Effects of MnDPDP, DPDP--, and MnCl2 on cardiac energy metabolism and manganese accumulation: An experimental study in the isolated perfused rat heart

Investigative Radiology

Volumn 32, Issue 4, 1997, Pages 205-211

  Brurok, Heidi ^a   Schjøtt, Jan ^a   Berg, Kirsti ^a   Karlsson, Jan O G ^b   Jynge, Per ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

^b NYCOMED IMAGING AS   (Norway)

Author keywords

cardiac metabolism; Magnetic resonance imaging; manganese; manganese uptake; rat heart

Indexed keywords

ADENOSINE TRIPHOSPHATE; CREATINE PHOSPHATE; DIPYRIDOXALDIPHOSPHATE; LACTATE DEHYDROGENASE; MANGAFODIPIR; MANGANESE; MANGANESE CHLORIDE; PHOSPHATE; PYRIDOXAL 5 PHOSPHATE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; BIOACCUMULATION; CONTROLLED STUDY; ENZYME RELEASE; HEART FUNCTION; HEART MUSCLE METABOLISM; ISOLATED HEART; MALE; NONHUMAN; PRIORITY JOURNAL; RAT;

EID: 0030898134     PISSN: 00209996     EISSN: None     Source Type: Journal    
DOI: 10.1097/00004424-199704000-00003     Document Type: Article

References (28)

1. Lauterbur PC, Mendonca Dias MH, Rudin AM. Augmentation of water proton spin-lattice relaxation rates by the in vivo addition of paramagnetic ions. In: Duton PC, ed. Frontiers of biological energetics. New York: Academic Press, 1978.
2. 1 response to manganese injection in the dog and rabbit. AJR Am J Roentgenol 1983;141:193-197.
3. Pomeroy OH, Wendland MF, Wagner S, et al. Magnetic resonance imaging of acute myocardial ischemia using a manganese chelate, Mn-DPDP. Invest Radiol 1989;24:531-536.
4. Fawwaz R, Bohdiewicz P, Lavallee D, et al. Use of metalloporphyrins in diagnostic imaging. Nucl Med Biol 1990;17:65-72.
5. Saeed M, Wendland MF, Takehara Y, Higgins CB. Reversible and irreversible injury in the reperfused myocardium: Differentiation with contrast material-enhanced MR imaging. Radiology 1990;175:633-637.
6. Schaefer S, Lange RA, Gutekunst DP, Parkey RW, Willerson JT, Peshock RM. Contrast-enhanced magnetic resonance imaging of hypoperfused myocardium. Invest Radiol 1991;26:551-556.
7. Nelson RC, Chezmar JL, Newberry LB, Malko JA, Gedgaudas-McClees RK, Bernardino ME. Manganese dipyridoxyl diphosphate: Effect of dose, time, and pulse sequence on hepatic enhancement in rats. Invest Radiol 1991;26:569-573.
8. Elizondo G, Fretz CJ, Stark DD, et al. Preclinical evaluation of MnDPDP: New paramagnetic hepatobiliary contrast agent for MR imaging. Radiology 1991;178:73-78.
9. Keen CL, Baly DL, Lönnerdal B. Metabolic effects of high doses of manganese in rats. Biol Trace Elem Res 1984;6:309-315.
10. Korc M. Manganese homeostasis in humans and its role in disease states. In: Prasad AS, ed. Essential and toxic trace elements in human health and disease. Chicester: John Wiley & Sons, 1988.
11. Archibald FS, Fridowich I. The scavenging of superoxide radical by manganous complexes: In vitro. Arch Biochem Biophys 1982;214:452-463.
12. Coraboeuf E, Vassort G. Effects of some inhibitors of ionic permeabilities on ventricular action potential and contraction of rat and guinea-pig hearts. J Electrocardiol 1968;1:19-30.
13. Øksendal AN, Jynge P. Myocardial protection by micromolar manganese in the calcium paradox and additive effects of verapamil. Basic Res Cardiol 1986;81:581-593.
14. Takaya K, Reiter M. Effect of divalent manganese ions on action potential and contractility of cardiac muscle. Naunyn Schmiedeberg's Arch Pharmacol 1972;275:213-226.
15. Sperelakis N. Physiological principles of cardiac toxicology. In: Baskin SI, ed. Principles of cardiac toxicology. Boca Raton: CRC Press, 1991.
16. Keene JJ, Seidel CL, Bohr DF. Manganese on calcium flux and norepinephrine-induced tension in arterial smooth muscle. Proc Soc Exp Biol 1972;28:1083.
17. 2 upon cardiac function: An experimental study in the Langendorff perfused rat heart. Invest Radiol 1995;30:159-167.
18. Langendorff O. Untersuchungen am überlebenden Säugetierherzen. Pflügers Arch Physiol 1895;61:291-332.
19. Krebs HA, Henseleit K. Untersuchungen über die Harnstoffbildung im Tierkörper. Hoppe-Seyler's Z Physiol Chem 1932;210:33-66.
20. Sellevold OFM, Jynge P, Aarstad K. High performance liquid chromatography: A rapid isocratic method for the determination of creatine compounds and adenine nucleotides in myocardial tissue. J Mol Cell Cardiol 1986;18:517-527.
21. Battacharya SK, Williams JC, Palnieri GMA. Determination of calcium and magnesium in cardiac and skeletal muscle by atomic absorbtion spectroscopy using stoichiometric nitrous oxide acetylene flame. Analytical Letters 1979;12:1451-1475.
22. Luterotti A, Zanic-Grubisic T, Juretic D. Rapid and simple method for the detection of copper, manganese, and zinc in rat liver by direct flame atomic absorbtion spectrometry. Analyst 1992; 117:141-143.
23. Keen CL, Lønnerdahl B, Hurley LS. Manganese. In: Frieden E, ed. Biochemistry of the essential ultratrace elements. New York: Plenum Press, 1984.
24. Hurley LS, Keen CI, Manganese. In: Trace elements in human and animal biology. Volume 1. New York: Academic Press, 1987.
25. Bihler I. Role of calcium in heart metabolism. Can J Physiol Pharmacol 1984;62:884-890.
26. Hunter DR, Haworth RA, Berkoff HA. Cellular manganese uptake by the isolated rat heart: A probe for the sarcolemma calcium channel. J Mol Cell Cardiol 1891;13:823-832.
27. 14C labelled MnDPDP in rats and dogs. In: Book of abstracts. Rome: ESMRMB 10th Annual Congress, 1993.
28. Davidsson L, Lönnerdahl B, Sandstrøm BM, Kunz C, Keen CL. Identification of transferrin as the major plasma carrier protein for manganese introduced orally or intravenously or after in vitro addition in the rat. J Nutr 1989;199:1461-1464.