Efficacy of methylcobalamin on lowering total homocysteine plasma concentrations in haemodialysis patients receiving high-dose folic acid supplementation

Nephrology Dialysis Transplantation

Volumn 17, Issue 5, 2002, Pages 916-922

  Koyama, Katsushi ^a   Usami, Takeshi ^a   Takeuchi, Oki ^a   Morozumi, Kunio ^a   Kimura, Genjiro ^a  

^a NAGOYA CITY UNIV MEDICAL SCHOOL   (Japan)

Author keywords

Chronic renal failure; Folic acid; Haemodialysis; Homocysteine; Methylcobalamin; Vitamin B12

Indexed keywords

FOLIC ACID; HOMOCYSTEINE; MECOBALAMIN; METHIONINE; PYRIDOXINE;

ARTICLE; ATHEROSCLEROSIS; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CHRONIC KIDNEY FAILURE; CLINICAL ARTICLE; CLINICAL TRIAL; COENZYME; CONCENTRATION RESPONSE; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DIET RESTRICTION; DRUG BLOOD LEVEL; DRUG EFFICACY; DRUG MEGADOSE; ENZYME ACTIVITY; HEMODIALYSIS; HEMODIALYSIS PATIENT; HUMAN; HYPERHOMOCYSTEINEMIA; LOADING TEST; MEDICAL ASSESSMENT; METHYLATION; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; RISK ASSESSMENT; SUPPLEMENTATION; VOLUNTEER;

EID: 0036092222     PISSN: 09310509     EISSN: None     Source Type: Journal    
DOI: 10.1093/ndt/17.5.916     Document Type: Article

References (24)

1. Serum total homocysteine and coronary heart disease
2. Hyperhomocysteinemia in end-stage renal disease: Prevalence, etiology and potential relationship to arteriosclerotic outcomes
3. Homocysteine and methionine metabolism in ESRD: A stable isotope study
4. Controlled comparison of L-5-methyltetrahydrofolate versus folic acid for the treatment of hyperhomocysteinemia in hemodialysis patients
5. 12 reduces hyperhomocysteinemia in end-stage renal disease
6. 12 decreases homocysteine and methylmalonic acid but also serum folate in patients with end-stage renal disease
7. Treatment of hyperhomocysteinemia in hemodialysis patients and renal transplant recipients
8. Abnormal cyanide metabolism in uraemic patients
9. 12 forms in human plasma
10. Fate of cobalamins in humans following oral and intramuscular administration of cyanocobalamin, hydroxycobalamin, adenosylcobalamin and methylcobalamin
11. Rapid high-performance liquid chromatographic assay for total homocysteine levels in human serum
12. Homocysteine and risk of premature coronary heart disease. Evidence for a common gene mutation
13. Plasma homocysteine in renal failure
14. Hyperhomocysteinemia in patients on dialysis, as determined by the methionine loading test
15. Hyperhomocysteinemia in chronic renal disease
16. High dose-B-vitamin treatment of hyperhomocysteinemia in dialysis patients
17. Effect of high dose folic acid therapy on hyperhomocysteinemia in hemodialysis patients: Results of the Vienna multicenter study
18. Treatment with different doses of folic acid in haemodialysis patients: Effects on folate distribution and aminothiol concentrations
19. Kinetic basis of hyperhomocysteinemia in patients with chronic renal failure
20. Plasma-cobalamins in neuro-ophthalmological diseases
21. Evidence for disturbed S-adenosylmethionine: S-adenosylhomocysteine ratio in patients with end-stage renal failure: A cause for disturbed methylation reactions?
22. Enzymatic methyl esterification of erythrocyte membrane proteins is impaired in chronic renal failure. Evidence for high levels of the natural inhibitor S-adenosylhomocysteine
23. Cloning and mapping of a cDNA for methionine synthase reductase, a flavoprotein defective in patients with homocystinuria