Non-amine dopamine transporter probe [3H]tropoxene distributes to dopamine-rich regions of monkey brain

Synapse

Volumn 34, Issue 1, 1999, Pages 20-27

  De La Garza II, Richard ^a   Meltzer, Peter C ^b   Madras, Bertha K ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

^b ORGANIX INC   (United States)

Author keywords

Autoradiography; Cocaine; Monoamines; Primates; Reuptake

Indexed keywords

3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID ISOPROPYL ESTER; 3BETA (4 IODOPHENYL) 2BETA TROPANECARBOXYLIC ACID METHYL ESTER; ALTROPANE; AMFEBUTAMONE; CITALOPRAM; DOPAMINE; DOPAMINE RECEPTOR AFFECTING AGENT; DOPAMINE TRANSPORTER; METHYLPHENIDATE; TROPOXENE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; CHEMICAL STRUCTURE; CONTROLLED STUDY; DOPAMINE UPTAKE; DRUG BRAIN LEVEL; DRUG STRUCTURE; FEMALE; INHIBITION KINETICS; MALE; MONKEY; NONHUMAN; PRIORITY JOURNAL; TISSUE DISTRIBUTION;

ANIMALS; AUTORADIOGRAPHY; BRAIN CHEMISTRY; CARRIER PROTEINS; CAUDATE NUCLEUS; COCAINE; DOPAMINE; DOPAMINE PLASMA MEMBRANE TRANSPORT PROTEINS; FEMALE; MACACA MULATTA; MALE; MEMBRANE GLYCOPROTEINS; MEMBRANE TRANSPORT PROTEINS; NERVE TISSUE PROTEINS; PUTAMEN; RADIOLIGAND ASSAY;

EID: 0004754799     PISSN: 08874476     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1098-2396(199910)34:1<20::AID-SYN3>3.0.CO;2-4     Document Type: Article

References (52)

1. Bergman J, Madras BK, Johnson SE, Spealman RD. 1989. Effects of cocaine and related drugs in nonhuman primates. III. Self-administration by squirrel monkeys. J Pharmacol Exp Ther 251:150-155.
2. 125I] RTI-55: a potent ligand for dopamine transporters. Eur J Pharmacol 194:133-134.
3. 125I] RTI-55 to dopamine and serotonin transporters in rat brain. Synapse 12: 27-36.
4. Bosse R, Fumagalli F, Jaber M, Giros B, Gainetdinov RR, Wetsel WC, Missale C, Caron MG. 1997. Anterior pituitary hypoplasia and dwarfism in mice lacking the dopamine transporter. Neuron 19:127-138.
5. Caine SB, Heinrichs SC, Coffin VL, Koob GF. 1995. Effects of the dopamine D-1 antagonist SCH 23390 microinjected into the accumbens, amygdala, or striatum on cocaine self-administration in the rat. Brain Res 692:47-56.
6. 1 receptors in the nucleus accumbens. Psychopharmacology 115:110-114.
7. 3H] CFT in monkey brain. Synapse 5:189-195.
8. Cerruti C, Walther DM, Kuhar MJ, Uhl GR. 1993. Dopamine transporter mRNA, expression is intense in rat midbrain neurons and modest outside midbrain. Mol Brain Res 18:181-186.
9. Ciliax BJ, Heilman C, Demchyshyn LL, Pristupa ZB, Ince E, Hersch SM, Niznik HB, Levey AI. 1995. The dopamine transporter: immunochemical characterization and localization in brain. J Neurosci 15:1714-1723.
10. 125I] RTI-55 to dopamine transporters: pharmacology and regional distribution with autoradiography. Synapse 12:37-46.
11. 125I] RTI-55. Brain Res 690:217-224.
12. Coyle JT, Snyder SH. 1969. Catecholamine uptake by synaptosomes in homogenates of rat brain: stereospecificity in different areas. J Pharmacol Exp Ther 170:221-231.
13. Demarest KT, Moore KE. 1979. Lack of a high affinity transport system for dopamine in the median eminence and posterior pituitary. Brain Res 171:545-551.
14. Freed C, Revay R, Vaughn RA, Kriek E, Grant S, Uhl GR, Kuhar MJ. 1995. Dopamine transporter immunoreactivity in rat brain. J Comp Neurol 359:340-349.
15. George SR, Van Loon GR. 1982. Characterization of high affinity dopamine uptake into the dopamine neurons of the hypothalamus. Brain Res 234:339-355.
16. Horn AS. 1978. Dopamine. Adv Biochem Psychopharmacol 19:25-34.
17. Horn AS. 1990. Dopamine uptake: a review of the progress in the last decade. Prog Neurobiol 34:387-400.
18. Kalivas PW, Duffy P. 1993a. Time course of extracellular dopamine and behavioral sensitization to cocaine. I. Dopamine axon terminals. J Neurosci 13:266-275.
19. Kalivas PW, Duffy P. 1993b. Time course of extracellular dopamine and behavioral sensitization to cocaine. II. Dopamine perikarya. J Neurosci 13:276-284.
20. 125I]RTI-55. Synapse 12:99-111.
21. 3H]CFT. Synapse 9:177-187.
22. Krieg WJS. 1975. Section atlas of the brain of Macacus rhesus. Evanston, IL: Brain Books.
23. Kuhar MJ. 1998. Recent biochemical studies of the dopamine transporter - a CNS drug target. Life Sci 62:1573-1575.
24. 125I] RTI-55 binding to cocaine-sensitive dopaminergic and serotonergic uptake sites in the human brain. J Neurochem 61:1996-2006.
25. 125I] RTI-121 binding sites in human striatum and medial temporal lobe. J Pharmacol Exp Ther 274:1473-1483.
26. 3H] cocaine binding sites in caudate putamen. J Pharmacol Exp Ther 251:131-141.
27. 3H] 2β-carbomethoxy-3β-(4-fluorophenyl)tropane. Mol Pharmacol 36:518-524.
28. 3H] cocaine receptors. Pharmacol Biochem Behav 35:949-953.
29. Madras BK, Pristupa ZB, Niznik HB, LiangAY, Blundell P, Gonzalez MD, Meltzer PC. 1996. Nitrogen-based drugs are not essential for blockade of monoamine transporters. Synapse 24:340-348.
30. Madras BK, Gracz LM, Fahey MA, Elmaleh DR, Meltzer PC, LiangAY, Stopa EG, Babich J, Fischman AJ. 1998a. Altopane, a SPECT or PET imaging probe for dopamine neurons. III. Human dopamine transporter in normal and Parkinson's diseased brain. Synapse 29:116-127.
31. Madras BK, Gracz LM, Meltzer PC, LiangAY, Elmaleh DR, Kaufman MJ, Fischman AJ. 1998b. Altopane, a SPECT or PET imaging probe for dopamine neurons. II. Distribution to dopamine-rich regions of primate brain. Synapse 29:105-115.
32. Maggos CE, Spangler R, Zhou Y, Schlussman SD, Ho A, Kreek MJ. 1997. Quantitation of dopamine transporter mRNA in the rat brain: Mapping, effects of "binge" cocaine administration and withdrawal. Synapse 26:55-61.
33. Maldonado R, Robledo P, Chover AJ, Caine SB, Koob GF. 1993. D1 dopamine receptors in the nucleus accumbens modulate cocaine self-administration in the rat. Pharmacol Biochem Behav 45:239-242.
34. Meister B, Eide R. 1993. Dopamine transporter mRNA in neurons of the rat hypothalamus. Neuroendocrinology 58:388-395.
35. Meltzer PC, Liang AY, Brownell A-L, Elmaleh DR, Madras BK. 1993. Substituted 3-phenyltropane analogs of cocaine: synthesis, inhibition of binding at cocaine recognition sites and positron emission tomography (PET) imaging. J Med Chem 36:855-862.
36. 99mSPECT imaging agent which targets the dopamine transporter in primate brain. J Med Chem 40:1835-1844.
37. Meltzer PC, Liang AY, Blundell P, Gonzalez MD, Chen Z, George C, Madras BK. 1997b. 2-Carbomethoxy-3-aryl-8oxabicyclo[3.2.1]-octanes: potent non-nitrogen inhibitors of monoamine transporters. J Med Chem 40:2661-2673.
38. Meltzer PC, Blundell P, Madras BK. 1998. Structure activity relationships of inhibition of the dopamine transporter by 3-arylbicyclo[3.2.1]octanes. Med Chem Res 8:12-34.
39. 1 receptors in rhesus monkeys. Synapse 28:1-9.
40. Nirenberg MJ, Vaughan RA, UhI GR, Kuhar MJ, Pickel VM. 1996. The dopamine transporter is localized to dendritic and axonal plasma membranes of nigrostriatal dopaminergic neurons. J Neurosci 16: 436-447.
41. Nirenberg MJ, Chan J, Pohorille A, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM. 1997a. The dopamine transporter: comparative ultrastructure of dopaminergic axons in limbic and motor compartments of the nucleus accumbens. J Neurosci 17:6899-6907.
42. Nirenberg MJ, Chan J, Vaughan RA, Uhl GR, Kuhar MJ, Pickel VM. 1997b. Immunogold localization of the dopamine transporter: an ultrastructural study of the rat ventral tegmental area. J Neurosci 17:5255-5262.
43. Pettit HO, Justice JB Jr. 1989. Dopamine in the nucleus accumbens during self-administration as studied by in vivo microdialysis. Pharmacol Biochem Behav 34:899-904.
44. Reith MEA, Meisler BE, Sershen H, Lajtha A. 1986. Structural requirements for cocaine congeners to interact with dopamine and serotonin uptake sites in mouse brain and to induce stereotyped behavior. Biochem Pharmacol 35:1123-1129.
45. Revay R, Vaughn R, Grant S, Kuhar MJ. 1996. Dopamine transporter immunohistochemistry in median eminence, amygdala, and other areas of rat brain. Synapse 22:93-99.
46. Ritz MC, Lamb RJ, Goldberg SR, Kuhar MJ. 1987. Cocaine receptors on dopamine transporters are related to self-administration of cocaine. Science 237:1219-1223.
47. Shimada S, Kitayama S, Walther D, Uhl G. 1994. Dopamine transporter mRNA: Dense expression in ventral midbrain neurons. Brain Res Mol Brain Res 13:359-362.
48. Snider R, Lee JC. 1961. A stereotaxic atlas of the monkey brain (Macaca mulatta). Chicago: University of Chicago Press.
49. Spealman RD, Madras BK, Bergman J. 1989. Effects of cocaine and related drugs in nonhuman primates. II. Stimulant effects on schedule controlled behavior. J Pharmacol Exp Ther 251:142-149.
50. 125I] RTI-55: in vitro binding and autoradiographic characterization. J Neurochem 62:549-556.
51. 125I] RTI-121. Synapse 21:364-372.
52. Vaughn RA, Brown VL, McCoy MT, Kuhar MJ. 1996. Species-and brain region-specific dopamine transporters: immunological and glycosylation characteristics. J Neurochem 66:2146-2152.