Study of the antioxidant effect of α-tocopherol on low-density lipoprotein peroxidation induced at low and high γ-radiation dose rates

Radiation Physics and Chemistry

Volumn 72, Issue 2-3, 2005, Pages 347-353

  Khalil, Abdelouahed ^a   Milochevitch, Christelle ^a  

^a UNIVERSITÉ DE SHERBROOKE   (Canada)

Author keywords

Radiation dose rate; Alpha tocopherol; Free radicals; LDL; Lipid peroxidation

Indexed keywords

ATHEROSCLEROSIS; LIPOPROTEINS; PEROXIDATION; VITAMIN E;

ALCOHOLS; FREE RADICALS; LIPIDS; OXIDATION; PROTEINS; RADIOLYSIS; REDUCTION; SOLUBILITY; VITAMINS;

ANTIOXIDANTS;

ALPHA TOCOPHEROL; FREE RADICAL; HYDROXYL RADICAL; LOW DENSITY LIPOPROTEIN; OXYGEN; THIOBARBITURIC ACID REACTIVE SUBSTANCE;

ANTIOXIDANT ACTIVITY; ARTICLE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG SOLUBILITY; GAMMA RADIATION; HUMAN; LIPID PEROXIDATION; MALE; NORMAL HUMAN; OXIDATIVE STRESS; RADIATION DOSE; RADIOLYSIS;

EID: 9644310483     PISSN: 0969806X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.radphyschem.2003.11.011     Document Type: Article

References (25)

1. P.M. Abuja, and H. Esterbauer Simulation of lipid peroxidation in low-density lipoprotein by a basic "skeleton" of reactions Chem. Res. Toxicol. 8 1995 753 790
2. R. Albertini, and P.M. Abuja Prooxidant and antioxidant properties of Trolox C, analogue of vitamin E, in oxidation of low-density lipoprotein Free Radic. Res. 30 1999 181 188
3. •- free radicals produced by gamma radiolysis Radiat. Res. 134 1993 271 282
4. H.T. Bowen, and S.T. Omaye Oxidative changes associated with beta-carotene and alpha-tocopherol enrichment of human low-density lipoproteins J. Am. Coll. Nutr. 7 1998 171 179
5. V.W. Bowry, and R. Stocker The prooxidant effect of vitamin E on the radical-initiated oxidation of human low-density lipoprotein J. Am. Chem. Soc. 115 1993 6019 6045
6. V.W. Bowry, D. Mohr, J. Cleary, and R. Stocker Prevention of tocopherol-mediated peroxidation in ubiquinol-10-free human low density lipoprotein J. Biol. Chem. 270 1995 5756 5763
7. S.L. Godfried, G.F. Combs Jr., J.M. Saroka, and L.A. Dillingham Potentiation of atherosclerotic lesions in rabbits by a high dietary level of vitamin E Br. J. Nutr. 61 1989 607 617
8. L. Jaouad, C. Milochevitch, and A. Khalil PON1 paraoxonase activity is reduced during HDL oxidation and is an indicator of HDL antioxidant capacity Free Radic. Res. 37 2003 77 83
9. I. Jialal, C.J. Fuller, and B.A. Huet The effect of alpha-tocopherol supplementation on LDL oxidation A dose-response study. Arterioscler. Thromb. Vasc. Biol. 15 1995 190 198
10. J.F. Keaney Jr., J.M. Gaziano, A. Xu, B. Frei, J. Curran-Celentano, G.T. Shwaery, J. Loscalzo, and J.A. Vita Low-dose alpha-tocopherol improves and high-dose alpha-tocopherol worsens endothelial vasodilator function in cholesterol-fed rabbits J. Clin. Invest. 93 1994 844 851
11. A. Khalil, and T. Fülöp A comparison of the kinetics of low-density lipoprotein oxidation induced by copper or by γ-rays influence of radiation-dose rate and copper concentration Can. J. Phys. Pharm. 29 2001 114 121
12. A. Khalil, J.P. Fortin, J.G. LeHoux, and T. Fulop Age-related decrease of dehydroepiandrosterone concentrations in low-density lipoproteins and its role in the susceptibility of low density lipoproteins to lipid peroxidation J. Lipid. Res. 41 2000 1552 1561
13. P. Koufen, D. Brdiczka, and G. Stark Inverse dose rate effects at the level of proteins observed in the presence of lipids Int. J. Radiat. Biol. 76 2000 625 631
14. S.M. Lynch, and B. Frei Reduction of copper, but not iron, by human low density lipoprotein (LDL). Implications for metal ion-dependent oxidative modification of LDL J. Biol. Chem. 270 1995 5158 5163
15. I. Pinchuk, and D. Lichtenberg Copper-induced LDL peroxidation interrelated dependencies of the kinetics on the concentrations of copper, hydroperoxides and tocopherol FEBS Lett. 450 1999 186 190
16. J.M. Proudfoot, K.D. Croft, I.B. Puddey, and L.J. Beilin The role of copper reduction by alpha-tocopherol in low-density lipoprotein oxidation Free Radic. Biol. Med. 23 1997 720 728
17. J.A. Raleigh, W. Kremers, and B. Gaboury Dose rate and oxygen effects in models of lipid membranes linoleic acid Int. J. Radiat. Biol. 31 1977 203 213
18. W. Sattler, D. Mohr, and R. Stocker Rapid isolation of lipoproteins and assessment of their peroxidation by high-performance liquid chromatography postcolumn chemiluminescence Methods Enzymol. 233 1994 469 489
19. J.W.T. Spinks, and R.J. Woods An Introduction to Radiation Chemistry third ed 1990 Wiley New York
20. S.R. Thomas, and R. Stocker Molecular action of vitamin E in lipoprotein oxidation implications for atherosclerosis Free Radic. Biol. Med. 28 2000 1795 1805
21. F. Visioli, R. Bordone, C. Perugini, M. Bagnati, C. Cau, and G. Bellomo The kinetics of copper-induced LDL oxidation depend upon its lipid composition and antioxidant content Biochem. Biophys. Res. Commun. 268 2000 818 822
22. A.R. Waldeck, and R. Stocker Radical-initiated lipid peroxidation in low density lipoproteins insights obtained from kinetic modeling Chem. Res. Toxicol. 9 1996 954 964
23. J.F. Weiss, and M.R. Landauer Protection against ionizing radiation by antioxidant nutrients and phytochemicals Toxicology 189 2003 1 20
24. K. Yagi A simple fluorometric assay for lipoperoxide in blood plasma Biochem. Med. 15 1976 212 216
25. Y. Yoshida, K. Kashiba, and E. Niki Free radical-mediated oxidation of lipids induced by hemoglobin in aqueous dispersions Biochim. Biophys. Acta. 1201 1994 165 172