Making the most of mucin: A novel target for tumor immunotherapy

Cancer Immunology Immunotherapy

Volumn 43, Issue 3, 1996, Pages 142-151

  Barratt Boyes, Simon M ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

Author keywords

mucin; tumor antigen; tumor immunotherapy; vaccines

Indexed keywords

CANCER VACCINE; MUCIN;

ANTIBODY RESPONSE; CANCER IMMUNOTHERAPY; CHIMPANZEE; CLINICAL TRIAL; CONFERENCE PAPER; GLYCOSYLATION; HUMAN; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; TRANSGENIC MOUSE;

ANIMALS; ANTIBODIES, NEOPLASM; ANTIGENS, NEOPLASM; CANCER VACCINES; CLINICAL TRIALS, PHASE I; DENDRITIC CELLS; EPITOPES; GLYCOSYLATION; HUMANS; IMMUNOTHERAPY; MICE; MUCINS; NEOPLASM PROTEINS; NEOPLASMS; PAN TROGLODYTES; T-LYMPHOCYTES, CYTOTOXIC;

EID: 0029902480     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050315     Document Type: Conference Paper

References (66)

1. Abdel-Motal UM, Berg L, Rosen A, Bengtsson M, Thorpe CJ, Kihlberg J, Dahmen J, Magnusson G, Karlsson K-A, Jondal M (1996) Immunization with glycosylated Kb-binding peptides generates carbohydrate-specific unrestricted cytotoxic T cells. Eur J Immunol 26: 544-551
2. Acres RB, Hareuveni M, Balloul J-M, Kieny M-P (1993) Vaccinia virus MUC1 immunization of mice: immune response and protection against the growth of murine tumors bearing the MUC1 antigen. J Immunother 14: 136-143
3. Apostolopolous V, McKenzie IFC (1994) Cellular mucins: targets for immunotherapy. Crit Rev Immunol 14: 293-309
4. Apostolopolous V, Xing P-X, McKenzie IFC (1994) Murine immune response to cells transfected with human MUC1: immunization with cellular and synthetic antigens. Cancer Res 54: 5186-5193
5. Apostolopolous V, Loveland BE, Pietersz GA, McKenzie IFC (1995) CTL in mice immunized with human mucin 1 are MHC-restricted. J Immunol 155: 5089-5094
6. Apostolopolous V, Pietersz GA, Loveland BE, Sandrin MS, McKenzie IFC (1995) Oxidative/reductive conjugation of mannan to antigen selects for T1 or T2 immune responses. Proc Natl Acad Sci USA 92: 10128-10132
7. Barnd DL, Lan MS, Metzgar RS, Finn OJ (1989) Specific, major histocompatability complex-unrestricted recognition of tumor-associated mucins by human cytotoxic T cells. Proc Natl Acad Sci USA 86: 7159-7163
8. Barratt-Boyes SM, Henderson RA, Finn OJ (1996) Chimpanzee dendritic cells with potent immunostimulatory function can be propagated from peripheral blood. Immunology 87: 528-534
9. Braga VMM, Pemberton LF, Duhig T, Gendler SJ (1992) Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development. Development 115: 427-437
10. Bramwell ME, Wiseman G, Shotton DM (1986) Electron microscopic studies of the CA antigen, epitectin. J Cell Sci 86: 249-261
11. Brockhausen I, Yang J-M, Burchell J, Whitehouse C, Taylor-Papadimitriou J (1995) Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells. Eur J Biochem 233: 607-618
12. Bu D, Doménech N, Lewis J, Taylor-Papadimitriou J, Finn OJ (1993) Recombinant vaccina mucin vector: in vitro analysis of expression of tumor-associated epitopes for antibody and human cytotoxic T-cell function. J Immunother 14: 127-135
13. Burchell J, Gendler S, Taylor-Papadimitriou J, Girling A, Lewis A, Millis R, Lamport D (1987) Development and characterization of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res 47: 5476-5482
14. Chen L, Linsley PS, Hellström KE (1993) Costimulation of T cells for tumor immunity. Immunol Today 14: 483-486
15. Ciborowski P, Finn OJ (1995) Recombinant epithelial cell mucin (MUC-1) expressed in baculovirus resembles antigenically tumor associated mucin, target for cancer immunotherapy. Biomed Peptides 1: 193-198
16. Denton G, Sekowski M, Price MR (1993) Induction of antibody responses to breast carcinoma associated mucins using synthetic peptide constructs as immunogens. Cancer Lett 70: 143-150
17. Ding L, Lalani E-N, Reddish M, Koganty R, Wong T, Samuel J, Yacyshyn MB, Meikle A, Fung PYS, Taylor-Papadimitriou J, Longnecker BM (1993) Immunogenicity of synthetic peptides related to the core peptide sequence encoded by the human MUC1 mucin gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene. Cancer Immunol Immunother 36: 9-17
18. Doménech N, Henderson RA, Finn OJ (1995) Identification of an HLA-A11-restricted epitope from the tandem repeat domain of the epithelial tumor antigen mucin. J Immunol 155: 4766-4774
19. Fink JH, Zea AH, Stanley J, Longo DL, Mizoguchi H, Tubbs RR, Wiltrout RH, O'Shea JJ, Kudoh S, Klein E, Bukowski RM, Ochoa AC (1993) Loss of T-cell receptor ζ chain and p56lck in T-cells infiltrating human renal cell carcinoma. Cancer Res 53: 5613-5616
20. Finn OJ, Jerome KR, Henderson RA, Pecher G, Doménech N, Magarian-Blander J, Barratt-Boyes SM (1995) MUC-1 epithelial tumor mucin-based immunity and cancer vaccines. Immunol Rev 145: 61-89
21. Finn OJ, McKolanis JR, Nalesnik MA, Clarke MR, Lotze MJ, Ochoa AC (1996) T cell defects in advanced breast, pancreatic and colon cancer and improvements after vaccination with a mucin peptide (abstract). Proc Am Assoc Cancer Res 37: 490
22. Fontenot JD, Tjandra N, Bu D, Ho C, Montelaro RC, Finn OJ (1993) Biophysical characterization of one-, two-, and three-tandem repeats of human mucin (MUC-1) protein core. Cancer Res 53: 5386-5394
23. Fung PYS, Madej M, Koganty K, Longnecker BM (1990) Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumor-associated glycoconjugate. Cancer Res 50: 4308-4314
24. Gendler SJ, Spicer AP (1995) Epithelial mucin genes. Annu Rev Physiol 57: 607-634
25. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani E-N, Wilson D (1990) Molecular cloning and expression of the human tumor-associated polymorphic epithelial mucin. J Biol Chem 265: 15286-15293
26. Gimi C, Morrison B, Boussiotis V, Gribben V, Kufe DW, Nadler LM (1996) MUC1/DF3 inhibits T cell mediated responses against breast cancer cells (abstract). Proc Am Assoc Cancer Res 37: 449
27. Graham RA, Burchell JM, Beverley P, Taylor-Papadimitriou J (1996) Intramuscular immunization with MUC1 cDNA can protect C57 mice challenged with MUC1-expressing syngeneic mouse tumor cells. Int J Cancer 65: 664-670
28. Graham RA, Burchell JM, Taylor-Papadimitriou J (1996) The polymorphic epithelial mucin: potential as an immunogen for a cancer vaccine. Cancer Immunol Immunother 42: 71-80
29. Graham RA, Stewart LS, Peat NP, Beverley P, Taylor-Papadimitriou J (1996) MUC1-based immunogens for tumor therapy: Development of murine model systems. Tumour Targeting 1: 211-221
30. Hareuveni M, Gautier C, Kieny M-P, Wreschner D, Chambon P, Lathe R (1990) Vaccination against tumor cells expressing breast cancer epithelial tumor antigen. Proc Natl Acad Sci USA 87: 9498-9502
31. Henderson RA, Nimgoankar MT, Watkins SC, Robbins PD, Ball ED, Finn OJ (1996) Human dendritic cells genetically engineered to express high levels of the human epithelial tumor antigen mucin (MUC-I). Cancer Res 56: 3763-3770
32. Hilkens J (1988) Biochemistry and function of mucins in malignant disease. Cancer Rev 11-12: 25-54
33. Hilkens J, Ligtenberg MJ, Vos HL, Litvinov SV (1992) Cell membrane-associated mucins and their adhesion-modulating property. Trends Biochem Sci 17: 359-363
34. Hird V, Maraveyas A, Snook, Dhokia B, Soutter WP, Meares C, Stewart JS, Mason P, Lambert HE, Epenetos AA (1993) Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody. Br J Cancer 68: 403-406
35. Hynes RO (1992) Integrins: versatility, modulation and signaling in cell adhesion. Cell 69: 11-25
36. Ioannides CG, Fisk B, Jerome KR, Irimura T, Wharton JT, Finn OJ (1993) Cytotoxic T cells from ovarian malignant tumors can recognize polymorphic epithelial mucin core peptides. J Immunol 151: 3693-3703
37. Jerome KR, Barnd DL, Bendt KM, Boyer CM, Taylor-Papadimitriou J, McKenzie IFC, Bast Jr. RC, Finn OJ (1991) Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res 51: 2908-2916
38. Kotera Y, Fontenot JD, Pecher G, Metzgar RS, Finn OJ (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC-1 in sera from breast, pancreatic, and colon cancer patients. Cancer Res 54: 2856-2860
39. Lalani E-N, Berdichevski F, Boshell M, Shearer M, Wilson D, Stauss H, Gendler SJ, Taylor-Papadimitriou J (1991) Expression of the gene encoding for a human mucin in mouse mammary tumor cells can affect their tumorigenicity. J Biol Chem 266: 15420-15426
40. Lan MS, Batra SK, Qi W-N, Metzgar RS, Hollingsworth MA (1990) Cloning and sequencing of a human pancreatic tumor mucin cDNA. J Biol Chem 265: 15294-15299
41. Longnecker BM, Reddish M, Koganty R, MacLean GD (1994) Specificity of the IgG response in mice and human breast cancer patients following immunization against synthetic sialyl-Tn, an epitope with possible functional significance in metastasis. In: Ceriani RL (ed) Antigen and antibody molecular engineering in breast cancer diagnosis. Plenum, New York, pp 105-124
42. MacLean GD, Bowen-Yacyshyn MB, Samuel J, Meikle A, Stuart G, Nation J, Poppema S, Jerry M, Koganty R, Wong T, Longnecker MB (1992) Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen-Friedenreich) determinants using a synthetic carbohydrate antigen. J Immunother 11: 292-305
43. MacLean GD, Reddish M, Koganty RR, Wong T, Ghandi S, Smolnski M, Samuel J, Nabholtz JM, Longnecker MB (1993) Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus detox adjuvant. Cancer Immunol Immunother 36: 215-222
44. McKolanis JR, Pecher G, Lotze MJ, Finn OJ (1996) Mucin reactive CTL induced by in vivo immunization (abstract). Proc Amer Assoc Cancer Res 37: 466
45. Metzgar RS, Rodriguez N, Finn OJ, Lan MS, Daasch VS, Fernsten PD, Meyers WC, Sindelar WS, Sandler RS, Siegler HF (1984) Detection of a pancreatic cancer-associated antigen (DUPAN-2 antigen) in serum and ascites of patients with adenocarcinoma. Proc Natl Acad Sci USA 81: 5242-5246
46. Mizoguchi H, O'Shea JJ, Longo DL, Loeffler CM, McVicar DW, Ochoa AC (1992) Alterations in signal transduction molecules in T lymphocytes from tumor-bearing mice. Science 258: 1795-1798
47. Morita CT, Beckman EM, Bukowski JF, Tanaka Y, Band H, Bloom BR, Golan DE, Brenner MB (1996) Direct presentation of nonpeptide prenyl pyrophosphate antigens to human γδ T cells. Immunity 3: 495-507
48. Mueller DL, Jenkins MK, Schwartz RH (1989) Clonal expansion versus functional clonal inactivation: a costimulatory signaling pathway determines the outcome of T cell antigen receptor occupancy. Annu Rev Immunol 7: 445-480
49. Nakagomi H, Petersson M, Magnusson I, Juhlin C, Matsuda M, Mellstedt H, Taupin J-L, Vivier E, Anderson P, Kiessling R (1993) Decreased expression of the signal-transducing ζ chains in tumor-infiltrating T-cells and NK cells of patients with colorectal carcinoma. Cancer Res 53: 5610-5612
50. Nishimori I, Johnson NR, Sanderson SD, Perini F, Mountjoy K, Cerny RL, Gross ML, Hollingsworth MA (1994) Influence of acceptor substrate primary amino acid sequence on the activity of human UDP-N-acetylgalactosamine : polypeptide N-acetylgalactosaminyltransferase. J Biol Chem 269: 16123-16130
51. Nishimori I, Perini F, Mountjoy KP, Sanderson SD, Johnson N, Cerny RL, Gross ML, Fontenot JD, Hollingsworth MA (1994) N-Acetylgalactosamine glycosylation of MUC1 tandem repeat peptides by pancreatic tumor cell extracts. Cancer Res 54: 3738-3744
52. Peat N, Gendler SJ, Lalani E-N, Duhig T, Taylor-Papadimitriou J (1992) Tissue-specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res 52: 1954-1960
53. Pecher G, Finn OJ (1996) Induction of cellular immunity in chimpanzees to human tumor-associated antigen mucin by vaccination with MUC-1 cDNA-transfected Epstein-Barr virus-immortalized autologous B cells. Proc Natl Acad Sci USA 93: 1699-1704
54. Price PW (1996) Biological evolution. Saunders College Publishing, Fort Worth
55. Rughetti A, Turchi V, Ghetti CA, Scambia G, Panici PB, Roncucci G, Mancusco S, Frati L, Nuti M (1993) Human B-cell immune responses to the polymorphic epithelial mucin. Cancer Res 53: 2457-2459
56. Schwartz RH (1992) Costimulation of T lymphocytes: the role of CD28, CTLA-4 and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065-1068
57. Sciammas R, Johnson RM, Sperling AI, Brady W, Linsley PS, Spear PG, Fitch FW, Bluestone JA (1994) Unique antigen recognition by a herpesvirus-specific TCR-γδ cell. J Immunol 152: 5392-5397
58. Siliciano RF, Hemesath TJ, Pratt JC, Dintzis RZ, Dintzis HM, Acuto O, Shin HS, Reinherz EL (1986) Direct evidence for the existence of nominal antigen binding sites on T cell surface Ti αβ heterodimers of MHC-restricted T cell clones. Cell 47: 161-171
59. Steinman RM (1991) The dendritic cell system and its role in immunogenicity. Annu Rev Immmunol 9: 217-296
60. Strous GJ, Dekker J (1992) Mucin-like glycoproteins. Crit Rev Biochem Mol Biol 27: 57-92
61. Takahashi T, Makiguchi Y, Hinoda Y, Kakiuchi H, Nakagawa N, Imai K, Yachi A (1994) Expression of MUC1 on myeloma cells and induction of HLA-unrestricted CTL against MUC1 from a multiple myeloma patient. J Immunol 153: 2102-2109
62. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Feigner PL, Dwarki VJ, Gromkowski SH, Deck RR, DeWitt CM, Friedman A, Hawe LA, Leadner KR, Martinez D, Perry HC, Shiver JW, Montgomery DL, Liu MA (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745-1749
63. Van Klinken BJ-W, Dekker J, Büller HA, Einerhand WC (1995) Mucin gene structure and expression: protection vs. adhesion. Am J Physiol 269: G613-G627
64. Wesseling J, Valk SW van der, Vos HL, Sonnenberg A, Hilkens J (1995) Episialin (MUC1) overexpression inhibits integrin-mediated cell adhesion to extracellular matrix components. J Cell Biol 129: 255-265
65. Xing P-X, Michael M, Apostolopolous V, Prenzoska J, Marshall C, Bishop J, McKenzie IFC (1995) Phase I study of synthetic MUC1 peptides in breast cancer. Int J Oncol 6: 1283-1289
66. Zotter S, Hageman PC, Lossnitzer A, Mooi WJ, Hilgers J (1988) Tissue and tumor distribution of human polymorphic epithelial mucin. Cancer Rev 11, 12: 55-101