Widespread early dendritic injury associated with loss of cortical MAP-2 immunostaining in a focal ovine head impact model

Journal of Clinical Neuroscience

Volumn 6, Issue 6, 1999, Pages 500-505

  Manavis, Jim ^a   Lee, Po Ling ^a   Blumbergs, Peter C ^a   Lewis, Steve B ^b   Finnie, John W ^a   Reilly, Peter L ^b   Jones, Nigel R ^c  

^a INSTITUTE OF MEDICAL AND VETERINARY SCIENCE   (Australia)

^b ROYAL ADELAIDE HOSPITAL   (Australia)

^c UNIVERSITY OF ADELAIDE   (Australia)

Author keywords

Dendrites; Head injury; Immunohistochemistry; Microtubule associated proteins; Sheep model

Indexed keywords

EID: 0003768494     PISSN: 09675868     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0967-5868(99)90010-3     Document Type: Article

References (38)

1. Tanaka E, Kirschner MW. The role of microtubules in growth cone turning at substrate boundaries. J Cell Biol 1995; 128: 127-137.
2. Maccioni RB, Cambiazo V. Role of microtubule-associated proteins in the control of microtubule assembly. Physiol Rev 1995; 75: 835-864.
3. Mandell JW, Banker GA. The microtubule cytoskeleton and the development of neuronal polarity. Neurobiol Aging 1995; 16: 229-238.
4. Matus A, Riederer B, Huber G. Influence of monoclonal antibodies on microtubule assembly. J Neurochem 1987; 49: 714-720.
5. Garner CC, Tucker RP, Matus A. Selective localization of messenger RNA for cytoskeletal protein MAP-2 in dendrites. Nature 1988; 336: 674-677.
6. Baringa M. Dendrites shed their dull image. Science 1995; 268: 200-201.
7. Kitagawa K, Matsumoto M, Niinobe M et al. Microtubule-associated protein 2 as a sensitive marker for cerebral ischaemic damage-immunohistochemical investigation of dendritic damage. Neuroscience 1989; 2: 401-411.
8. Matesic DF, Lin SC. Microtubule-associated protein 2 as an early indicator of ischaemia-induced neurodegeneration in the gerbil forebrain. J Neurochem 1994; 63: 1012-1020.
9. Folkerts MM, Berman RF, Muizelaar JP, Rafols JA. Disruption of MAP-2 immunostaining in rat hippocampus after traumatic brain injury. J Neurotrauma 1998; 15: 349-63.
10. Hicks RR, Smith DH, McIntosh TK. Temporal response and effects of excitatory amino acid antagonism on microtubule-associated protein 2 immunoreactivity following experimental brain injury in rats. Brain Res 1995; 678: 151-160.
11. Hicks RR, Baldwin SA, Scheff SW. Serum extravasation and cytoskeletal alterations following traumatic brain injury in rats. Molecular and Chemical Neuropathology 1997; 32: 1-16.
12. Lewen A, Li GL, Olsson Y, Hillered L. Changes in microtubule-associated protein 2 and amyloid precursor protein immunoreactivity following traumatic brain injury in rat: influence of MK-801 treatment. Brain Res 1996; 719: 161-171.
13. Posmantur RM, Kampfl A, Liu SJ, Heck K et al. Cytoskeletal derangements of cortical neuronal processes following traumatic brain injury in rats: an immunofluorescence study. J neuropathol exp. neurol 1996; 55: 68-80.
14. Posmantur RM, Kampfl A, Taft WC, Bhattacharjee M. Diminished microtubule-associated protein 2 (MAP-2) immunoreactivity following cortical impact brain injury. J Neurotrauma 1996; 13: 125-137.
15. Taft WC, Yang K, Dixon CE, Hayes RL. Microtubule-associated protein 2 levels decrease in hippocampus following traumatic brain injury. J. Neurotrauma 1992; 9: 281-290.
16. Taft WC, Yang K, Dixon CE, Clifton GL, Hayes RL. Hypothermia attenuates the loss of hippocampal microtubule-associated protein 2 (MAP2) following traumatic brain injury. J Cereb Blood Flow Metab 1993; 13: 796-802.
17. Faddis B, Hasbani J, Goldberg MP. Calpain activation contributes to dendritic remodeling after brief excitotoxic injury in vitro. J Neuroscience 1997; 3: 951-959.
18. Park JS, Bateman MC, Goldberg MP. Rapid alterations in dendrite morphology during sublethal hypoxia or glutamate receptor activation. Neurobiology of Disease 1996; 3: 215-227.
19. Siman R, Noszek JC. Excitatory amino acids activate calpain 1 and induce structural protein breakdown in vivo. Neuron 1988; 1: 279-287.
20. Siman R, Noszek JC, Kagerise C. Calpain I activation is specifically related to excitatory amino acid induction of hippocampal damage. J Neurosci 1989; 9: 1579-1590.
21. Multani P, Myers RH, Blume HW, Schomer DL. Sotrel A. Neocortical dendritic pathology in human partial epilepsy: a quantitative Golgi study. Epilepsia 1994; 35: 728-736.
22. Schormair C, Bingmann D, Wittkowski W, Speckmann EJ. Morphology of CA3 neurons in hippocampal slices with non-epileptic and epileptic activity: a light and electron microscopic study. Brain Res Bull 1993; 32: 329-338.
23. Lewis SB, Finnie JW, Blumbergs PC et al. A head impact model of early axonal injury in the sheep. J. Neurotrauma 1996; 13: 505-514.
24. Lighthall JW, Anderson TE. In vivo models of experimental brain and spinal cord trauma. In: Salzman SK, Faden Al (Eds). The Neurobiology of Central Nervous System Trauma. New York: Oxford University Press, 1994; 3-11.
25. Upton R, Grant C, Ludbrook G. An ultrasonic Doppler venous outflow method for the continuous measurement of cerebral blood flow in sheep. J Cereb Blood Flow Metab 1994; 14: 680-688.
26. Finnie J, Lewis S, Manavis J, Blumbergs PC, Van Den Heuvel C, Jones N. Traumatic axonal injury in lambs: a model for paediatric axonal damage. J Clin Neurosci 1999; 6: 38-42.
27. Van Den Heuvel C, Lewis S, Wong M et al. Diffuse neuronal perikaryon APP immunoreactivity in a focal head impact sheep model. Acta Neurochir Suppl (Wien) 1998; 71: 209-11.
28. Lyeth BG, Jenkins LW, Hamm RJ et al. Prolonged memory impairment in the absence of hippocampal cell death following traumatic brain injury in the rat. Brain Res 1990; 526: 249-258.
29. Kudo T, Kunitoshi T, Takeda M, Nishimura T. Learning Impairment and Microtubule-associated protein 2 decrease in Gerbils Under Chronic Cerebral Hypoperfusion. Stroke 1990; 21: 1205-1209.
30. Regehr WG, Tank DW. Dendritic calcium dynamics. Curr Opin Neurobiol 1994; 4: 373-382.
31. Yuste R, Gutnick MJ, Saar D, Delaney KR, Tank DW. Calcium accumulations in dendrites of neocortical pyramidal neurons: an apical band and evidence for two functional compartments. Neuron 1994; 13: 23-43.
32. Kampfl A, Posmantur R, Nixon R et al. MU-calpain activation and calpain-mediated cytoskeletal proteolysis following traumatic brain injury. J Neurochem 1996; 67: 1575-83.
33. Wang KK, Yuen PW. Calpain inhibition: an overview of their therapeutic potential. Trends Pharmacol. Sci. 1994; 15: 412-419.
34. Johnson GVW, Jope RS. The role of microtubule-associated protein 2 (MAP-2) in neuronal growth, plasticity, and degeneration. J Neurosci Research 1992; 33: 505-512.
35. Caceres A, Busciglio J, Ferreira A, Oswald S. An immunocytochemical and biochemical study of microtubule-associated protein MAP-2 during post-lesion dendritic remodeling in the central nervous system of adult rats. Mol. Brain Res 1988; 3: 233-246.
36. 2+-and calmodulin-dependent phosphorylation of microtubule-associated protein 2 and Tfactor, and inhibition of microtubule assembly. J. Neurochem. 1983; 41: 1119-1125.
37. Kaufmann WE, Taylor CV, Lishaa NA. Immunoblotting patterns of cytoskeletal dendritic protein expression in human neocortex. Mol Chem Neuropathol 1997; 31: 235-44.
38. Evers P, Uylings HBM. Effects of microwave pretreatment on immunocytochemical staining of vibratome sections and tissue blocks of human cerebral cortex stored in formaldehyde fixative for long periods. J. Neurosci. Meth 1994; 55: 163-172.