. Neurol. 23, 611-614.
32. Sato, A., and Nakajima, T. (1979a). A structure-activity relationship of some chlorinated hydrocarbons. Arch. Environ. Health, March/Apr., 69-75.
33. Sato, A., and Nakajima, T. (1979b). A vial-equilibration method to evaluate the drug-metabolizing enzyme activity for volatile hydrocarbons. Toxicol. Appl. Pharmacol. 47, 41-46.
34. Sato, A., and Nakajima, T. (1979c). Dose-dependent metabolic interaction between benzene and toluene in vivo and in vitro. Toxicol. Appl. Pharmacol. 48, 249-256.
35. Tardif, R., Lapare, S., Krishnan, K., and Brodeur, J. (1993). Physiologically based modeling of the toxicokinetic interaction between toluene and m-xylene in the rat. Toxicol. Appl. Pharmacol. 120, 266-273.
36. Tardif, R., Plaa, G. L., and Brodeur, J. (1992). Influence of various mixtures of inhaled toluene and xylene on the biological monitoring of exposure to these solvents in rats. Can. J. Physiol. Pharmacol. 70, 385-393.
37. Wallen, M., Johanson, G., and Nordqvist, M. B. (1985). The effects of ethanol on the kinetics of toluene in the perfused rat liver. Toxicol. Lett. 26, 59-64.
38. Wang, R. S., and Nakajima, T. (1991). Kinetic studies on toluene metabolism in ethanol and phenobarbital-induced rat liver microsomes in vitro. Arch. Toxicol. 65, 39-44.
39. WHO (1985). Environmental Health Perspectives 52, Toluene. World Health Organization, Geneva.
40. Yang, R. S. H., and Andersen, M. E. (1994). Pharmacokinetics. In Introduction to Biochemical Toxicology (E. Hodgson, and P.E. Levi, Eds.), pp. 49-73. Appleton & Lange, East Norwalk, CT.