Interconversion of the kinetic identities of the tandem catalytic domains of receptor-like protein-tyrosine phosphatase PTPα by two point mutations is synergistic and substrate-dependent

Journal of Biological Chemistry

Volumn 273, Issue 44, 1998, Pages 28986-28993

  Lim, Kah Leong ^a   Kolatkar, Prasanna R ^b   Ng, Kwok Peng ^a   Ng, Chee Hoe ^a   Pallen, Catherine J ^a  

^a INSTITUTE OF MOLECULAR AND CELL BIOLOGY   (Singapore)

^b NATIONAL UNIVERSITY HOSPITAL   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ALPHA CHAIN; AMINO ACID SEQUENCE; ANIMAL CELL; ARTICLE; CATALYSIS; CELL STRAIN COS1; DEPHOSPHORYLATION; ENZYME KINETICS; ENZYME SPECIFICITY; GENE CONVERSION; MICHAELIS CONSTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PHOSPHORYLATION; PROTEIN TERTIARY STRUCTURE; REACTION TIME; SEQUENCE ANALYSIS;

AMINO ACID SEQUENCE; AMINO ACID SUBSTITUTION; ANIMALS; BASE SEQUENCE; CATALYTIC DOMAIN; COS CELLS; DNA PRIMERS; KINETICS; MOLECULAR SEQUENCE DATA; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-FYN; SEQUENCE HOMOLOGY, AMINO ACID; SUBSTRATE SPECIFICITY;

EID: 0000666554     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.273.44.28986     Document Type: Article

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