In vitro detection of mdr1 mRNA in murine leukemia cells with 111In-labeled oligonucleotide

European Journal of Nuclear Medicine and Molecular Imaging

Volumn 31, Issue 11, 2004, Pages 1523-1529

  Bai, Jingming ^a   Yokoyama, Kunihiko ^a   Kinuya, Seigo ^a   Shiba, Kazuhiro ^a   Matsushita, Ryo ^a   Nomura, Masaaki ^b   Michigishi, Takatoshi ^a   Tonami, Norihisa ^a  

^a KANAZAWA UNIVERSITY   (Japan)

^b KANAZAWA UNIVERSITY HOSPITAL   (Japan)

Author keywords

111InCl3; 99mTc MIBI; Leukemia; Multidrug resistance; Oligonucleotide

Indexed keywords

ANTISENSE OLIGODEOXYNUCLEOTIDE; GLYCOPROTEIN P; INDIUM 111; MESSENGER RNA; METHOXY ISOBUTYL ISONITRILE TECHNETIUM TC 99M; MULTIDRUG RESISTANCE PROTEIN 1; OLIGONUCLEOTIDE; PENTETIC ACID;

ANIMAL CELL; ARTICLE; CELL MEMBRANE PERMEABILITY; COMPARATIVE STUDY; CONTROLLED STUDY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HYBRIDIZATION; INCUBATION TIME; ISOTOPE LABELING; NONHUMAN; PH MEASUREMENT; PROTEIN DETERMINATION; PROTEIN EXPRESSION; PROTEIN RNA BINDING; RADIATION DETECTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA ANALYSIS;

ANIMALS; CELL LINE, TUMOR; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; FEASIBILITY STUDIES; INDIUM RADIOISOTOPES; LEUKEMIA; METABOLIC CLEARANCE RATE; MICE; OLIGONUCLEOTIDES; P-GLYCOPROTEIN; RADIOPHARMACEUTICALS; RNA;

EID: 9944231561     PISSN: 16197070     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00259-004-1666-y     Document Type: Article

References (25)

1. Motomura S, Motoji T, Takanashi M, Wang YH, Shiozaki H, Sugawara I, et al. Inhibition of P-glycoprotein and recovery of drug sensitivity of human acute leukemic blast cells by multidrug resistance gene (mdrl) antisense oligonucleotides. Blood 1998;91:3163-71.
2. Ballinger JR. Imaging multidrug resistance with radiolabeled substrates for P-glycoprotein and multidrug resistance protein. Cancer Biother Radiopharm 2001;16:1-7.
3. 99mTc-MIBI bone marrow imaging in patients with untreated leukemia. Nucl Med Commun 2003;24:397-402.
4. 99mTc-hexakis-2- methoxyisobutyl isonitrile SPECT. J Nucl Med 1999;40:1778-83.
5. 99mTc-tetrofosmin uptake in MRP-expressing breast cancer cells under hypoxic conditions is independent of MRP function. Eur J Nucl Med Mol Imaging 2003;30:1529-31.
6. Dewanjee MK, Ghafouripour AK, Kapadvanjwala M, Dewanjee S, Serafini AN, Lopez DM, Sfakianakis GN. Non-invasive imaging of c-myc oncogene messenger RNA with indium-111-antisense probes in a mammary tumor-bearing mouse model. J Nucl Med 1994;35:1054-63.
7. Urbain JC, Shore SK, Vekemans MC, Cosenza SC, Deriel K, Patel GV, et al. Scintigraphic imaging of oncogenes with antisense probes: does it make sense? Eur J Nucl Med 1995;22:499-504.
8. Hnatowich DJ. Antisense imaging: where are we now? Cancer Biother Radiopharm 2000;15:447-57.
9. Nakashima E, Matsushita R, Negishi H, Nomura M, Harada S, Yamamoto H, et al. Reversal of drug sensitivity in MDR subline of P388 leukemia by gene-targeted antisense oligonucleotides. J Pharm Sci 1995;84:1205-9.
10. Barrand MA, Twentyman PR. Differential recognition of mdrla and mdrlb gene products in multidrug resistant mouse tumor cell lines by different monoclonal antibodies. Br J Cancer 1992;65:239-45.
11. 111In-labeled antisense DNA probe with multi-chelating sites (MCS-probe) showing high specific radioactivity and labeling efficiency. Nucl Med Biol 1999;26:17-21.
12. 99mTc. J Nucl Med 1995;36:2306-14.
13. Belikova AM, Zarytova VF, Grineva NI. Synthesis of ribonucleosides and diribonucleoside phosphates containing 2-chloroethylamine and nitrogen mustard residues. Tetrahedron Lett 1967;37:3557-62.
14. Karamychev VN, Reed MW, Neumann RD, Panyutin IG. Distribution of DNA strand breaks produced by iodine-123 and indium-111 in synthetic oligodeoxynucleotides. Acta Oncol 2000;39:687-92.
15. Zhang YM, Liu N, Zhu ZH, Rusckowski M, Hnatowich DJ. Influence of different chelators (HYNIC, MAG3 and DTPA) on tumor cell accumulation and mouse biodistribution of technetium-99m labeled to antisense DNA. Eur J Nucl Med 2000;27:1700-7.
16. Touboul M, Gauchez AS, Dhardemare ADM, Lunardi J, Deverre JR, Pernin C, et al. Early detection of chemoresistance in vivo through the use of a radiolabeled antisense oligonucleotide. Anticancer Res 2002;22:3349-56.
17. Velculescu VE. Tantalizing transcriptomes-SAGE and its use in global gene expression analysis. Science 1999;286:1491-2.
18. Gambhir SS, Barrio JR, Herschman HR, Phelps ME. Imaging gene expression: principles and assays. J Nucl Cardiol 1999;6:219-33.
19. Loke SL, Stein CA, Zhang XH, Mori K, Nakanishi M, Subasinghe C, et al. Characterization of oligonucleotide transport into living cells. Proc Natl Acad Sci USA 1989;86:3473-8.
20. Sato N, Kobayashi H, Saga T, Nakamoto Y, Ishimori T, Togashi K, et al. Tumor targeting and imaging of intraperitoneal tumors by use of antisense oligo-DNA complexed with dendrimers and/or avidin in mice. Clin Cancer Res 2001;7:3606-12.
21. Urbain JC. Sense, antisense, and common sense. J Nucl Med 2001;42:1670-1.
22. Thierry AR, Rahman A, Dritschilo A. Overcoming multidrug resistance in human tumor cells using free and liposomally encapsulated antisense oligonucleotides. Biochem Biophys Res Commun 1993;190:952-60.
23. Farhood H, Serbina N, Huang L. The role of dioleoyl phosphatidylethanolamine in cationic liposome mediated gene transfer. Biochim Biophys Acta 1995;1235:289-95.
24. Akhtar S, Hughes MD, Khan A, Bibby M, Hussain M, Nawaz Q, et al. The delivery of antisense therapeutics. Adv Drug Deliv Rev 2000;44:3-21.
25. Semple SC, Klimuk SK, Harasym TO, Dos Santos N, Ansell SM, Wong KF, et al. Efficient encapsulation of antisense oligonucleotides in lipid vesicles using ionizable aminolipids: formation of novel small multilamellar vesicle structures. Biochim Biophys Acta 2001;1510:152-66.