Effects of sodium channel block with mexiletine to reverse action potential prolongation in in vitro models of the long QT syndrome

Journal of Cardiovascular Electrophysiology

Volumn 8, Issue 11, 1997, Pages 1280-1290

  Sicouri, Serge ^a   Antzelevitch, Daniel ^a   Heilmann, Cory ^a   Antzelevitch, Charles ^a  

^a MASONIC MEDICAL RESEARCH LABORATORY   (United States)

Author keywords

ATX II; Cardiac arrhythmias; Cardiac electrophysiology; d sotalol; Early afterdepolarization; Heterogeneity; M cells; Mexiletine

Indexed keywords

MEXILETINE; SODIUM CHANNEL; SODIUM CHANNEL BLOCKING AGENT; SOTALOL;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOG; DOSE RESPONSE; DRUG ACTIVITY; DRUG EFFECT; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; LONG QT SYNDROME; MALE; MICROELECTRODE; NONHUMAN; PRIORITY JOURNAL;

EID: 0030724030     PISSN: 10453873     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1540-8167.1997.tb01019.x     Document Type: Article

References (44)

1. Wang Q, Shen J, Splawski I,et al: SCN5A mutations associated with an inherited cardiac arrhythmia, long QT syndrome. Cell 1995;80:805-811.
2. Curran ME, Splawski I, Timothy KW,et al: A molecular basis for cardiac arrhythmia: HERG mutations cause long QT syndrome. Cell 1995;80:795-803.
3. Kr potassium channel. Cell 1995;81:299-307.
4. Wang Q, Curran ME, Splawski I,et al: Positional cloning of a novel potassium channel gene: KVLQT1 mutations cause cardiac arrhythmias. Nature Genet 1996;12:17-23.
5. Ks potassium channel. Nature 1996;384:80-83.
6. + channel blockade and to increases in heart rate: Implica-tions for gene-specific therapy. Circulation 1995;92: 3381-3386.
7. + channel blockade, β-adrenergic simulation, and rapid pacing in a cellular model mimicking the SCN5A and HERG defects present in the long-QT syndrome. Circ Res 1996;78:1009-1015.
8. Shimizu W, Antzelevitch C: Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade de pointes in LQT2 as well as LQT3 models of the long-QT syndrome. Circulation 1997;96:2038-2047.
9. El-Sherif N, Caref EB, Yin H,et al: The electrophysiological mechanism of ventricular arrhythmias in the long QT syndrome: Tridimensional mapping of activation and recovery patterns. Circ Res 1996;79:474-492.
10. Ks cardiac potassium current. Nature 1996;384:78-80.
11. Liu DW, Gintant G A, Antzelevitch C: Ionic bases for electrophysiological distinctions among epicardial, midmyocardial, and endocardial myocytes from the free wall of the canine left ventricle. Circ Res 1993;72: 671-687.
12. Ks contributes to the longer action potential of the M cell. Circ Res 1995;76:351-365.
13. Sicouri S, Antzelevitch C: A subpopulation of cells with unique electrophysiological properties in the deep subepicardium of the canine ventricle: The M cell. Circ Res 1991;68:1729-1741.
14. Anyukhovsky EP, Sosunov EA, Rosen MR: Regional differences in electrophysiologic properties of epicardium, midmyocardium and endocardium: In vitro and in vivo correlations. Circulation 1996;94:1981-1988.
15. Antzelevitch C, Sun ZQ, Zhang ZQ,et al: Cellular and ionic mechanisms underlying erythromycin-induced long QT and torsade de pointes. J Am Coll Cardiol 1996;28:1836-1848.
16. Antzelevitch C, Nesterenko VV, Van GX: The role of M cells in acquired long QT syndrome, U waves and torsade de pointes. J Electrocardiol 1996;28(Suppl): 131-138.
17. Weissenburger J, Nesterenko VV, Antzelevitch C: Intramural monophasic action potentials (MAP) display steeper APD-rate relations and higher sensitivity to Class agents than epicardial and endocardial MAPs: Characteristics of the M cell in vivo. (Abstract) Circulation 1995;92:I-300.
18. Weissenburger J, Nesterenko VV, Antzelevitch C: M cells contribute to transmural dispersion of repolarization and to the development of Torsade de Pointes in the canine heart in vivo. (Abstract) PACE 1996;19(Pt II):707.
19. Antzelevitch C: The M cell. (Editorial Comment) J Cardiovasc Pharmacol Ther 1997;2:73-76.
20. Sicouri S, Antzelevitch C: Electrophysiologic characteristics of M cells in the canine left ventricular free wall. J Cardiovasc Electrophysiol 1995;6:591-603.
21. Sicouri S, Fish J, Antzelevitch C: Distribution of M cells in the canine ventricle. J Cardiovasc Electrophysiol 1994;5:824-837.
22. Drouin E, Charpentier F, Gauthier C,et al: Electrophysiological characteristics of cells spanning the left ventricular wall of human heart: Evidence for the presence of M cells. J Am Coll Cardiol 1995;26:185-192.
23. Li GR, Feng J, Carrier M,et al: Transmural electrophysiologic heterogeneity in the human ventricle. (Abstract) Circulation 1995;92:I-158.
24. Sicouri S, Quist M, Antzelevitch C: Evidence for the presence of M cells in the guinea pig ventricle. J Cardiovasc Electrophysiol 1996;7:503-511.
25. +-channel blocking agents on subendocardium and mid-wall slices of human, rabbit, and guinea pig myocardium. (Abstract) Pflugers Arch 1996;431:R130.
26. Rodriguez-Sinovas A, Cinca J, Tapias A,et al: Lack of evidence of M-cells in porcine left ventricular myocardium. Cardiovasc Res 1997;33:307-313.
27. Antzelevitch C: Are M cells present in the ventricular myocardium of the pig? A question of maturity. Cardiovasc Res 1997; (In press).
28. Eddlestone GT, Zygmunt AC, Antzelevitch C: Larger late sodium current contributes to the longer action potential of the M cell in canine ventricular myocardium. (Abstract) PACE 1996;19(Pt II):569.
29. Sicouri S, Antzelevitch C: Afterdepolarizations and triggered activity develop in a select population of cells (M cells) in canine ventricular myocardium: The effects of acetylstrophanthidin and Bay K 8644. PACE 1991;14:1714-1720.
30. Sicouri S, Antzelevitch C: Drug-induced afterdepolarizations and triggered activity occur in a discrete subpopulation of ventricular muscle cell (M cells) in the canine heart: Quinidine and digitalis. J Cardiovasc Electrophysiol 1993;4:48-58.
31. Antzelevitch C, Sicouri S: Clinical relevance of cardiac arrhythmias generated by afterdepolarizations: The role of M cells in the generation of U waves, triggered activity and torsade de pointes. J Am Coll Cardiol 1994;23:259-277.
32. Sicouri S, Moro S, Elizari MV: d-Sotalol induces marked action potential prolongation and early afterdepolarizations in M but not epicardial or endocardial cells of the canine ventricle. J Cardiovasc Pharmacol Ther 1997;2:27-38.
33. Wang DW, Yazawa K, Makita N,et al: Pharmacological targeting of long QT mutant sodium channels. J Clin Invest 1997; (In press).
34. + channel-linked long-QT syndrome. Circ Res 1996;78:916-924.
35. Ono K, Kiyosue T, Arita M: Comparison of the inhibitory effects of mexiletine and lidocaine on the calcium current of single ventricular cells. Life Sei 1986;39: 1465-1470.
36. Herman ND, Loukides JE: A comparison of the cellular electrophysiology of mexiletine and sotalol, singly and combined, in canine Purkinje fibers. J Cardiovasc Pharmacol 1988;12:286-292.
37. Varro A, Lathrop DA: Sotalol and mexiletine-Combination of rate-dependent electrophysiological effects. J Cardiovasc Pharmacol 1990; 16:557-567.
38. Chezalviel-Guilbert F, Davy JM, Poirier JM,et al: Mexiletine antagonizes effects of sotalol on QT interval duration and its proarrhythmic effects in a canine model of torsade de pointes. J Am Coll Cardiol 1995; 26:787-792.
39. Shimizu W, Ohe T, Kurita T,et al: Effects of verapamil and propranolol on early afterdepolarizations and ventricular arrhythmias induced by epinephrine in congenital long QT syndrome. J Am Coll Cardiol 1995; 26:1299-1309.
40. Dessertenne F: La tachycardie ventriculaire a deux foyers opposes variables. Arch Mal Coeur 1966;59: 263-272.
41. 2+ channel agonist Bay K 8644. Circ Res 1988;62:563-571.
42. Antzelevitch C, Sicouri S, Lukas A,et al: Regional differences in the electrophysiology of ventricular cells: Physiological and clinical implications. In Zipes DP, Jalife J, eds: Cardiac Electrophysiology: From Cell to Bedside. WB Saunders Co., Philadelphia, 1995, pp. 228-245.
43. Sicouri S, Moro S, Nicola Siri L, Elizari MV,et al: Chronic amiodarone delays ventricular repolarization and reduces transmural dispersion of repolarization in the canine heart. (Abstract) PACE 1996;19(Pt II):638.
44. Sun ZQ, Eddlestone GT, Antzelevitch C: Ionic mechanisms underlying the effects of sodium pentobarbital to diminish transmural dispersion of repolarization. (Abstract) PACE 1997;20(Pt II): 1116.