p53-Dependent apoptosis suppresses tumor growth and progression in vivo

Cell

Volumn 78, Issue 4, 1994, Pages 703-711

  Symonds, Holly ^a   Krall, Leonard ^a   Remington, Lee ^c   Saenz Robles, Mayte ^b   Lowe, Scott ^c   Jacks, Tyler ^b,c   Van Dyke, Terry ^a  

^a UNIVERSITY OF NORTH CAROLINA   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ALLELE; ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL FUNCTION; CELL PROLIFERATION; CHOROID PLEXUS; GENE EXPRESSION; GROWTH INHIBITION; MOUSE; NONHUMAN; NULL CELL; PRIORITY JOURNAL; STOCHASTIC MODEL; TRANSGENE; TUMOR GROWTH;

ANIMALIA; MUS MUSCULUS;

EID: 0028169994     PISSN: 00928674     EISSN: None     Source Type: Journal    
DOI: 10.1016/0092-8674(94)90534-7     Document Type: Article

References (32)

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5. Thymocyte apoptosis induced by p53-dependent and independent pathways
6. Wild-type p53 mediates apoptosis by E1A which is inhibited by E1B
7. Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
8. A genetic model for colorectal tumorigenesis
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15. Altered cell cycle arrest and gene amplification potential accompany loss of wild-type p53
16. p53 is required for radiation-induced apoptosis in mouse thymocytes
17. Abrogation of oncogene-associated apoptosis allows transformation of p53-deficient cells
18. Tumor suppressor genes
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20. Induction of apoptosis by adenovirus type 5 ElA in rat cells requires a proliferation block
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23. Phagocyte recognition of cells undergoing apoptosis
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27. Analysis of viral-host protein interactions and tumorigenesis in transgenic mice
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31. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles
32. Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6