Effect of variation in membrane excitability on propagation velocity of simulated action potentials for cardiac muscle and smooth muscle in the electric field model for cell-to-cell transmission of excitation

IEEE Transactions on Biomedical Engineering

Volumn 51, Issue 12, 2004, Pages 2216-2219

  Sperelakis, Nicholas ^a   Kalloor, Bijoy ^a  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

Author keywords

Cardiac muscle propagation; Electric field transmission; Excitability and propagation velocity; Junctional cleft potential; PSpice simulation; Simulated action potentials; Smooth muscle propagation

Indexed keywords

SODIUM CHANNEL;

ARTICLE; COMPUTER SIMULATION; ELECTRIC FIELD; ELECTROSTIMULATION; HEART MUSCLE POTENTIAL; MATHEMATICAL ANALYSIS; MEMBRANE DEPOLARIZATION; MODEL; MUSCLE EXCITATION; NONHUMAN; SMOOTH MUSCLE;

ACTION POTENTIALS; ANIMALS; CELL MEMBRANE; COMPUTER SIMULATION; ELECTRIC IMPEDANCE; HUMANS; MEMBRANE POTENTIALS; MODELS, CARDIOVASCULAR; MODELS, NEUROLOGICAL; MYOCYTES, CARDIAC; MYOCYTES, SMOOTH MUSCLE; SYNAPTIC TRANSMISSION;

EID: 9644302429     PISSN: 00189294     EISSN: None     Source Type: Journal    
DOI: 10.1109/TBME.2004.836528     Document Type: Article

References (15)

1. S.A. Cohen,"Immunocytochemical localizationof rH1 sodium channel in adult rat heart atria and ventricle. Presence in terminal intercalated disks," Circulation, vol. 74, pp. 1071-1096, 1994.
2. P. J. Diaz, Y. Rudy, and R. Plonsey, "Intercalated discs as a cause for discontinuous propagation in cardiac muscle: A theoretical simulation," Ann Biomed Eng., vol. 11, pp. 177-189, 1983.
3. D. E. Gutstein et al., "Conduction slowing and sudden arrhythmic death in mice with cardiac restricted inactivation of connexin43," Circ. Res., vol. 88, pp. 333-339, 2001.
4. J. P. Kucera, S. Rohr, and Y. Rudy, "Localization of sodium channels in intercalated disks modulates cardiac conduction," Circ Res., vol. 91, pp. 1176-1182, 2002.
5. J. B. Picone, N. Sperelakis, and J. E. Mann Jr., "Expanded model of the electric field hypothesis for propagation in cardiac muscle," Math. & Computer Modeling, vol. 15, pp. 17-35, 1991.
6. M. S. Spach et al., "The discontinuous nature of propagation in normal canine cardiac muscle. Evidence for recurrent discontinuity of intracellular resistance that affects the membrane currents," Circ Res., vol. 48, pp. 39-54, 1981.
7. N. Sperelakis, "Cable properties and propagation of action potentials," in Cell Physiology Source Book, 1st ed: Academic Press Publishers, 1995, ch. 18, pp. 245-254.
8. -, "Editorial: An electric field mechanism for transmission of excitation between myocardial cells" Circ. Res., vol. 91, pp. 985-987, 2002.
9. -, "Propagation of action potentials between parallel chains of cardiac muscle cells in PSpice simulation," Can. J. Physiol. Pharmacol., vol. 81, pp. 1-11, 2003.
10. N. Sperelakis and J. E. Mann Jr., "Evaluation of electric field changes in the cleft between excitable cells," J. Theor. Biol., vol. 64, pp. 71-96, 1977.
11. N. Sperelakis and K. McConnell, "Electric field interactions between closely-abutting excitable cells," IEEE-EMB, vol. 21, pp. 77-89, 2002.
12. N. Sperelakis and K. P. V. Murali, "Combined electric field and gap junctions on propagation of action potentials in cardiac muscle and smooth muscle in PSpice simulation," J. Electrocardiol., vol. 36, no. 4, pp. 279-293, 2003.
13. N. Sperelakis and L. Ramasamy, "Propagation in cardiac muscle and smooth muscle based on electric field transmission at cell junctions: An analysis by PSpice," IEEE-EMB, vol. 21, pp. 130-143, 2002.
14. H. S. Tamaddon et al., "High resolution' optical mapping of the right bundle branch in connexin40 knockout mice reveals slow conduction in the specialized conduction system," Circ. Res., vol. 87, pp. 929-936, 2000.
15. D. Vaidya et al., "Null mutation of connexin43 causes slow propagation of verntricular activation in the late stages of mouse embryonic development," Circ. Res., vol. 88, pp. 1196-1202, 2001.