-
11
-
-
0000528756
-
-
Reactant-based selection, which attempts to maximize diversity in the building blocks, results in noticeably less diverse libraries than if the selection is performed at the product level. Sampling plan strategies are provided for balancing the ease of synthesis of the reactant-based selections against the product diversity selection criteria.
-
Gillet VJ, Willett P, Bradshaw J: The effectiveness of reactant pools for generating structurally-diverse combinatorial libraries. J Inform Comp Sei (1997) 37:731-740. Reactant-based selection, which attempts to maximize diversity in the building blocks, results in noticeably less diverse libraries than if the selection is performed at the product level. Sampling plan strategies are provided for balancing the ease of synthesis of the reactant-based selections against the product diversity selection criteria.
-
Willett P, Bradshaw J: the Effectiveness of Reactant Pools for Generating Structurally-diverse Combinatorial Libraries. J Inform Comp Sei (1997) 37:731-740.
-
-
Gillet, V.J.1
-
12
-
-
0027934780
-
-
(1994) 37:2678-2685.
-
Zuckerman RN, Martin EJ, Spellmeyer DC, Stauber GB, Shoemaker KR, Kerr JM, Figliozzi GM, Gold DA, Siani MA, Simon RJ, Banville SC, Brown EG, Wang L, Richter LS, Moos WH: Discovery of nanomolar ligands for 7-transmembrane G-protein-coupled receptors from a diverse N-(subst'rtuted) glycine peptoid library. J Med Chem (1994) 37:2678-2685.
-
Martin EJ, Spellmeyer DC, Stauber GB, Shoemaker KR, Kerr JM, Figliozzi GM, Gold DA, Siani MA, Simon RJ, Banville SC, Brown EG, Wang L, Richter LS, Moos WH: Discovery of Nanomolar Ligands for 7-transmembrane G-protein-coupled Receptors from A Diverse N-(subst'rtuted) Glycine Peptoid Library. J Med Chem
-
-
Zuckerman, R.N.1
-
14
-
-
33746503873
-
-
Chem(\ 995) 38:1432-1436.
-
Martin EJ, Blaney JM, Siani MA, Spellmeyer, DC, Wong AK, et at. Measuring diversity: experimental design of combinatorial libraries. J Med Chem(\ 995) 38:1432-1436.
-
Blaney JM, Siani MA, Spellmeyer, DC, Wong AK, et At. Measuring Diversity: Experimental Design of Combinatorial Libraries. J Med
-
-
Martin, E.J.1
-
21
-
-
0029240364
-
-
& E/b/csry(1995)2:107-118.
-
Kauvar LM, Higgins DL, Villar HO, Sportsman JR, EngqvistGoldstein AE, Bukar R, Bauer KE, Dilley H, Rocke DM: Predicting ligand binding to proteins by affinity finger-printing. Chemistry & E/b/csry(1995)2:107-118.
-
Higgins DL, Villar HO, Sportsman JR, EngqvistGoldstein AE, Bukar R, Bauer KE, Dilley H, Rocke DM: Predicting Ligand Binding to Proteins by Affinity Finger-printing. Chemistry
-
-
Kauvar, L.M.1
-
22
-
-
0032508654
-
-
proteins.
-
Kauvar LM, Villar HO, Sportsman JR, Higgins DL, Schmidt Jr DE: Protein Affinity Map of Chemical Space. J Chromatogr (1998) in press. Affinity fingerprinting is explained and illustrated, and then used to identify a class of ligands termed "master keys' which empirically recognize conserved features in a variety of proteins.
-
Villar HO, Sportsman JR, Higgins DL, Schmidt Jr DE: Protein Affinity Map of Chemical Space. J Chromatogr (1998) in Press. Affinity Fingerprinting Is Explained and Illustrated, and Then Used to Identify A Class of Ligands Termed "Master Keys' Which Empirically Recognize Conserved Features in A Variety of
-
-
Kauvar, L.M.1
-
32
-
-
0029836953
-
-
paradigm.
-
Shuker SB, Hajduk PJ, Meadows RP, Fesik SW: Discovering high affinity ligands to proteins: SAR by NMR. Science (1996)274:1531-1534. Weak ligands binding to adjacent sites are linked to form a more potent compound. If one site is conserved among a protein family, and one is variable, a direct route to high affinity compounds is enabled that fits easily into the current combinatorial chemistry paradigm.
-
Hajduk PJ, Meadows RP, Fesik SW: Discovering High Affinity Ligands to Proteins: SAR by NMR. Science (1996)274:1531-1534. Weak Ligands Binding to Adjacent Sites Are Linked to Form A More Potent Compound. if One Site Is Conserved among A Protein Family, and One Is Variable, A Direct Route to High Affinity Compounds Is Enabled That Fits Easily into the Current Combinatorial Chemistry
-
-
Shuker, S.B.1
-
38
-
-
0030704683
-
-
A catalytic antibody's activity was used as a selectable phenotype for growth of phage displaying the antibody as a surface protein. Applied to enzymes implicated in natural product synthesis, this approach offers a promising route to novel catalysts for building structurally diverse libraries.
-
Gao C, Lin CH, Lo CHL, Mao S, Wirsching P, Lemer RA, Janda KD: Making chemistry selectable by linking it to infectivity. Proc NatlAcad Sei USA (1997) 94:11777-11782. A catalytic antibody's activity was used as a selectable phenotype for growth of phage displaying the antibody as a surface protein. Applied to enzymes implicated in natural product synthesis, this approach offers a promising route to novel catalysts for building structurally diverse libraries.
-
Lin CH, Lo CHL, Mao S, Wirsching P, Lemer RA, Janda KD: Making Chemistry Selectable by Linking It to Infectivity. Proc NatlAcad Sei USA (1997) 94:11777-11782.
-
-
Gao, C.1
-
39
-
-
0029325254
-
-
(1995)268:1738-1740.
-
Xiang XD, Sun X, Briceno G, Lou Y, Wang KA, Chang H, Wallace-Freedman WG, Chen SW, Schultz PG: A combinatorial approach to materials discovery. Science (1995)268:1738-1740.
-
Sun X, Briceno G, Lou Y, Wang KA, Chang H, Wallace-Freedman WG, Chen SW, Schultz PG: A Combinatorial Approach to Materials Discovery. Science
-
-
Xiang, X.D.1
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