Detection of mutations in the gyrA and parC genes in quinolone-resistant clinical isolates of Enterobacter cloacae

Journal of Antimicrobial Chemotherapy

Volumn 40, Issue 4, 1997, Pages 543-549

  Deguchi, Takashi ^a   Yasuda, Mitsuru ^a   Nakano, Masahiro ^a   Ozeki, Shigehiko ^a   Kanematsu, Emiko ^a   Nishino, Yoshinori ^a   Ishihara, Satoshi ^a   Kawada, Yukimichi ^a  

^a GIFU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL PROTEIN; CIPROFLOXACIN; DNA TOPOISOMERASE (ATP HYDROLYSING); NALIDIXIC ACID; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANTIBIOTIC RESISTANCE; ANTIBIOTIC SENSITIVITY; ARTICLE; CONTROLLED STUDY; ENTEROBACTER CLOACAE; ESCHERICHIA COLI; GENE MUTATION; GENE SEQUENCE; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STRAIN DIFFERENCE; URINARY TRACT INFECTION;

AMINO ACID SEQUENCE; ANTI-INFECTIVE AGENTS; BASE SEQUENCE; DNA GYRASE; DNA TOPOISOMERASE IV; DNA TOPOISOMERASES, TYPE II; ENTEROBACTER CLOACAE; FLUOROQUINOLONES; GENES, BACTERIAL; HUMANS; MICROBIAL SENSITIVITY TESTS; MOLECULAR SEQUENCE DATA; MUTATION;

EID: 0030726378     PISSN: 03057453     EISSN: None     Source Type: Journal    
DOI: 10.1093/jac/40.4.543     Document Type: Article

References (26)

1. Hooper, D. C. & Wolfson, J. S. (1991). Fluoroquinolone antimicrobial agents. New England Journal of Medicine 324, 384-94.
2. Yoshida, H., Bogaki, M., Nakamura, M., Yamanaka, L. M. & Nakamura, S. (1991). Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrobial Agents and Chemotherapy 35, 1647-50.
3. Khodursky, A. B., Zechiedrich, E. L. & Cozzarelli, N. R. (1995). Topoisomerase IV is a target of quinolones in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America 92, 11801-5.
4. Kumagai, Y., Kato, J.-I., Hoshino, K., Akasaka, T., Sato, K. & Ikeda, H. (1996). Quinolone-resistant mutants of Escherichia coli DNA topoisomerase IV parC gene. Antimicrobial Agents and Chemotherapy 40, 710-4.
5. Belland, R. J., Morrison, S. G., Ison, C. & Huang, W. M. (1994). Neisseria gonorrhoeae acquires mutations in analogous regions of gyrA and parC in fluoroquinolone-resistant isolates. Molecular Microbiology 14, 371-80.
6. Deguchi, T., Yasuda, M., Nakano, M., Ozeki, S., Ezaki, T., Saito, I. et al. (1996). Quinolone-resistant Neisseria gonorrhoeae: correlation of alterations in the GyrA subunit of DNA gyrase and the ParC subunit of topoisomerase IV with antimicrobial susceptibility profiles. Antimicrobial Agents and Chemotherapy 40, 1020-3.
7. Georgiou, M., Muñoz, R., Román, F., Cantón, R., Gómez-Lus, R., Campos, J. et al. (1996). Ciprofloxacin-resistant Haemophilus influenzae strains possess mutations in analogous positions of GyrA and ParC. Antimicrobial Agents and Chemotherapy 40, 1741-4.
8. Ferrero, L., Cameron, B., Manse, B., Lagneaux, D., Crouzet, J., Famechon, A. et al. (1994). Cloning and primary structure of Staphylococcus aureus DNA topoisomerase IV: a primary target of fluoroquinolones. Molecular Microbiology 13, 641-53.
9. Ng, E. Y., Trucksis, M. & Hooper, D. C. (1996). Quinolone resistance mutations in topoisomerase IV: relationship to the flqA locus and genetic evidence that topoisomerase IV is the primary target and DNA gyrase is the secondary target of fluoroquinolones in Staphylococcus aureus. Antimicrobial Agents and Chemotherapy 40, 1881-8.
10. Pan, X. S. & Fisher, L. M. (1996). Cloning and characterization of the parC and parE genes of Streptococcus pneumoniae encoding DNA topoisomerase IV: role in fluoroquinolone resistance. Journal of Bacteriology 178, 4060-9.
11. Muñoz, R. & de la Campa, A. G. (1996). ParC subunit of DNA topoisomerase IV of Streptococcus pneumoniae is a primary target of fluoroquinolones and cooperates with DNA gyrase A subunit in forming resistance phenotype. Antimicrobial Agents and Chemotherapy 40, 2252-7.
12. Pan, X.-S., Ambler, J., Mehtar, S. & Fisher, L. M. (1996). Involvement of topoisomerase IV and DNA gyrase as ciprofloxacin targets in Streptococcus pneumoniae. Antimicrobial Agents and Chemotherapy 40, 2321-6.
13. Nikaido, H. (1994). Prevention of drug access to bacterial targets: permeability barriers and active efflux. Science 264, 382-8.
14. Gutmann, L., Williamson, R., Moreau, N., Kitzis, M. D., Collatz, E., Acar, J. F. et al. (1985). Cross-resistance to nalidixic acid, trimethoprim, and chloramphenicol associated with alterations in outer membrane proteins of Klebsiella, Enterobacter, and Serratia. Journal of Infectious Diseases 151, 501-7.
15. Power, E. G., Muñoz-Bellido, J. L. & Phillips, I. (1992). Detection of ciprofloxacin resistance in Gram-negative bacteria due to alterations in gyrA. Journal of Antimicrobial Chemotherapy 29, 9-17.
16. Swanberg, S. L. & Wang, J. C. (1987). Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase. Journal of Molecular Biology 197, 729-36.
17. Kato, J., Nishimura, Y., Imamura, R., Niki, H., Hiraga, S. & Suzuki, H. (1990). New topoisomerase essential for chromosome segregation in E. coli. Cell 63, 393-404.
18. Deguchi, T., Yasuda, M., Asano, M., Tada, K., Iwata, H., Komeda, H. et al. (1995). DNA gyrase mutations in quinolone-resistant clinical isolates of Neisseria gonorrhoeae. Antimicrobial Agents and Chemotherapy 39, 561-3.
19. Moriya, S., Ogasawara, N. & Yoshikawa, H. (1985). Structure and function of the region of the replication origin of the Bacillus subtilis chromosome. III. Nucleotide sequence of some 10,000 base pairs in the origin region. Nucleic Acids Research 13, 2251-65.
20. Margerrison, E. E., Hopewell, R. & Fisher, L. M. (1992). Nucleotide sequence of the Staphylococcus aureus gyrB-gyrA locus encoding the DNA gyrase A and B proteins. Journal of Bacteriology 174, 1596-603.
21. Wang, Y., Huang, W. M. & Taylor, D. E. (1993). Cloning and nucleotide sequence of the Campylobacter jejuni gyrA and characterization of quinolone resistance mutations. Antimicrobial Agents and Chemotherapy 37, 457-63.
22. Takiff, H. E., Salzar, L., Guerrero, C., Phillipp, W., Huang, W. M., Kreiswirth, B. et al. (1994). Cloning and nucleotide sequence of Mycobacterium tuberculosis gyrA and gyrB genes and detection of quinolone resistance mutations. Antimicrobial Agents and Chemotherapy 38, 773-80.
23. Yoshida, H., Bogaki, M., Nakamura, M., Yamanaka, L, M. & Nakamura, S. (1991). Quinolone resistance-determining region in the DNA gyrase gyrB gene of Escherichia coli. Antimicrobial Agents and Chemotherapy 35, 1647-50.
24. Stein, D. C., Danaher, R. J. & Cook, T. M. (1991). Characterization of a gyrB mutation responsible for low-level nalidixic acid resistance in Neisseria gonorrhoeas. Antimicrobial Agents and Chemotherapy 35, 622-6.
25. Breines, D. M., Ouabdesselam, S., Ng, E. Y., Tankovic, J., Shah, S., Soussy, C. J. et al. (1997). Quinolone resistance locus nfxD of Escherichia coli is a mutant allele of the parE gene encoding a subunit of topoisomerase IV. Antimicrobial Agents and Chemotherapy 41, 175-9.
26. Everett, M. J., Jin, Y. F., Ricci, V. & Piddock, L. J. V. (1996). Contributions of individual mechanisms to fluoroquinolone resistance in 36 Escherichia coli strains isolated from human and animals. Antimicrobial Agents and Chemotherapy 40, 2380-6.