Study of the preferred modification sites of the quinone methide intermediate resulting from the latent trapping device of the activity probes for hydrolases

Biochemical and Biophysical Research Communications

Volumn 326, Issue 1, 2004, Pages 30-35

  Lo, Lee Chiang ^a   Chiang, Ying Ling ^a,b   Kuo, Chi Hsien ^a   Liao, Hsin Kai ^c   Chen, Yu Ju ^c   Lin, Jing Jer ^b  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b INSTITUTE OF CHEMISTRY   (Taiwan)

^c NATIONAL YANG MING UNIVERSITY   (Taiwan)

Author keywords

Activity probe; Cysteine; Glucosidase; Hydrolases; Labeling; Mechanism based; Protein tyrosine phosphatase; Proteome; Quinone methide

Indexed keywords

AMINO ACID; CYSTEINE; HYDROLASE; PROTEIN TYROSINE PHOSPHATASE 1B; QUINONE DERIVATIVE; QUINONE METHIDE 3; THIOL DERIVATIVE; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CATALYSIS; CHEMICAL ANALYSIS; COVALENT BOND; DEVICE; ENZYME ACTIVITY; PRIORITY JOURNAL; PROTEIN MODIFICATION; SEQUENCE ANALYSIS; TANDEM MASS SPECTROMETRY;

BINDING SITES; ENZYME ACTIVATION; GENE EXPRESSION PROFILING; HUMANS; HYDROLASES; INDOLEQUINONES; MASS SPECTROMETRY; MOLECULAR PROBES; PROTEIN BINDING; PROTEIN-TYROSINE-PHOSPHATASE; PROTEOMICS; STAINING AND LABELING; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 9644302408     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2004.11.003     Document Type: Article

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