Natural vitamin D3 response elements formed by inverted palindromes: Polarity-directed ligand sensitivity of vitamin D3 receptor-retinoid X receptor heterodimer-mediated transactivation

Molecular and Cellular Biology

Volumn 15, Issue 3, 1995, Pages 1154-1161

  Schräder, Magdalena ^a   Nayeri, Sepideh ^a   Kahlen, Jean Pierre ^a   Müller, Kai M ^a   Carlberg, Carsten ^a  

^a GENEVA UNIVERSITY HOSPITALS   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

CALBINDIN; CALCITRIOL; CALCITRIOL RECEPTOR; CALCIUM BINDING PROTEIN, VITAMIN D DEPENDENT; CHLORAMPHENICOL ACETYLTRANSFERASE; LIGAND; OSTEOCALCIN; PRIMER DNA; RECOMBINANT PROTEIN; RETINOIC ACID RECEPTOR; RETINOID; RETINOID X RECEPTOR; THYROID HORMONE RECEPTOR; TRANSCRIPTION FACTOR; RETINOIC ACID;

ANIMAL; ARTICLE; BIOSYNTHESIS; BREAST TUMOR; CELL CULTURE; CELL LINE; CELL NUCLEUS; GENETIC TRANSCRIPTION; GENETIC TRANSFECTION; GENETICS; HUMAN; KINETICS; MACROMOLECULE; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; PROMOTER REGION; RAT; RNA TRANSLATION; TRANSACTIVATION; BINDING AFFINITY; CELL STIMULATION; DNA BINDING; DRUG EFFECT; GENE SEQUENCE; NONHUMAN; PRIORITY JOURNAL;

ANIMAL; BASE SEQUENCE; BREAST NEOPLASMS; CALCITRIOL; CALCIUM-BINDING PROTEIN, VITAMIN D-DEPENDENT; CELL LINE; CELL NUCLEUS; CHLORAMPHENICOL O-ACETYLTRANSFERASE; DNA PRIMERS; HUMAN; KINETICS; LIGANDS; MACROMOLECULAR SYSTEMS; MOLECULAR SEQUENCE DATA; OSTEOCALCIN; OSTEOSARCOMA; POLYMERASE CHAIN REACTION; PROMOTER REGIONS (GENETICS); RATS; RECEPTORS, CALCITRIOL; RECEPTORS, RETINOIC ACID; RECEPTORS, THYROID HORMONE; RECOMBINANT PROTEINS; RETINOIDS; SUPPORT, NON-U.S. GOV'T; TRANS-ACTIVATION (GENETICS); TRANSCRIPTION FACTORS; TRANSCRIPTION, GENETIC; TRANSFECTION; TRANSLATION, GENETIC; TUMOR CELLS, CULTURED;

EID: 0028985184     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.15.3.1154     Document Type: Article

References (49)

1. Baniahmad, A., C. Steiner, A. C. Köhne, and R. Renkawitz. 1990. Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell 61:505-514.
2. 3. J. Biol. Chem. 268: 27371-27380.
3. Carlberg, C. 1993. RXR-independent action of the receptors for thyroid hormone, retinoic acid, and vitamin D on inverted palindromes. Biochem. Biophys. Res. Commun. 195:1345-1353.
4. Carlberg, C., I. Bendik, A. Wyss, E. Meier, L. J. Sturzenbecker, J. F. Grippo, and W. Hunziker. 1993. Two nuclear signalling pathways for vitamin D. Nature (London) 361:657-660.
5. Carlberg, C., J.-H. Saurat, and G. Siegenthaler. 1993. 9-cis retinoic acid is a natural antagonist for the retinoic acid receptor response pathway. Biochem. J. 295:343-346.
6. 3 receptor (VDR) homodimers into VDR-retinoid X receptor heterodimers. Mol. Cell. Biol. 14:3329-3338.
7. Darwish, H. M., and H. F. DeLuca. 1992. Identification of a 1,25-dihydroxyvitamin D3-response element in the 5′-flanking region of the rat calbindin D-9k gene. Proc. Natl. Acad. Sci. USA 89:603-607.
8. 3. Proc. Natl. Acad. Sci. USA 87:369-373.
9. 3. Proc. Natl. Acad. Sci. USA 89:8097-8101.
10. Durand, B., M. Saunders, P. Leroy, M. Leid, and P. Chambon. 1992. All-trans and 9-cis retinoic acid induction of CRABPII transcription is mediates by RAR-RXR heterodimers bound to DR1 and DR2 repeated motifs. Cell 71:73-85.
11. Evans, R. M. 1988. The steroid and thyroid hormone receptor superfamily. Science 240:889-895.
12. Farsetti, A., B. Desvergne, P. Hallenbeck, J. Robbins, and V. R. Nikodem. 1992. Characterization of myelin basic protein thyroid hormone response element and its function in the context of native and heterologous promoter. J. Biol. Chem. 267:15784-15788.
13. 3- and butyrate-inducible responses. Proc. Natl. Acad. Sci. USA 90:2984-2988.
14. Glass, C. K. 1994. Differential recognition of target genes by nuclear receptor monomers, dimers, and heterodimers. Endocrine Rev. 15:391-407.
15. 24 gene. Nucleic Acids Res. 22:2410-2416.
16. Jeung, E.-B., P. C. K. Leung, and J. Krisinger. 1994. The human calbindin-D9k gene: complete structure and implications on steroid hormone regulation. J. Mol. Biol. 235:1231-1238.
17. Kahlen, J.-P., and C. Carlberg. 1994. Identification of a vitamin D receptor homodimer-type response element in the rat calcitriol 24-hydroxylase gene promoter. Biochem. Biophys. Res. Commun. 202:1366-1372.
18. 3. Proc. Natl. Acad. Sci. USA 86:4455-4459.
19. Kurokawa, R., V. C. Yu, A. Näär, S. Kyakumoto, Z. Han, S. Silverman, M. G. Rosenfeld, and C. K. Glass. 1993. Differential orientations of the DNA-binding domain and carboxy-terminal dimerization interface regulate binding site selection by nuclear receptor heterodimers. Genes Dev. 7:1423-1435.
20. 3 response: hormonal cross talk by ligand-induced squelching. Mol. Cell. Biol. 13:7698-7707.
21. Leid, M., P. Kastner, and P. Chambon. 1992. Multiplicity generates diversity in the retinoic acid signalling pathways. Trends Biochem. 17:427-433.
22. Luckow, B., and G. Schütz. 1987. CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res. 15:5490.
23. 3-activated expression of the rat osteocalcin gene. Mol. Cell. Biol. 13:5907-5917.
24. Mader, S., J.-Y. Chen, Z. Chen, J. White, P. Chambon, and H. Gronemeyer. 1993. The patterns of binding of RAR, RXR and TR homo- and heterodimers to direct repeats are dictated by the binding specificities of the DNA binding domains. EMBO J. 12:5029-5041.
25. Morrison, N. A., J. Shine, J.-C. Fragonas, V. Verkest, M. L. McMenemey, and J. A. Eisman. 1989. 1,25-Dihydroxyvitamin D-responsive element and glucocorticoid repression in the osteocalcin gene. Science 246:1158-1161.
26. 3 enhancement of mouse secreted phosphoprotein 1 (Spp-1 or osteopontin) gene expression. Proc. Natl. Acad. Sci. USA 87:9995-9999.
27. O'Malley, B. W. 1990. The steroid receptor superfamily: more excitement predicted for the future. Mol. Endocrinol. 4:363-369.
28. Parker, M. G. 1993. Steroid and related receptors. Curr. Opin. Cell Biol. 5:499-504.
29. Perlmann, T., P. N. Rangarajan, K. Umesono, and R. M. Evans. 1993. Determinants for selective RAR and TR recognition of direct repeat HREs. Genes Dev. 7:1411-1422.
30. 3 receptors: structure and function in transcription. Annu. Rev. Nutr. 11:189-216.
31. Pothier, F., M. Ouellet, J.-P. Julien, and S. L. Guérin. 1992. An improved CAT assay for promoter analysis in either transgenic mice or tissue culture cells. DNA Cell Biol. 11:83-90.
32. Predki, P. F., D. Zamble, B. Sarkar, and V. Giguère. 1994. Ordered binding of retinoic acid and retinoid-X receptors to asymmetric response elements involves determinants adjacent to the DNA-binding domain. Mol. Endocrinol. 8:31-39.
33. 3 response element of chicken carbonic anhydrase-II. DNA Cell Biol. 14:1181-1187.
34. Raisher, B. D., T. Gulick, Z. Zhang, A. W. Strauss, D. D. Moore, and D. P. Kelly. 1992. Identification of a novel retinoid-responsive element in the promoter region of the medium chain acyl-coenzyme A dehydrogenase gene. J. Biol. Chem. 267:20264-20269.
35. Rhodes, S. J., R. Chen, G. E. DiMattia, K. M. Scully, K. A. Kalla, S.-C. Lin, V. C. Yu, and M. G. Rosenfeld. 1993. A tissue-specific enhancer confers Pit-1-dependent morphogen inducibility and autoregulation on the pit-1 gene. Genes Dev. 7:913-932.
36. Schräder, M., M. Becker-André, and C. Carlberg. 1994. Thyroid hormone receptor monomers can function as ligand-inducible transcription factors on octamer sequences: consequences also for heterodimerization. J. Biol. Chem. 269:6444-6449.
37. Schräder, M., I. Bendik, M. Becker-André, and C. Carlberg. 1993. Interaction between retinoic acid and vitamin D signalling pathways. J. Biol. Chem. 268:17830-17836.
38. Schräder, M., and C. Carlberg. 1994. Thyroid hormone and retinoic acid receptors form heterodimers with retinoid X receptors on direct repeats, palindromes and inverted palindromes. DNA Cell Biol. 13:333-341.
39. Schräder, M., K. M. Müller, M. Becker-André, and C. Carlberg. 1994. Response element selectivity for heterodimerization of vitamin D receptors with retinoic acid and retinoid X receptors. J. Mol. Endocrinol. 12:327-339.
40. Schräder, M., K. M. Müller, and C. Carlberg. 1994. Specificity and flexibility of vitamin D signalling: modulation of the activation of natural vitamin D response elements by thyroid hormone. J. Biol. Chem. 269:5501-5504.
41. Schräder, M., K. M. Müller, S. Nayeri, J.-P. Kahlen, and C. Carlberg. 1994. VDR-T3R heterodimer polarity directs ligand sensitivity of transactivation. Nature (London) 370:382-386.
42. Schräder, M., A. Wyss, L. J. Sturzenbecker, J. F. Grippo, P. LeMotte, and C. Carlberg. 1993. RXR-dependent and RXR-independent transactivation by retinoic acid receptors. Nucleic Acids Res. 21:1231-1237.
43. Tini, M., G. Otulakowski, M. L. Breitman, L.-C. Tsui, and V. Giguère. 1993. An everted repeat mediates retinoic acid induction of the γF-crystallin gene: evidence of a direct role for retinoids in lens development. Genes Dev. 7:295-307.
44. Umesono, K., K. K. Murakami, C. C. Thompson, and R. M. Evans. 1991. Direct repeats as selective response elements for the thyroid hormone, retinoic acid, and vitamin D3 receptors. Cell. 65:1255-1266.
45. Wahlström, G. M., M. Sjöberg, M. Andersson, K. Nordström, and B. Vennström. 1992. Binding characteristics of the thyroid hormone receptor homo- and heterodimers to consensus AGGTCA repeat motifs. Mol. Endocrinol. 6:1013-1022.
46. Walters, M. R. 1992. Newly identified actions of the vitamin D endocrine system. Endocrine Rev. 13:719-764.
47. Yu, V. C., A. M. Näär, and M. G. Rosenfeld. 1992. Transcriptional regulation by the nuclear receptor superfamily. Curr. Opin. Biotechnol. 3:597-602.
48. Zechel, C., X.-Q. Shen, J.-Y. Chen, Z.-P. Chen, P. Chambon, and H. Gronemeyer. 1994. The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full-length receptors to direct repeats. EMBO J. 13:1425-1433.
49. 3) 24-hydroxylase gene. Proc. Natl. Acad. Sci. USA 91:900-902.