Postnatal brain development and neural cell differentiation modulate mitochondrial Bax and BH3 peptide-induced cytochrome c release

Cell Death and Differentiation

Volumn 10, Issue 3, 2003, Pages 365-370

  Polster, B M ^a   Robertson, C L ^a   Bucci, C J ^a   Suzuki, M ^b   Fiskum, G ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Bax; BH3; Brain mitochondria; Cytochrome c; Nerve growth factor; Pheochromocytoma

Indexed keywords

BCL 2 HOMOLOGY 3 DEATH DOMAIN PEPTIDE; CYTOCHROME C; MITOCHONDRIAL PROTEIN; NERVE GROWTH FACTOR; PROTEIN BAX; PROTEIN BCL 2; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG;

AGE DISTRIBUTION; ANALYSIS OF VARIANCE; ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; BRAIN DEVELOPMENT; BRAIN MITOCHONDRION; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DOWN REGULATION; ENZYME RELEASE; IMMUNOBLOTTING; NERVE CELL DIFFERENTIATION; NEUROMODULATION; NONHUMAN; POSTNATAL DEVELOPMENT; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LOCALIZATION; RAT; SENSITIVITY ANALYSIS;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BRAIN; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELLS, CULTURED; CYTOCHROMES C; DOSE-RESPONSE RELATIONSHIP, DRUG; IMMUNOBLOTTING; MITOCHONDRIA; NEURONS; PEPTIDE FRAGMENTS; PEPTIDES; PROTEIN STRUCTURE, TERTIARY; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-BCL-2; RATS; RATS, SPRAGUE-DAWLEY; RECOMBINANT PROTEINS; TIME FACTORS;

ANIMALIA;

EID: 0013268258     PISSN: 13509047     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.cdd.4401158     Document Type: Article

References (34)

1. Deshmukh M and Johnson EM Jr (1997) Programmed cell death in neurons: focus on the pathway of nerve growth factor deprivation-induced death of sympathetic neurons. Mol. Pharmacol. 51: 897-906
2. Sadoul R (1998) Bcl-2 family members in the development and degenerative pathologies of the nervous system. Cell Death Differ. 5: 805-815
3. Deckwerth TL, Elliott JL, Knudson CM, Johnson EMJ, Snider WD and Korsmeyer SJ (1996) BAX is required for neuronal death after trophic factor deprivation and during development. Neuron 17: 401-411
4. Miller TM, Moulder KL, Knudson CM, Creedon DJ, Deshmukh M, Korsmeyer SJ and Johnson EM Jr (1997) Bax deletion further orders the cell death pathway in cerebellar granule cells and suggests a caspase-independent pathway to cell death. J. Cell Biol. 139: 205-217
5. White FA, Keller-Peck CR, Knudson CM, Korsmeyer SJ and Snider WD (1998) Widespread elimination of naturally occurring neuronal death in Bax-deficient mice. J. Neurosci. 18: 1428-1439
6. Lindsten T, Ross AJ, King A, Zong WX, Rathmell JC, Shiels HA Ulrich E, Waymire KG, Mahar P, Frauwirth K, Chen Y, Wei M, Eng VM, Adelman DM, Simon MC, Ma A, Golden JA, Evan G, Korsmeyer SJ, MacGregor GR and Thompson CB (2000). The combined functions of proapoptotic Bcl-2 family members bak and bax are essential for normal development of multiple tissues. Mol. Cell 6: 1389-1399
7. Fan H, Favero M and Vogel MW (2001) Elimination of Bax expression in mice increases cerebellar purkinje cell numbers but not the number of granule cells. J. Comp. Neurol. 436: 82-91
8. Putcha GV, Deshmukh M and Johnson EM Jr (1999) BAX translocation is a critical event in neuronal apoptosis: regulation by neuroprotectants, BCL-2, and caspases. J. Neurosci. 19: 7476-7485
9. McGinnis KM, Gnegy ME and Wang KK (1999) Endogenous bax translocation in SH-SY5Y human neuroblastoma cells and cerebellar granule neurons undergoing apoptosis. J. Neurochem. 72: 1899-1906
10. Harris CA and Johnson EM Jr (2001) BH3-only bcl-2 family members are coordinately regulated by the jnk pathway and require bax to induce apoptosis in neurons. J. Biol. Chem. 276: 37754-37760
11. Imaizumi K, Tsuda M, Imai Y, Wanaka A, Takagi T and Tohyama M (1997) Molecular cloning of a novel polypeptide, DP5, induced during programmed neuronal death. J. Biol. Chem. 272: 18842-18848
12. Whitfield J, Neame SJ, Paquet L, Bernard O and Ham J (2001) Dominant-negative c-Jun promotes neuronal survival by reducing BIM expression and inhibiting mitochondrial cytochrome c release. Neuron 29: 629-643
13. Putcha GV, Moulder KL, Golden JP, Bouillet P, Adams JA, Strasser A and Johnson EM Jr (2001) Induction of BIM, a proapoptotic BH3-only BCL-2 family member, is critical for neuronal apoptosis. Neuron 29: 615-628
14. Vekrellis K, McCarthy MJ, Watson A, Whitfield J, Rubin LL and Ham J (1997) Bax promotes neuronal cell death and is downregulated during the development of the nervous system. Development 124: 1239-1249
15. Polster BM, Kinnally KW and Fiskum G (2001) BH3 death domain peptide induces cell type-selective mitochondrial outer membrane permeability. J. Biol. Chem. 276: 37887-37894
16. Greene LA and Tischler AS (1976) Establishment of a noradrenergic clonal line of rat adrenal pheochromocytoma cells which respond to nerve growth factor. Proc. Natl. Acad. Sci. USA 73: 2424-2428
17. Fukuyama R, Chandrasekaran K and Rapoport SI (1993) Nerve growth factor-induced neuronal differentiation is accompanied by differential induction and localization of the amyloid precursor protein (APP) in PC12 cells and variant PC12S cells. Brain Res. Mol. Brain Res. 17: 17-22
18. Smaili SS, Hsu YT, Sanders KM, Russell JT and Youle RJ (2001) Bax translocation to mitochondria subsequent to a rapid loss of mitochondrial membrane potential. Cell Death Differ. 8: 909-920
19. Wei MC, Lindsten T, Mootha VK, Weiler S, Gross A, Ashiya M, Thompson CB and Korsmeyer SJ (2000) tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c. Genes Dev 14: 2060-2071
20. Wei MC, Zong WX, Cheng EH, Lindsten T, Panoutsakopoulou V, Ross AJ, Roth KA, MacGregor GR, Thompson CB and Korsmeyer SJ (2001) Proapoptotic BAX and BAK: a requisite gateway to mitochondrial dysfunction and death. Science 292: 727-730
21. Putcha GV, Harris CA, Moulder KL, Easton RM, Thompson CB and Johnson EM Jr (2002) Intrinsic and extrinsic pathway signaling during neuronal apoptosis: lessons from the analysis of mutant mice. J. Cell Biol. 157: 441-453
22. Beilharz EJ, Williams CE, Dragunow M, Sirimanne ES and Gluckman PD (1995) Mechanisms of delayed cell death following hypoxic-ischemic injury in the immature rat: evidence for apoptosis during selective neuronal loss. Brain Res. Mol. Brain Res. 29: 1-14
23. Sidhu RS, Tuor UI and Del Bigio MR (1997) Nuclear condensation and fragmentation following cerebral hypoxia-ischemia occurs more frequently in immature than older rats. Neurosci. Lett. 223: 129-132
24. Nakajima W, Ishida A, Lange MS, Gabrielson KL, Wilson MA, Martin LJ, Blue ME and Johnston MV (2000) Apoptosis has a prolonged role in the neurodegeneration after hypoxic ischemia in the newborn rat. J. Neurosci. 20: 7994-8004
25. Northington FJ, Ferriero DM, Flock DL and Martin LJ (2001) Delayed neurodegeneration in neonatal rat thalamus after hypoxia-ischemia is apoptosis. J. Neurosci. 21: 1931-1938
26. Puka-Sundvall M, Wallin C, Gilland E, Hallin U, Wang X, Sandberg M, Karlsson J, Blomgren K and Hagberg H (2000) Impairment of mitochondrial respiration after cerebral hypoxia-ischemia in immature rats: relationship to activation of caspase-3 and neuronal injury. Brain Res. Dev. Brain Res. 125: 43-50
27. Hu BR, Liu CL, Ouyang Y, Blomgren K and Siesjo BK (2000) Involvement of caspase-3 in cell death after hypoxia-ischemia declines during brain maturation. J. Cereb. Blood Flow Metab. 20: 1294-1300
28. Bittigau P, Sifringer M, Pohl D, Stadthaus D, Ishimaru M, Shimizu H, Ikeda M, Lang D, Speer A, Olney JW and Ikonomidou C (1999) Apoptotic neurodegeneration following trauma is markedly enhanced in the immature brain. Ann. Neurol. 45: 724-735
29. Pohl D, Bittigau P, Ishimaru MJ, Stadthaus D, Hubner C, Olney JW, Turski L and Ikonomidou C (1999) N-Methyl-D-aspartate antagonists and apoptotic cell death triggered by head trauma in developing rat brain. Proc. Natl. Acad. Sci. USA 96: 2508-2513
30. Rosenthal RE, Hamud F, Fiskum G, Varghese PJ, Sharpe S (1987) Cerebral ischemia and reperfusion: prevention of brain mitochondrial injury by lidoflazine. J. Cereb. Blood Flow Metab. 7: 752-758
31. Moreadith RW and Fiskum G (1984) Isolation of mitochondria from ascites tumor cells permeabilized with digitonin. Anal. Biochem. 137: 360-367
32. Lohret TA and Kinnally KW (1995) Targeting peptides transiently block a mitochondrial channel. J. Biol. Chem. 270: 15950-15953
33. Suzuki M, Youle RJ and Tjandra N (2000) Structure of Bax: coregulation of dimer formation and intracellular localization. Cell 103: 645-654
34. Kushnareva YE, Polster BM, Sokolove PM, Kinnally KW and Fiskum G (2001) Mitochondrial precursor signal peptide induces a unique permeability transition and release of cytochrome c from liver and brain mitochondria. Arch. Biochem. Biophys. 386: 251-260