The polymorphic epithelial mucin: Potential as an immunogen for a cancer vaccine

Cancer Immunology Immunotherapy

Volumn 42, Issue 2, 1996, Pages 71-80

  Graham, Rosalind A ^a   Burchell, Joy M ^a   Taylor Papadimitriou, Joyce ^a  

^a IMPERIAL CANCER RESEARCH FUND   (United Kingdom)

Author keywords

Active specific immunotherapy; Cancer associated antigens; MUC1 based immunogens; Murine tumour models

Indexed keywords

CANCER VACCINE; MUCIN; TUMOR ANTIGEN;

ANTIGEN PRESENTATION; CANCER IMMUNOTHERAPY; CLINICAL TRIAL; EPITHELIUM; GLYCOSYLATION; HUMAN; IMMUNE RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; REVIEW;

ANIMALS; ANTIGENS, NEOPLASM; CA-15-3 ANTIGEN; CARBOHYDRATE SEQUENCE; HUMANS; IMMUNOTHERAPY, ACTIVE; MOLECULAR SEQUENCE DATA; VACCINES, SYNTHETIC;

EID: 0029877649     PISSN: 03407004     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002620050254     Document Type: Review

References (61)

1. Acres RB, Hareuveni M, Balloul J-M, Kieny M-P (1993) Vaccinia virus MUC1 immunisation of mice: immune response and protection against the growth of murine tumours bearing the MUC1 antigen. J Immunother 14: 136-143
2. Agrawal B, Reddish MA, Krantz MJ, Longenecker M (1995) Does pregnancy immunize against breast cancer? Cancer Res 55: 2257-2261
3. Apostolopoulos V, Xing P-X, McKenzie IFC (1994) Murine immune response to cells transfected with human MUC1: immunisation with cellular and synthetic antigens. Cancer Res 54: 5186-5193
4. Balloul J-M, Acres RB, Geist M, Dott K, Steffani L, Schmitt D, Drillien R, Spehner D, Mckenzie I, Xing P-X, Kieny MP (1994) Recombinant MUC1 vaccinia virus: a potential vector for immunotherapy of breast cancer. Cell Mol Biol 40: 49-59
5. Barnd DL, Lan MS, Metzgar RS, Finn OJ (1989) Specific, major histocompatability complex-unrestricted recognition of tumour-associated mucins by human cytotoxic T cells. Proc Natl Acad Sci USA 86: 7159-7164
6. Braga VMM, Pemberton LF, Duhig T, Gendler SJ (1992) Spatial and temporal expression of an epithelial mucin, Muc-1, during mouse development. Development 115: 427-437
7. Brichard V, Van Pel A, Wolfel T, Wolfel C, De Plaen E, Lethe B, Coulie P, Boon T (1993) The tyrosinase gene encodes for an antigen recognised by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med 178: 489-495
8. Brockhausen I (1995) Biosynthesis of O-glycans of the N-acetylgalactosamine-α-Ser/Thr linkage type. In: Montreuil J, Schachter H, Vliegenthart JFG, (eds) Glycoproteins. New comprehensive biochemistry, Elsevier, New York, pp 201-225
9. Brockhausen I, Yang, J-M, Burchell J, Whitehouse C, Taylor-Papadimitriou J (1995) Mechanisms underlying aberrant glycosylation of MUC1 mucin in breast cancer cells. Eur J Biochem 233: 607-618
10. Burchell J, Gendler SJ, Taylor-Papadimitriou J, Girling A, Lewis A, Millis R, Lamport D (1989) Development and characterisation of breast cancer reactive monoclonal antibodies directed to the core protein of the human milk mucin. Cancer Res 47: 5476-5482
11. Burchell J, Taylor-Papadimitriou J, Boshell M, Gendler SJ, Duhig T (1989) A short sequence within the amino acid tandem repeat of a cancer associated mucin, contains immunodominant epitopes. Int J Cancer 44: 691-696
12. Conry RM, Lobuglio AF, Loechel F, Moore SE, Sumerel LA, Barlow DL, Curiel DT (1995) A carcinoembryonic antigen polynucleotide vaccine has in vivo antitumour activity. Gene Ther 2: 59-65
13. Coulie PG, Brichard V, Van Pel A, Wolfel T, Schneider J, Traversari C, Mattei S, De Plaen E, Lurquin C, Szikora J-P, Renauld J-C, Boon T (1994) A new gene coding for a differentiation antigen recognised by autologous cytolytic T lymphocytes on HLA-A2 melanomas. J Exp Med: 35-42
14. Ding L, Lalani E-N, Reddish M, Koganti R, Wong T, Samuel J, Yacyshyn MB, Meikle A, Fung PYS, Taylor-Papadimitriou J, Longenecker BM (1993) Immunogenicity of synthetic peptides related to the core protein sequence encoded by the human MUC1 gene: effect of immunization on the growth of murine mammary adenocarcinoma cells transfected with the human MUC1 gene. J Cancer Immunol Immunother 36: 9-17
15. Domenech N, Finn OJ (1995) In-vitro studies of MHC-restricted recognition of a peptide from the MUC1 tandem repeat domain by CTL. FASEB J 9: A1023
16. Finn OJ, Jerome KR, Henderson RA, Pecher G, Domenech N, Magarian-Blander J, Barratt-Boyes SM (1995) MUC-1 epithelial tumor mucin-based immunity and cancer vaccines. Immunol Rev 145: 61-89
17. Fung PYS, Madej M, Koganty K, Longenecker BM (1990) Active specific immunotherapy of a murine mammary adenocarcinoma using a synthetic tumour-associated glycoconjugate. Cancer Res 50: 4308-4314
18. Fung PY, Longenecker BM (1991) Specific immunosuppressive activity of epiglycanin, a mucin-like glycoprotein secreted by a murine adenocarcinoma (TA3-HA). Cancer Res 51: 1170-1176
19. Gendler SJ, Lancaster CA, Taylor-Papadimitriou J, Duhig T, Peat N, Burchell J, Pemberton L, Lalani E-N, and Wilson D (1990) Molecular cloning and expression of the human tumour-associated polymorphic epithelial mucin. J Biol Chem 265: 15286-15293
20. Girling A, Bartkova J, Burchell J, Gendler S, Gillet C, Taylor-Papadimitriou J (1989) A core protein epitope of the polymorphic epithelial mucin detected by the monoclonal antibody SM-3 is selectively exposed in a range of primary carcinomas. Int J Cancer 43: 1072-1076
21. Gourevitch MM, Mensdorff-Pouilly S von, Litvinov SV, Kenemons P, Kamp GJ van, Verstraeten AA, Hilger J (1995) Polymorphic epithelial mucin (MUC-1)-containing circulating immune complexes in carcinoma patients. Br J Cancer 72: 934-938
22. Graham RA, Stewart LS, Peat NP, Beverley P, Taylor-Papadimitriou J (1996) MUC-1 based immunogens for tumour therapy: Development of murine model systems. Tumour Targeting 1: 211-221
23. Graham RA, Burchell JM, Beverley P, Taylor-Papadimitriou J (1996) Intramuscular immunisation with MUC1 cDNA can protect C57 mice challenged with MUC1 expressing syngeneic mouse tumour cells. Int J Cancer (in press)
24. Harevueni M, Gautier C, Kieny M-P, Wreschner D, Chambon P, Lathe R (1990) Vaccination against tumour cells expressing breast cancer epithelial tumour antigen. Proc Natl Acad Sci USA 87: 9498-9502
25. Hird V, Maraveyas A, Snook D, Dhokia B, Soutter WP, Meares C, Stewart JSW, Mason P, Lambert HE, Epenetos AA (1993) Adjuvant therapy of ovarian cancer with radioactive monoclonal antibody. Br J Cancer 68: 403-406
26. Hohlfeld R, Engel AG (1994) The immunobiology of muscle. Immunol Today 15: 269-274
27. Ioannides CG, Fisk B, Jerome KR, Tatsuro I, Taylor Wharton J, Finn OJ (1993) Cytotoxic T cells from ovarian malignant tumours can recognise polymorphic epithelial mucin core peptides. J Immunol 7: 3693-3703
28. Jentoft N (1990) Why are proteins O-glycosylated? Trends Biochem Sci 15: 291-294
29. Jerome KR, Barnd DL, Bendt KM, Boyer CM, Taylor-Papadimitriou J, McKenzie IFC, Bast RC, Finn OJ (1989) Cytotoxic T-lymphocytes derived from patients with breast adenocarcinoma recognize an epitope present on the protein core of a mucin molecule preferentially expressed by malignant cells. Cancer Res 51: 2908-2916
30. Jioa SS, Williams P, Berg RK, Hodgeman BA, Liu LJ, Pepetto G, Wolff JA (1992) Direct gene-transfer in nonhuman primate myofibres in vivo. Hum Gene Ther 3: 21-33
31. Kosmas C, Epenetos AA, Courtenay NS (1994) Activation of cellular immunity after intracavitary monoclonal antibody therapy of ovarian cancer. Cancer 73: 3000-3010
32. Kotera Y, Fontenot JD, Pecher G, Metzgar RS, Finn OJ (1994) Humoral immunity against a tandem repeat epitope of human mucin MUC1 in sera from breast, pancreatic and colon cancer patients. Cancer Res 54: 2856-2860
33. Kovarik A, Peat N, Wilson D, Gendler S, Taylor-Papadimitriou J (1993) Analysis of the tissue-specific promoter of the MUC1 gene. J Biol Chem 268: 9917-9926
34. Lalani E-N, Berdichevsky F, Boshell M, Shearer M, Wilson D, Stauss H, Gendler SJ, Taylor-Papadimitriou J (1991) Expression of the gene encoding for a human mucin in mouse mammary tumour cells can affect their tumourigenicity. J Biol Chem 266: 15420-15426
35. Lan MS, Batra SK, Qi W-N, Metzgar RS, Hollingsworth MA (1990) Cloning and sequence=ing of human pancreatic tumor mucin cDNA. J Biol Chem 265: 15294-15299
36. Ligtenberg MJL, Vos HL, Gennissen AMC, Hilkens J (1990) Episialin, a carcinoma-associated mucin, is generated by a polymorphic gene encoding splice variants with alternative amino termini. J Biol Chem 265: 5573-5578
37. Ligtenberg MJL, Buijs F, Vos HL, Hilkens J (1992) Suppression of cellular aggregation by high levels of episialin. Cancer Res 52: 2318-2324
38. Ljunggren H-G, Karre K (1985) Host resistance directed selectivity against H-2-difficient lymphoma variants. Analysis of the mechanism. J Exp Med 162: 1745-1759
39. Longenecker BM, Reddish M, Koganty R, Maclean GD (1993) Immune response of mice and human breast cancer patients following immunisation with synthetic sialyl-Tn conjugated to KLH plus Detox adjuvant. Ann N Y Acad Sci 690: 276-291
40. Maclean GD, Bowen-Yacyshyn MB, Samuel J, Meikle A, Stuart G, Nation J, Poppema S, Jerry M, Koganty R, Wong T, Longenecker BM (1992) Active immunization of human ovarian cancer patients against a common carcinoma (Thomsen-Friedenreich) determinant using a synthetic carbohydrate antigen. J Immunother 11: 292-305
41. Maclean GD, Reddish M, Koganty RR, Wong T, Gandhi S, Smolnski M, Samuel J, Nabholtz JM, Longenecker BM (1993) Immunization of breast cancer patients using a synthetic sialyl-Tn glycoconjugate plus detox adjuvant. Cancer Immunol Immunother 36: 215-222
42. Miles DW, Happerfield LC, Smith P, Gillibrand R, Bobrow LG, Gregory WM, Rubens RD (1994) Expression of sialyl-Tn predicts the utility of adjuvant chemotherapy in node positive breast cancer. Br J Cancer 70: 1272-1275
43. Parry G, Beck JC, Moss L, Bartley J, Ojakian GK (1990) Determination of apical mambrane polarity in mammary epithelial cells cultures: the role of cell-cell, cell-substratum, and membrane-cytoskeleton interactions. Exp Cell Res 188: 302-311
44. Peat N, Gendler SJ, Lalani E-N, Duhig T, Taylor-Papadimitriou J (1992) Tissue specific expression of a human polymorphic epithelial mucin (MUC1) in transgenic mice. Cancer Res 52: 1954-1960
45. Raz E, Carson DA, Parker SE, Parr TB, Abai AM, Aichinger G, Gromkowski SH, Singh M, Lew D, Yankauckas MA, Baird SM, Rhodes GH (1994) Intradermal gene immunization: the possible role of DNA uptake in the induction of cellular immunity to viruses. Proc Natl Acad Sci USA 91: 9519-9523
46. Robinson HL, Hunt LA, Webster RG (1993) Protection against a lethal influenza virus challenge by immunisation with a haemagglutinin-expressing plasmid DNA. Vaccine 11: 957-960
47. Rughetti A, Turchi V, Ghetti CA, Scambia G, Panici PB, Roncucci G, Mancuso S, Frati L, Nuti M (1993) Human B-cell immune response to the polymorphic epithelial mucin. Cancer Res 53: 2457-2459
48. Schwartz RH (1992) Costimulation of T lymphocytes: the role of CD28, CTLA-4 and B7/BB1 in interleukin-2 production and immunotherapy. Cell 71: 1065-1068
49. Singhal A, Fohn M, Hakomori S (1991) Induction of a N-acetylgalactosamine-O-serine/threonine (Tn) antigen-mediated cellular immune response for active specific immunotherapy in mice. Cancer Res 51: 1406-1411
50. Sorensen T, White T, Wandall HH, Clausen H (1995) UDP-GalNAc: polypeptide N-acetylgalactosaminyltransferase: identification and separation of two distinct transferase activities. J Biol Chem 270: 24166-24173
51. Spacer AP, Parry G, Patton S, Gendler SJ (1991) Molecular cloning and analysis of the mouse homologue of the tumour-associated mucin, MUC1, reveals conservation of potential O-glycosylation sites, transmembrane, and cytoplasmic domains and a loss of minisatellite-like polymorphism. J Biol Chem 266: 15099-15109
52. Spicer AP, Rowse GJ, Lidner TK, Gendler SJ (1995) Delayed mammary tumour progression in Muc-1 null mice. J Biol Chem 270: 30093-30101
53. Swallow DM, Gendler S, Griffith B, Corney G, Taylor-Papadimitriou J, Bramwell ME (1987) The human tumour-associated epithelial mucins are coded for by an expressed hypervariable gene locus PUM. Nature 328: 82-84
54. Taylor-Papadimitriou J, Stewart L, Burchell J, Beverley P (1993) The polymorphic epithelial mucin as a target for immunotherapy. Ann N Y Acad Sci 690: 69-79
55. Thompson J, Grunert F, Zimmerman W (1991) CEA gene family: molecular biology and clinical perspectives. J Clin Lab Anal 5: 344-366
56. Ulmer JB, Donnelly JJ, Parker SE, Rhodes GH, Feigner PL, Dwarki VJ, Gromkowski SH, Deck RR, DeWitt CM, Friedman A, Hawe LA, Leadner KR, Martinez D, Perry HC, Shiver JW, Montgomery DL, Liu MA (1993) Heterologous protection against influenza by injection of DNA encoding a viral protein. Science 259: 1745-1749
57. Ulmer JB, Deck RR, DeWitt CM, Friedman A, Donnelly JJ, Liu MA (1994) Protective immunity by intramuscular injection of low doses of influenza virus DNA vaccines. Vaccine 12: 1541-1544
58. Wesseling J, Vandervalk SW, Vos HL, Sonnenberg A, Hilkens J (1995) Episialin (MUC1) overexpression inhibits integrin-mediated cell-adhesion to extracellular-matrix components. J Cell Biol 129: 255-265
59. Wolff JA, Malone RW, Williams P, Chong W, Acsadia G, Jani A, Felgner PL (1990) Direct gene transfer into mouse muscle in vivo. Science 247: 1465-1468
60. Wreschner DH, Hareuveni M, Tsarfaty I, Smorodinsky N, Horev J, Zaretsky J, Kotkes P, Weiss M, Lathe R, Keydar I (1990) Human epithelial tumor antigen cDNA sequences: differential splicing may generate multiple protein forms. Eur J Biochem 189: 463-473
61. Xing P-X, Michael M, Apostolopoulos V, Prenzoska J, Marshall C, Bishop J, McKenzie IFC (1995) Phase I study of synthetic MUC1 peptides in breast cancer. Int J Oncol 6: 1283-1289