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Volumn 1, Issue 1, 1998, Pages 66-70

The diversity challenge in combinatorial chemistry

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[No Author keywords available]

Indexed keywords


EID: 0003091381     PISSN: 13676733     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article
Times cited : (17)

References (47)
  • 11
    • 0000528756 scopus 로고    scopus 로고
    • Reactant-based selection, which attempts to maximize diversity in the building blocks, results in noticeably less diverse libraries than if the selection is performed at the product level. Sampling plan strategies are provided for balancing the ease of synthesis of the reactant-based selections against the product diversity selection criteria.
    • Gillet VJ, Willett P, Bradshaw J: The effectiveness of reactant pools for generating structurally-diverse combinatorial libraries. J Inform Comp Sei (1997) 37:731-740. Reactant-based selection, which attempts to maximize diversity in the building blocks, results in noticeably less diverse libraries than if the selection is performed at the product level. Sampling plan strategies are provided for balancing the ease of synthesis of the reactant-based selections against the product diversity selection criteria.
    • Willett P, Bradshaw J: the Effectiveness of Reactant Pools for Generating Structurally-diverse Combinatorial Libraries. J Inform Comp Sei (1997) 37:731-740.
    • Gillet, V.J.1
  • 38
    • 0030704683 scopus 로고    scopus 로고
    • A catalytic antibody's activity was used as a selectable phenotype for growth of phage displaying the antibody as a surface protein. Applied to enzymes implicated in natural product synthesis, this approach offers a promising route to novel catalysts for building structurally diverse libraries.
    • Gao C, Lin CH, Lo CHL, Mao S, Wirsching P, Lemer RA, Janda KD: Making chemistry selectable by linking it to infectivity. Proc NatlAcad Sei USA (1997) 94:11777-11782. A catalytic antibody's activity was used as a selectable phenotype for growth of phage displaying the antibody as a surface protein. Applied to enzymes implicated in natural product synthesis, this approach offers a promising route to novel catalysts for building structurally diverse libraries.
    • Lin CH, Lo CHL, Mao S, Wirsching P, Lemer RA, Janda KD: Making Chemistry Selectable by Linking It to Infectivity. Proc NatlAcad Sei USA (1997) 94:11777-11782.
    • Gao, C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.