The vascular endothelial barrier - selective retention of lipoproteins

Current Opinion in Lipidology

Volumn 7, Issue 5, 1996, Pages 269-273

  Nordestgaard, Børge G ^a  

^a GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

CHYLOMICRON; LIPOPROTEIN A; LOW DENSITY LIPOPROTEIN; OXIDIZED LOW DENSITY LIPOPROTEIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL TISSUE; ARTERY INJURY; ARTERY INTIMA; HUMAN; HUMAN TISSUE; LIPID OXIDATION; NONHUMAN; PRIORITY JOURNAL; SHORT SURVEY; VASCULAR ENDOTHELIUM;

ANIMALIA;

EID: 0029834031     PISSN: 09579672     EISSN: None     Source Type: Journal    
DOI: 10.1097/00041433-199610000-00002     Document Type: Short Survey

References (24)

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6. Nielsen LB, Nordestgaard BG, Stender S, Niendorf A, Kjeldsen K: Transfer of lipoprotein(a) and LDL into aortic intima in normal and in cholesterol-fed rabbits. Arterioscler Thromb Vasc Biol 1995, 15:1492-1502. The results suggest that Lp(a) is transferred into the aortic intima by a mechanism similar to that for LDL, and that Lp(a) can be taken up by intimal foam cells in vivo.
7. Nielsen LB, Stender S, Kjeldsen K, Nordestgaard BG: Specific accumulation of lipoprotein(a) in balloon-injured rabbit aorta in vivo. Circ Res 1996, 78:615-626. Lp(a) injected intravenously into rabbits accumulated twice as much as LDL in balloon injured, but not in normal aortic intima-inner media. This might be explained by a 70% lower fractional loss for Lp(a) compared with LDL at the injured intima-inner media. The data suggest that the accumulation of Lp(a) is much larger in injured vessels than in normal vessels, and support the idea of a specific accumulation of Lp(a) compared with LDL in injured vessels.
8. Nielsen LB, Stender S, Jauhiainen M, Nordestgaard BG: Preferential influx and decreased fractional loss of lipoprotein(a) in atherosclerotic compared to non-lesioned rabbit aorta. J Clin Invest 1996, 98:563-571. Fractional loss of labelled Lp(a) and labelled LDL in atherosclerotic aortas were on average 25 and 43%, respectively, of that in nonlesioned aortas. Fractional loss of Lp(a) was 73% of that of LDL (P = 0·07).
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11. Jensen JS: Renal and systemic transvascular albumin leakage in severe atherosclerosis. Arterioscler Thromb Vasc Biol 1995, 15:1324-1329. In patients with severe atherosclerosis, urinary albumin excretion and generalized transvascular leakage of albumin were both increased compared with control individuals. If the generalized transvascular leakage also included lipid induction into arteries, microalbuminuria (a potent cardiovascular risk factor) may be a marker of increased arterial wall permeability.
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19. Nordestgaard BG, Wootton R, Lewis B: Selective retention of VLDL, IDL and LDL in the arterial intima of genetically hyperlipidemic rabbits in vivo. Molecular size as a determinant of fractional loss from the intima-inner media. Arterioscler Thromb Vasc Biol 1995, 15:534-542. In the St. Thomas's Hospital rabbit strain with genetically elevated levels of VLDL, IDL and LDL, the fractional loss from intima of these lipoproteins, HDL and albumin was found to be inversely related to macromolecular size. This suggests that after uptake into the arterial intima, VLDL and IDL as well as LDL are selectively retained compared with HDL and albumin.
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