Study of caffeine in urine and saliva of horses subjected to urinary acidification

Journal of Applied Toxicology

Volumn 24, Issue 6, 2004, Pages 513-518

  Carregaro, A B ^a   Mataqueiro, M I ^b   Soares, O A B ^b   Queiroz Neto, A ^b  

^a UNIVERSIDADE DE FRANCA   (Brazil)

^b SÃO PAULO STATE UNIVERSITY UNESP   (Brazil)

Author keywords

Ascorbic acid; Caffeine; Horses; Saliva; Urinary acidification; Urine

Indexed keywords

ASCORBIC ACID; CAFFEINE;

ANAEROBIC METABOLISM; ARTICLE; DIURESIS; GAS CHROMATOGRAPHY; HORSE; NONHUMAN; PKA; PRIORITY JOURNAL; SALIVA; URINE; URINE ACIDIFICATION;

ANIMALS; ASCORBIC ACID; CAFFEINE; CENTRAL NERVOUS SYSTEM STIMULANTS; CHROMATOGRAPHY, GAS; DOPING IN SPORTS; HORSES; HYDROGEN-ION CONCENTRATION; KINETICS; REPRODUCIBILITY OF RESULTS; SALIVA; URINE;

EQUIDAE;

EID: 9644282929     PISSN: 0260437X     EISSN: None     Source Type: Journal    
DOI: 10.1002/jat.1011     Document Type: Article

References (27)

1. Aramaki S, Suzuki E, Ishidaka O, Momose A, Umemura K. 1991. Pharmacokinetics of caffeine and its metabolites in horses after intravenous, intramuscular or oral administration. Chem. Pharm. Bull. 39: 2999-3002.
2. Aramaki S, Suzuki E, Ishidaka O, Momose A. 1995. Effects of exercise on plasma concentrations of caffeine and its metabolites in horses. Biol. Pharm. Bull. 18: 1607-1609.
3. Aramaki S, Ishidaka O, Suzuki E, Momose A, Umemura K. 1996. Theoretical relashionship between the post-administration time and plasma or urinary concentration of a metabolite and the unchanged drug. Administration of caffeine to horses. Biol. Pharm. Bull. 19: 1341-1346.
4. Bowman WC, Rand MJ. 1985. Textbook of Pharmacology. Blackwell Scientific Publications: Melbourne.
5. Charmey DS, Heniger GR, Jatlow PI. 1985. Increased anxiogenic effects of caffeine in panic disorders. Arch. Gen. Psychiat. 42: 233-243.
6. Dyke TM. 1994. Post-exercise acidosis and other determinants of the urinary concentration of drugs. Proceedings of the Testing for Therapeutic Medications, Environmental and Dietary Substances in Racing Horses, Lexington, pp. 175-183.
7. Dyke TM, Sams RA. 1998. Detection and determination of theobromine and caffeine in urine after administration of chocolate-coated peanuts to horses. J. Anal. Toxicol. 22: 112-116.
8. George AJ. 2000. Central nervous system stimulants. Best Pract. Res. Clin. Endocrinol. Metab. 14: 79-88.
9. Greene EW, Woods WE, Tobin T. 1983. Pharmacology, pharmacokinetics and behavioral effects of caffeine in horses. Am. J. Vet. Res. 44: 57-63.
10. Hansen LB. 2001. A stable gas chromatography-mass spectrometry analysis to characterize Ma Huang products found in health foods and supplements. J. Pharm. Sci. 90: 943-948.
11. Harkins JD, Rees WA, Mundy GD, Stanley SD, Tobin T. 1998. An overview of methylxanthines and their regulation in the horse. Equine Pract. 20: 10-16.
12. Hoel PG. 1974. Elementary Statistics. John Wley: New York.
13. Kamber M, Baume N, Saugy M, Rivier L. 2001. Nutritional supplements as a source for positive doping cases? Int. J. Sport Nutr. Exerc. 11: 258-263.
14. Moss MS. 1977. A review of drug 'clearance times' in racehorses. Equine Vet. J. 9: 53-56.
15. Myers MG. 1988. Caffeine and cardiac arrhythmias. Chest 94: 4.
16. Queiroz-Neto A, Zamur G, Carregaro AB, Mataqueiro MI, Salvadori MC, Azevedo CP, Harkins JD, Tobin T. 2001. Effects of caffeine on locomotor activity of horses: determination of the no-effect threshold. J. Appl. Toxicol. 21: 229-234.
17. Rodopoulos N, Norman A. 1996. Assessment of dimethylxanthine formation from caffeine in healthy adults: comparison between plasma and saliva concentrations and urinary excretion of metabolites. Scand. J. Clin. Lab. Invest. 56:259-268.
18. Salvadori MC, Rieser EM, Ribeiro-Neto LM, Nascimento ES. 1994. Determination of xantines by high-performance liquid chromatography and thin-layer chromatography in horse urine after ingestion of guarana powder. Analyst 119: 2701-2703.
19. Schumacher J, Spano JS, Wilson RC, DeGraves FJ, Duran SH, Ruffin DC. 1994. Caffeine clearance in the horse. Vet. Res. Commun. 18: 367-372.
20. Serafin WR. 1996. Drugs used in the treatment of asthma. In The Pharmacological Basis of Therapeutics, Goodman LS, Gilman A (eds). McMillan Publishing: New York; 659-682.
21. Sinclair CJ, Geiger JD. 2000. Caffeine use in sports: a pharmacological review. J. Sport Med. Phys. Fit. 40: 71-79.
22. Tobin T, Woods WE. 1979. Pharmacology review: drug metabolism and elimination in horses. J. Equine Med. Surg. 3: 150-156.
23. Tobin T, Combie BS, Shults BS. 1979. Pharmacology review: actions of central stimulant drugs in the horse II. J. Equine Med. Surg. 3: 102-109.
24. Tobin T, Mundy GD, Stanley SD, Sams RA, Crone DL. 1995. Testing for Therapeutic Medications, Environmental and Dietary Substances in Racing Horses. Maxwell H. Gluck Equine Research Center: Kentucky.
25. Walther H, Banditt P, Kohler E. 1983. Significance of caffeine values in serum, saliva and urine - determination of pharmacokinetic data by non-invasive methods in psychopharmacologic studies. Pharmacopsychiatria 16: 166-170.
26. Wells DJ, Hanks BM, Yarbrough CS, Davis MA. 1988. Determination of methylxanthine stimulants in urine of racing greyhounds by high-performance liquid chromatography. Resolution of a contested drug administration case. J. Anal. Toxicol. 12: 30-32.
27. Wood T, Weckman TJ, Henry PA, Chang S-L, Blake JW, Tobin T. 1990. Equine urine pH: normal population distributions and methods of acidification. Equine Vet. J. 22: 118-121.