Structure-activity relationships in platelet-activating factor. 12. Synthesis and biological evaluation of platelet-activating factor antagonists with anti-HIV-1 activity

Journal of Medicinal Chemistry

Volumn 47, Issue 25, 2004, Pages 6410-6419

  Serradji, Nawal ^a   Martin, Marc ^b   Bensaid, Okkacha ^a,d   Cisternino, Salvatore ^c   Rousselle, Christophe ^c   Dereuddre Bosquet, Nathalie ^b   Huet, Jack ^a   Redeuilh, Catherine ^a   Lamouri, Aazdine ^a   Dong, Chang Zhi ^a   Clayette, Pascal ^b   Scherrmann, Jean Michel ^c   Dormont, Dominique ^b   Heymans, Françoise ^a  

^a Laboratoire de Pharmacochimie   (France)

^b INSTITUT DE RADIOPROTECTION ET DE SÛRETÉ NUCLÉAIRE   (France)

^c HÔPITAL FERNAND WIDAL   (France)

^d UNIVERSITY OF TLEMCEN   (Algeria)

Author keywords

[No Author keywords available]

Indexed keywords

2 (HEXYLAMINOCARBONYLAMINOMETHYL) 1,4 BIS(3,4,5 TRIMETHOXYBENZOYL)PIPERAZINE; 2 (N BUTYLAMINOCARBONYLOXYMETHYL) 1,4 BIS(3,4,5 TRIMETHOXYBENZOYL)PIPERAZINE; ANTIRETROVIRUS AGENT; CARBAMIC ACID DERIVATIVE; NEUROTOXIN; PIPERAZINE DERIVATIVE; PMS 601; THROMBOCYTE ACTIVATING FACTOR; THROMBOCYTE ACTIVATING FACTOR ANTAGONIST; UNCLASSIFIED DRUG; UREA DERIVATIVE;

AIDS RELATED COMPLEX; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; BRAIN PERFUSION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TRANSPORT; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IC 50; MACROPHAGE ACTIVATION; MALE; MICROGLIA; MOUSE; NEUROLOGIC DISEASE; NEUROTOXICITY; NONHUMAN; PARAMETER; PATHOPHYSIOLOGY; PHARMACOKINETICS; PROTEIN FUNCTION; RAT; RAT STRAIN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION; TECHNIQUE; THROMBOCYTE AGGREGATION INHIBITION;

EID: 9744229932     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm040860g     Document Type: Article

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