The role of genomics in studying genetic susceptibility to infectious disease

Genome Research

Volumn 7, Issue 10, 1997, Pages 967-973

  Weatherall, David ^a   Clegg, John ^a   Kwiatkowski, Dominic ^a  

^a JOHN RADCLIFFE HOSPITAL   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL INFECTION; DISEASE PREDISPOSITION; DISEASE TRANSMISSION; ETIOLOGY; GENE FREQUENCY; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HUMAN; HUMAN CELL; INFECTION; MALARIA; PARASITOSIS; PRIORITY JOURNAL; REVIEW; VIRUS INFECTION;

BACTERIA (MICROORGANISMS);

EID: 0030663851     PISSN: 10889051     EISSN: None     Source Type: Journal    
DOI: 10.1101/gr.7.10.967     Document Type: Review

References (42)

1. Allison, A.C. 1964. Polymorphism and natural selection in human populations. Cold Spring Harbor Symp. Quant. Biol. 29: 137-149.
2. Almari, A. and J.R. Batchelor. 1994. HLA and hepatitis B infection. Lancet 344: 1194.
3. Cabrera, M., M.-A. Shaw, C. Sharples, H. Williams, M. Castes, C. Convit, and J.M. Blackwell. 1995. Polymorphism in tumor necrosis factor genes associated with mucocutaneous leishmaniasis. J. Exp. Med. 182: 1259-1264.
4. Conway, D.J., M.J. Holland, R.L. Bailey, A.E. Campbell, O.S.M. Mahdi, R. Jennings, E. Mbena, and D.C.W. Mabey. 1997. Scarring trachoma is associated with polymorphism in the tumor necrosis factor (TNF-α) gene promoter and with elevated TNF-α levels in tear fluid. Infect. Immun. 65: 1003-1006.
5. Flint, J., A.V.S. Hill, D.K. Bowden, S.J. Oppenheimer, P.R. Sill, S.W. Serjeantson, J. Bana-Koiri, K. Bhatia, M.P. Alpers, A.J. Boyce, D.J. Weatherall, and J.B. Clegg. 1986. High frequencies of α thalassaemia are the result of natural selection by malaria. Nature 321: 744-750.
6. Flint, J., R.M. Harding, A.J. Boyce, and J.B. Clegg. 1993. The population genetics of the haemoglobinopathies. Clin. Haematol. 6: 215-262.
7. Garrod, A.E. 1931. The inborn factors in disease. An essay. Oxford University Press, Oxford, UK.
8. Haldane, J.B.S. 1948. The rate of mutation of human genes. Proceedings of the Eighth International Congress of Genetics and Heredity. Hereditas Suppl. 35.
9. Higgs, D.R., M.A. Vickers, A.O.M. Wilkie, I.-M. Pretorius, A.P. Jarman, and D.J. Weatherall. 1989. A review of the molecular genetics of the human α-globin gene cluster. Blood 73: 1081-1104.
10. Hill, A.V.S. 1996 Genetics of infectious disease resistance. Curr. Opin. Genet. Dev. 6: 348-353.
11. Hill, A.V.S., C.E.M. Allsopp, D. Kwiatkowski, N.M. Anstey, P. Twumasi, P.A. Rwoe, S. Bennett, D. Brewster, A.J. McMichael, and B.M. Greenwood. 1991. Common west African HLA antigens are associated with protection from severe malaria. Nature 352: 595-600.
12. Hill, A.V.S., J. Elvin, A. Willis, M. Aidoo, C.E.M. Allsopp, P.M. Gotch, X.M. Gao, M. Takiguchi, B.M. Greenwood, A.R.M. Townsend, A.J. McMichael, and H.C. Whittle. 1992. Molecular analysis of the association of HLA-B53 and resistance to severe malaria. Nature 360: 434-439.
13. Kelly, R.J., S. Rouquier, D. Giorgi, G.G. Lennon, and J.B. Lowe. 1995. Sequence and expression of a candidate for the human secretor blood group alpha(1,2)fucosyltransferase gene (FUT2). Homozygosity for an enzyme-inactivating nonsense mutation commonly correlates with the non-secretor phenotype. J. Biol. Chem. 270: 4640-4649.
14. Kwiatkowski, D. 1995. Malarial toxins and the regulation of parasite density. Parasitol. Today 11: 206-212.
15. Lipscombe, R.J., M. Sumiya, A.V. Hill, Y.L. Lau, R.J. Levinsky, J.A. Summerfield, and M.W. Turner. 1992. High frequencies in African and non-African populations of independent mutations in the mannose binding protein gene. Hum. Mol. Genet. 1: 709-715.
16. Liu, R., W.A. Paxton, S. Choe, D. Ceradini, S.R. Martin, R. Horuk, M.E. MacDonald, H. Stuhlmann, R.A. Koup, and N.R. Landau. 1996. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV infection. Cell 86: 367-377.
17. Madsen, H.O., P. Garred, J.A. Kurtzhais, L.U. Lamm, L.P. Ryder, S. Thiel, and A. Svejgaard. 1994. A new frequent allele is the missing link in the structural polymorphism of the human mannan-binding protein. Immunogenetics 40: 37-44.
18. Maitland, K., T.N. Williams, and C.I. Newbold. 1997. Plasmodium vivax and P. falciparum: Biological interactions and the possibility of cross-species immunity. Parasitol. Today 13: 227-231.
19. Marquet, S., L. Abel, D. Hillaire, H. Dessein, J. Kalil, J. Feingold, J. Weissenbach, and A.J. Dessein. 1996. Genetic localization of a locus controlling the intensity of infection by Schistoma mansoni on chromosome 5q31-q33. Nature Genet. 14: 181-184.
20. McGuire, W., A.V.S. Hill, C.E.M. Allsopp, B.M. Greenwood, and D. Kwiatkowski. 1994. Variation in the TNF-α promotor region associated with susceptibility to cerebral malaria. Nature 371: 508-511.
21. McLeod, R., E. Buschman, L.D. Arbuckle, and E. Skamene. 1995. Immunogenetics in the analysis of resistance to intracellular pathogens. Curr. Opin. Immunol. 7: 539-552.
22. Meyer, C.G., M. Gallin, K.D. Erttmann, N. Brattig, L. Schnittger, A. Gelhaus, E. Tannich, A.B. Begovich, H.A. Erlich, and R.D. Horstmann. 1994. HLA-D alleles associated with generalized disease, localized disease, and putative immunity in Onchocerca volvulus infection. Proc. Natl. Acad. Sci. 91: 7515-7519.
23. Miller, L.H. 1994. Impact of malaria on genetic polymorphism and genetic diseases in Africans and African Americans. Proc. Natl. Acad. Sci. 91: 2415-2419.
24. Miller, L.H. 1996. Protective selective pressure. Nature 383: 480-481.
25. Moxon, E.R. and D.S. Thaler. 1997. The tinkerer's evolving tool-box. Nature 387: 659-662.
26. Murphy, P.M. 1993. Molecular mimicry and the generation of host defense protein diversity. Cell 72: 823-826.
27. Nadel, S., M.J. Newport, R. Booy, and M. Levin. 1996. Variation in the tumor necrosis factor-α gene promoter region may be associated with death from meningococcal disease. J. Infect. Dis. 174: 878-880.
28. Newport, M.J., C.M. Huxley, S. Huston, C.M. Hawrylowicz, B.A. Oostra, R. Williamson, and M. Levin. 1996. A mutation in the interferon-γ-receptor gene and susceptibility to mycobacterial infection. N. Engl. J. Med. 335: 1941-1949.
29. Olumese, P.E., A.A. Adeyemo, O.G. Ademowo, R.A. Gbadegesin, O. Sodeinde, and O. Walker. 1997. The clinical manifestations of cerebral malaria among Nigerian children with sickle cell trait. Ann. Trop. Paediatr. 17: 141-145.
30. Roy, S., W. McGuire, C.G.N. Mascie-Taylor, B. Saha, S.K. Hazra, A.V.S. Hill, and D. Kwiatkowski. 1997. TNF promoter polymorphism and susceptibility to lepromatous leprosy. J. Infect. Dis. (in press).
31. Ruwende, C., S.C. Khoo, R.W. Snow, S.N.R. Yates, D. Kwiatkowski, S. Gupta, P. Warn, C.E.M. Allsopp, S.C. Gilbert, N. Peschu, C.I. Newbold, B.M. Greenwood, and A.V.S. Hill. 1995. Natural selection of hemi-and heterozygotes for glucose-6-phosphate-dehydrogenase deficiency by resistance to severe malaria. Nature 376: 246-249.
32. Sniegowski, P.D., P.J. Gerrish, and R.E. Lenski. 1997. Evolution of high mutation rates in experimental populations of E. coli. Nature 387: 703-705.
33. Taddei, F., M. Radman, J. Maynard-Smith, B. Toupance, P.H. Gouyon, and B. Godelle. 1997. Role of mutator alleles in adaptive evolution. Nature 387: 700-702.
34. Thompson, E.A. and J.V. Neel. 1997. Allelic disequilibrium and allele frequency distribution as a function of social and demographic history. Am. J. Hum. Genet. 60: 197-204.
35. Thursz, M.R., D. Kwiatkowski, C.E. Allsopp, B.M. Greenwood, H.C. Thomas, and A.V. Hill. 1995. Association between an MHC class II allele and clearance of hepatitis B virus in the Gambia. N. Eng. J. Med. 332: 1065-1069.
36. Tournamille, C., Y. Colin, J.P. Cartron, and C.L.V. Kim. 1995. Disruption of a GATA motif in the Duffy gene promoter abolishes erythroid gene expression in Duffy-negative individuals. Nature Genet. 10: 224-228.
37. Tracey, K.J. 1995. TNF and Mae West or: Death from too much of a good thing. Lancet 345: 75-76.
38. Weatherall, D.J. 1996. Host genetics and infectious disease. Parasitology 112: S23-S29.
39. Westendorp, R.G.J., J.A.M. Langermans, T.W.J. Huizinga, A.H. Elouali, C.L. Verwejj, D.I. Boomsma, and J.P. Vandenbrouk. 1997. Genetic influence on cytokine production and fatal meningococcal disease. Lancet 349: 170-173.
40. Williams, T.N., K. Maitland, S. Bennett, M. Ganczakowski, T.E.A. Peto, C.I. Newbold, D.K. Bowden, D.J. Weatherall, and J.B. Clegg. 1996. High incidence of malaria in α-thalasssaemic children. Nature 383: 522-525.
41. Wilson, A.G., J.A. Symons, T.L. McDowell, H.O. McDevitt, and G.W. Duff. 1997. Effects of a polymorphism in the human TNF-alpha promoter on transcriptional activation. Proc. Natl. Acad. Sci. 94: 3195-3199.
42. Yazdanbaksh, M., E. Sartono, Y.C.M. Kruize, A. Kurniawan, F. Portono, R.M. Maziels, G.M.T. Schreuder, R. Schipper, and R.R.P. De Vries. 1995. HLA and elephantiasis in lymphatic filariasis. Hum. Immunol. 44: 58-61.