Diacylglycerol production in Xenopus laevis oocytes after microinjection of p21ras proteins is a consequence of activation of phosphatidylcholine metabolism

Molecular and Cellular Biology

Volumn 10, Issue 1, 1990, Pages 333-340

  Lacal, Juan Carlos ^a  

^a INSTITUTO DE INVESTIGACIONES BIOMÉDICAS ALBERTO SOLS   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

XENOPUS LAEVIS; ANIMALIA; ANURA;

DIACYLGLYCEROL; PHOSPHATIDYLCHOLINE; PROTEIN P21;

ANIMAL CELL; ARTICLE; CELL CULTURE; NONHUMAN; OOCYTE; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; TOAD;

ANIMAL; CHOLINE KINASE; CYTIDINE DIPHOSPHATE CHOLINE; DIGLYCERIDES; GLYCERIDES; INOSITOL PHOSPHATES; MEIOSIS; MICROINJECTIONS; ONCOGENE PROTEIN P21(RAS); OOCYTES; PHOSPHATIDYLCHOLINES; SUPPORT, NON-U.S. GOV'T; XENOPUS LAEVIS;

EID: 0025181886     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.10.1.333     Document Type: Article

References (29)

1. Barbacid, M. 1987. ras genes. Annu. Rev. Biochem. 56:779-827.
2. Berridge, M. J. 1987. Inositol trisphosphates and diacylglycerol: two interacting second messengers. Annu. Rev. Biochem. 56: 159-193.
3. Birchmeier, C., D. Broek, and M. Wigler. 1985. Ras proteins can induce meiosis in Xenopus oocytes. Cell 43:615-621.
4. ras. Mol. Cell. Biol. 6:116-122.
5. ras proteins involves palmitoylation of the tetrapeptide containing cysteine-186. J. Virol. 56:607-612.
6. Dugan, L. L., P. Demediuk, C. E. Pendley II, and L. A. Horrocks. 1986. Separation of phospholipids by high-performance liquid chromatography: all major classes, including ethanolamine and choline plasmalogens, and most minor classes, including lysophosphatidylethanolamine. J. Chromatogr. 378: 317-327.
7. Fleischman, L. F., S. B. Chahwala, and L. Cantley. 1986. Ras-transformed cells: altered levels of phosphatidylinisitol-4,5-bisphosphate and catabolites. Science 231:407-410.
8. Hancock, J. F., A. I. Magee, J. E. Childs, and C. J. Marshall. 1989. All ras proteins are polyisoprenylated but only some are palmitoylated. Cell 58:1167-1177.
9. ras elevates inositol phospholipid breakdown in two cell systems. Oncogene 3:187-193.
10. Ishidate, K., K. Furusawa, and Y. Nakasawa. 1985. Complete copurification of choline kinase and ethanolamine kinase from rat kidney and immunological evidence for both kinase activities residing on the same enzyme protein(s) in rat tissues. Biochem. Biophys. Acta 620:59-68.
11. Lacal, J. C., P. de la Peña, J. Moscat, P. Garcia-Barreno, P. Anderson, and S. A. Aaronson. 1987. Rapid stimulation of diacylglycerol production in Xenopus oocytes by microinjection of H-ras p21. Science 238:533-536.
12. Lacal, J. C., T. P. Fleming, B. S. Warren, P. M. Blumberg, and S. A. Aaronson. 1987. Involvement of functional protein kinase C in the mitogenic response to the H-ras oncogene product. Mol. Cell. Biol. 7:4146-4149.
13. Lacal, J. C., J. Moscat, and S. A. Aaronson. 1987. Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature (London) 330:269-272.
14. Lacal, J. C., and S. R. Tronick. 1988. The ras oncogene, p. 257-304 and 535-550. in E. P. Reddy, A. M. Skalka, and T. Curran (ed.), The oncogene handbook. Elsvier/Science Publishers B.V., Amsterdam.
15. Lacal, P. M., C. Y. Pennington, and J. C. Lacal. 1988. Transforming activity of ras proteins translocated to the plasma membrane by a myristoylation sequence from the src gene product. Oncogene 2:533-537.
16. Macara, I. G. 1989. Elevated phosphocholine concentration in ras-transformed NIH 3T3 cells arises from increased choline kinase activity, not from phosphatidylcholine breakdown. Mol. Cell. Biol. 9:325-328.
17. Paddon, H. B., C. Vigo, and D. E. Vance. 1982. Biochim. Biophys. Acta 710:112-115.
18. Pelech, S. L., and D. E. Vance. 1984. Regulation of phosphatidylcholine biosynthesis. Biochim. Biophys. Acta 779:217-251.
19. Pelech, S. L., and D. E. Vance. 1989. Signal transduction via phosphatidylcholine cycles. Trends Biochem. Sci. 14:28-30.
20. Preiss, J., C. R. Loomis, W. R. Bishop, R. Stein, J. E. Niedel, and R. M. Bell. 1986. Quantitative measurement of sn-1,2-diacylglycerols present in platelets, hepatocytes and ras- and sis-transformed normal rat kidney cells. J. Biol. Chem. 261: 8597-8600.
21. Seuwen, K., A. Lagarde, and J. Pouyssegur. 1988. Deregulation of hamster fibroblast proliferation by mutated ras oncogenes is not mediated by constitutive activation of phosphoinositidespecific phospholipase C. EMBO J. 7:161-168.
22. Shih, T. Y., M. O. Weeks, P. Gruss, R. Dhar, S. Oroszlan, and E. M. Scolnick. 1982. Identification of a precursor in the biosynthesis of the p21 transforming protein of Harvey murine sarcoma virus. J. Virol. 42:253-261.
23. Trahey, M., and F. McCormick. 1987. A cytoplasmic protein stimulates normal N-ras p21 GTPase, but does not affect oncogenic mutants. Science 238:542-545.
24. Ulane, R. E., L. L. Stephenson, and P. M. Farrel. 1978. Biochim. Biophys. Acta 531:295-300.
25. Wakelam, M. J. O., S. A. Davies, M. D. Houslay, I. McCay, C. J. Marshall, and A. Hall. 1986. Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature (London) 323:173-176.
26. Walker, D. H., and L. J. Pike. 1987. Phosphatidylinositol kinase is activated in membranes derived from cells treated with epidermal growth factors. Proc. Natl. Acad. Sci. USA 84: 7513-7517.
27. Willumsen, B. M., A. Christensen, N. L. Hubbert, A. G. Papageorge, and D. R. Lowy. 1984. The p21 ras C-terminus is required for transformation and membrane association. Nature (London) 310:583-586.
28. Willumsen, B. M., K. Norris, A. G. Papageorge, N. L. Hubbert, and D. R. Lowy. 1984. Harvey murine sarcoma virus p21 ras protein: biological and biochemical significance of the cysteine nearest the carboxy terminus. EMBO J. 3:2581-2585.
29. Wolfman, A., and I. G. Macara. 1987. Elevated levels of diacylglycerol and decreased phorbol ester sensitivity in rastransformed fibroblasts. Nature (London) 325:359-361.