Behavioural profiles in the mouse defence test battery suggest anxiolytic potential of 5-HT(1A) receptor antagonists

Psychopharmacology

Volumn 144, Issue 2, 1999, Pages 121-130

  Griebel, Guy ^a   Rodgers, R John ^b   Perrault, Ghislaine ^a   Sanger, David J ^a  

^a SANOFI   (France)

^b UNIVERSITY OF LEEDS   (United Kingdom)

Author keywords

5 HT(1A) receptor antagonist; Anxiety; Defensive behaviour; Diazepam; Flight; Risk assessment; Swiss mice

Indexed keywords

BENZODIAZEPINE RECEPTOR BLOCKING AGENT; DIAZEPAM; N [2 [4 (2 METHOXYPHENYL) 1 PIPERAZINYL]ETHYL] N (2 PYRIDYL)CYCLOHEXANECARBOXAMIDE;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DEFENSIVE BEHAVIOR; DRUG SCREENING; FLIGHT; LOCOMOTION; MOUSE; NONHUMAN; POSTSYNAPTIC POTENTIAL; PRIORITY JOURNAL; RISK ASSESSMENT; SCREENING TEST; TRANQUILIZING ACTIVITY;

ANIMALS; ANTI-ANXIETY AGENTS; DIAZEPAM; ESCAPE REACTION; MALE; MICE; MOTOR ACTIVITY; RATS; RATS, LONG-EVANS; RECEPTORS, SEROTONIN; RECEPTORS, SEROTONIN, 5-HT1; RISK ASSESSMENT; SEROTONIN ANTAGONISTS;

EID: 0004542692     PISSN: 00333158     EISSN: None     Source Type: Journal    
DOI: 10.1007/s002130050984     Document Type: Article

References (72)

1. 1A receptor selective ligands, (R)-S-OH-DPAT and (S)-UH-301, differentially affect the activity of midbrain dopamine neurons. Naunyn-Schmiedeberg's Arch Pharmacol 347:353-362
2. 1A antagonist, WAY 100135. Soc Neurosci Abstr 21:1854
3. 1B receptors. Neuropharmacology 35:213-222
4. 1A-agonist EMD 68843. Soc Neurosci Abstr 22:613
5. 1A antagonist, on social and agonistic behaviour in male albino mice. Pharmacol Biochem Behav 46:67-72
6. 1A receptor antagonists (+)WAY100135 and WAY100635. Neuropharmacology 34:805-811
7. Bickerdike MJ, Wright IK, Marsden CA (1993) Social isolation attenuates rat forebrain 5-HT release induced by KCl stimulation and exposure to a novel environment. Behav Pharmacol 4:231-236
8. Blanchard DC, Blanchard RJ (1988) Ethoexperimental approaches to the biology of emotion. In: Rosenzweig MR, Porter LW (eds) Annual review of psychology. Annual Reviews Inc, Palo Alto, pp 43-68
9. Blanchard RJ, Blanchard DC (1984) Affect and aggression: an animal model applied to human behavior. In: Blanchard RJ, Blanchard DC (eds) Advances in the study of aggression. Academic Press, Orlando, pp 1-62
10. Blanchard DC, Blanchard RJ, Rodgers RJ (1991) Risk assessment and animal models of anxiety. In: Olivier B, Mos J, Slangen JL (eds) Animal models in psychopharmacology. Birkhauser, Basel, pp 117-134
11. Blanchard RJ, Taukulis HK, Rodgers RJ, Magee LK, Blanchard DC (1993a) Yohimbine potentiates active defensive responses to threatening stimuli in Swiss-Webster mice. Pharmacol Biochem Behav 44:673-681
12. Blanchard RJ, Yudko EB, Rodgers RJ, Blanchard DC (1993b) Defense system psychopharmacology: an ethological approach to the pharmacology of fear and anxiety. Behav Brain Res 58:155-165
13. Blanchard RJ, Griebel G, Henrie JA, Blanchard DC (1997) Differentiation of anxiolytic and panicolytic drugs by effects on rat and mouse defense test batteries. Neurosci Biobehav Rev 21:783-789
14. Blanchard DC, Griebel G, Rodgers RJ, Blanchard RJ (1998) Benzodiazepine and serotonergic modulation of antipredator and conspecific defense. Neurosci Biobehav Rev 22:597-612
15. 1A autoreceptors: S15535 and 8-OH-DPAT block ultrasonic vocalizations and aggression in a WAY 100,635-reversible fashion. Soc Neurosci Abstr 22:236
16. 1A receptor antagonist, in the murine elevated plus-maze. Psychopharmacology 129:365-371
17. 1A. Pharmacol Biochem Behav 58:583-591
18. 1A receptor antagonism on plus-maze behaviour in mice. 2. WAY 100635, SDZ 216-525 and NAN-190. Pharmacol Biochem Behav 58:593-603
19. 1A receptor antagonist, WAY 100635. Neurosci Biobehav Rev 23:247-257
20. 1A receptor antagonist NAN-190 on rat brain serotonergic transmission. Eur J Pharmacol 204:71-77
21. 1A receptor inverse agonist, SL88.0338. Soc Neurosci Abstr 24:1364
22. 1A antagonist, WAY 100635. Psychopharmacology 132:35-43
23. File SE, Zangrossi H, Andrews N (1993) Social interaction and elevated plus-maze tests: changes in release and uptake of 5-HT and GABA. Neuropharmacology 32:217-221
24. 1A receptor modulation of anxiety in two ethological animal tests. J Neurosci 16:4810-4815
25. 1A receptors. Eur J Pharmacol 237:283-291
26. 1A receptor antagonists: utility as research tools and therapeutic agents. Trends Pharmacol Sci 14:41-48
27. 1A receptor antagonist. Behav Brain Res 73:337-353
28. 1A receptor antagonist, WAY-100635. Eur J Pharmacol 281:81-88
29. Gardner CR (1986) Recent developments in 5HT-related pharmacology of animal models of anxiety. Pharmacol Biochem Behav 24:1479-1485
30. 1A agonist 8-hydroxy-2-(di-n-propylamino)tetralin (8-OH-DPAT). Eur J Pharmacol 154:339-341
31. 3H-PAT. Nature 305:140-142
32. Griebel G (1995) 5-Hydroxytryptamine-interacting drugs in animal models of anxiety disorders: more than 30 years of research. Pharmacol Ther 65:319-395
33. Griebel G, Blanchard DC, Jung A, Blanchard RJ (1995a) A model of "antipredator" defense in Swiss-Webster mice: effects of benzodiazepine receptor ligands with different intrinsic activities. Behav Pharmacol 6:732-745
34. 2A antagonist pirenperone. Pharmacol Biochem Behav 51:235-244
35. Griebel G, Blanchard DC, Blanchard RJ (1996a) Evidence that the behaviours in the mouse defense test battery relate to different emotional states: a factor analytic study. Physiol Behav 60:1255-1260
36. Griebel G, Blanchard DC, Blanchard RJ (1996b) Predator-elicited flight responses in Swiss-Webster an experimental model of panic attacks. Prog Neuro-Psychopharmacol Biol Psychiatry 20:185-205
37. Griebel G, Sanger DJ, Perrault G (1996c) The mouse defense test battery: evaluation of the effects of non-selective and BZ-1 (ω1) selective, benzodiazepine receptor ligands. Behav Pharmacol 7:560-572
38. Griebel G, Perrault G, Sanger DJ (1997a) Behavioural profiles of the reversible monoamine-oxidase-A inhibitors befloxatone and moclobemide in an experimental model for screening anxiolytic and anti-panic drugs. Psychopharmacology 131:180-186
39. Griebel G, Sanger DJ, Perrault G (1997b) Genetic differences in the mouse defense test battery. Aggress Behav 23:19-31
40. Griebel G, Curet O, Perrault G, Sanger DJ (1998a) Behavioural effects of phenelzine in an experimental model for screening anxiolytic and anti-panic drugs: correlation with changes in monoamine-oxidase activity and monoamine levels. Neuropharmacology 37:927-935
41. Griebel G, Perrault G, Sanger DJ (1998b) Characterization of the behavioural profile of the non-peptide CRF receptor antagonist CP-154,526 in anxiety models in rodents. Comparison with diazepam and buspirone. Psychopharmacology 138:55-66
42. 1A receptor antagonist has anxiogenic effects in rats and does not block stress-induced rises in stress hormones. Soc Neurosci Abstr 21:1366
43. 1A-receptor antagonist. J Med Chem 33:1541-1544
44. Hjorth S, Carlsson A (1982) Buspirone: effects on central monoaminergic transmission - possible relevance to animal experimental and clinical findings. Eur J Pharmacol 83:299-303
45. 1A receptors: behavioural and in vivo brain microdialysis studies. Life Sci 46:955-963
46. 1 recognition sites. J Recept Res 8:59-81
47. 1A receptor. Soc Neurosci Abstr 23:2150
48. 1A receptor ligands in a modified Geller-Seifter conflict model in the rat. Eur J Pharmacol 325:121-128
49. 1A receptor antagonist: p-MPPI. Life Sci 55:1459-1462
50. 1A sites in rat brain: in vitro binding and autoradiographic studies. J Pharmacol Exp Ther 272:429-437
51. 2 receptors. Life Sci 28:1015-1022
52. 1A receptor antagonist. Pharmacol Biochem Behav 38:555-559
53. 1A receptor-mediated activity in the rat: a pharmacological characterization of the actions of novel agonists and antagonists. J Pharmacol Exp Ther 264:1364-1376
54. 1A) receptors. 2. Modulation of hippocampal serotonin release in relation to potential anxiolytic properties. J Pharmacol Exp Ther 282:148-161
55. 1A receptors. Med Chem Res 4:161-169
56. Norman TR, Judd FK (1989) Panic attacks, buspirone, and serotonin function. Lancet ii:15
57. 1A receptor mediated. Eur J Pharmacol 342:177-182
58. Overshiner CD, Benvenga MJ, Leander JD (1995) Comparison of punished responding and conditioned suppression in pigeons and rats. Soc Neurosci Abstr 21:1131
59. Pazos A, Probst A, Palacios JM (1987) Serotonin receptors in the human brain - III. Autoradiographic mapping of serotonin-1 receptors. Neuroscience 21:97-122
60. Pierson ME, Lyon RA, Titeler M, Schulman SB, Kowalski P, Glennon RA (1990) Design and synthesis of propranolol analogues as serotonergic agents. J Med Chem 33:1270
61. 1A receptors are critically involved in the anxiolytic effects of 8-OH-DPAT. Psychopharmacology 125:89-91
62. Rodgers RJ (1997) Animal models of "anxiety": where next? Behav Pharmacol 8:477-496
63. 1A receptor antagonists. Behav Brain Res 73:153-156
64. 1A receptor partial agonist, increases rates of punished responding in rats: comparison with chlordiazepoxide, ipsapirone and WAY 100635. Soc Neurosci Abstr 22:607
65. 1A receptors play an important role in modulation of behaviour of rats in a two-compartment black and white box. Behav Pharmacol 7:788-797
66. Schreiber R, Melon C, Devry J (1998) The role of 5-HT receptor subtypes in the anxiolytic effects of selective serotonin reuptake inhibitors in the rat ultrasonic vocalization test. Psychopharmacology 135:383-391
67. 1A antagonist, BMY 7378. Eur J Pharmacol 176:331-340
68. 1A receptor agonists, partial agonists and a silent antagonist on the performance of the conditioned emotional response test in the rat. Psychopharmacology 128:293-303
69. 1A receptors. J Pharmacol Exp Ther 277:661-670
70. 1A receptors and relationship to anxiolytic effect. Eur J Pharmacol 323:59-68
71. 1A receptor in rat and guinea-pig hippocampal membranes. Eur J Pharmacol 137:293-294
72. 1A ligand. J Med Chem 37:1406-1407