The use of a dithiane protected benzoin photolabile safety catch linker for solid-phase synthesis

Tetrahedron Letters

Volumn 38, Issue 7, 1997, Pages 1227-1230

  Routledge, Anne ^a   Abell, Chris ^a   Balasubramanian, Shankar ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CHOLESTEROL;

ARTICLE; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IN VITRO STUDY; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; PHOTOLYSIS;

EID: 0031575621     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0040-4039(96)02478-1     Document Type: Article

References (15)

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15. 15. Procedure for the photolysis of 3 The resin 3 (0.1 g, 0.022 mmol of loaded Fmoc-β-alanine) was swollen in THF:MeOH (3:1, 40 ml), Fmoc-serine (8 mg) was added as an internal standard for HPLC and the solution degassed with nitrogen for 10 min. The solution was photolysed in a Pyrex vessel at 350 nm using a Rayonet photochemical reactor. Aliquots of solvent (0.5 ml) were removed at various time intervals and analysed by HPLC (UV and SEDEX evaporative light scattering detection).