Synthesis and activity of 8-substituted benzo[c]quinolizin-3-ones as dual inhibitors of human 5α-reductases 1 and 2

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 1, 2005, Pages 145-148

  Ferrali, Alessandro ^a   Menchi, Gloria ^a   Occhiato, Ernesto G ^a   Danza, Giovanna ^a   Mancina, Rosa ^a   Serio, Mario ^a   Guarna, Antonio ^a  

^a UNIVERSITY OF FLORENCE   (Italy)

Author keywords

5 Reductase; Benzo c quinolizinones; Dihydrotestosterone; Fluorine; Inhibition

Indexed keywords

5ALPHA REDUCTASE 1; 5ALPHA REDUCTASE 2; ENZYME INHIBITOR; ISOENZYME; KETONE DERIVATIVE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ARTICLE; DRUG ACTIVITY; DRUG DESIGN; DRUG EFFECT; DRUG INDICATION; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME INHIBITION; IC 50; STRUCTURE ACTIVITY RELATION;

ENZYME INHIBITORS; ISOENZYMES; QUINOLIZINES; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 9644290864     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.017     Document Type: Article

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