Intravenous treatment of hyperhomocysteinemia in patients on chronic hemodialysis - A pilot study

Renal Failure

Volumn 26, Issue 6, 2004, Pages 703-708

  Pöge, Uwe ^a   Look, M ^a   Gerhardt, T ^a   Klehr, H U ^a   Sauerbruch, T ^a   Woitas, R P ^a  

^a UNIVERSITY OF BONN   (Germany)

Author keywords

Hemodialysis; Homocysteine; Intravenous therapy

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; PYRIDOXINE; VITAMIN;

ADULT; AGED; AMINO ACID BLOOD LEVEL; ARTICLE; CLINICAL ARTICLE; DRUG MEGADOSE; FEMALE; FOLLOW UP; HEMODIALYSIS; HUMAN; HYPERHOMOCYSTEINEMIA; INTRAVENOUS ADMINISTRATION; KIDNEY FAILURE; LONG TERM CARE; LOW DRUG DOSE; MAINTENANCE THERAPY; MALE; PILOT STUDY; PRIORITY JOURNAL; REBOUND;

AGED; COMBINED MODALITY THERAPY; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG ADMINISTRATION SCHEDULE; DRUG THERAPY, COMBINATION; FEMALE; FOLIC ACID; FOLLOW-UP STUDIES; HUMANS; HYPERHOMOCYSTEINEMIA; INFUSIONS, INTRAVENOUS; KIDNEY FAILURE, CHRONIC; KIDNEY FUNCTION TESTS; MALE; MIDDLE AGED; PERITONEAL DIALYSIS, CONTINUOUS AMBULATORY; PILOT PROJECTS; PROBABILITY; PROSPECTIVE STUDIES; PYRIDOXINE; RISK ASSESSMENT; SEVERITY OF ILLNESS INDEX; TREATMENT OUTCOME; VITAMIN B 12;

EID: 9644280943     PISSN: 0886022X     EISSN: None     Source Type: Journal    
DOI: 10.1081/JDI-200037108     Document Type: Article

References (25)

1. Mallamaci, F.; Zoccali, C.; Tripepi, G.; Fermo, I.; Benedetto, F.A.; Cataliotti, A.; Bellanuova, I.; Malatino, L.S.; Soldarini, A. Hyperhomocysteinemia predicts cardiovascular outcomes in hemodialysis patients. Kidney Int. 2002, 61 (2), 609-614.
2. Moustapha, A.; Naso, A.; Nahlawi, M.; Gupta, A.; Arheart, K.L.; Jacobsen, D.W.; Robinson, K.; Dennis, V.W. Prospective study of hyperhomocysteinemia as an adverse cardiovascular risk factor in end-stage renal disease. Circulation 1998, 97 (2), 138-141.
3. Woodside, J.V.; Yarnell, J.W.; McMaster, D.; Young, I.S.; Harmon, D.L.; McCrum, E.E.; Patterson, C.C.; Gey, K.F.; Whitehead, A.S.; Evans, A. Effect of B-group vitamins and antioxidant vitamins on hyperhomocysteinemia: a double-blind, randomized, factorial-design, controlled trial. Am. J. Clin. Nutr. 1998, 67 (5), 858-866.
4. Bostom, A.G.; Culleton, B.F. Hyperhomocysteinemia in chronic renal disease. J. Am. Soc. Nephrol. 1999, 10 (4), 891-900.
5. Look, M.P.; Riezler, R.; Reichel, C.; Brensing, K.A.; Rockstroh, J.K.; Stabler, S.P.; Spengler, U.; Berthold, H.K.; Sauerbruch, T. Is the increase in serum cystathionine levels in patients with liver cirrhosis a consequence of impaired homocysteine transsulfuration at the level of gamma-cystathionase? Scand. J. Gastroenterol. 2000, 35 (8), 866-872.
6. van Guldener, C.; Kulik, W.; Berger, R.; Dijkstra, D.A.; Jakobs, C.; Reijngoud, D.J.; Donker, A.J.; Stehouwer, C.D.; De Meer, K. Homocysteine and methionine metabolism in ESRD: a stable isotope study. Kidney Int. 1999, 56 (3), 1064-1071.
7. Dierkes, J.; Domrose, U.; Ambrosch, A.; Bosselmann, H.P.; Neumann, K.H.; Luley, C. Response of hyperhomocysteinemia to folic acid supplementation in patients with end-stage renal disease. Clin. Nephrol. 1999, 51 (2), 108-115.
8. Bostom, A.G.; Shemin, D.; Lapane, K.L.; Hume, A.L.; Yoburn, D.; Nadeau, M.R.; Bendich, A.; Selhub, J.; Rosenberg, I.H. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients. Kidney Int. 1996, 49 (1), 147-152.
9. Thambyrajah, J.; Landray, M.J.; McGlynn, F.J.; Jones, H.J.; Wheeler, D.C.; Townend, J.N. Does folic acid decrease plasma homocysteine and improve endothelial function in patients with predialysis renal failure? Circulation 2000, 102 (8), 871-875.
10. Sombolos, K.; Fragia, T.; Natse, T.; Bartholomatos, G.; Karagianni, A.; Katsaris, G.; Christidou, F.; Bamichas, G.; Stangou, M.; Papagalanis, N. The effect of long-term intravenous high dose B-complex vitamins with or without folic acid on serum homocysteine in hemodialysis patients. J. Nephrol. 2002, 15 (6), 671-675.
11. Sunder-Plassmann, G.; Fodinger, M.; Buchmayer, H.; Papagiannopoulos, M.; Wojcik, J.; Kletzmayr, J.; Enzenberger, B.; Janata, O.; Winkelmayer, W.C.; Paul, G.; Auinger, M.; Barnas, U.; Horl, W.H. Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: results of the Vienna multicenter study. J. Am. Soc. Nephrol. 2000, 11 (6), 1106-1116.
12. 12 reduces hyperhomocysteinemia in end-stage renal disease. J. Clin. Invest. Med. 2001, 24 (1), 5-11.
13. 12. Nephrol. Dial. Transplant. 2002, 17 (5), 865-870.
14. Koyama, K.; Usami, T.; Takeuchi, O.; Morozumi, K.; Kimura, G. Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in hemodialysis patients receiving high-dose folic acid supplementation. Nephrol. Dial. Transplant. 2002, 17 (5), 916-922.
15. Touam, M.; Zingraff, J.; Jungers, P.; Chadefaux-Vekemans, B.; Drucke, T.; Massy, Z.A. Effective correction of hyperhomocysteinemia in hemodialysis patients by intravenous folinic acid and pyridoxine therapy. Kidney Int. 1999, 56 (6), 2292-2296.
16. Lentz, S.R. Homocysteine and vascular dysfunction. Life Sci. 1997, 61 (13), 1205-1215.
17. Bostom, A.G.; Shemin, D.; Verhoef, P.; Nadeau, M.R.; Jacques, P.F.; Selhub, J.; Dworkin, L.; Rosenberg, I.H. Elevated fasting total plasma homocysteine levels and cardiovascular disease outcomes in maintenance dialysis patients. A prospective study. Arterioscler. Thromb. Vasc. Biol. 1997, 17 (11), 2554-2558.
18. Arnadottir, M.; Brattstrom, L.; Simonsen, O.; Thysell, H.; Hultberg, B.; Andersson, A.; Nilsson-Ehle, P. The effect of high-dose pyridoxine and folic acid supplementation on serum lipid and plasma homocysteine concentrations in dialysis patients. Clin. Nephrol. 1993, 40 (4), 236-240.
19. 12. Nephrol. Dial. Transplant. 2002, 17 (3), 455-461.
20. Trimarchi, H.; Schiel, A.; Freixas, E.; Diaz, M. Randomized trial of methylcobalamin and folate effects on homocysteine in hemodialysis patients. Nephron 2002, 91 (1), 58-63.
21. Lacour, B.; Parry, C.; Drueke, T.; Touam, M.; Kreis, H.; Bailly, M.; Durand, D. Pyridoxal 5′-phosphate deficiency in uremic undialyzed, hemodialyzed, and non-uremic kidney transplant patients. Clin. Chim. Acta 1983, 127 (2), 205-215.
22. Said, H.M.; Vaziri, N.D.; Kariger, R.K.; Hollander, D. Intestinal absorption of 5-methyltetrahydrofolate in experimental uremia. Acta Vitaminol. Enzymol. 1984, 6 (4), 339-346.
23. Tremblay, R.; Bonnardeaux, A.; Geadah, D.; Busque, L.; Lebrun, M.; Ouimet, D.; Leblanc, M. Hyperhomocysteinemia in hemodialysis patients: effects of 12-month supplementation with hydrosoluble vitamins. Kidney Int. 2000, 58 (2), 851-858.
24. Buccianti, G.; Bamonti, C.F.; Patrosso, C.; Corghi, E.; Novembrino, C.; Baragetti, I.; Lando, G.; De Franceschi, M.; Maiolo, A.T. Reduction of the homocysteine plasma concentration by intravenously administered folinic acid and vitamin B(12) in uraemic patients on maintenance haemodialysis. Am. J. Nephrol. 2001, 21 (4), 294-299.
25. Corghi, E.; Patrosso, C.; Bamonti, F.; Baragetti, E.; Novembrino, C.; Lando, G.; De Franceschi, M.; Buccianti, G. Intravenous folinic acid and vitamin B12 supplementation and homocysteine concentration in hemodialysis patients. G. Ital. Nefrol. 2002, 19 (3), 301-307.