Lack of evidence for linkage to chromosomes 13 and 8 for schizophrenia and schizoaffective disorder

American Journal of Medical Genetics - Neuropsychiatric Genetics

Volumn 96, Issue 2, 2000, Pages 235-239

  Delisi, Lynn E ^a   Shaw, Sarah ^b   Crow, Timothy J ^c   Shields, Gail ^a   Smith, Angela B ^a   Larach, Veronica W ^d   Wellman, Nigel ^c   Loftus, Josephine ^c   Nathankumar, Betsy ^b   Razi, Kamran ^a   Kushner, Maureen ^a   Stewart, John ^a   Vita, Antonio ^d   Comazzi, Margherita ^d   Sherrington, Robin ^b  

^a STONY BROOK UNIVERSITY   (United States)

^b Axys Pharmaceuticals Inc   (United States)

^c WARNEFORD HOSPITAL   (United Kingdom)

^d NONE

Author keywords

Chromosome 13; Chromosome 8; Genes; Linkage; Schizophrenia

Indexed keywords

ARTICLE; CHROMOSOME 13; CHROMOSOME 8; FAMILY STUDY; GENE MAPPING; GENETIC ANALYSIS; GENETIC LINKAGE; GENOTYPE; HUMAN; MAJOR CLINICAL STUDY; PRIORITY JOURNAL; SCHIZOPHRENIA;

CHROMOSOMES, HUMAN, PAIR 13; CHROMOSOMES, HUMAN, PAIR 8; GENETIC MARKERS; GENOTYPE; HUMANS; LINKAGE (GENETICS); PSYCHOTIC DISORDERS; SCHIZOPHRENIA; STATISTICS, NONPARAMETRIC;

GENETTA;

EID: 0009964816     PISSN: 15524841     EISSN: 1552485X     Source Type: Journal    
DOI: 10.1002/(SICI)1096-8628(20000403)96:2<235::AID-AJMG21>3.0.CO;2-L     Document Type: Article

References (24)

1. Blouin J-L, Dombroski BA, Nath SK, Lasseter VK, Wolyniec PS, Nestadt G, Thornquist M, Ullrich G, McGrath J, Kasch L, Lamacz M, Thomas MG, Gerrig C, Radhakrishna U, Snyder SC, Balk KG, Neufeld K, Swartz KL,. DeMarchi N, Papadimitriou GN, Dikeus DG, Stefanis CN, Chakravarti A, Childs B, Pulver AE. 1998. Schizophrenia susceptibility loci on chromosome 13q32 and 8p21. Nat Genet 20:70-73.
2. Brzustowicz LM, Honer WG, Chow EW, Little D, Hogan J, Hodgkinson K, Bassett AS. 1999. Linkage of familial schizophrenia to chromosome 13q32. Am J Hum Genet 65:1096-1103.
3. Crow TJ, DeLisi LE, Johnstone EC. 1989. Concordance by sex in sibling pairs with schizophrenia is paternally inherited: evidence for a pseudoautosomal locus. Br J Psychiatry 155:92-97.
4. DeLisi LE. 1999. A critical overview of recent investigations into the genetics of schizophrenia. Curr Opin Psychiatry 12:29-39.
5. DeLisi LE, Crow TJ. 1999. The 2nd annual chromosome workshops: critical overview and state of the field. Am J Med Genet (Neuropsych Genet) 88:215-218.
6. DeLisi LE, Devoto M, Lofthouse R, Poulter M, Smith A, Shields G, Bass N, Chen G, Vita A, Morganti C, Ott J, Crow TJ.1994. Search for linkage to schizophrenia on the X and Y chromosomes. Am J Med Genet (Neuropsych Genet) 54:113-121.
7. DeLisi LE, Shaw S. Sherrington R, Nanthakumar B, Shields G, Smith AB, Wellman N, Larach VW, Loflus J, Razi K, Stewart J, Kushner M, Vita A, De Hert M, Crow TJ. 2000. Failure to establish linkage on the X chromosome in 301 families with schizophrenia or schizo-affective disorder. Am J Med Genet (Neuropsych Genet), in press.
8. Dib C, Faure S, Fizames C, Samson D, Drouot N, Vignal A, Millasseau P, Marc S, Hazan J, Seboun E, Lathrop M. Gyapay G, Morissette J. Weissenbach J. 1996. A comprehensive genetic map of the human genome based on 5,264 microsatellites. Nature 380(6570):152-154.
9. Garner C, Kelly M, Cardon L, Joslyn G, Carey A, LeDuc C, Lichter J, Harris T, Loftus J, Shields G, Comazzi M, Vita A, Smith AM, Dann J, Crow TJ, DeLisi LE. 1996. Linkage analyses of schizophrenia to chromosome 6p24-p22: an attempt to replicate. Am J Med Genet (Neuropsych Genet) 67:595-610.
10. Hall JM, Le Duc CA, Watson AR. Roter AH. 1996. An approach to high-throughput genotyping. Genome Res 6:781-790.
11. Kendler KS, MacLean CJ, O'Neill FA, Burke J, Murphy B, Duke F, Shinkwin R, Easter SM, Webb BT, Zhang J. Walsh D, Straub RE. 1996. Evidence for a schizophrenia vulnerability locus on chromosome 8p in the Irish study of high-density schizophrenic families. Am J Psychiatry 153:1534-1540.
12. Kruglyuk L, Daly MJ, Reeve-Daly MP, Lander ES. 1996. Parametric and non-parametric linkage analysis: a unified multipoint approach. Am J Hum Genet 58:1347-1363.
13. Kruglyak L, Daly MJ, Lander ES. 1995. Complete multipoint sib-pair analysis of qualitative and quantitative traits. Am J Hum Genet 57: 439-454.
14. Lander E and Kruglyak L. 1995. Genetic dissection of complex traits: guidelines for interpreting and reporting linkage results. Nat Genet 11:241-247.
15. Lin MW, Curtis D, Williams N, Arranz M, Nanko S, Collier D, McGuffin P, Murray R, Owen M, Gill M, McGuffin P, Murray M. 1995. Psychiatric Genetics 5:117-126.
16. Nurnberger JI, Blehar MC, Kaufman CA, York-Cooler C, Simpson SG, Harkavy-Friedman J, Severe JB, Malaspina D, Reich T. 1994. Diagnostic interview for genetic studies: rationale, unique features and training. Arch Gen Psychiatry 51:849-862.
17. Pfohl B, Blum M, Zimmerman M, Stangl D. 1990. Structured Interview for DSM-III-R Personality Disorders-Revised (SIDP-R), University of Iowa, Iowa City.
18. Pulver AE, Karayiorgou M, Wolyniec PS, Lasseter V, Kasch L, Nestadt G, Antonarakis S, Housman D, Kazazian HH, Meyers D, Ott J, Lamacz M, Liang K-Y, Hanfelt J, Ulrich G, DeMarchi N, Ranu E, McHugh PR, Adler L, Thomas M, Carpenter WT, Manschreck T, Gordon CT, Kimberland M, Babb R, Puck J, Childs B. 1994. Sequential strategy to identify a susceptibility gene for schizophrenia: report of a potential linkage on chromosome 22q12-q13.1, Part I. Am J Med Genet (Neuropsych Genet 54:36-43.
19. Pulver AE, Lasseter VK, Kash L, Wolyniec P, Nestadt G, Blouin J-L, Kimberland M, Babb R, Vourlis S, Chen H, Lalioti M, Morris MA, Karayiorgou M, Ott J, Meyers D, Antonarakis SE, Housman D, Kazazian HH. 1995. Schizophrenia: a genome scan targets chromosome 3p and 8p as potential sites of susceptibility genes. Am J Med Genet (Neuropsych Genet) 60:252-260.
20. Schizophrenia Collaborative Linkage Group for Chromosomes 3,6, and 8. 1996. Support for schizophrenia linkage findings on chromosomes 6 and 8: a multicenter study. Am J Med Genet (Neuropsych Genet) 67: 580-594.
21. Shaw SH, Kelly M, Smith AB, Shields G, Hopkins PJ, Loftus J, Laval SH, Vita A, De Hert M, Cardon LR, Crow TJ, Sherrington R, DeLisi LE. 1998. A genome-wide screen for linkage to schizophrenia. Am J Med Genet (Neuropsych Genet) 81: 364-376.
22. Spitzer RL, Endicott J. 1978. Schedule for Affective Disorders and Schizophrenia (SADS), New York State Psychiatric Institute, New York.
23. Suarez BK, Hampe CL, Van Eerdewegh P. 1994. Problems of replicating linkage claims in psychiatry. In: Gershon ES, Cloninger CR, Barrett JE, editors. Genetic approaches in mental disorders. Washington, DC: American Psychiatric Press, p. 23-46.
24. Williams NM, Rees MI, Holmans P, Norton N, Cardno AG, Jones LA, Murphy KC, Sanders RD, McCarthy G. Gray MY, Fenton I, McGuffin P, Owen MJ. 1999. A two-stage sib-pair genome scan of schizophrenia susceptibility genes in 196 affected sibling pairs. Hum Mol Genet 8: 1729-1740.