Oxidation of plasma low-density lipoprotein accelerates its accumulation and degradation in the arterial wall in vivo

Circulation

Volumn 94, Issue 7, 1996, Pages 1698-1704

  Juul, Klaus ^a   Nielsen, Lars B ^a,e   Munkholm, Klaus ^a   Stender, Steen ^c   Nordestgaard, Børge G ^b,d  

^a University of Copenhagen   (Denmark)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

^c UNIVERSITY OF SOUTHERN DENMARK   (Denmark)

^d GENTOFTE UNIVERSITY HOSPITAL   (Denmark)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

atherosclerosis; lipoproteins

Indexed keywords

LOW DENSITY LIPOPROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERY INTIMA; ARTERY WALL; ARTICLE; ATHEROGENESIS; ATHEROSCLEROSIS; CONTROLLED STUDY; LIPID OXIDATION; LIPOPROTEIN BLOOD LEVEL; LIPOPROTEIN METABOLISM; NONHUMAN; PRIORITY JOURNAL; RABBIT;

EID: 0029741926     PISSN: 00097322     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.CIR.94.7.1698     Document Type: Article

References (39)

1. Pyörälä K, De Backer G, Graham I, Poole-Wilson P, Wood D. Prevention of coronary heart disease in clinical practice: recommendations of the Task Force of the European Society of Cardiology, European Atherosclerosis Society and European Society of Hypertension. Eur Heart J. 1994;15:1300-1331.
2. Steinberg D, Parthasarathy S, Carew TE, Khoo JC, Witztum JL. Beyond cholesterol: modifications of low-density lipoprotein that increase its atherogenicity. N Engl J Med. 1989;320:915-924.
3. Steinberg D. Modified forms of low-density lipoprotein and atherosclerosis. J Intern Med. 1993;233:227-232.
4. Penn MS, Chisolm GM. Oxidized lipoproteins, altered cell function and atherosclerosis. Atherosclerosis. 1994;108(suppl):S21-S29.
5. Henriksen T, Mahoney EM, Steinberg D. Enhanced macrophage degradation of biologically modified low density lipoprotein. Arteriosclerosis. 1983;3:149-159.
6. Chisolm GM, Morel DW. Lipoprotein oxidation and cytotoxicity: effect of probucol on streptozotocin-treated rats. Am J Cardiol. 1988;62:20B-26B.
7. Quinn MT, Parthasarathy S, Fong LG, Steinberg D. Oxidatively modified low density lipoproteins: a potential role in recruitment and retention of monocyte/macrophages during atherogenesis. Proc Natl Acad Sci USA. 1987;84:2995-2998.
8. Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL. Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb. 1994;14: 32-40.
9. Rosenfeld ME, Palinski W, Yla-Herttuala S, Butler S, Witztum JL. Distribution of oxidation specific lipid-protein adducts and apolipo-protein B in atherosclerotic lesions of varying severity from WHHL rabbits. Arteriosclerosis. 1990;10:336-349.
10. Yla-Herttuala S, Palinski W, Rosenfeld ME, Parthasarathy S, Carew TE, Butler S, Witztum JL, Steinberg D. Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest. 1989;84:1086-1095.
11. Steinbrecher UP, Witztum JL, Parthasarathy S, Steinberg D. Decrease in reactive amino groups during oxidation or endothelial cell modification of LDL: correlation with changes in receptor-mediated catabolism. Arteriosclerosis. 1987;7:135-143.
12. Nagelkerke JF, Havekes L, van Hinsbergh VW, van Berkel TJ. In vivo catebolism of biologically modified LDL. Arteriosclerosis. 1984;4:256-264.
13. Avogaro P, Bon GB, Cazzolato G. Presence of a modified low density lipoprotein in humans. Arteriosclerosis. 1988;8:79-87.
14. Hodis HN, Kramsch DM, Avogaro P, Bittolo Bon G, Cazzolato G, Hwang J, Peterson H, Sevanian A. Biochemical and cytotoxic characteristics of an in vivo circulating oxidized low density lipoprotein (LDL-). J Lipid Res. 1994;35:669-677.
15. Raymond TL, Reynolds SA, Swanson JA. In vitro incubation of low-density lipoproteins with inflammatory cells causes enhanced degradation by macrophages in culture. Inflammation. 1987;11:335-344.
16. Raymond TL, Reynolds SA. Lipoproteins of the extravascular space: alterations in low density lipoproteins of interstitial inflammatory fluid, J Lipid Res. 1983;24:113-119.
17. Witztum JL, Steinberg D. Role of oxidized low density lipoprotein in atherogenesis. J Clin Invest. 1991;88:1785-1792.
18. Nielsen LB, Slender S, Kjeldsen K, Nordestgaard BG. Effect of angiotensin II and enalapril on transfer of low-density lipoprotein into aortic intima in rabbits. Circ Res. 1994;75:63-69.
19. Zilversmit DB, Shea TM. Quantitation of apoB-48 and apoB-100by gel scanning or radio-iodination. J Lipid Res. 1989;30:1639-1646.
20. McFarlane AS. Efficient trace-labelling of proteins with iodine. Nature. 1958;182:53.
21. Bilheimer DW. Eisenberg S, Levy RI. The metabolism of very low density lipoprotein proteins, I: preliminary in vitro and in vivo observations. Biochim Biophys Acta. 1972;260:212-221.
22. Pittman RC, Carew TE, Glass CK, Green SR, Taylor CA, Attie AD. A radioiodinated, intracellularly trapped ligand for determining the sites of plasma protein degradation in vivo. Biochem J. 1983; 212:791-800.
23. Esterbauer H, Striegl G, Puhl H, Rotheneder M. Continuous monitoring of in vitro oxidation of human low density lipoprotein. Free Radic Res Commun. 1989;6:67-75.
24. Schwenke DC, Carew TE. Quantification in vivo of increased LDL content and rate of LDL degradation in normal rabbit aorta occurring at sites susceptible to early atherosclerotic lesions. Circ Res. 1988; 62:699-710.
25. Carew TE, Pittman RC, Marchand ER, Steinberg D. Measurement in vivo of irreversible degradation of low density lipoprotein in the rabbit aorta: predominance of intimal degradation. Arteriosclerosis. 1984;4:214-224.
26. 131I-labeled plasma proteins. Phys Med Biol. 1957;2:36-53.
27. Schwenke DC, Carew TE. Initiation of atherosclerotic lesions in cholesterol-fed rabbits, I: focal increases in arterial LDL concentration precede development of fatty streak lesions. Arteriosclerosis. 1989; 9:895-907.
28. Nielsen LB, Nordestgaard BG, Slender S, Kjeldsen K. Aortic permeability to LDL as a predictor of aortic cholesterol accumulation in cholesterol-fed rabbits. Arterioscler Thromb. 1992;12:1402-1409.
29. Sparrow CP, Parthasarathy S, Steinberg D. A macrophage receptor , that recognizes oxidized low density lipoprotein but not acetylated low density lipoprotein. J Biol Chem. 1989;264:2599-2604.
30. Nordestgaard BG, Zilversmit DB. Comparison of arterial intimal clearances of LDL from diabetic and nondiabetic cholesterol-fed rabbits: differences in intimal clearance explained by size differences. Arteriosclerosis. 1989;9:176-183.
31. Baldwin AL, Chien S. Endothelial transport of anionized and canonized ferritin in the rabbit thoracic aorta and vasa vasorum. Arteriosclerosis. 1984;4:372-382.
32. Simionescu M, Simionescu N. Functions of the endothelial cell surface. Annu Rev Physiol. 1986;48:279-293.
33. Kim MJ, Dawes J, Jessup W. Transendothelial transport of modified low-density lipoproteins. Atherosclerosis. 1994;108:5-17.
34. Wiklund O, Carew TE, Steinberg D. Role of the low density lipoprotein receptor in penetration of low density lipoprotein into rabbit aortic wall. Arteriosclerosis. 1985;5:135-141.
35. Schwenke DC, Zilversmit DB. The arterial barrier to lipoprotein influx in the hypercholesterolemic rabbit, 1 : studies during the first two days after mild aortic injury. Atherosclerosis. 1989;77:91-103.
36. Chang MY, Lees AM, Lees RS. Low-density lipoprotein modification and arterial wall accumulation in a rabbit model of atherosclerosis. Biochemistry. 1993;32:8518-8524.
37. 125I-labelled low density lipoprotein. Biochim Biophys Acta. 1980;620:631-635.
38. Pitas RE, Boyles J, Mahley RW, Montgomery Bissel D. Uptake off chemically modified low density lipoproteins in vivo is mediated by specific endothelial cells. J Cell Biol. 1985;100:103-117.
39. Pittman RC, Carew TE, Attie AD, Witztum JL, Watanabe Y, Steinberg D. Receptor-dependent and receptor-independent degradation of low density lipoprotein in normal rabbits and in receptor-deficient mutant rabbits. J Biol Chem. 1982;257:7994-8000.