Relaxation enhancing properties of MnDPDP in human myocardium

Journal of Magnetic Resonance Imaging

Volumn 20, Issue 6, 2004, Pages 948-952

  Skjold, Arne ^a,c   Vangberg, Torgil R ^b   Kristoffersen, Anders ^b   Haraldseth, Olav ^a   Jynge, Per ^a   Larsson, Henrik B W ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b TRONDHEIM UNIVERSITY HOSPITAL   (Norway)

^c NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Contrast media; Magnetic resonance imaging; Manganese; MnDPDP; Myocardium

Indexed keywords

MANGAFODIPIR;

ADULT; ARTICLE; BODY WEIGHT; CONTRAST ENHANCEMENT; CONTRAST RADIOGRAPHY; DIAGNOSTIC VALUE; DOSE RESPONSE; FEMALE; HEART LEFT VENTRICLE; HEART MUSCLE; HUMAN; HUMAN EXPERIMENT; HUMAN TISSUE; IMAGING SYSTEM; INVERSION RECOVERY; LIVER; MALE; NORMAL HUMAN; PRIORITY JOURNAL; RELAXATION TIME; STATISTICAL SIGNIFICANCE;

ADULT; CONTRAST MEDIA; DOSE-RESPONSE RELATIONSHIP, DRUG; EDETIC ACID; ELECTROCARDIOGRAPHY; FEMALE; HEART RATE; HUMANS; LIVER; MAGNETIC RESONANCE IMAGING; MALE; MANGANESE; MYOCARDIAL CONTRACTION; MYOCARDIUM; PYRIDOXAL PHOSPHATE;

EID: 9644279538     PISSN: 10531807     EISSN: None     Source Type: Journal    
DOI: 10.1002/jmri.20200     Document Type: Article

References (28)

1. Hunter DR, Haworth RA, Berkoff HA. Cellular manganese uptake by the isolated perfused rat heart: a probe for the sarcolemma calcium channel. J Mol Cell Cardiol 1981;13:823-832.
2. Hu TC, Pautler RG, MacGowan GA, Koretsky AP. Manganese-enhanced MRI of mouse heart during changes in inotropy. Magn Reson Med 2001;46:884-890.
3. Nordhøy W, Anthonsen HW, Bruvold M, Jynge P, Krane J, Brurok H. Manganese ions as intracellular contrast agents: proton relaxation and calcium interactions in rat myocardium. NMR Biomed 2003;16:82-95.
4. Brurok H, Schjott J, Berg K, Karlsson JO, Jynge P. Manganese and the heart: acute cardiodepression and myocardial accumulation of manganese. Acta Physiologica Scandinavia 1997;159:33-40.
5. Brady TJ, Goldman MR, Pykett IL, et al. Proton nuclear magnetic resonance imaging of regionally ischemic canine hearts: effect of paramagnetic proton signal enhancement. Radiology 1982;144:343-347.
6. Goldman MR, Brady TJ, Pykett IL, et al. Quantification of experimental myocardial infarction using nuclear magnetic resonance imaging and paramagnetic ion contrast enhancement in excised canine hearts. Circulation 1982;66:1012-1016.
7. Schaefer S, Lange RA, Kulkarni PV, et al. In vivo nuclear magnetic resonance imaging of myocardial perfusion using the paramagnetic contrast agent manganese gluconate. J Am Coll Cardiol 1989;14:472-480.
8. Bremerich J, Saeed M, Arheden H, Higgins CB, Wendland MF. Normal and infarcted myocardium: differentiation with cellular up-take of manganese at MR imaging in a rat model. Radiology 2000;216:524-530.
9. Wendland MF, Saeed M, Bremerich J, Arheden H, Higgins CB. Thallium-like test for myocardial viability with MnDPDP-enhanced MRI. Acad Radiol 2002:9 (Suppl 1):82-83.
10. Brurok H, Skoglund T, Berg K, Skarra S, Karlsson JO, Jynge P, Myocardial manganese elevation and proton relaxivity enhancement with manganese dipyridoxyl diphosphate. Ex vivo assessments in normally perfused and ischemic guinea pig hearts. NMR Biomed 1999;12:364-372.
11. Southon TE, Grant D, Bjoernerud A, et al. NMR relaxation studies with MnDPDP. Acta Radiol 1997;38:708-716.
12. Wolf GL, Baum L. Cardiovascular toxicity and tissue proton T1 response to manganese injection in the dog and rabbit. AJR Am J Roentgenol 1983;141:193-197.
13. Brurok H, Schjott J, Berg K, Karlsson JO, Jynge P. Effects of MnDPDP, DPDP2-, and MnC12 on cardiac energy metabolism and manganese accumulation. An experimental study in the isolated perfused rat heart. Invest Radiol 1997;32:205-211.
14. Brurok H, Berg K, Sneen L, Grant D, Karlsson JO, Jynge P. Cardiac metal contents after infusions of manganese. An experimental evaluation in the isolated rat heart. Invest Radiol 1999;34:470-476.
15. Brurok H, Schjott J, Berg K, Karisson JO, Jynge P. Effects of manganese dipyridoxyl diphosphate, dipyridoxyl diphosphate-, and manganese chloride on cardiac function. An experimental study in the Langendorff perfused rat heart. Invest Radiol 1995;30:159-167.
16. Schmidt PP, Toft KG, Skotland T, Andersson K. Stability and transmetallation of the magnetic resonance contrast agent MnDPDP measured by EPR. J Biol Inorg Chem. 2002;7:241-248.
17. Ni Y, Petre C, Bosmans H, Miao Y, Grant D, Baert AL, Marchai G. Comparison of manganese biodistribution and MR contrast enhancement in rats after intravenous injection of MnDPDP and MnC12. Acta Radiol 1997;38:700-707.
18. Jynge P, Brurok H, Asplund A, Towart R, Refsum H, Karlsson JO. Cardiovascular safety of MnDPDP and MnC12. Acta Radiol 1997;38:740-749.
19. Rocklage SM, Cacheris WP, Quay SC, Hahn FE, Raymond KN. Manganese(II) N,N′-dipyridoxylethylenediamine-N,N′-diacetate 5.5′- bis(phosphate). Synthesis and characterization of a paramagnetic chelate for magnetic resonance imaging enhancement. Inorg Chem 1989;28:477.
20. Rocklage SM, Watson A, Carvlin MJ. Contrast agents in magnetic resonance imaging. In: Stark DD. Bradley WG, editors. Magnetic resonance imaging. St. Louis: Mosby-Year Book: 1994. p 372-437.
21. Toft KG, Hustvedt SO, Grant D, et al. Metabolism and pharmacokinetics of MnDPDP in man. Acta Radiol 1997;38:677-689.
22. Fritz-Hansen T, Rostrup E, Ring PB, Larsson HBW. Quantification of gadolinium-DTPA concentrations for different inversion times using an IR-turbo FLASH pulse sequence: a study on optimizing multislice perfusion imaging. Magn Reson Imaging 1998;16:893-899.
23. Larsson HBW, Stubgaard M, Soendergaard L, Henriksen O. In vivo quantification of the unidirectional influx constant for Gd-DTPA diffusion across the myocardial capillaries with MR imaging. J Magn Reson Imaging 1994;4:433-440.
24. Larsson HB, Fritz-Hansen T, Rostrup E, Sondergaard L, Ring P, Henriksen O. Myocardial perfusion modeling using MRI. Magn Reson Med 1996;35:716-726.
25. Lagarias JC, Reeds JA, Wright MH, Wright PE. Convergence properties of the Nelder-Mead simplex method in low dimensions. SIAM J Optimization 1998;9:112-147.
26. Simonetti OP, Kim RJ, Fieno DS, et al. An improved MR imaging technique for the visualization of myocardial infarction. Radiology 2001;218:215-223.
27. Bydder GM, Hajnal JV, Young IR. Use of the inversion recovery pulse sequence. In: Stark DD. Bradley WG. editors. Magnetic resonance imaging. St. Louis: Mosby: 1999. p 72.
28. Larsson HB, Rosenbaum S, Fritz-Hansen T. Quantification of the effect of water exchange in dynamic contrast MRI perfusion measurements in the brain and heart. Magn Reson Med 2001;46:272-281.