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Volumn 6, Issue 6, 1996, Pages 312-336

Regulators of Life and Death: The Bcl-2 Gene Family

Author keywords

Apoptosis; Bax; Bcl 2; Bcl 2 related genes; Bcl x

Indexed keywords

CALCIUM; PROTEIN BAX;

EID: 0030459311     PISSN: 10158987     EISSN: 14219778     Source Type: Journal    
DOI: 10.1159/000154836     Document Type: Article
Times cited : (16)

References (113)
  • 1
    • 0021679848 scopus 로고
    • Cloning of thechromosomic breakpoint of neoplastic B cells with the t(14:18) chromosome translocation
    • Tsujimoto Y. Finger LR. Tunis J, Nowell PC. Croce CM: Cloning of thechromosomic breakpoint of neoplastic B cells with the t(14:18) chromosome translocation. Science 1984:226:1097-1099.
    • (1984) Science , vol.226 , pp. 1097-1099
    • Tsujimoto, Y.1    Finger, L.R.2    Tunis, J.3    Nowell, P.C.4    Croce, C.M.5
  • 2
    • 0021934042 scopus 로고
    • Cloning the chromosomal break-point of the if 14:18) human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18
    • Bakhshi A. Jensen JP. Goldman P. Wright JJ. McBride OW, Epstein AL. Korsmcycr SJ: Cloning the chromosomal break-point of the if 14:18 human lymphomas: Clustering around JH on chromosome 14 and near a transcriptional unit on 18. Cell 1985:41:889-906.
    • (1985) Cell , vol.41 , pp. 889-906
    • Bakhshi, A.1    Jensen, J.P.2    Goldman, P.3    Wright, J.J.4    Mc Bride, O.W.5    Epstein, A.L.6    Korsmcycr, S.J.7
  • 3
    • 0022971142 scopus 로고
    • Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2 immunoglobulin transcript resulting from the t(14:18) translocation
    • Cleary ML. Smith SD. Sklar J: Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2 immunoglobulin transcript resulting from the t(14:18) translocation. Cell 1986;47:19-28.
    • (1986) Cell , vol.47 , pp. 19-28
    • Cleary, M.L.1    Smith, S.D.2    Sklar, J.3
  • 4
    • 0023786047 scopus 로고
    • Bcl-2 promotes the survival of haemo-poietic cells and cooperates with c-myc to immortalise pre-B cells
    • Vaux Dl. Cory S. Adams TM: Bcl-2 promotes the survival of haemo-poietic cells and cooperates with c-myc to immortalise pre-B cells. Nature 1988:335:440-442.
    • (1988) Nature , vol.335 , pp. 440-442
    • Vaux, D.L.1    Cory, S.2    Adams, T.M.3
  • 5
    • 0025204548 scopus 로고
    • Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death
    • Hockenberv D. Nunez G. Milliman C, Schreibcr RD. Korsmever S: Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death. Nature 1990: 348:334-336.
    • (1990) Nature , vol.348 , pp. 334-336
    • Hockenberv, D.1    Nunez, G.2    Milliman, C.3    Schreibcr, R.D.4    Korsmever, S.5
  • 6
    • 0019225636 scopus 로고
    • Cell death: The significance of apoptosis
    • Wyllie All
    • Wyllie All: Cell death: The significance of apoptosis. Int Rev C'ytol 1980;68:251-306.
    • (1980) Int Rev C'ytol , vol.68 , pp. 251-306
    • Wyllie, A.1
  • 7
    • 0025751550 scopus 로고
    • Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thvmocvtes
    • Scntman CL. Shutter JR, Hockcn-bery D. KanagawaO. Korsmcycr SJ: Bcl-2 inhibits multiple forms of apoptosis but not negative selection in thvmocvtes. Cell 1991:68:879-888. '
    • (1991) Cell , vol.68 , pp. 879-888
    • Scntman, C.L.1    Shutter, J.R.2    Hockcn-Bery, D.3
  • 8
    • 0025786164 scopus 로고
    • Bel-2 transgenc inhibits T cell death and perturbs thymic self-censorship
    • Strasser A. Harris AW. Cory S: Bel-2 transgenc inhibits T cell death and perturbs thymic self-censorship. Cell 1991:67:889-899.
    • (1991) Cell , vol.67 , pp. 889-899
    • Strasser, A.1    Harris, A.W.2    Cory, S.3
  • 12
    • 0028829802 scopus 로고
    • Surv ival and death of pre-lymphomatous B-cells from N-rnyc/ bcl-2 double transgenic mice correlates with the regulation of intracellular Ca++ (Luxes
    • Zornig M. Bush G. Beneke R. Gul-bins E. Lang F. Ma A. Korsmcycr S. Môroy T: Surv ival and death of pre-lymphomatous B-cells from N-rnyc/ bcl-2 double transgenic mice correlates with the regulation of intracellular Ca++ Duxes. Oncogene 1995: 11:2165-2174.
    • (1995) Oncogene , vol.11 , pp. 2165-2174
    • Zornig, M.1    Bush, G.2    Beneke, R.3    Gul-Bins, E.4    Lang, F.5    Ma, A.6    Korsmcycr, S.7    Môroy, T.8
  • 14
    • 0028297141 scopus 로고
    • Bel-2 expression promotes B- but not T-lymphoid development in scid mice
    • Strasscr A. Harris AW, Corcoran LM. Cory S: Bel-2 expression promotes B- but not T-lymphoid development in scid mice. Nature 1994: 368:457-460.
    • (1994) Nature , vol.368 , pp. 457-460
    • Strasscr, A.1    Harris, A.W.2    Corcoran, L.M.3    Cory, S.4
  • 15
    • 0024521441 scopus 로고
    • Bcl-2-immunoglobu-lin transgenic mice demonstrate extended B cell survival and follicular lymphoprolifération
    • McDonnell TJ. Deane N. Plaît FM. Nunez G. Jaeger U. McKeam JP, Korsmcyer SJ: Bcl-2-immunoglobu-lin transgenic mice demonstrate extended B cell survival and follicular lymphoprolifération. Cell 1989:57: 79-88.
    • (1989) Cell , vol.57 , pp. 79-88
    • Mc Donnell, T.J.1    Deane, N.2    Plaît, F.M.3    Nunez, G.4    Jaeger, U.5    Mc Keam, J.P.6    Korsmcyer, S.J.7
  • 16
    • 0026053958 scopus 로고
    • Progression front lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenie for the l(14:18)
    • McDonnell TJ. Korsmcyer SJ: Progression front lymphoid hyperplasia to high-grade malignant lymphoma in mice transgenie for the l(14:18). Nature 1991:349:254-256.
    • (1991) Nature , vol.349 , pp. 254-256
    • Mc Donnell, T.J.1    Korsmcyer, S.J.2
  • 17
    • 0026454763 scopus 로고
    • Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene
    • Garcia I. Martinou I. Tsujimoto Y, Martinou J-C: Prevention of programmed cell death of sympathetic neurons by the bcl-2 proto-oncogene. Science 1992:258:302-304.
    • (1992) Science , vol.258 , pp. 302-304
    • Garcia, I.1    Martinou, I.2    Tsujimoto, Y.3    Martinou, J.-C.4
  • 19
    • 0027243086 scopus 로고
    • The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis
    • Allsopp TE. Wyatt S. Paterson HF. Davies AM: The proto-oncogene bcl-2 can selectively rescue neurotrophic factor-dependent neurons from apoptosis. Cell 1993:73:295- 307.
    • (1993) Cell , vol.73
    • Allsopp, T.E.1    Wyatt, S.2    Paterson, H.F.3    Davies, A.M.4
  • 20
    • 0029056049 scopus 로고
    • Role of Bcl-2 in the brain-derived neurotrophic factor survival response
    • Allsopp TE. Kiselev S. Wyatt S. Davies AM: Role of Bcl-2 in the brain-derived neurotrophic factor survival response. Eur J Neurosci 1995:7:1266-1272.
    • (1995) Eur J Neurosci , vol.7 , pp. 1266-1272
    • Allsopp, T.E.1    Kiselev, S.2    Wyatt, S.3    Davies, A.M.4
  • 21
    • 8044248000 scopus 로고
    • Neonatal motoneurons overex-pressing the bcl-2 protooncogene in transgenie mice are protected from axotomy-induced cell death
    • Dubois-Dauphin M. Frankowald H. Tsujimoto Y. Huarte J. Martinou JC: Neonatal motoneurons overex-pressing the bcl-2 protooncogene in transgenie mice are protected from axotomy-induced cell death. Proc Natl Acad Sci USA 1994:7:663-698.
    • (1994) Proc Natl Acad Sci USA , vol.7 , pp. 663-698
    • Dubois-Dauphin, M.1    Frankowald, H.2    Tsujimoto, Y.3    Huarte, J.4    Martinou, J.C.5
  • 23
    • 0029047946 scopus 로고
    • Bcl-2 transgene expression can protect neurons against developmental and induced cell death
    • Farlie PG. Dringen R. Rees SM. Kannourakis G, Bernard O: Bcl-2 transgene expression can protect neurons against developmental and induced cell death. Proc Natl Acad Sci USA 1995:92:4397-4401.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4397-4401
    • Farlie, P.G.1    Dringen, R.2    Rees, S.M.3    Kannourakis, G.4    Bernard, O.5
  • 25
    • 0022380768 scopus 로고
    • The c-mve oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice
    • S. Palmitcr RD. Brinster RL: The c-mve oncogene driven by immunoglobulin enhancers induces lymphoid malignancy in transgenic mice. Nature 1985:318:533-538.
    • (1985) Nature , vol.318 , pp. 533-538
    • Palmitcr, S.R.D.1    Brinster, R.L.2
  • 26
    • 0025251664 scopus 로고
    • Bath ML, Cory S: Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2
    • Strasser A. Harris AW. Bath ML, Cory S: Novel primitive lymphoid tumours induced in transgenic mice by cooperation between myc and bcl-2. Nature 1990:348:331-333.
    • (1990) Nature , vol.348 , pp. 331-333
    • Strasser, A.1    Harris, A.W.2
  • 27
    • 0028178385 scopus 로고
    • Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS
    • Merry DE. Vcis DJ. Hickey WF. Korsmcyer S.I: Bcl-2 protein expression is widespread in the developing nervous system and retained in the adult PNS. Development 1994:120: 301-311.
    • (1994) Development , vol.120 , pp. 301-311
    • Merry, D.E.1    Vcis, D.J.2    Hickey, W.F.3    Korsmcyer, S.I.4
  • 29
    • 0027715083 scopus 로고
    • Expression of bcl-2 in fetal tissues suggests role in morphogenesis
    • LeBrun DP. Wamke RA, Cleary ML: Expression of bcl-2 in fetal tissues suggests role in morphogenesis. Am J Pathol 1993:142:743-753.
    • (1993) Am J Pathol , vol.142 , pp. 743-753
    • Lebrun, D.P.1    Wamke, R.A.2    Cleary, M.L.3
  • 31
    • 0028105796 scopus 로고
    • Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes
    • Merino R. Ding L. Veis DJ. Korsmcyer SJ. Nunez G: Developmental regulation of the Bcl-2 protein and susceptibility to cell death in B lymphocytes. EMBO J 1994:13:683-691.
    • (1994) EMBO J , vol.13 , pp. 683-691
    • Merino, R.1    Ding, L.2    Veis, D.J.3    Korsmcyer, S.J.4    Nunez, G.5
  • 32
    • 0028448483 scopus 로고
    • Bcl-2 is uprcgulated at theCD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points
    • Linette GP. Grusby MJ. Hedrick SM. Hansen TH, Glimcher l.H. Korsmcyer SJ: Bcl-2 is uprcgulated at theCD4+ CD8+ stage during positive selection and promotes thymocyte differentiation at several control points. Immunity 1994:1:197-205.
    • (1994) Immunity , vol.1 , pp. 197-205
    • Linette, G.P.1    Grusby, M.J.2    Hedrick, S.M.3    Hansen, T.H.4    Glimcher, I.H.5    Korsmcyer, S.J.6
  • 33
    • 0025213270 scopus 로고
    • Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro
    • Chen-Levy Z. Cleary ML: Membrane topology of the Bcl-2 proto-oncogenic protein demonstrated in vitro. J Biol Chem 1990:265 4929-4933.
    • (1990) J Biol Chem , vol.265 , pp. 4929-4933
    • Chen-Levy, Z.1    Cleary, M.L.2
  • 34
    • 0027525536 scopus 로고
    • Targeting of Bel-2 to the mitochondrial outer membrane by a COOH-tcrminal signal anchor sequence
    • Nguyen M. Millar DG. Yong VW. Korsmeyer SJ. Shore GC: Targeting of Bel-2 to the mitochondrial outer membrane by a COOH-tcrminal signal anchor sequence. J Biol Client 1993:268:25265-25268.
    • (1993) J Biol Client , vol.268 , pp. 25265-25268
    • Nguyen, M.1    Millar, D.G.2    Yong, V.W.3    Korsmeyer, S.J.4    Shore, G.C.5
  • 35
    • 0027166048 scopus 로고
    • Bcl-2 heterodimerizes in vivo with a conserved homologue. Bax. That accelerates programmed cells death
    • Oltvai ZN. Milliman CL. Korsmcyer SJ: Bcl-2 heterodimerizes in vivo with a conserved homologue. Bax. That accelerates programmed cells death. Cell 1993:74:609-619.
    • (1993) Cell , vol.74 , pp. 609-619
    • Oltvai, Z.N.1    Milliman, C.L.2    Korsmcyer, S.J.3
  • 38
    • 0028939139 scopus 로고
    • RaffMC: Programmed cell death and Bcl-2 protection in very low oxygen
    • Jacobson M. RaffMC: Programmed cell death and Bcl-2 protection in very low oxygen. Nature 1995:374: 814-816.
    • (1995) Nature , vol.374 , pp. 814-816
    • Jacobson, M.1
  • 41
    • 0028216444 scopus 로고
    • Evidence that Bcl-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca:+ fluxes
    • Lam M, Dubyak G, Chen L, Nunez G. Miesfeld RL. Distclhorst CW: Evidence that Bcl-2 represses apoptosis by regulating endoplasmic reticulum-associated Ca + fluxes. Proc Natl Acad Sci USA 1994:91: 6569-6573.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 6569-6573
    • Lam, M.1    Dubyak, G.2    Chen, L.3    Nunez, G.4    Miesfeld, R.L.5    Distclhorst, C.W.6
  • 42
    • 0027427492 scopus 로고
    • Bcl-2-deficienl mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair
    • Veis DJ, Sorenson CM, Shutter JR. Korsmeyer SJ: Bcl-2-deficienl mice demonstrate fulminant lymphoid apoptosis, polycystic kidneys, and hypopigmented hair. Cell 1993:75: 229-240.
    • (1993) Cell , vol.75 , pp. 229-240
    • Veis, D.J.1    Sorenson, C.M.2    Shutter, J.R.3    Korsmeyer, S.J.4
  • 43
    • 0028833859 scopus 로고
    • Bcl-2 deficiency in mice leads to pleiotropic abnormalities: Accelerated lymphoid cell death in the thymus and spleen, polycystic kidney, hair hypopigmentation and distorted small intestine
    • Kamada S. Shinto AA. Tsujimura Y. Takahashi T. Noda T. Kitamura Y. Kondoh H, Tsujimoto Y: Bcl-2 deficiency in mice leads to pleiotropic abnormalities: Accelerated lymphoid cell death in the thymus and spleen, polycystic kidney, hair hypopigmentation and distorted small intestine. Cancer Res 1995;55:354-359.
    • (1995) Cancer Res , vol.55 , pp. 354-359
    • Kamada, S.1    Shinto, A.A.2    Tsujimura, Y.3    Takahashi, T.4    Noda, T.5    Kitamura, Y.6    Kondoh, H.7    Tsujimoto, Y.8
  • 44
    • 0028175759 scopus 로고
    • Targeted disruption ofbcl-2 beta in mice-occurrence of grey hair, polycystic kidney disease, and lymphocytopenia
    • Nakayama K-I. Nakayama K. Negi-shi I. Kuida K. Sawa H. Loh DY: Targeted disruption ofbcl-2 beta in mice-occurrence of grey hair, polycystic kidney disease, and lymphocytopenia. Proc Natl Acad Sci USA 1994:91:3700-3704.
    • (1994) Proc Natl Acad Sci USA , vol.91 , pp. 3700-3704
    • Nakayama, K.-I.1    Nakayama, K.2    Negi-Shi, I.3    Kuida, K.4    Sawa, H.5    Loh, D.Y.6
  • 45
    • 0028887385 scopus 로고
    • Fulminant metanephrie apoptosis and abnormal kidney development in bel-2 deficient mice
    • Sorenson CM. Rogers SA. Kors-mever SJ. Hammerman MR: Fulminant metanephrie apoptosis and abnormal kidney development in bel-2 deficient mice. Am J Physiol 1995: 268:F73-F81.
    • (1995) Am J Physiol , vol.268 , pp. F73-F81
    • Sorenson, C.M.1    Rogers, S.A.2    Kors-Mever, S.J.3    Hammerman, M.R.4
  • 47
    • 1842456916 scopus 로고    scopus 로고
    • Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development
    • Michaelidis TM. Sendtner M. Cooper JD. Airaksinen MS. Hollman B. Meyer M. Thocnen H: Inactivation of bcl-2 results in progressive degeneration of motoneurons, sympathetic and sensory neurons during early postnatal development. Neuron 1996:17:75-89.
    • (1996) Neuron , vol.17 , pp. 75-89
    • Michaelidis, T.M.1    Sendtner, M.2    Cooper, J.D.3    Airaksinen, M.S.4    Hollman, B.5    Meyer, M.6    Thocnen, H.7
  • 48
    • 0028149786 scopus 로고
    • Checkpoints of dueling dimers foil death wishes
    • Oltvai ZN. Korsmcyer SJ: Checkpoints of dueling dimers foil death wishes. Cell 1995:79:189-192.
    • (1995) Cell , vol.79 , pp. 189-192
    • Oltvai, Z.N.1    Korsmcyer, S.J.2
  • 49
    • 0028206341 scopus 로고
    • BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and hctcrodimerization with Bax
    • Yin XM. Oltvai Z. Korsmcyer SJ: BH1 and BH2 domains of Bcl-2 are required for inhibition of apoptosis and hctcrodimerization with Bax. Nature 1994:369:321-323.
    • (1994) Nature , vol.369 , pp. 321-323
    • Yin, X.M.1    Oltvai, Z.2    Korsmcyer, S.J.3
  • 53
    • 0028036895 scopus 로고
    • Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2
    • Krajcwski S. Krajewska M. Shabaik A. Miyashita T. Wang HG, Reed JC: Immunohistochemical determination of in vivo distribution of Bax, a dominant inhibitor of Bcl-2. Am .1 Pathol 1994:145:1323-1336.
    • (1994) Am .1 Pathol , vol.145 , pp. 1323-1336
    • Krajcwski, S.1    Krajewska, M.2    Shabaik, A.3    Miyashita, T.4    Wang, H.G.5    Reed, J.C.6
  • 56
    • 0028970662 scopus 로고
    • Bcl-xi. Displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice
    • Grillot DA, Merino R. Nunez G: Bcl-xi. Displays restricted distribution during T cell development and inhibits multiple forms of apoptosis but not clonal deletion in transgenic mice. J Exp Med 1995:182:1973-1983.
    • (1995) J Exp Med , vol.182 , pp. 1973-1983
    • Grillot, D.A.1    Merino, R.2    Nunez, G.3
  • 58
    • 0028922885 scopus 로고
    • Negishi LScnjuS. ZhangQ. Fujii S. Loh D: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficiem mice
    • Motoyama N. Wang F, Roth KA. Sawa H, Nakayama K. Nakayama K. Negishi LScnjuS. ZhangQ. Fujii S. Loh D: Massive cell death of immature hematopoietic cells and neurons in Bcl-x-deficiem mice. Science 1995;267:1506-1510.
    • (1995) Science , vol.267 , pp. 1506-1510
    • Motoyama, N.1    Wang, F.2    Roth, K.A.3    Sawa, H.4    Nakayama, K.5    Nakayama, K.6
  • 60
    • 0027326012 scopus 로고
    • Characterisation of Al. A novel hemopoietic-specific early response gene with sequence similarity to bcl-2
    • Lin EY. Orlofsky A. Berger MS. Prystowsky MB: Characterisation of Al. A novel hemopoietic-specific early response gene with sequence similarity to bcl-2. J Immunol 1993: 151:1979-1988.
    • (1993) J Immunol , vol.151 , pp. 1979-1988
    • Lin, E.Y.1    Orlofsky, A.2    Berger, M.S.3    Prystowsky, M.B.4
  • 61
    • 0030053684 scopus 로고    scopus 로고
    • A I, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation
    • Lin EY, Orlofsky A. Wang HG. Reed JC. Prystowsky MB: A I, a Bcl-2 family member, prolongs cell survival and permits myeloid differentiation. Blood 1996:87:983-992.
    • (1996) Blood , vol.87 , pp. 983-992
    • Lin, E.Y.1    Orlofsky, A.2    Wang, H.G.3    Reed, J.C.4    Prystowsky, M.B.5
  • 63
    • 0027480450 scopus 로고
    • MCL1, a gene expressed in programmed myeloid differentiation, has sequence similarity to Bcl-2
    • Kozopas KM, Yang T. Buchan HI. Zhou P. Craig RW: MCL1, a gene expressed in programmed myeloid differentiation, has sequence similarity to Bcl-2. Proc Nall Acad Sei USA 1993:90:3516-3520.
    • (1993) Proc Nall Acad Sei USA , vol.90 , pp. 3516-3520
    • Kozopas, K.M.1    Yang, T.2    Buchan, H.I.3    Zhou, P.4    Craig, R.W.5
  • 64
    • 0028609620 scopus 로고
    • Mcl-1. A member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells
    • Reynolds JE. Yang T, Qian L. Jcn-kinson JD. Zhou P. Eastman A. Craig RW: Mcl-1. A member of the Bcl-2 family, delays apoptosis induced by c-Myc overexpression in Chinese hamster ovary cells. Cancer Res 1994:54:6348-6352.
    • (1994) Cancer Res , vol.54 , pp. 6348-6352
    • Reynolds, J.E.1    Yang, T.2    Qian, L.3    Jcn-Kinson, J.D.4    Zhou, P.5    Eastman, A.6    Craig, R.W.7
  • 65
    • 0028824266 scopus 로고    scopus 로고
    • A novel Bcl-2 related gene. Bfl-1. Is overexpressed in stomach cancer and preferentially expressed in bone marrow
    • Choi SS. Park IC. Yun JW, Sung YC, Hong SI. Shin HS: A novel Bcl-2 related gene. Bfl-1. Is overexpressed in stomach cancer and preferentially expressed in bone marrow. Oncogene 1996:11:1693-1698.
    • (1996) Oncogene , vol.11 , pp. 1693-1698
    • Choi, S.S.1    Park, I.C.2    Yun, J.W.3    Sung, Y.C.4    Hong, S.I.5    Shin, H.S.6
  • 66
    • 9244246789 scopus 로고    scopus 로고
    • Identification of a novel Bcl-2 related gene. BRAG-1, in human glioma
    • Das R. Reddy EP. Chatterjee D. Andrews DW: Identification of a novel Bcl-2 related gene. BRAG-1, in human glioma. Oncogene 1996:12: 947-951.
    • (1996) Oncogene , vol.12 , pp. 947-951
    • Das, R.1    Reddy, E.P.2    Chatterjee, D.3    Rews, D.W.4
  • 67
    • 0026773471 scopus 로고
    • The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cy-tolysis by tumor necrosis factor alpha
    • White E. Sabbatini P, Debbas M, Wold WS. Kusher DL Gooding LR: The 19-kilodalton adenovirus E1B transforming protein inhibits programmed cell death and prevents cy-tolysis by tumor necrosis factor alpha. Mol Cell Biol 1992:12:2570-2580.
    • (1992) Mol Cell Biol , vol.12 , pp. 2570-2580
    • White, E.1    Sabbatini, P.2    Debbas, M.3    Wold, W.S.4    Kusher Dl Gooding, L.R.5
  • 69
    • 0027264124 scopus 로고
    • An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstcin-Barr virus gene BHRF1
    • Neilan JG. Lu Z. Afonso CL, Kutish GF. Sussman MD. Rock DL: An African swine fever virus gene with similarity to the proto-oncogene bcl-2 and the Epstcin-Barr virus gene BHRF1. J Virol 1993:67:4391-4394.
    • (1993) J Virol , vol.67 , pp. 4391-4394
    • Neilan, J.G.1    Lu, Z.2    Afonso, C.L.3    Kutish, G.F.4    Sussman, M.D.5    Rock, D.L.6
  • 70
    • 0027260656 scopus 로고
    • Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2. Protects human B cells from programmed cell death
    • Henderson S. Huen D. Rowe M, Dawson C. Johnson G. Rickinson A: Epstein-Barr virus-coded BHRF1 protein, a viral homologue of Bcl-2. Protects human B cells from programmed cell death. Proc Natl Acad Sci USA 1993:90:8479-8483.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8479-8483
    • Henderson, S.1    Huen, D.2    Rowe, M.3    Dawson, C.4    Johnson, G.5    Rickinson, A.6
  • 72
    • 0029868112 scopus 로고    scopus 로고
    • The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-indueiblc and death-promoting Bax protein
    • Han J, Sabbalini P, Perez D. Rao L. Modha D. White H: The E1B 19K protein blocks apoptosis by interacting with and inhibiting the p53-indueiblc and death-promoting Bax protein. Genes Dev 1996; 10:461 - 477.
    • (1996) Genes Dev , vol.10
    • Han, J.1    Sabbalini, P.2    Perez, D.3    Rao, L.4    Modha, D.5    White, H.6
  • 73
    • 0028809209 scopus 로고
    • Bad. A heterodinreric partner for Bcl-xL and Bcl-2. Displaces Bax and promotes cell death
    • Yang E. Zha J. Jockel J. Boise LH, Thompson CB. Korsmeyer SJ: Bad. A heterodinreric partner for Bcl-xL and Bcl-2. Displaces Bax and promotes cell death. Cell 1995:80:285-291.
    • (1995) Cell , vol.80 , pp. 285-291
    • Yang, E.1    Zha, J.2    Jockel, J.3    Boise, L.H.4    Thompson, C.B.5    Korsmeyer, S.J.6
  • 75
    • 0029669929 scopus 로고    scopus 로고
    • T cells from bax alpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53
    • Brady HJM, Salomons GS, Bobel-dijk RC. Bcrns AJM: T cells from bax alpha transgenic mice show accelerated apoptosis in response to stimuli but do not show restored DNA damage-induced cell death in the absence of p53. EMBO J 1996: 15:1221-1230.
    • (1996) EMBO J , vol.15 , pp. 1221-1230
    • Brady, H.1    Salomons, G.S.2    Bobel-Dijk, R.C.3    Bcrns, A.4
  • 76
    • 0029671112 scopus 로고    scopus 로고
    • G-Radiation induces uprcgulation of Bax protein and apoptosis in radiosensitive cells in vivo
    • Kitada S. Krajewski S. Miyashita T. Krajewska M. Reed JC: g-Radiation induces uprcgulation of Bax protein and apoptosis in radiosensitive cells in vivo. Oncogene 1996:12:187-192.
    • (1996) Oncogene , vol.12 , pp. 187-192
    • Kitada, S.1    Krajewski, S.2    Miyashita, T.3    Krajewska, M.4    Reed, J.C.5
  • 78
    • 0030052107 scopus 로고    scopus 로고
    • Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cere\i-siae
    • Greenhalf W. Stephan C. Chaudhu-ri B: Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cere\i-siae. FEBS Lett 1996:380:169-175.
    • (1996) FEBS Lett , vol.380 , pp. 169-175
    • Greenhalf, W.1    Stephan, C.2    Chaudhu-Ri, B.3
  • 79
    • 0029893702 scopus 로고    scopus 로고
    • The origin of programmed cell death
    • Ameisen J: The origin of programmed cell death. Science 1996: 272:1278-1279.
    • (1996) Science , vol.272 , pp. 1278-1279
    • Ameisen, J.1
  • 82
    • 0029990550 scopus 로고    scopus 로고
    • Immunohistochemical analysis of in vivo patterns of Bak expression. A proapoptotic member of the Bcl-2 protein family
    • Krajewski S. Krajewska M. Reed JC: Immunohistochemical analysis of in vivo patterns of Bak expression. A proapoptotic member of the Bcl-2 protein family. Cancer Res 1996:56:2849-2855.'
    • (1996) Cancer Res , vol.56 , pp. 2849-2855
    • Krajewski, S.1    Krajewska, M.2    Reed, J.C.3
  • 83
    • 0029945789 scopus 로고    scopus 로고
    • Elevated expression of Bcl-x and reduced Bak in primary colorectal adenocarcinomas
    • Krajewska M. Moss SF. Krajewski S. Song K. Holt PR. Reed JC: Elevated expression of Bcl-x and reduced Bak in primary colorectal adenocarcinomas. Cancer Res 1996: 56:2422-2427.
    • (1996) Cancer Res , vol.56 , pp. 2422-2427
    • Krajewska, M.1    Moss, S.F.2    Krajewski, S.3    Song, K.4    Holt, P.R.5    Reed, J.C.6
  • 85
    • 0028847915 scopus 로고
    • Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity
    • Takayama S. Sato T, Krajewski S. Kochel K. Irie S, Millan JA. Reed JC: Cloning and functional analysis of BAG-1: A novel Bcl-2-binding protein with anti-cell death activity. Cell 1995:80:279-284.
    • (1995) Cell , vol.80 , pp. 279-284
    • Takayama, S.1    Sato, T.2    Krajewski, S.3    Kochel, K.4    Irie, S.5    Millan, J.A.6    Reed, J.C.7
  • 86
    • 0027171066 scopus 로고
    • Ubiquilin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis
    • Délie J. Morange M, Magdelcnat H: Ubiquilin pathway involvement in human lymphocyte gamma-irradiation-induced apoptosis. Mol Cell Biol 1993:13:4875-4883.
    • (1993) Mol Cell Biol , vol.13 , pp. 4875-4883
    • Délie, J.1    Morange, M.2    Magdelcnat, H.3
  • 87
    • 0029937303 scopus 로고    scopus 로고
    • Bcl-2 interacting protein. Bag-1, binds to and activates the kinase Raf-t
    • Wang H-G. Takayama S. Rapp U. Reed JC: Bcl-2 interacting protein. Bag-1, binds to and activates the kinase Raf-t. Proc Natl Acad Sci USA 1996:93:7063-7068.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7063-7068
    • Wang, H.-G.1    Takayama, S.2    Rapp, U.3    Reed, J.C.4
  • 88
    • 0025937489 scopus 로고
    • Constitutive c-myc expression in an IL-3-depcn-dent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis
    • Askew DS. Ashmun RA, Simmons BC. Cleveland JL: Constitutive c-myc expression in an IL-3-depcn-dent myeloid cell line suppresses cell cycle arrest and accelerates apoptosis. Oncogene 1991:6:1915-1922.
    • (1991) Oncogene , vol.6 , pp. 1915-1922
    • Askew, D.S.1    Ashmun, R.A.2    Simmons, B.C.3    Cleveland, J.L.4
  • 90
    • 0028158099 scopus 로고
    • Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by scrum reduction, interferon-gamma. Heparin, and cyclic nucleotide analyogucs and induces apoptosis
    • Bennett MR. Evan GI. Newby AC: Deregulated expression of the c-myc oncogene abolishes inhibition of proliferation of rat vascular smooth muscle cells by scrum reduction, interferon-gamma. heparin, and cyclic nucleotide analyogucs and induces apoptosis. Circ Res 1994:74:525- 536.
    • (1994) Circ Res , vol.74
    • Bennett, M.R.1    Evan, G.I.2    Newby, A.C.3
  • 92
    • 0026722655 scopus 로고
    • Cooperative interaction between c-myc and bcl-2 proto-oncogene
    • Fanidi A, Harrington EA. Evan G: Cooperative interaction between c-myc and bcl-2 proto-oncogene. Nature 1992;359:554-556.
    • (1992) Nature , vol.359 , pp. 554-556
    • Fanidi, A.1    Harrington, E.A.2    Evan, G.3
  • 93
    • 0028263811 scopus 로고
    • C-Myc-induccd apoptosis in fibroblasts is inhibited by specific cytokines
    • Harrington EA. Bennett MR. Fa-nidi A. Evan GI: C-Myc-induccd apoptosis in fibroblasts is inhibited by specific cytokines. EMBO J 1994; 13:3286-3295.
    • (1994) EMBO J , vol.13 , pp. 3286-3295
    • Harrington, E.A.1    Bennett, M.R.2    Fa-Nidi, A.3    Evan, G.I.4
  • 94
    • 0027440568 scopus 로고
    • Bcl-2 associates with the ras-rclated protein R-ras p23
    • Femandez-Sarabia MJ. Bischof TJR: Bcl-2 associates with the ras-rclated protein R-ras p23. Nature 1993:366:274-275.
    • (1993) Nature , vol.366 , pp. 274-275
    • Femandez-Sarabia, M.J.1    Bischof, T.2
  • 95
    • 0029063175 scopus 로고
    • Activated H-ras rescues ElA-induced apoptosis and cooperates with El A to overcome p53-dependent growth arrest
    • Lin H-JL. Eivner V. Prendcrgast GC, White E: Activated H-ras rescues ElA-induced apoptosis and cooperates with El A to overcome p53-dependent growth arrest. Mol Cell Biol 1995; 15:4536-4544.
    • (1995) Mol Cell Biol , vol.15 , pp. 4536-4544
    • Lin, H.-J.L.1    Eivner, V.2    Prendcrgast, G.C.3    White, E.4
  • 96
    • 0029029743 scopus 로고
    • R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 supprcssible mechanism
    • Wang H-G. Milan JA. Cox AD. Der CJ, Rapp UR, Beck T, Zha H. Reed JC: R-ras promotes apoptosis caused by growth factor deprivation via a Bcl-2 supprcssible mechanism. J Cell Biol 1995:129: 1103-1114.
    • (1995) J Cell Biol , vol.129 , pp. 1103-1114
    • Wang, H.-G.1    Milan, J.A.2    Cox, A.D.3    Der, C.J.4    Rapp, U.R.5    Beck, T.6    Zha, H.7    Reed, J.C.8
  • 99
    • 0028883179 scopus 로고
    • Tumor suppressor p53 is a direct transcriptional activator of human bax gene
    • Miyashita T. Reed JC: Tumor suppressor p53 is a direct transcriptional activator of human bax gene. Cell 1995:80:293-299.
    • (1995) Cell , vol.80 , pp. 293-299
    • Miyashita, T.1    Reed, J.C.2
  • 100
    • 0028292480 scopus 로고
    • Identification of a p53-dependent negative response element in the bcl-2 gene
    • Miyashita T. Harigai M. Hanada M. Reed JC: Identification of a p53-dependent negative response element in the bcl-2 gene. Cancer Res 1995:54:3131-3135.
    • (1995) Cancer Res , vol.54 , pp. 3131-3135
    • Miyashita, T.1    Harigai, M.2    Hanada, M.3    Reed, J.C.4
  • 103
    • 0027496935 scopus 로고
    • The p21 CDK-intcracting protein Cipl is a potent inhibitor of G! cyclin-de-pendent kinases
    • Harper JW. Adami GR. Wei N. Keyomarsi K, Elledge SJ: The p21 CDK-intcracting protein Cipl is a potent inhibitor of G! cyclin-de-pendent kinases. Cell 1993:75: 805-816.
    • (1993) Cell , vol.75 , pp. 805-816
    • Harper, J.W.1    Adami, G.R.2    Wei, N.3    Keyomarsi, K.4    Elledge, S.J.5
  • 104
    • 0028070989 scopus 로고
    • Karin M: P53-dependenl apoptosis in the absence of transcriptional activation of p53-target genes
    • Caches C. Helmberg A. Karin M: p53-dependenl apoptosis in the absence of transcriptional activation of p53-target genes. Nature 1994;370:220-223.
    • (1994) Nature , vol.370 , pp. 220-223
    • Caches, C.1    Helmberg, A.2
  • 105
    • 0030046508 scopus 로고    scopus 로고
    • Life, death, and the pursuit of apoptosis
    • White E: Life, death, and the pursuit of apoptosis. Genes Dev 1996; 10:1-15.
    • (1996) Genes Dev , vol.10 , pp. 1-15
    • White, E.1
  • 106
    • 0028973301 scopus 로고
    • Interleukin-1 betaconverting enzyme-related proteases (IRPs) and mammalian cell death: Dissociation of IRP-in-duccd oligonuclcosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle
    • Flaws JA. Kugu K. Trbovich AM. DeSanti A. Tilly Kl. Hirshficld AN, Tilly JL: Interleukin-1 betaconverting enzyme-related proteases (IRPs) and mammalian cell death: Dissociation of IRP-in-duccd oligonuclcosomal endonuclease activity from morphological apoptosis in granulosa cells of the ovarian follicle. Endocrinology 1995:136:5042-5053.
    • (1995) Endocrinology , vol.136 , pp. 5042-5053
    • Flaws, J.A.1    Kugu, K.2    Trbovich, A.M.3    Desanti, A.4    Tilly, K.L.5    Hirshficld, A.N.6    Tilly, J.L.7
  • 107
    • 0028978248 scopus 로고
    • Purification of an interleukin-1 beta converting enzyme-related cystcineprotease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembranc domains
    • W'ang X. Pai JT. Wicdcnfeld EA. Medina JC. Slaughter CA. Goldstein JL, Brown MS: Purification of an interleukin-1 beta converting enzyme-related cystcineprotease that cleaves sterol regulatory element-binding proteins between the leucine zipper and transmembranc domains. J Biol Chcm 1995:270: 18044-18050.
    • (1995) J Biol Chcm , vol.270 , pp. 18044-18050
    • W'ang, X.1    Pai, J.T.2    Wicdcnfeld, E.A.3    Medina, J.C.4    Slaughter, C.A.5    Goldstein, J.L.6    Brown, M.S.7
  • 109
    • 0022497852 scopus 로고
    • Genetic control of programmed cell death in the nematode C. Elegans
    • Ellis HM. Horvitz HR: Genetic control of programmed cel! death in the nematode C. elegans. Cell 1980:44:817-829.
    • (1980) Cell , vol.44 , pp. 817-829
    • Ellis, H.M.1    Horvitz, H.R.2
  • 111
    • 0029984098 scopus 로고    scopus 로고
    • Bcl-2 expression prevents activation of the ICE protease cascade
    • Shimizu S. Eguchi Y. Kamiikc W. Matsuda H. Tsujimoto Y: Bcl-2 expression prevents activation of the ICE protease cascade. Oncogene 1996; 12:2251-2257.
    • (1996) Oncogene , vol.12 , pp. 2251-2257
    • Shimizu, S.1    Eguchi, Y.2    Kamiikc, W.3    Matsuda, H.4    Tsujimoto, Y.5
  • 112
    • 0029609086 scopus 로고    scopus 로고
    • Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis
    • Strasser A. Harris AW. Huang DC. Krammcr PH. Cory S: Bcl-2 and Fas/APO-1 regulate distinct pathways to lymphocyte apoptosis. EM BO J 1996:14:6136-6147.
    • (1996) EM BO J , vol.14 , pp. 6136-6147
    • Strasser, A.1    Harris, A.W.2    Huang, D.C.3    Krammcr, P.H.4    Cory, S.5


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