Benzo[c]quinolizin-3-ones: A novel class of potent and selective nonsteroidal inhibitors of human steroid 5α-reductase 1

Journal of Medicinal Chemistry

Volumn 43, Issue 20, 2000, Pages 3718-3735

  Guarna, A ^a   Machetti, F ^a   Occhiato, E G ^a   Scarpi, D ^a   Comerci, Alessandra ^a   Danza, Giovanna ^a   Mancina, Rosa ^a   Serio, Mario ^a   Hardy, Kimber ^b  

^a UNIVERSITY OF FLORENCE   (Italy)

^b SERONO PHARMACEUTICAL RES INSTITUTE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

1H TETRAHYDROBENZO[C]QUINOLIZIN 3 ONE DERIVATIVE; 8 CHLORO 1,2,3,4,4A,5,6,10B OCTAHYDRO 4 METHYLBENZO[F]QUINOLIN 3(2H) ONE; 8 CHLORO 1,2,3,4,4A,5,6,10B OCTAHYDRO 4 METHYLBENZO[F]QUINOLIN 3(2H) ONE DUTASTERIDE; BENZO[C]QUINOLIZIN 3 ONE DERIVATIVE; CHLORINE; FINASTERIDE; HYDROGEN; METHYL GROUP; QUINOLIZINE DERIVATIVE; STEROID 5ALPHA REDUCTASE; STEROID 5ALPHA REDUCTASE 1; STEROID 5ALPHA REDUCTASE 2; STEROID 5ALPHA REDUCTASE INHIBITOR; UNCLASSIFIED DRUG;

ACNE; ALOPECIA; ANIMAL CELL; ARTICLE; CATALYSIS; CHO CELL; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG SYNTHESIS; ENDOCRINE DISEASE; ENZYME INHIBITION; HIRSUTISM; HOMOGENATE; HUMAN; HUMAN TISSUE; HYDROGEN BOND; NONHUMAN; PROSTATE; PROSTATE HYPERTROPHY; SCALP; STEREOCHEMISTRY;

ANIMALS; CHO CELLS; CRICETINAE; ENZYME INHIBITORS; HUMANS; ISOENZYMES; MALE; MODELS, MOLECULAR; MOLECULAR CONFORMATION; MONTE CARLO METHOD; PROSTATE; QUINOLIZINES; RECOMBINANT PROTEINS; SCALP; STRUCTURE-ACTIVITY RELATIONSHIP; TESTOSTERONE 5-ALPHA-REDUCTASE;

EID: 0034609834     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm000945r     Document Type: Article

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