Oxidative changes associated with β-carotene and α-tocopherol enrichment of human low-density lipoproteins

Journal of the American College of Nutrition

Volumn 17, Issue 2, 1998, Pages 171-179

  Bowen, Hazel T ^a   Omaye, Stanley T ^a  

^a UNIVERSITY OF NEVADA   (United States)

Author keywords

Lipid peroxidation; Low density lipoproteins; Toxicity; tocopherol; carotene

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; BETA CAROTENE; LOW DENSITY LIPOPROTEIN;

ADULT; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD ANALYSIS; CHEMICAL REACTION KINETICS; CONTROLLED STUDY; HUMAN; LIPID OXIDATION; NORMAL HUMAN;

ADOLESCENT; ADULT; ANTIOXIDANTS; BETA CAROTENE; COPPER; HUMANS; KINETICS; LIPOPROTEINS, LDL; OXIDATION-REDUCTION; THIOBARBITURIC ACID REACTIVE SUBSTANCES; VITAMIN E;

EID: 0031947153     PISSN: 07315724     EISSN: 15411087     Source Type: Journal    
DOI: 10.1080/07315724.1998.10718743     Document Type: Article

References (43)

1. Brown MS, Goldstein JL: Receptor-mediated control of cholesterol metabolism. Science 191:150-153, 1976.
2. Goldstein JL, Brown MS: The low-density lipoprotein pathway and relation to atherosclerosis. Ann Rev Biochem 46:897-930, 1977.
3. Goldstein JL, Ho YK, Basu SK, Brown MS: Binding site on macrophages that mediates uptake and degradation of acetylated low density lipoprotein, producing massive cholesterol deposition. Proc Natl Acad Sci 76:333-337, 1979.
4. Yagi K: Lipid peroxides and human diseases. Chem Phys Lipids 45:337-351, 1987.
5. Schuh J, Fairclough GF, Haschemeyer RH: Oxygen-mediated heterogeneity of apo-low-density lipoprotein. Proc Natl Acad Sci 75:3173-3177, 1978.
6. Avogaro P, Bon Bittolo G, Cazzolato G: Presence of a modified low density lipoprotein in humans. Arteriosclerosis 8:79-87, 1988.
7. Haberlan ME, Fong D, Cheng L: Malondialdehyde-altered protein occurs in atheroma of Watanabe heritable lyperlipidemic rabbits. Science 241:215-218, 1988.
8. Palinski W, Rosenfeld M, Yla-Herttuala S, Gurtner G, Socher S, Butler S, Parasarathy S, Carew TE, Steinberg D, Witztum J: Low density lipoprotein undergoes oxidative modification in vivo. Proc Natl Acad Sci 86:1372-1376, 1989.
9. Blackman BC, White P, Tsou W, Finkel D: Peroxidation of plasma and platelet lipids in chronic cigarette smokers and insulindependent diabetics. Ann NY Acad Sci 435:385-387, 1984.
10. Esterbauer E, Dieber-Rotheneder M, Striegl G, Waeg G: Role of vitamin E in preventing the oxidation of low-density lipoprotein. Am J Clin Nutr 53:314S-321S, 1991.
11. Ledwozyw A, Michalak J, Steplan A, Kadziolka A: The relationship between plasma triglycerides, cholesterol, total lipid and lipid peroxidation products during human atherosclerosis. Clin Chim Acta 155:275-284, 1986.
12. Rosenfeld ME, Palinski W, Yla-Herttuala S, Butler S, Wiotztum JL: Distribution of oxidation specific lipo-protein adducts and apolipoprotein B in atherosclerotic lesions of varying severity from WHHL rabbits. Arteriosclerosis 10:336-349, 1990.
13. Esterbauer H, Puhl H, Dieber-Rotheneder M, Waeg G, Rabl H: Effect of antioxidants on oxidative modification of LDL. Ann Med 23:573-581, 1991.
14. Yla-Herttuala S, Palinski W, Rosenfeld ME: Evidence for the presence of oxidatively modified low density lipoprotein in atherosclerotic lesions of rabbit and man. J Clin Invest 84:1086-1095, 1989.
15. Yla-Herttuala S, Palinski W, Butler SW, Picard S, Steinberg D, Witztum JL: Rabbit and human atherosclerotic lesions contain IgG that recognizes epitopes of oxidized LDL. Arterioscler Thromb 14:32-40, 1994.
16. Holvoet P, Perez G, Bernar H, Brouwers E, Vanloo B, Rosseneu M, Collen D: Stimulation with a monoclonal antibody (mAb4E4) or scavenger receptor-mediated uptake of chemically modified low density lipoproteins by THP-1-derived macrophages enhances foam cell generation. J Clin Invest 93:89-98, 1994.
17. Gey FK: On the antioxidant hypothesis with regard to arteriosclerosis. Bibl Nutr Diet 37:53-91, 1986.
18. Bowen HT, Omaye ST: a-Tocopherol, b-carotene, and oxidative modification of human low-density lipoprotein. In Baskin SJ, Salem H (eds): Lipid Peroxidation and Antioxidants. Washington, DC: Taylor and Francis, pp 113-123, 1997.
19. Cathcart ME, Morel DW, Chisolm GM: Monocytes and neutrophils oxidize low density lipoprotein making it cytotoxic. J Leukocyte Biol 38:341-350, 1985.
20. Jessup W, Rankin SM, DeWalley CV, Hoult RS, Scott J, Leake DS: Alpha-tocopherol consumption during low-density-lipoprotein oxidation. Biochem J 265:399-405, 1990.
21. Dieber-Rotheneder M, Puhl H, Waeg G, Streigl G, Esterbauer H: Effect of oral supplementation with d-alpha-tocopherol on the vitamin E content of human low density lipoproteins and resistance to oxidation. J Lipid Res 32:1325-1332, 1991.
22. Jialal I, Grundy SM: Effect of dietary supplementation with alphatocopherol on the oxidative modification of low density lipoprotein. J Lipid Res 33:899-906, 1992.
23. Eserbauer E, Dieber-Rotheneder M, Striegl G, Waeg G: Vitamin E and other lipophilic antioxidants protect LDL against oxidation. Fat Sci Technol 91:316-324, 1989.
24. Frei B: Ascorbic acid protects lipid in human plasma and lowdensity lipoprotein against oxidative damage. Am J Clin Nutr 54:1113S-1118S, 1991.
25. Sato K, Niki E, Shimasaki H: Free radical-mediated chain oxidation of low density lipoprotein and its synergistic inhibition by vitamin E and vitamin C. Arch Biochem Biophys 279:402-405, 1990.
26. Peto R, Doll RJ, Buckley JD, Scorn MD: Can dietary b-carotene materially reduce human cancer rates? Nature 290:201-208, 1981.
27. Gaziano JM, Manson JE, Buring JE, Hennekens CH: Dietary antioxidants and cardiovascular disease. Ann NY Acad Sci 669: 249-259, 1992.
28. Omaye ST, Zhang P: Phytochemical interactions: b-carotene, tocopherol and ascorbic acid. In Bidlack WR, Omaye ST (eds): “Phytochemicals: Today’s Knowledge for Tomorrow’s Products.” Lancaster, PA: Technomic Publishing Co., Inc., In press, 1998.
29. Handelman CJ, Van Kuijk FJ, Chatterjee A, Krinsky NI: Characterization of products formed during autoxidation of b-carotene. Free Rad Biol Med 10:427-437, 1991.
30. Jialal I, Norkus EP, Cristol L, Grundy SM: Beta-carotene inhibits the oxidative modification of low-density lipoprotein. Biochim Biophys Acta 1086:134-138, 1991.
31. Omaye ST, Krinsky NI, Kagan VE, Mayne ST, Liebler DC, Bidlack WR: b-Carotene: friend or foe? Fundam Appl Toxicol 40:163-174, 1997.
32. Machlin LJ: “Vitamin E: A Comprehensive Treatise.” New York NY: Marcel Decker, Inc., 1980.
33. Olson JA, Krinsky NI: The colorful, fascinating world of the carotenoids: important physiologic modulator. FASEB J 9:1547-1558, 1995.
34. Gaziano JM, Hatta A, Flynn M, Johnson EJ, Krinsky N, Ridker PM, Hennekens CH, Frei B: Supplementation with beta-carotene in vivo and in vitro does not inhibit low density lipoprotein oxidation. Atherosclerosis 112:187-195, 1995.
35. Chung BH, Segrest JP, Ray MJ, Brinzell JD, Hokanson JE, Krause RM, Beaudrie K, Gone JT: Preparation of plasma lipoproteins: single vertical spin density gradient ultracentrifugation Meths Enzymology 128:181-201, 1986.
36. Buege JA, Aust SD: Microsomal lipid peroxidation. Meth Enzymol 52:303-310, 1978.
37. Kahlon TS, Chow FI, Hoefer JL, Betschart AA: Bioavailability of vitamin A and E as influenced by wheat bran and bran particle size. Cereal Chem 63:490-493, 1986.
38. Ringer TM, DeLoof MJ, Winterrowd GE, Francom SF, Gaylor SK, Ryan JA, Sanders ME, Hughes GS: Beta-carotene’s effects on serum lipoproteins and immunologic indices in humans. Am J Clin Nutr 53:688-694, 1991.
39. Snedecor GW, Cochran WC: “Statistical Methods.” Ames, IA: The Iowa State University Press, 1980.
40. Kane JP: A rapid electrophoretic technique for identification of subunit species of apoproteins in serum lipoproteins. Anal Biochem 53:350-364, 1973.
41. Jialal I, Fuller CJ, Huet BA: The effect of alpha-tocopherol supplementation on LDL oxidation: a dose-response study. Arterioscler Thromb Vasc Biol 15:190-198, 1995.
42. Reaven PD, Khow A, Beltz W, Parasarathy S, Witztum JL: Effect of dietary antioxidant combinations in humans. Protection of LDL by vitamin E but not by beta-carotene. Arterioscler Thromb 133: 590-600, 1993.
43. Burton GW, Ingold KU: Beta-carotene: an unusual type of lipid antioxidant. Science 224:569-573, 1984.