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Volumn 7, Issue 4, 1998, Pages 499-518

Ion channel modulators that enhance acetylcholine release: Potential therapies for Alzheimer’s disease

Author keywords

ACh release enhancement; Alzheimer s disease; BDZ GABAA receptor ligands; calcium channel activators; ligand gated ion channel; M current; nicotinic cholinergic agonists; potassium channel blockers; voltage gated ion channel

Indexed keywords


EID: 0000694559     PISSN: 13543784     EISSN: 17447658     Source Type: Journal    
DOI: 10.1517/13543784.7.4.499     Document Type: Review
Times cited : (14)

References (140)
  • 1
    • 0001921207 scopus 로고
    • Neuropsycho-logical features of memory disorders
    • Terry RD, Katzman R, Bick KL (Eds.), Raven Press, New York, USA
    • BONDI MW, SALMON DP, BUTTERS NM: Neuropsycho-logical features of memory disorders. In: Alzheimer's Disease. Terry RD, Katzman R, Bick KL (Eds.), Raven Press, New York, USA (1993): 41 – 64.
    • (1993) In: Alzheimer's Disease. , pp. 41-64
    • BONDI, M.W.1    SALMON, D.P.2    BUTTERS, N.M.3
  • 2
    • 0028267440 scopus 로고
    • Normal and abnormal biology of the I3-am-yloid precursor protein
    • Cowan WM (Ed.)
    • SELKOE DJ: Normal and abnormal biology of the I3-am-yloid precursor protein. Ann. Rev. Neurosci. Cowan WM (Ed.) (1994): 489 – 518.
    • (1994) Ann. Rev. Neurosci. , pp. 489-518
    • SELKOE, D.J.1
  • 3
    • 0029896354 scopus 로고    scopus 로고
    • Mechanisms of neuronal degeneration in Alzheimer's disease
    • YANKNER BA: Mechanisms of neuronal degeneration in Alzheimer's disease. Neuron (1996) 16 (5): 921 – 932.
    • (1996) Neuron , vol.16 , Issue.5 , pp. 921-932
    • YANKNER, B.A.1
  • 4
    • 0027420369 scopus 로고
    • Tau protein and the neuroflbrillary pa-thology of Alzheimer's disease
    • GOEDERT M: Tau protein and the neuroflbrillary pa-thology of Alzheimer's disease. Trends Neurosci. (1993) 16 (10460 – 465.
    • (1993) Trends Neurosci. , vol.16 , pp. 10460-10465
    • GOEDERT, M.1
  • 5
    • 0029875437 scopus 로고    scopus 로고
    • Immune mechanisms in neu-rodegenerative disorders
    • MCGEER PL, MCGEER EG: Immune mechanisms in neu-rodegenerative disorders. Drugs Today (1996) 32: 149 – 158.
    • (1996) Drugs Today , vol.32 , pp. 149-158
    • MCGEER, P.L.1    MCGEER, E.G.2
  • 6
    • 0029879704 scopus 로고    scopus 로고
    • Neuroinflammatory mecha-nisms in Alzheimer's disease: opportunities of drug discoveries
    • COCHRAN FR, VITEK MP: Neuroinflammatory mecha-nisms in Alzheimer's disease: opportunities of drug discoveries. Exp. Opin. Invest. Drugs (1996) 5: 449 – 455.
    • (1996) Exp. Opin. Invest. Drugs , vol.5 , pp. 449-455
    • COCHRAN, F.R.1    VITEK, M.P.2
  • 7
    • 0026447529 scopus 로고
    • Complement activation by I3-amyloid in Alzheimer's disease
    • ROGERS J, COOPER NR, WEBSTER S et al.: Complement activation by I3-amyloid in Alzheimer's disease. Proc. Natl Acad. ScL USA (1992) 89: 10016 – 10020.
    • (1992) Proc. Natl Acad. ScL USA , vol.89 , pp. 10016-10020
    • ROGERS, J.1    COOPER, N.R.2    WEBSTER, S.3
  • 8
    • 0030483709 scopus 로고    scopus 로고
    • Neurochemical studies of Alzheimer's dis- ease
    • PALMER AM: Neurochemical studies of Alzheimer's dis- ease. Neurodegeneration (1996) 5: 381 – 391.
    • (1996) Neurodegeneration , vol.5 , pp. 381-391
    • PALMER, A.M.1
  • 9
    • 0019972810 scopus 로고
    • The cho-linergic hypothesis of geriatric memory dysfunction
    • BARTUS RT, DEAN RL, III., BEER B, LIPPA AS: The cho-linergic hypothesis of geriatric memory dysfunction. Science (1982) 217: 408 – 417.
    • (1982) Science , vol.217 , pp. 408-417
    • BARTUS, R.T.1    DEAN, R.L.2    BEER, B.3    LIPPA, A.S.4
  • 10
    • 0021962590 scopus 로고
    • Loss of M2 muscar-inic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation
    • MASH DC, FLYNN DD, POTTER LT: Loss of M2 muscar-inic receptors in the cerebral cortex in Alzheimer's disease and experimental cholinergic denervation. Science (1985) 228: 1115 – 1157.
    • (1985) Science , vol.228 , pp. 1115-1157
    • MASH, D.C.1    FLYNN, D.D.2    POTTER, L.T.3
  • 11
    • 0025607117 scopus 로고
    • Nicotinicacetylcholine receptor subtytpes in human frontal cortex: changes in Alzheimer's disease
    • SUGAYA K, GIACOBINI E, CHIAPPINELLI VA: Nicotinicacetylcholine receptor subtytpes in human frontal cortex: changes in Alzheimer's disease. J. Neurosci. Res. (1990) 27: 349 – 359.
    • (1990) J. Neurosci. Res. , vol.27 , pp. 349-359
    • SUGAYA, K.1    GIACOBINI, E.2    CHIAPPINELLI, V.A.3
  • 12
    • 0023516670 scopus 로고
    • Nicotinic and muscariniccholinergic receptors in Alzheimer's disease and re-lated disorders
    • WHITEHOUSE PJ, KELLAR KJ: Nicotinic and muscariniccholinergic receptors in Alzheimer's disease and re-lated disorders. J. Neural Transm. Suppl. (1987) 24: 175 – 182.
    • (1987) J. Neural Transm. Suppl. , vol.24 , pp. 175-182
    • WHITEHOUSE, P.J.1    KELLAR, K.J.2
  • 13
    • 0025989976 scopus 로고
    • Coupling of M1 muscarinic re-ceptors to G-proteins in Alzheimer's disease
    • PEARCE B, POTTER LT: Coupling of M1 muscarinic re-ceptors to G-proteins in Alzheimer's disease. Alz. Dis. Assoc. Disord. (1991) 5: 163 – 172.
    • (1991) Alz. Dis. Assoc. Disord. , vol.5 , pp. 163-172
    • PEARCE, B.1    POTTER, L.T.2
  • 14
    • 0038272048 scopus 로고
    • Central cholinergic systems, cholinergic drugs and Alzheimer's disease - an overview
    • DEFEUDIS FV: Central cholinergic systems, cholinergic drugs and Alzheimer's disease - an overview. Drugs To-day (1988) 24 (7): 473 – 490.
    • (1988) Drugs To-day , vol.24 , Issue.7 , pp. 473-490
    • DEFEUDIS, F.V.1
  • 15
    • 13544273898 scopus 로고
    • The cholinergic hypothesis of dementia
    • IVERSON LL: The cholinergic hypothesis of dementia. Trends Pharm. Sci. (1986) (Suppl.): 44 – 45.
    • (1986) Trends Pharm. Sci. , pp. 44-45
    • IVERSON, L.L.1
  • 16
    • 0018078940 scopus 로고
    • Correlationof cholinergic abnormalities with senile plaques and mental test scores in senile dementia
    • PERRY EK, TOMLINSON BE, BLESSED G et al: Correlationof cholinergic abnormalities with senile plaques and mental test scores in senile dementia. Br. Med. J. (1978) 2: 1457 – 1459.
    • (1978) Br. Med. J. , vol.2 , pp. 1457-1459
    • PERRY, E.K.1    TOMLINSON, B.E.2    BLESSED, G.3
  • 17
    • 0022645755 scopus 로고
    • The cholinergic hypothesis - ten years on
    • PERRY EK: The cholinergic hypothesis - ten years on. Br. Med. Bull. (1986) 42 (1): 63 – 69.
    • (1986) Br. Med. Bull. , vol.42 , Issue.1 , pp. 63-69
    • PERRY, E.K.1
  • 18
    • 0020686674 scopus 로고
    • Alzheimer's disease: a disorder of cortical cholinergic innervation
    • COYLE JT, PRICE DL, DELONG MR: Alzheimer's disease: a disorder of cortical cholinergic innervation. Science (1983) 219: 1184 – 1190.
    • (1983) Science , vol.219 , pp. 1184-1190
    • COYLE, J.T.1    PRICE, D.L.2    DELONG, M.R.3
  • 19
    • 0020072221 scopus 로고
    • Alz-heimer's disease and senile dementia: loss of neurons in the basal forebrain
    • WHITEHOUSE PJ, PRICE DL, STRUBLE RG et al.: Alz-heimer's disease and senile dementia: loss of neurons in the basal forebrain. Science (1982) 215: 1237 – 1239.
    • (1982) Science , vol.215 , pp. 1237-1239
    • WHITEHOUSE, P.J.1    PRICE, D.L.2    STRUBLE, R.G.3
  • 20
    • 0030910311 scopus 로고    scopus 로고
    • Measurement of ace-tycholinesterase by positron emission tomography in the brains of healthy controls and patients with Alz-heimer's disease
    • IYO M, NAMBA H, FUKUSHI H et al: Measurement of ace-tycholinesterase by positron emission tomography in the brains of healthy controls and patients with Alz-heimer's disease. Lancet (1997) 349: 1805 – 1809.
    • (1997) Lancet , vol.349 , pp. 1805-1809
    • IYO, M.1    NAMBA, H.2    FUKUSHI, H.3
  • 21
    • 0027753043 scopus 로고
    • Clinical studies in Alzheimer patients with positron emission tomography
    • NORDBERG A: Clinical studies in Alzheimer patients with positron emission tomography. Behav. Brain Res. (1993) 57: 215 – 224.
    • (1993) Behav. Brain Res. , vol.57 , pp. 215-224
    • NORDBERG, A.1
  • 22
    • 0029808280 scopus 로고    scopus 로고
    • In vivo map-ping of cholinergic terminals in normal aging, Alz-heimer's disease, and Parkinson's disease
    • KUHL DE, MINOSHIMA S, FESSLER JA et al: In vivo map-ping of cholinergic terminals in normal aging, Alz-heimer's disease, and Parkinson's disease. Ann. Neurol (1996) 40 (3): 399 – 410.
    • (1996) Ann. Neurol , vol.40 , Issue.3 , pp. 399-410
    • KUHL, D.E.1    MINOSHIMA, S.2    FESSLER, J.A.3
  • 23
    • 0022386340 scopus 로고
    • Func- tional and neurochemical cortical cholinergic impair-ment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat
    • EL-DEFRAWY SR, COLOMA F, JHAMANDAS K et al Func- tional and neurochemical cortical cholinergic impair-ment following neurotoxic lesions of the nucleus basalis magnocellularis in the rat. Neurobiol. Aging (1985) 6: 325 – 330.
    • (1985) Neurobiol. Aging , vol.6 , pp. 325-330
    • EL-DEFRAWY, S.R.1    COLOMA, F.2    JHAMANDAS, K.3
  • 25
    • 0022373859 scopus 로고
    • YA-MAMURA HI: Effects of bilateral ibotenate-induced le-sions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex
    • WATSON M, VICKROY TW, FIBIGER HC, ROESKE WR, YA-MAMURA HI: Effects of bilateral ibotenate-induced le-sions of the nucleus basalis magnocellularis upon selective cholinergic biochemical markers in the rat anterior cerebral cortex. Brain Res. (1985) 346: 387 – 391.
    • (1985) Brain Res. , vol.346 , pp. 387-391
    • WATSON, M.1    VICKROY, T.W.2    FIBIGER, H.C.3    ROESKE, W.R.4
  • 26
    • 0018256391 scopus 로고
    • Evidence for a direct cholinergic involve-ment in the scopolamine induced amnesia in mon-keys: effects of concurrent administration of physostigmine and methylphenidate with scopola-mine
    • BARTUS RT: Evidence for a direct cholinergic involve-ment in the scopolamine induced amnesia in mon-keys: effects of concurrent administration of physostigmine and methylphenidate with scopola-mine. Pharmacol. Biochem. Behav. (1978) 9(6) 833 – 836.
    • (1978) Pharmacol. Biochem. Behav. , vol.9 , Issue.6 , pp. 833-836
    • BARTUS, R.T.1
  • 27
    • 17344392330 scopus 로고
    • Intracerebroventricular hemicholinium-3 (HC-3) impairs learning of a passive avoidance task in mice
    • CAULFIELD MP, FORTUNE DH, ROBERTS PM, STUBLEY JK: Intracerebroventricular hemicholinium-3 (HC-3) impairs learning of a passive avoidance task in mice. Br. J. Pharmacol (1981) 74: 865.
    • (1981) Br. J. Pharmacol , vol.74 , pp. 865
    • CAULFIELD, M.P.1    FORTUNE, D.H.2    ROBERTS, P.M.3    STUBLEY, J.K.4
  • 28
    • 0028270519 scopus 로고
    • A 30-weekrandomized controlled trial of high dose tacrine in pa-tients with Alzheimer's disease
    • KNAPP MJ, KNOPMAN DS, SOLOMON PR etal: A 30-weekrandomized controlled trial of high dose tacrine in pa-tients with Alzheimer's disease. JAMA (1994) 271: 985 – 991.
    • (1994) JAMA , vol.271 , pp. 985-991
    • KNAPP, M.J.1    KNOPMAN, D.S.2    SOLOMON, P.R.3
  • 29
    • 0001854077 scopus 로고    scopus 로고
    • E2020 produces both clinical global and cognitive test im-provement in patients with mild to moderately severe Alzheimer's disease: results of a 30-week Phase III trial
    • ROGERS SL, DOODY R, MOHS R, FRIEDHOFF LT: E2020 produces both clinical global and cognitive test im-provement in patients with mild to moderately severe Alzheimer's disease: results of a 30-week Phase III trial. Neurology (1996) 46 (Suppl.): A217.
    • (1996) Neurology , vol.46 , pp. A217
    • ROGERS, S.L.1    DOODY, R.2    MOHS, R.3    FRIEDHOFF, L.T.4
  • 31
    • 0026620028 scopus 로고
    • Tacrine re-stores cholinergic nicotinic and glucose metabolism in Alzheimer patients as visualized by positron emis-sion tomography
    • NORDBERG A, LILJA A, HARTVIG P et al.: Tacrine re-stores cholinergic nicotinic and glucose metabolism in Alzheimer patients as visualized by positron emis-sion tomography. Neurobiol. Aging (1992) 13: 747 – 758.
    • (1992) Neurobiol. Aging , vol.13 , pp. 747-758
    • NORDBERG, A.1    LILJA, A.2    HARTVIG, P.3
  • 32
    • 0029592066 scopus 로고
    • Acetylcholine release enhancing agents: potential therapeutics for Alz-heimer's disease
    • CHORVAT RJ, EARL RA, ZACZEK R: Acetylcholine release enhancing agents: potential therapeutics for Alz-heimer's disease. Drugs Fut. (1995) 20: 1145 – 1162.
    • (1995) Drugs Fut. , vol.20 , pp. 1145-1162
    • CHORVAT, R.J.1    EARL, R.A.2    ZACZEK, R.3
  • 33
    • 0021284541 scopus 로고
    • Release of acetylcholine from rat brain synaptosomes by various agents in the ab-sence of external calcium ions
    • ADAM-VIZI V, LIGETI E: Release of acetylcholine from rat brain synaptosomes by various agents in the ab-sence of external calcium ions. J. Physiol. (fond.) (1984) 353: 505 – 521.
    • (1984) J. Physiol. (fond.) , vol.353 , pp. 505-521
    • ADAM-VIZI, V.1    LIGETI, E.2
  • 34
    • 0018873513 scopus 로고
    • Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes
    • CATTERALL WA: Neurotoxins that act on voltage-sensitive sodium channels in excitable membranes. Ann. Rev. Pharmacol. Toxicol. (1980) 20: 15 – 43.
    • (1980) Ann. Rev. Pharmacol. Toxicol. , vol.20 , pp. 15-43
    • CATTERALL, W.A.1
  • 35
    • 0025216441 scopus 로고
    • DUP 996(3,3-bis (4-pyrindinylmethy0-1-phenylindolin-2-one enhances the stimulus-induced release of acetylcho-line from rat brain in vitro and in vivo
    • NICKOLSON VJ, TAM SW, MYERS MJ, COOK L: DUP 996(3,3-bis (4-pyrindinylmethy0-1-phenylindolin-2-one enhances the stimulus-induced release of acetylcho-line from rat brain in vitro and in vivo. Drug Dev. Res. (1990) 19: 285 – 300.
    • (1990) Drug Dev. Res. , vol.19 , pp. 285-300
    • NICKOLSON, V.J.1    TAM, S.W.2    MYERS, M.J.3    COOK, L.4
  • 37
    • 0030744573 scopus 로고    scopus 로고
    • The acetyl-choline releaser linopirdine increases parietal regional blood flow in Alzheimer's disease
    • VAN DYCK CH, LIN CH, ROBINSON R et al: The acetyl-choline releaser linopirdine increases parietal regional blood flow in Alzheimer's disease. Psycho-pharmacology (1997) 132: 217 – 226.
    • (1997) Psycho-pharmacology , vol.132 , pp. 217-226
    • VAN DYCK, C.H.1    LIN, C.H.2    ROBINSON, R.3
  • 38
    • 0001186564 scopus 로고
    • Axo-somatic and axo-dexdritic synapses ofthe cerebral cortex: an electron microscope study
    • GRAY EG: Axo-somatic and axo-dexdritic synapses ofthe cerebral cortex: an electron microscope study. J. Anat. (1959) 93: 420 – 433.
    • (1959) J. Anat. , vol.93 , pp. 420-433
    • GRAY, E.G.1
  • 39
    • 0027489573 scopus 로고
    • Cytoskeleton dynamics dur- ing neurotransmitter release
    • TRIFARO J-M, VITALE ML: Cytoskeleton dynamics dur- ing neurotransmitter release. Trends Neurosci. (1993) 16 (10466 – 472.
    • (1993) Trends Neurosci. , vol.16 , pp. 10466-10472
    • TRIFARO, J.-M.1    VITALE, M.L.2
  • 40
    • 0026939128 scopus 로고
    • The transport of neurotransmitters into synaptic vesicles
    • EDWARDS RH: The transport of neurotransmitters into synaptic vesicles. Curr. Opin. Neurobiol (1992) 2: 586 – 594.
    • (1992) Curr. Opin. Neurobiol , vol.2 , pp. 586-594
    • EDWARDS, R.H.1
  • 41
    • 0029863653 scopus 로고    scopus 로고
    • Monte Carlo simulation of fast excitatory synaptic transmission at at a hippocampal synapse
    • WAHL LM, POUZAT C, STRATFORD KJ: Monte Carlo simulation of fast excitatory synaptic transmission at at a hippocampal synapse. J. Neurophysiol. (1996) 75 (2): 597 – 608.
    • (1996) J. Neurophysiol. , vol.75 , Issue.2 , pp. 597-608
    • WAHL, L.M.1    POUZAT, C.2    STRATFORD, K.J.3
  • 42
    • 0029876527 scopus 로고    scopus 로고
    • Transmitter timecourse in the synaptic cleft: its role in central synaptic function
    • CLEMENS JD: Transmitter timecourse in the synaptic cleft: its role in central synaptic function. Trends Neuro-sci. (1996) 19 (5): 163 – 171.
    • (1996) Trends Neuro-sci. , vol.19 , Issue.5 , pp. 163-171
    • CLEMENS, J.D.1
  • 43
    • 0027338262 scopus 로고
    • A low affinity Ca ++ recep-tor controls the final steps in peptide secretion from pituitary melanotrophs
    • THOMAS P, WONG JG, LEE AK: A low affinity Ca ++ recep-tor controls the final steps in peptide secretion from pituitary melanotrophs. Neuron (1993) 11: 93 – 104.
    • (1993) Neuron , vol.11 , pp. 93-104
    • THOMAS, P.1    WONG, J.G.2    LEE, A.K.3
  • 44
    • 0028950269 scopus 로고
    • The biochemistry of neu-rotransmitter secretion
    • BAJJALIEH SM SCHELLER RH: The biochemistry of neu-rotransmitter secretion. J. Biol. Chem. (1995) 270: 1971 – 1974
    • (1995) J. Biol. Chem. , vol.270 , pp. 1971-1974
    • BAJJALIEH, S.M.1    SCHELLER, R.H.2
  • 45
    • 0027258953 scopus 로고
    • Regulated exocytosis
    • BURGOYNE RD, MORGAN A: Regulated exocytosis. Bio-chem J. (1993) 293: 305 – 316.
    • (1993) Bio-chem J. , vol.293 , pp. 305-316
    • BURGOYNE, R.D.1    MORGAN, A.2
  • 46
    • 0026399923 scopus 로고
    • The calcium signal for transmitter secretion from presynaptic nerve terminals
    • AUGUSTINE GJ, ADLER EM, CHARLTON MP: The calcium signal for transmitter secretion from presynaptic nerve terminals. Ann. NY Acad. Sci. (1991) 635: 365 – 381.
    • (1991) Ann. NY Acad. Sci. , vol.635 , pp. 365-381
    • AUGUSTINE, G.J.1    ADLER, E.M.2    CHARLTON, M.P.3
  • 47
    • 0026600228 scopus 로고
    • The synaptic vesicle protein synaptotagmin associates with calcium chan-nels and is a putative Lambert-Eaton myasthenic syn-drome antigen
    • LEVEQUE C, HOSHINO T, DAVID P: The synaptic vesicle protein synaptotagmin associates with calcium chan-nels and is a putative Lambert-Eaton myasthenic syn-drome antigen. Proc. NatL Acad. Sci. USA (1992) 89: 3625 – 3629.
    • (1992) Proc. NatL Acad. Sci. USA , vol.89 , pp. 3625-3629
    • LEVEQUE, C.1    HOSHINO, T.2    DAVID, P.3
  • 48
    • 0027127386 scopus 로고
    • Neurotrans-mitter release from synaptotagmin-deficient clonal variants of PC12 cells
    • SHOJI-KASAI Y, YOSHIDA A, SATO K et al.: Neurotrans-mitter release from synaptotagmin-deficient clonal variants of PC12 cells. Science (1992) 256: 1820 - 1823.
    • (1992) Science , vol.256 , pp. 1820-1823
    • SHOJI-KASAI, Y.1    YOSHIDA, A.2    SATO, K.3
  • 49
    • 0027197065 scopus 로고
    • Synaptogamin: a calcium sensitive inhibi-tor of exocytosis
    • POPOV SV: Synaptogamin: a calcium sensitive inhibi-tor of exocytosis. Cell (1993) 73: 1247 – 1249.
    • (1993) Cell , vol.73 , pp. 1247-1249
    • POPOV, S.V.1
  • 50
    • 85018867726 scopus 로고
    • Models and mechanisms of neurotrans-mission
    • Powis DA, Bunn SJ (Eds.), Cambridge University Press, Cambridge, UK
    • BENNETT MR: Models and mechanisms of neurotrans-mission. In: Neurotransmitter Release and Its Modulation. Powis DA, Bunn SJ (Eds.), Cambridge University Press, Cambridge, UK (1995): 38 – 54.
    • (1995) In: Neurotransmitter Release and Its Modulation. , pp. 38-54
    • BENNETT, M.R.1
  • 51
    • 0018649657 scopus 로고
    • Estimates of the quantal content dur-ing 'chemical potentiation' of transmitter release
    • KATZ B, MILEDI R: Estimates of the quantal content dur-ing 'chemical potentiation' of transmitter release. Proc. Royal. Soc. London, Series B (1979) 205: 369 – 378.
    • (1979) Proc. Royal. Soc. London, Series B , vol.205 , pp. 369-378
    • KATZ, B.1    MILEDI, R.2
  • 52
    • 0024472084 scopus 로고
    • Multiplicity of GABAA-benzodiazepine receptors
    • SIEGHART W: Multiplicity of GABAA-benzodiazepine receptors. Trends Pharm. Sci. (1989) 10: 407 – 411.
    • (1989) Trends Pharm. Sci. , vol.10 , pp. 407-411
    • SIEGHART, W.1
  • 53
    • 0023824373 scopus 로고
    • Electrophysiology of GABAA and GABAB receptor sybtypes
    • © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4)
    • BORMANN J: Electrophysiology of GABAA and GABAB receptor sybtypes. Trends Neurosci. (1988) 11:112-116. © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4)
    • (1988) Trends Neurosci. , vol.11 , pp. 112-116
    • BORMANN, J.1
  • 54
    • 0026615116 scopus 로고
    • GABAA receptors: ligand-gated cr ion channels modulated by multiple drug-binding sites
    • SIEGHART W: GABAA receptors: ligand-gated cr ion channels modulated by multiple drug-binding sites. Trends Pharm. Sci. (1992) 13: 446 – 450.
    • (1992) Trends Pharm. Sci. , vol.13 , pp. 446-450
    • SIEGHART, W.1
  • 55
    • 0018905056 scopus 로고
    • Modulation by GABA of cholinergic transmission in the striatum
    • SCATTON B, BARTHOLINI G: Modulation by GABA of cholinergic transmission in the striatum. Brain Res. (1980) 183: 211 – 216.
    • (1980) Brain Res. , vol.183 , pp. 211-216
    • SCATTON, B.1    BARTHOLINI, G.2
  • 56
    • 0020052857 scopus 로고
    • Gamma-aminobutyric acid (GABA) receptor stimulation. IV. Effect of proga-bide (SL 76002) and other GABAergic agents on acetyl-choline turnover in rat brain areas
    • SCATTON B, BARTHOLINI G: Gamma-aminobutyric acid (GABA) receptor stimulation. IV. Effect of proga-bide (SL 76002) and other GABAergic agents on acetyl-choline turnover in rat brain areas. J. Pharmacol Exp. Ther. (1982) 220: 689 – 695.
    • (1982) J. Pharmacol Exp. Ther. , vol.220 , pp. 689-695
    • SCATTON, B.1    BARTHOLINI, G.2
  • 57
    • 0018772110 scopus 로고
    • GABA modu-lates the release of dopamine and acetylcholine from rat caudate nucleus slices
    • STOOF JC, DENBREEJEN EJS, MULDER AH: GABA modu-lates the release of dopamine and acetylcholine from rat caudate nucleus slices. Eur. J. Pharmacol (1979) 57: 35 – 42.
    • (1979) Eur. J. Pharmacol , vol.57 , pp. 35-42
    • STOOF JC, D.E.1    MULDER, A.H.2
  • 58
    • 0021955763 scopus 로고
    • Modulation of acetylcho-line release from rat striatal slices by the GABA/benzo-diazepine receptor complex
    • SUPAVILAI P, KAROBATH M: Modulation of acetylcho-line release from rat striatal slices by the GABA/benzo-diazepine receptor complex. Life Sci. (1985) 36: 417 – 426.
    • (1985) Life Sci. , vol.36 , pp. 417-426
    • SUPAVILAI, P.1    KAROBATH, M.2
  • 59
    • 0027330154 scopus 로고
    • GABAA and GABAB receptors differentially regulate striatal acetylcholine release in vivo
    • ANDERSON JJ, KUO S, CHASE TN, ENGBER TM: GABAA and GABAB receptors differentially regulate striatal acetylcholine release in vivo. NeuroscI Letts. (1993) 160: 126 – 130.
    • (1993) NeuroscI Letts. , vol.160 , pp. 126-130
    • ANDERSON, J.J.1    KUO, S.2    CHASE, T.N.3    ENGBER, T.M.4
  • 60
    • 70350717296 scopus 로고
    • Benzodiazepine impairs and I3-carboline en-hances performance in learning and memory tasks
    • VENAULT P, CHAPOUTHIER G, PRADO DE CARVALHO L et al Benzodiazepine impairs and I3-carboline en-hances performance in learning and memory tasks. Nature (1986) 321 – 864.
    • (1986) Nature , pp. 321-864
    • VENAULT, P.1    CHAPOUTHIER, G.2    PRADO DE, C.L.3
  • 61
    • 0023127909 scopus 로고
    • Effects of diazepam on cognitive processes in normal subjects
    • ROY-BYRNE PP, UHDE TW, HOLCOMB H et al.: Effects of diazepam on cognitive processes in normal subjects. Psychopharmacology (Ben) (1987) 91: 30.
    • (1987) Psychopharmacology (Ben) , vol.91 , pp. 30
    • ROY-BYRNE, P.P.1    UHDE, T.W.2    HOLCOMB, H.3
  • 62
    • 0023092123 scopus 로고
    • Pro-tection against the lethal effects of pentobarbital in mice by a benzodiazepine receptor inverse agonist, 6,7-dimethoxy-4-ethyl-3-carbmethoxy-b-carboline
    • HAVOUNDJIAN H, REED GF, PAUL SM, SKOLNICK P: Pro-tection against the lethal effects of pentobarbital in mice by a benzodiazepine receptor inverse agonist, 6,7-dimethoxy-4-ethyl-3-carbmethoxy-b-carboline. J. Clin. Invest. (1987) 79: 473 – 477.
    • (1987) J. Clin. Invest. , vol.79 , pp. 473-477
    • HAVOUNDJIAN, H.1    REED, G.F.2    PAUL, S.M.3    SKOLNICK, P.4
  • 63
    • 0019996866 scopus 로고
    • PE-TERSEN EN: Interaction of convulsive ligands with ben-zodiazepine receptors
    • BRAESTRUP C, SCHMIECHEN R, NEEF G, NIELSEN M, PE-TERSEN EN: Interaction of convulsive ligands with ben-zodiazepine receptors. Science (1982) 216: 1241 – 1243.
    • (1982) Science , vol.216 , pp. 1241-1243
    • BRAESTRUP, C.1    SCHMIECHEN, R.2    NEEF, G.3    NIELSEN, M.4
  • 64
    • 85018935016 scopus 로고
    • Cognition enhancement medi-ated via transsynaptic, behavior-dependent stimula-tion of cortical acetylcholine release
    • SARTER M, BRUNO JP: Cognition enhancement medi-ated via transsynaptic, behavior-dependent stimula-tion of cortical acetylcholine release. Neuropsychopharmacology (1994) 10(3S/Part 1): S65 – 282.
    • (1994) Neuropsychopharmacology , vol.10 , Issue.3S/Part 1 , pp. S65-282
    • SARTER, M.1    BRUNO, J.P.2
  • 65
    • 0027458144 scopus 로고
    • Bidirectional modula-tion of stimulated cortical acetylcholine release by benzodiazepine receptor ligands
    • MOORE H, SARTER M, BRUNO JP: Bidirectional modula-tion of stimulated cortical acetylcholine release by benzodiazepine receptor ligands. Brain Res. (1993) 627: 267 – 274.
    • (1993) Brain Res. , vol.627 , pp. 267-274
    • MOORE, H.1    SARTER, M.2    BRUNO, J.P.3
  • 66
    • 0026452292 scopus 로고
    • Age-dependent modula-tion of in vivo cortical acetylcholine release by benzo-diazepine receptor ligands
    • MOORE H, SARTER M, BRUNO J: Age-dependent modula-tion of in vivo cortical acetylcholine release by benzo-diazepine receptor ligands. Brain Res. (1992) 596: 17 – 29.
    • (1992) Brain Res. , vol.596 , pp. 17-29
    • MOORE, H.1    SARTER, M.2    BRUNO, J.3
  • 67
    • 0028977859 scopus 로고
    • Effects of ZK 93426, a beta-carboline benzodiazepine receptor antagonist on night sleep patterns in healthy male volunteers
    • DUKA T, GOERKE D, FICHTE K: Effects of ZK 93426, a beta-carboline benzodiazepine receptor antagonist on night sleep patterns in healthy male volunteers. Psy-chopharmacology (Berl.) (1995) 117 (2): 178 – 185.
    • (1995) Psy-chopharmacology (Berl.) , vol.117 , Issue.2 , pp. 178-185
    • DUKA, T.1    GOERKE, D.2    FICHTE, K.3
  • 68
    • 0028046692 scopus 로고
    • Basal fore-brain injections of the benzodiazephine partial in-verse agonist FG 7142 enhance memory of rats in the double Y-maze
    • SMITH CG, BENINGER RJ, RICHARD J et al.: Basal fore-brain injections of the benzodiazephine partial in-verse agonist FG 7142 enhance memory of rats in the double Y-maze. Brain Res. (1994) 655 (1): 61 – 67.
    • (1994) Brain Res. , vol.655 , Issue.1 , pp. 61-67
    • SMITH, C.G.1    BENINGER, R.J.2    RICHARD, J.3
  • 69
    • 0028225557 scopus 로고
    • The benzodiazepine receptor antagonist flumazenil increases acetylcholine release in rat hippocampus
    • IMPERATO A, DAZZI L, OBINU MC, GESSA LG, BIGGIO G: The benzodiazepine receptor antagonist flumazenil increases acetylcholine release in rat hippocampus. Brain Res. (1994) 647: 167 – 171.
    • (1994) Brain Res. , vol.647 , pp. 167-171
    • IMPERATO, A.1    DAZZI, L.2    OBINU, M.C.3    GESSA, L.G.4    BIGGIO, G.5
  • 70
    • 0029802676 scopus 로고    scopus 로고
    • Cognitive ef-fects of flumazenil in patients with Alzheimer's dis-ease
    • OTT BR, THOMPSON JA, WHELIHAN WM: Cognitive ef-fects of flumazenil in patients with Alzheimer's dis-ease. J. Clin. Psychopharmacol (1996) 16(5) 400 – 402.
    • (1996) J. Clin. Psychopharmacol , vol.16 , Issue.5 , pp. 400-402
    • OTT, B.R.1    THOMPSON, J.A.2    WHELIHAN, W.M.3
  • 71
  • 72
    • 0029944298 scopus 로고    scopus 로고
    • Synthesis and structure-activirty relationships of fused imidazopyri-dines: a new series of benzodiazepine receptor ligands
    • TAKADA S, SASATANI T, CHOMEI N et al: Synthesis and structure-activirty relationships of fused imidazopyri-dines: a new series of benzodiazepine receptor ligands. J Med. Chem. (1996) 39: 2844 – 2851.
    • (1996) J Med. Chem. , vol.39 , pp. 2844-2851
    • TAKADA, S.1    SASATANI, T.2    CHOMEI, N.3
  • 73
    • 85018908308 scopus 로고    scopus 로고
    • The nicotinic acetylcholine receptor
    • Hammond C (Ed.), Academic Press, San Diego, CA, USA
    • HAMMOND C: The nicotinic acetylcholine receptor. In: Cellular and Molecular Neurobiology. Hammond C (Ed.), Academic Press, San Diego, CA, USA (1996): 214 – 247.
    • (1996) In: Cellular and Molecular Neurobiology. , pp. 214-247
    • HAMMOND, C.1
  • 74
    • 0030175612 scopus 로고    scopus 로고
    • Nicotinic receptors in the develop-ment and modulation of CNS synapses
    • ROLE LW, BERG DK: Nicotinic receptors in the develop-ment and modulation of CNS synapses. Neuron (1996) 16: 1077 – 1085.
    • (1996) Neuron , vol.16 , pp. 1077-1085
    • ROLE, L.W.1    BERG, D.K.2
  • 75
    • 0029800519 scopus 로고    scopus 로고
    • Pharmacological characterization of a nicotinic auto-receptor in rat hippocampal synaptosomes
    • WILKIE GI, HUTSON P, SULLIVAN JP, WONNACOTT S: Pharmacological characterization of a nicotinic auto-receptor in rat hippocampal synaptosomes. Neuro-chem. Res. (1996) 21 (9): 1141 – 1148.
    • (1996) Neuro-chem. Res. , vol.21 , Issue.9 , pp. 1141-1148
    • WILKIE, G.I.1    HUTSON, P.2    SULLIVAN, J.P.3    WONNACOTT, S.4
  • 76
    • 0030047768 scopus 로고    scopus 로고
    • Cholinergic channel modulators as a novel therapeutic strategy for Alzheimer's disease
    • ARNERIC SP, HOLLADAY MW, SULLIVAN JP: Cholinergic channel modulators as a novel therapeutic strategy for Alzheimer's disease. Exp. Opin. Invest. Drugs (1996) 5: 79 – 100
    • (1996) Exp. Opin. Invest. Drugs , vol.5 , pp. 79-100
    • ARNERIC, S.P.1    HOLLADAY, M.W.2    SULLIVAN, J.P.3
  • 77
    • 0001237770 scopus 로고
    • CNS nicotinic receptors: possible therapeutic targets in neurodegenerative disorders
    • COURT JA, PERRY EK: CNS nicotinic receptors: possible therapeutic targets in neurodegenerative disorders. CNS Drugs (1994) 2: 216 – 233.
    • (1994) CNS Drugs , vol.2 , pp. 216-233
    • COURT, J.A.1    PERRY, E.K.2
  • 78
    • 0026593533 scopus 로고
    • KEL-LAR KJ: A subtype of nicotinic cholinergic receptor in rat brain is composed of a4 and 132 subunits and is up-regulated by chronic nicotine treatment
    • FLORES CM, ROGERS SW, PABREZA LA, WOLFE BB, KEL-LAR KJ: A subtype of nicotinic cholinergic receptor in rat brain is composed of a4 and 132 subunits and is up-regulated by chronic nicotine treatment. Mol. Pharm. (1992) 41: 31 – 37.
    • (1992) Mol. Pharm. , vol.41 , pp. 31-37
    • FLORES, C.M.1    ROGERS, S.W.2    PABREZA, L.A.3    WOLFE, B.B.4
  • 79
    • 0022350728 scopus 로고
    • Autoradiographic localization of putative nicotinic receptors in the rat brain using [125I]-neuronal bungarotoxin
    • CLARKE PBS, PERT A: Autoradiographic localization of putative nicotinic receptors in the rat brain using [125I]-neuronal bungarotoxin. Brain Res. (1985) 348: 355 – 358.
    • (1985) Brain Res , vol.348 , pp. 355-358
    • CLARKE, P.B.S.1    PERT, A.2
  • 80
    • 0027518923 scopus 로고
    • Molecular cloning, functional properties, and distribution of rat brain a7: a nicotinic cation channel highly permeable to calcium
    • SHIGUELA P, WADICHE J, DINELEY-MILLER K, DANI JA, PATRICK JW: Molecular cloning, functional properties, and distribution of rat brain a7: a nicotinic cation channel highly permeable to calcium. J. Neurosci. (1993) 13: 596 – 604.
    • (1993) J. Neurosci. , vol.13 , pp. 596-604
    • SHIGUELA, P.1    WADICHE, J.2    DINELEY-MILLER, K.3    DANI, J.A.4    PATRICK, J.W.5
  • 81
    • 0028194977 scopus 로고
    • Cytoprotective actions of 2,4-dimethylbenzylidene anabasine in dif-ferentiated PC12 cells and septal cholinergic neurons
    • MARTIN EJ, PANICKER KS, KING MA etal: Cytoprotective actions of 2,4-dimethylbenzylidene anabasine in dif-ferentiated PC12 cells and septal cholinergic neurons. Drug Dev. Res. (1994) 13: 131 – 141.
    • (1994) Drug Dev. Res. , vol.13 , pp. 131-141
    • MARTIN, E.J.1    PANICKER, K.S.2    KING, M.A.3
  • 82
    • 0028343246 scopus 로고
    • (5)-3-methy1-5-(1methyl-2-pyrrolidinyl)isoxazole (ABT-418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: 1. In vitro charac-terization
    • © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4)
    • ARNERIC SP, SULLIVAN JP, BRIGGS CA et al.:(5)-3-methy1-5-(1methyl-2-pyrrolidinyl)isoxazole (ABT-418): a novel cholinergic ligand with cognition-enhancing and anxiolytic activities: 1. In vitro charac-terization. J. Pharmacol. Exp.Ther. (1994) 270:310-318. © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4)
    • (1994) J. Pharmacol. Exp.Ther. , vol.270 , pp. 310-318
    • ARNERIC, S.P.1    SULLIVAN, J.P.2    BRIGGS, C.A.3
  • 83
    • 0028243316 scopus 로고
    • (S)-3-Methyl-5-(1-methyl-2-pyrrolidiinyl)isoxazole (ABT-418): a novel cholinergic ligand with cognition-enhancing and amdolytic activities: ii in vivo charac-terization
    • DECKER MW, BRIONI JD, SULLIVAN JP et al.: (S)-3-Methyl-5-(1-methyl-2-pyrrolidiinyl)isoxazole (ABT-418): a novel cholinergic ligand with cognition-enhancing and amdolytic activities: ii. in vivo charac-terization. J. Pharmacol. Exp. Ther. (1994) 270 (1) 319 – 328.
    • (1994) J. Pharmacol. Exp. Ther. , vol.270 , Issue.1 , pp. 319-328
    • DECKER, M.W.1    BRIONI, J.D.2    SULLIVAN, J.P.3
  • 84
    • 0029120195 scopus 로고
    • Comparative pharmacology of nicotine and ABT-418, a new nico-tinic agonist
    • DAMAJ MI, CREASY KR, WELCH SP et al.: Comparative pharmacology of nicotine and ABT-418, a new nico-tinic agonist. Psychopharmacology (Berl.) (1995) 120(4) 483 – 490.
    • (1995) Psychopharmacology (Berl.) , vol.120 , Issue.4 , pp. 483-490
    • DAMAJ, M.I.1    CREASY, K.R.2    WELCH, S.P.3
  • 85
    • 0030981799 scopus 로고    scopus 로고
    • Im-provement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic re-ceptor agonist ABT-418
    • PENDERGRAST MA, TERRY AV, Jr., JACKSON WJ et al: Im-provement in accuracy of delayed recall in aged and non-aged, mature monkeys after intramuscular or transdermal administration of the CNS nicotinic re-ceptor agonist ABT-418. Psychopharmacology (Berl.) (1997) 130 (3): 276 – 284.
    • (1997) Psychopharmacology (Berl.) , vol.130 , Issue.3 , pp. 276-284
    • PENDERGRAST, M.A.1    TERRY, A.V.2    JACKSON, W.J.3
  • 86
    • 0031003185 scopus 로고    scopus 로고
    • Functional characterization of the novel neuronal nicotinic ace-tylcholine receptor ligand GTS-21 in vitro and in vivo
    • BRIGGS CA, ANDERSON DJ, BRIONI JD et al.: Functional characterization of the novel neuronal nicotinic ace-tylcholine receptor ligand GTS-21 in vitro and in vivo. Pharmacol. Biochem. Behav. (1997) 57 (1-2): 231 – 241.
    • (1997) Pharmacol. Biochem. Behav. , vol.57 , Issue.1-2 , pp. 231-241
    • BRIGGS, C.A.1    ANDERSON, D.J.2    BRIONI, J.D.3
  • 87
    • 0030858491 scopus 로고    scopus 로고
    • Nicotinic agonist modulation of neurotransmitter levels in the rat fron-toparietal cortex
    • SUMMERS KL, KEM WR, GIACOBINI E: Nicotinic agonist modulation of neurotransmitter levels in the rat fron-toparietal cortex. Jpn.J. Pharmacol (1997) 74(2) 139 – 146.
    • (1997) Jpn.J. Pharmacol , vol.74 , Issue.2 , pp. 139-146
    • SUMMERS, K.L.1    KEM, W.R.2    GIACOBINI, E.3
  • 88
    • 0014078590 scopus 로고
    • The timing of calcium action during neuromuscular transmission
    • KATZ B MILEDI R: The timing of calcium action during neuromuscular transmission. J. Physiol. (1967) 189: 535 – 544.
    • (1967) J. Physiol. , vol.189 , pp. 535-544
    • KATZ, B.1    MILEDI, R.2
  • 89
    • 0024491079 scopus 로고
    • Calcium channels: struc-ture and function
    • WRAY W, NORMAN RI, HESS P: Calcium channels: struc-ture and function. Ann. NY Acad. Sci. (1989) 560: 1 – 475.
    • (1989) Ann. NY Acad. Sci. , vol.560 , pp. 1-475
    • WRAY, W.1    NORMAN, R.I.2    HESS, P.3
  • 90
    • 0027105121 scopus 로고
    • Presynaptic calcium concentration microdomains and transmitter release
    • LLINAS R, SUGIMORI M, SILVER RB: Presynaptic calcium concentration microdomains and transmitter release. Physiol. (1992) 86 (1-3): 135 – 138.
    • (1992) Physiol. , vol.86 , Issue.1-3 , pp. 135-138
    • LLINAS, R.1    SUGIMORI, M.2    SILVER, R.B.3
  • 92
    • 0028985125 scopus 로고
    • Exocytotic Ca2+ chan-nels in mammalian central neurons
    • DUNLAP K, LUEBKE JI, TURNER TJ: Exocytotic Ca2+ chan-nels in mammalian central neurons. Trends Neurosci. (1995) 18: 89 – 98
    • (1995) Trends Neurosci , vol.18 , pp. 89-98
    • DUNLAP, K.1    LUEBKE, J.I.2    TURNER, T.J.3
  • 93
    • 0021130271 scopus 로고
    • Nootropic drugs: animal models for studying effects on cognition
    • SCHINDLER U, RUSH DK, FIELDING S: Nootropic drugs: animal models for studying effects on cognition. Drug Dev. Res. (1984) 4 (5): 567 – 76.
    • (1984) Drug Dev. Res. , vol.4 , Issue.5 , pp. 567-576
    • SCHINDLER, U.1    RUSH, D.K.2    FIELDING, S.3
  • 94
    • 0028224652 scopus 로고
    • Piracetam and other struc-turally related nootropics
    • GOULIAEV AH, SENNING A: Piracetam and other struc-turally related nootropics. Brain Res. Rev. (1994) 19: 180 – 222.
    • (1994) Brain Res. Rev. , vol.19 , pp. 180-222
    • GOULIAEV, A.H.1    SENNING, A.2
  • 95
    • 0028207467 scopus 로고
    • Effects of nefiracetam on drug-induced impairment of latent learning mice in a water finding task
    • NABESHIMA T, NAKAYAMA S, ICHIHARA K et al.: Effects of nefiracetam on drug-induced impairment of latent learning mice in a water finding task. Eur. J. Pharmacol (1994) 255: 57 – 65.
    • (1994) Eur. J. Pharmacol , vol.255 , pp. 57-65
    • NABESHIMA, T.1    NAKAYAMA, S.2    ICHIHARA, K.3
  • 96
    • 0024523079 scopus 로고
    • Effects of N-(2,6-dimethylpheny1)-2-(2-oxo-1 - pyrrolidinyfiacetamide (DM-9384) on learning and memory in rats
    • SAKURAI T, OJIMA H, YAMASAKI T, KOJIMA H, AKASHI A: Effects of N-(2,6-dimethylpheny1)-2-(2-oxo-1 - pyrrolidinyfiacetamide (DM-9384) on learning and memory in rats. Jpn. J. Pharmacol (1989) 50 (1): 47 – 53.
    • (1989) Jpn. J. Pharmacol , vol.50 , Issue.1 , pp. 47-53
    • SAKURAI, T.1    OJIMA, H.2    YAMASAKI, T.3    KOJIMA, H.4    AKASHI, A.5
  • 97
    • 85018905250 scopus 로고
    • Effects ofnefiracetam on impairment of attention in latent learning task in mice
    • NAKAYAMA S, ICHIHARA K, YAMADA K et al: Effects ofnefiracetam on impairment of attention in latent learning task in mice. Neuropsychopharmaology (1994) 10: 58 – 89.
    • (1994) Neuropsychopharmaology , vol.10 , pp. 58-89
    • NAKAYAMA, S.1    ICHIHARA, K.2    YAMADA, K.3
  • 98
    • 0024992731 scopus 로고
    • YA-MASAKI T: Effect of DM-9384 on extracellular acetyl-choline in the rat frontal cortex measured with microdialysis
    • KAWAJIRI S, TANIGUCKI K, SAKURAI T, KOJIMA H, YA-MASAKI T: Effect of DM-9384 on extracellular acetyl-choline in the rat frontal cortex measured with microdialysis. Eur. j Pharmacol (1990) 183 (3): 928.
    • (1990) Eur. j Pharmacol , vol.183 , Issue.3 , pp. 928
    • KAWAJIRI, S.1    TANIGUCKI, K.2    SAKURAI, T.3    KOJIMA, H.4
  • 99
    • 0028173017 scopus 로고
    • Ne-firacetam enhances acetylcholine outflow from the frontal cortex: in vivo microdialysis study in the rat
    • KAWAJIRI S, TANIGUCKI K, SAKURAI T, YAMASAKI T: Ne-firacetam enhances acetylcholine outflow from the frontal cortex: in vivo microdialysis study in the rat. J. Neural. Trans. (1994) 98: 15 – 22.
    • (1994) J. Neural. Trans. , vol.98 , pp. 15-22
    • KAWAJIRI, S.1    TANIGUCKI, K.2    SAKURAI, T.3    YAMASAKI, T.4
  • 100
    • 0000688093 scopus 로고
    • Excitatory amino acid receptors: multiplicity and structural requirements for activation and block-ade
    • Wheal HV, Thomson AM (Eds.), Academic Press, London, UK
    • KROGSGAARD-LARSEN P, LUND M, JOERGENSEN S, BREHM L: Excitatory amino acid receptors: multiplicity and structural requirements for activation and block-ade. In: Excitatory Amino Acids and Synaptic Transmission. Wheal HV, Thomson AM (Eds.), Academic Press, London, UK (1990: 1 – 17.
    • (1990) In: Excitatory Amino Acids and Synaptic Transmission. , pp. 1-17
    • KROGSGAARD-LARSEN, P.1    LUND, M.2    JOERGENSEN, S.3    BREHM, L.4
  • 101
    • 0028297182 scopus 로고
    • Enhancement of neuronal cal-cium channel currents by the nootropic agent, nefi-racetam (DM-9384), in NG108-15 cells
    • YOSHII M, WATABE S: Enhancement of neuronal cal-cium channel currents by the nootropic agent, nefi-racetam (DM-9384), in NG108-15 cells. Brain Res. (1994) 642: 123 – 131.
    • (1994) Brain Res , vol.642 , pp. 123-131
    • YOSHII, M.1    WATABE, S.2
  • 102
    • 0027744324 scopus 로고
    • Single calcium channels and acetylcho-line release at a presynaptic nerve terminal
    • STANLEY EF: Single calcium channels and acetylcho-line release at a presynaptic nerve terminal. Neuron (1993) 11: 1007 – 1011.
    • (1993) Neuron , vol.11 , pp. 1007-1011
    • STANLEY, E.F.1
  • 103
    • 0029826626 scopus 로고    scopus 로고
    • Nefiracetam (new drug profile)
    • GOA KL, BENFIELD P: Nefiracetam (new drug profile). CNS Drugs (1996) 6 (4): 331 – 337.
    • (1996) CNS Drugs , vol.6 , Issue.4 , pp. 331-337
    • GOA, K.L.1    BENFIELD, P.2
  • 104
    • 85018932480 scopus 로고
    • Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction
    • NABESHIMA T: Ameliorating effects of nefiracetam (DM-9384) on brain dysfunction. Shinkei Seishin Yakuri (1994) 16 (5): 309 – 333.
    • (1994) Shinkei Seishin Yakuri , vol.16 , Issue.5 , pp. 309-333
    • NABESHIMA, T.1
  • 106
    • 0024388960 scopus 로고
    • Basic mechanism and local modulation of nerve impulse-induced secretion of neurotransmit-ters from individual sympathetic nerve varicosities
    • STJARNE L: Basic mechanism and local modulation of nerve impulse-induced secretion of neurotransmit-ters from individual sympathetic nerve varicosities. Rev. Physiol. Biochem. Pharmacol (1989) 112: 1 – 138.
    • (1989) Rev. Physiol. Biochem. Pharmacol , vol.112 , pp. 1-138
    • STJARNE, L.1
  • 107
    • 0025918548 scopus 로고
    • It and Ca2+ channel blockers may enhance or depress sympa-thetic tramsmitter release via a Ca +-dependent mechanism 'upstream' of the release site
    • STJARNE L, STJARNE E, MSGHINA M, BAO JX: It and Ca2+ channel blockers may enhance or depress sympa-thetic tramsmitter release via a Ca +-dependent mechanism 'upstream' of the release site. Neuroscience (1991) 44: 673 – 692.
    • (1991) Neuroscience , vol.44 , pp. 673-692
    • STJARNE, L.1    STJARNE, E.2    MSGHINA, M.3    BAO, J.X.4
  • 108
    • 0023580340 scopus 로고
    • Multiple potassium conductances at the mammalian motor nerve termi-nal
    • SAINT DA, QUASTEL DM, GUAN YY: Multiple potassium conductances at the mammalian motor nerve termi-nal. Pflugers Arch. (1987) 410 (4-5): 408 – 412.
    • (1987) Pflugers Arch. , vol.410 , Issue.4-5 , pp. 408-412
    • SAINT, D.A.1    QUASTEL, D.M.2    GUAN, Y.Y.3
  • 109
    • 0027943785 scopus 로고
    • Studies on the role of KF, a- and Na+ ion permeabilities in the acetyl-choline release enhancing effects of linopirdine (DuP 996) in rat cerebral cortical slices
    • MACIAG CM, LOGUE AR, TINKER WJ et al.: Studies on the role of KF, a- and Na+ ion permeabilities in the acetyl-choline release enhancing effects of linopirdine (DuP 996) in rat cerebral cortical slices. J. Pharmacol Exp. Then. (1994) 271: 891 – 7.
    • (1994) J. Pharmacol Exp. Then. , vol.271 , pp. 891-897
    • MACIAG, C.M.1    LOGUE, A.R.2    TINKER, W.J.3
  • 110
    • 0021357235 scopus 로고
    • Effects of 4-aminopyridine in elderly patients with Alz-heimer's disease
    • WEISSLING H, AGOSTON S, VAN DAM GBP et al.: Effects of 4-aminopyridine in elderly patients with Alz-heimer's disease. New Eng. J. Med. (1984) 310: 988 – 989.
    • (1984) New Eng. J. Med. , vol.310 , pp. 988-989
    • WEISSLING, H.1    AGOSTON, S.2    VAN DAM, G.B.P.3
  • 111
    • 0023859179 scopus 로고
    • The pharmacology of potassium channels and their therapeutic potential
    • COOK NS: The pharmacology of potassium channels and their therapeutic potential. Trends Pharmacol. Sci. (1988) 9: 21 – 28.
    • (1988) Trends Pharmacol. Sci. , vol.9 , pp. 21-28
    • COOK, N.S.1
  • 112
    • 0018866737 scopus 로고
    • Facilitatory effects of 4-aminopyridine on normal neuromuscular trans-mission
    • © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4)
    • KIM YI, GOLDNER MM, SANDERS DB: Facilitatory effects of 4-aminopyridine on normal neuromuscular trans-mission. Muscle Nerve (1980) 3:105-111. © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4)
    • (1980) Muscle Nerve , vol.3 , pp. 105-111
    • KIM, Y.I.1    GOLDNER, M.M.2    SANDERS, D.B.3
  • 113
    • 0017662116 scopus 로고
    • Effects of 4-aminopyridine on transmission in excita-tory and inhibitory synapses in the spinal cord
    • JANKOWSKA E, LUNDBERG A, RUDOMIN P, SYKOVA E: Effects of 4-aminopyridine on transmission in excita-tory and inhibitory synapses in the spinal cord. Brain Res. (1977) 136: 387 – 392.
    • (1977) Brain Res , vol.136 , pp. 387-392
    • JANKOWSKA, E.1    LUNDBERG, A.2    RUDOMIN, P.3    SYKOVA, E.4
  • 114
    • 0021369656 scopus 로고
    • Effects of several aminopyri-dines and analogs on the calcium dependence of syn-aptic transmission
    • MITSUHIKO M, RIKER WK: Effects of several aminopyri-dines and analogs on the calcium dependence of syn-aptic transmission. J. Pharmacol. Exp. Ther. (1984) 228: 573 – 578.
    • (1984) J. Pharmacol. Exp. Ther. , vol.228 , pp. 573-578
    • MITSUHIKO, M.1    RIKER, W.K.2
  • 116
    • 77956779751 scopus 로고
    • Neurotrans-mitter release enhancement as a possible therapy for neurodegenerative diseases: update on linopirdine (DUP996)
    • Giacobini E, Becker RE (Eds.), Birkhauser, Bos-ton, MA, USA
    • ZACZEK R, CHORVAT RJ, EARL RA, TAM SW: Neurotrans-mitter release enhancement as a possible therapy for neurodegenerative diseases: update on linopirdine (DUP996). In: Alzheimer's Disease: Therapeutic Ap-proaches. Giacobini E, Becker RE (Eds.), Birkhauser, Bos-ton, MA, USA (1990 252 – 255.
    • (1990) In: Alzheimer's Disease: Therapeutic Ap-proaches. , pp. 252-255
    • ZACZEK, R.1    CHORVAT, R.J.2    EARL, R.A.3    TAM, S.W.4
  • 117
    • 0024367939 scopus 로고
    • 3,4,-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome
    • MCEVOY KM, WINDEBANK AJ, DAUBE JR, LOW PA: 3,4,-Diaminopyridine in the treatment of Lambert-Eaton myasthenic syndrome. New Eng. J. Med. (1989) 23 (23): 1567 – 1571.
    • (1989) New Eng. J. Med. , vol.23 , Issue.23 , pp. 1567-1571
    • MCEVOY, K.M.1    WINDEBANK, A.J.2    DAUBE, J.R.3    LOW, P.A.4
  • 118
    • 0028101224 scopus 로고
    • Tacrine increases stimulation-evoked acetylcholine release from rat hippocampal slices
    • SUZUKI T, NONAKA H, FUJIMOTO K, KAWASHIMA K: Tacrine increases stimulation-evoked acetylcholine release from rat hippocampal slices. Jpn. J. Pharmacol. (1994) 65: 337 – 342.
    • (1994) Jpn. J. Pharmacol. , vol.65 , pp. 337-342
    • SUZUKI, T.1    NONAKA, H.2    FUJIMOTO, K.3    KAWASHIMA, K.4
  • 119
    • 0026322494 scopus 로고
    • NIK-247 blocks voltage-dependent ionic currents in crayfish axon
    • KOJIMA J, SUGAWARA Y, OBARA S: NIK-247 blocks voltage-dependent ionic currents in crayfish axon. Jpn Pharmacol. (1991) 57 (545 – 552).
    • (1991) Jpn Pharmacol , vol.57 , pp. 545-552
    • KOJIMA, J.1    SUGAWARA, Y.2    OBARA, S.3
  • 120
    • 0026515418 scopus 로고
    • Evaluation of a cholinergic drug, 9-amino-2,3,5,6,7,8-hexahydro-1 H-cyclopenta-(b)-qu-inoline (NIK-247), as an enhancer of endogenous ef-flux of acetylcholine from brain slices
    • ISHII Y, SUMI T: Evaluation of a cholinergic drug, 9-amino-2,3,5,6,7,8-hexahydro-1 H-cyclopenta-(b)-qu-inoline (NIK-247), as an enhancer of endogenous ef-flux of acetylcholine from brain slices. Neuropharmacology (1992) 31: 61 – 66.
    • (1992) Neuropharmacology , vol.31 , pp. 61-66
    • ISHII, Y.1    SUMI, T.2
  • 121
    • 0028575329 scopus 로고
    • Effect of NIK-247 on basal concentrations of extracellular ace-tycholine in the cerebral cortex of conscious, freely moving rats
    • ISHII Y, KOJIMA J, IKEDA N, KAWASHIMA K: Effect of NIK-247 on basal concentrations of extracellular ace-tycholine in the cerebral cortex of conscious, freely moving rats. Jpn. J. Pharmacol. (1994) 66: 289 – 293.
    • (1994) Jpn. J. Pharmacol. , vol.66 , pp. 289-293
    • ISHII, Y.1    KOJIMA, J.2    IKEDA, N.3    KAWASHIMA, K.4
  • 122
    • 0030691841 scopus 로고    scopus 로고
    • Linopirdine: phar-macology of a neurotransmitter release enhancer
    • ZACZEK R, CHORVAT RJ, BROWN BS: Linopirdine: phar-macology of a neurotransmitter release enhancer. CNS Drug Rev. (1997) 3 (2): 103 – 119.
    • (1997) CNS Drug Rev. , vol.3 , Issue.2 , pp. 103-119
    • ZACZEK, R.1    CHORVAT, R.J.2    BROWN, B.S.3
  • 123
    • 0027739616 scopus 로고
    • Presynaptic cholinergic actions by the putative cognitive enhancing agent DuP 996
    • VICKROY TW: Presynaptic cholinergic actions by the putative cognitive enhancing agent DuP 996. J. Phar-macol. Exp. Ther. (1993) 264 (2): 910 – 917.
    • (1993) J. Phar-macol. Exp. Ther. , vol.264 , Issue.2 , pp. 910-917
    • VICKROY, T.W.1
  • 124
    • 85018886709 scopus 로고
    • Effects of li-nopirdine (DuP 996) on KC1 and CaC12 dose response of potassium evoked release of NI acetylcholine from superfused hippocampal slices
    • TINKER WJ, MACIAG C, TAM SW, ZACZEK R: Effects of li-nopirdine (DuP 996) on KC1 and CaC12 dose response of potassium evoked release of NI acetylcholine from superfused hippocampal slices. Soc. Neurosci. Abstr. (1992) 18: 518 – 512.
    • (1992) Soc. Neurosci. Abstr. , vol.18 , pp. 512-518
    • TINKER, W.J.1    MACIAG, C.2    TAM, S.W.3    ZACZEK, R.4
  • 125
    • 26444583011 scopus 로고
    • Electrophysiological effects of DuP 996 on hippocampal CA1 neurons
    • LAMPE BW, BROWN BS: Electrophysiological effects of DuP 996 on hippocampal CA1 neurons. Soc. Neurosci. Abstr. (1991) 17: 1588.
    • (1991) Soc. Neurosci. Abstr. , vol.17 , pp. 1588
    • LAMPE, B.W.1    BROWN, B.S.2
  • 126
    • 0029088690 scopus 로고
    • Reduc-tion of spike frequency adaptation and blockade of M-current in rat CA1 pyramidal neurones by linopirdine (DuP 996), a neurotransmitter release enhancer
    • AIKEN SP, LAMPE BJ, MURPHY PA, BROWN BS: Reduc-tion of spike frequency adaptation and blockade of M-current in rat CA1 pyramidal neurones by linopirdine (DuP 996), a neurotransmitter release enhancer. Br. J. Pharmacol. (1995) 115: 1163 – 1168.
    • (1995) Br. J. Pharmacol. , vol.115 , pp. 1163-1168
    • AIKEN, S.P.1    LAMPE, B.J.2    MURPHY, P.A.3    BROWN, B.S.4
  • 127
    • 0031039651 scopus 로고    scopus 로고
    • Linopirdine reduces stimulus intensity threshold for induction of long-term potentiation in the Schaffer collateral/CA1 pathway in rat hippocampal slices
    • LAMPE BJ, GASKILL JL, KEIM SC, BROWN BS: Linopirdine reduces stimulus intensity threshold for induction of long-term potentiation in the Schaffer collateral/CA1 pathway in rat hippocampal slices. Neurosci. Letts. (1997) 222: 135 – 137.
    • (1997) Neurosci. Letts. , vol.222 , pp. 135-137
    • LAMPE, B.J.1    GASKILL, J.L.2    KEIM, S.C.3    BROWN, B.S.4
  • 129
    • 0002595981 scopus 로고
    • Depolarization activated releas-ers of transmitters as therapeutics for dementia: pre-clinical characterization of linopirdine (DuP 996)
    • ZACZEK R, SAYDOFF J: Depolarization activated releas-ers of transmitters as therapeutics for dementia: pre-clinical characterization of linopirdine (DuP 996). Curr. Opin. Invest. Drugs (1993) 2 (10): 1097 – 1104.
    • (1993) Curr. Opin. Invest. Drugs , vol.2 , Issue.10 , pp. 1097-1104
    • ZACZEK, R.1    SAYDOFF, J.2
  • 130
    • 0025322605 scopus 로고
    • Potassium currents in hippocampal pyrami-dal cells
    • Storm-Mathisen J, Zimmer J, Ottersen OP (Eds.), Elsevier, Amsterdam
    • STORM JF: Potassium currents in hippocampal pyrami-dal cells. In: Progress in Brain Research. Storm-Mathisen J, Zimmer J, Ottersen OP (Eds.), Elsevier, Amsterdam (1990 161 – 187.
    • (1990) In: Progress in Brain Research. , pp. 161-187
    • STORM, J.F.1
  • 131
    • 0018886033 scopus 로고
    • Muscarinic suppression of a novel voltage-sensitive It current in a vertebrate neu-rone
    • BROWN DA, ADAMS PR: Muscarinic suppression of a novel voltage-sensitive It current in a vertebrate neu-rone. Nature (1980) 283: 673 – 676.
    • (1980) Nature , vol.283 , pp. 673-676
    • BROWN, D.A.1    ADAMS, P.R.2
  • 132
    • 0023899304 scopus 로고
    • M-currents: an update
    • BROWN DA: M-currents: an update. Trends Neurosci. (1988) 11: 294 – 299.
    • (1988) Trends Neurosci. , vol.11 , pp. 294-299
    • BROWN, D.A.1
  • 133
    • 0029682660 scopus 로고    scopus 로고
    • Pharmacology of the neurotransmitter release enhancer linopirdine (DuP996), and insights into its mechanism of action
    • AIKEN SP, ZACZEK R, BROWN BS: Pharmacology of the neurotransmitter release enhancer linopirdine (DuP996), and insights into its mechanism of action. Adv. Pharmacol. (1996) 35: 349 – 384
    • (1996) Adv. Pharmacol. , vol.35 , pp. 349-384
    • AIKEN, S.P.1    ZACZEK, R.2    BROWN, B.S.3
  • 134
    • 0030959835 scopus 로고    scopus 로고
    • Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents (Imm)) and some other voltage-and ligand-gates membrane currents in rat sympa-thetic neurons
    • LAMAS JA, SELYANKO AA, BROWN DA: Effects of a cognition-enhancer, linopirdine (DuP 996), on M-type potassium currents (Imm)) and some other voltage-and ligand-gates membrane currents in rat sympa-thetic neurons. Eur. j Neurosci. (1997) 9: 605 – 616.
    • (1997) Eur. j Neurosci. , vol.9 , pp. 605-616
    • LAMAS, J.A.1    SELYANKO, A.A.2    BROWN, D.A.3
  • 135
    • 0028889856 scopus 로고
    • Single-dose pharmacokinetics, safety, and tolerance of lino-pirdine (DuP 996) in healthy young adults and elderly volunteers
    • PIENIASZEK HJ, JR., FISKE WD, SAXTON TD et al.: Single-dose pharmacokinetics, safety, and tolerance of lino-pirdine (DuP 996) in healthy young adults and elderly volunteers. J. Clin. Pharmacol. (1995) 35 (1): 22 – 30.
    • (1995) J. Clin. Pharmacol. , vol.35 , Issue.1 , pp. 22-30
    • PIENIASZEK, H.J.1    FISKE, W.D.2    SAXTON, T.D.3
  • 136
    • 0025721918 scopus 로고
    • EEG mapping cntral effects of multiple doses of linopirdine - a cogni-tive enhancer - in healthy elderly male subjects
    • SALETU B, DARRAGH A, BREUEL HP et al.: EEG mapping cntral effects of multiple doses of linopirdine - a cogni-tive enhancer - in healthy elderly male subjects. Hu-man PsychopharmacoL (1991) 6: 267 – 275.
    • (1991) Hu-man PsychopharmacoL , vol.6 , pp. 267-275
    • SALETU, B.1    DARRAGH, A.2    BREUEL, H.P.3
  • 137
    • 0027956093 scopus 로고
    • Determination of linopirdine and its N-oxide metabolites in rat plasma by liquid chromatography
    • RAKESTRAW DC, BILSKI DA, LAM GN: Determination of linopirdine and its N-oxide metabolites in rat plasma by liquid chromatography. J. Pharm. Biomed. Anal. (1994) 12 (8): 1055 – 1061.
    • (1994) J. Pharm. Biomed. Anal. , vol.12 , Issue.8 , pp. 1055-1061
    • RAKESTRAW, D.C.1    BILSKI, D.A.2    LAM, G.N.3
  • 139
    • 85018860496 scopus 로고    scopus 로고
    • Pharmacokinetics, safety and toler-ance of DMP-543, a potential cognitive enhancer, in © Ashley Publications Ltd. All rights reserved
    • young and elderly male subjects after single oral doses. J. OM. Pharmacol. (1997) 37 (9): 867.
    • PIENIASZEK HJ, Jr., GARNER DM, KLINGERMAN CA, KORNHAUSER DM: Pharmacokinetics, safety and toler-ance of DMP-543, a potential cognitive enhancer, in © Ashley Publications Ltd. All rights reserved.Exp. Opin. Invest. Drugs (1998) 7(4) young and elderly male subjects after single oral doses. J. OM. Pharmacol. (1997) 37 (9): 867.
    • (1998) Exp. Opin. Invest. Drugs , vol.7 , Issue.4
    • PIENIASZEK, H.J.1    GARNER, D.M.2    KLINGERMAN, C.A.3    KORNHAUSER, D.M.4
  • 140
    • 0026602899 scopus 로고
    • A group of potassium-channel blockers - acetylcholine releasers: new poten-tials for Alzheimer's disease?
    • E.P., LAVRETSKY, L.F., JARVIK, A group of potassium-channel blockers - acetylcholine releasers: new poten-tials for Alzheimer's disease?, JOM. Psychopharm., (1992), 12, 2, 110-118
    • (1992) JOM. Psychopharm. , vol.12 , Issue.2 , pp. 110-118
    • LAVRETSKY, E.P.1    JARVIK, L.F.2


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