Early pathophysiologic feature of arthropathy in juvenile dogs induced by ofloxacin, a quinolone antimicrobial agent

Veterinary Pathology

Volumn 41, Issue 6, 2004, Pages 673-681

  Yabe, K ^a   Satoh, H ^a   Ishii, Y ^a   Jindo, T ^a   Sugawara, T ^a   Furuhama, K ^a   Goryo, M ^b   Okada, K ^b  

^a DAIICHI SANKYO CO   (Japan)

^b IWATE UNIVERSITY   (Japan)

Author keywords

Arthropathy; Articular cartilage; Juvenile dogs; Proteoglycan; Quinolone antimicrobial agent

Indexed keywords

DNA; OFLOXACIN; PROTEIN; PROTEOGLYCAN; QUINOLINE DERIVED ANTIINFECTIVE AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTHROPATHY; ARTICLE; ARTICULAR CARTILAGE; CARTILAGE; CARTILAGE CELL; CELL ISOLATION; CELL ULTRASTRUCTURE; CELL VACUOLE; CLINICAL FEATURE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS; DOG; DOG DISEASE; DRUG EXPOSURE; DRUG MECHANISM; FEMUR HEAD; HUMERUS HEAD; IN VITRO STUDY; IN VIVO STUDY; JUVENILE; MALE; MORPHOLOGY; NONHUMAN; PATHOPHYSIOLOGY; PROTEIN DEPLETION; PROTEIN SYNTHESIS; PROTEOGLYCAN SYNTHESIS; ROUGH ENDOPLASMIC RETICULUM; STAINING;

AGE FACTORS; ANIMALS; ANTI-BACTERIAL AGENTS; CARTILAGE, ARTICULAR; CELLS, CULTURED; CHONDROCYTES; DOGS; JOINT DISEASES; JOINTS; MALE; OFLOXACIN;

ANIMALIA; CANIS FAMILIARIS;

EID: 9644276932     PISSN: 03009858     EISSN: None     Source Type: Journal    
DOI: 10.1354/vp.41-6-673     Document Type: Article

References (25)

1. Bendele AM, Hulman JF, Harvey AK, Hrubey PS, Chandrasekhar S: Passive role of articular chondrocytes in quinolone-induced arthropathy in guinea pigs. Toxicol Pathol 18:304-312, 1990
2. Bolton MC, Dudhia J, Bayliss MT: Age-related changes in the synthesis of link protein and aggrecan in human articular cartilage: implications for aggregate stability. Biochem J 337:77-82, 1999
3. Burkhardt JE, Hill MA, Carlton WW, Kesterson JW: Histologic and histochemical changes in articular cartilages of immature Beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 27:162-169, 1990
4. Burkhardt JE, Hill MA, Lamar CH, Smith GNJ, Carlton WW: Effect of difloxacin on the metabolism of glycosaminoglycans and collagen in organ cultures of articular cartilage. Fundam Appl Toxicol 20:257-263, 1993
5. Burkhardt JE, Hill MA, Turek JJ, Carlton WW: Ultrastructural changes in articular cartilages of immature Beagle dogs dosed with difloxacin, a fluoroquinolone. Vet Pathol 29:230-238, 1992
6. DeGroot J, Verzijl N, Bank RA, Lafeber FPJG, Bijlsma JWJ, TeKoppele JM: Age-related decrease in proteoglycan synthesis of human articular chondrocytes: the role of nonenzymatic glycation. Arthritis Rheum 42:1003-1009, 1999
7. Domagala JM: Structure-activity and structure-side-effect relationships for the quinolone antibacterials. J Antimicrob Chemother 33:685-706, 1994
8. Gough A, Barsoum NJ, Mitchell L, McGuire EJ, De La Iglesia FA: Juvenile canine drug-induced arthropathy: clinicopathological studies on articular cartilage lesions caused by oxolinic and pipemidic acids. Toxicol Appl Pharmacol 51:177-187, 1979
9. Gough AW, Kasali OB, Sigler RE, Baragi V: Quinolone arthropathy - acute toxicity to immature articular cartilage. Toxicol Pathol 20:436-450, 1992
10. Hayem G, Petit PX, Levacher M, Gaudin C, Kahn MF, Pocidalo JJ: Cytofluorometric analysis of chondrotoxicity of fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother 38:243-247, 1994
11. Hildebrand H, Kempka G, Schluter G, Schmidt M: Chondrotoxicity of quinolones in vivo and in vitro. Arch Toxicol 67:411-415, 1993
12. Hooper DC: Mode of action of fluoroquinolones. Drugs 58(Suppl 2): 6-10, 1999
13. Ingham B, Brentnall DW, Dale EA, McFadzan JA: Arthropathy induced by antibacterial fused N-alkyl-4-pyridone-3-carboxylic acids. Toxicol Lett 1:21-26, 1977
14. 3H]thymidine by articular cartilage cells in the rat. Toxicol Lett 44:131-142, 1988
15. Kato M, Onodera T: Morphological investigation of cavity formation in articular cartilage induced by ofloxacin in rats. Fundam Appl Toxicol 11:110-119, 1988
16. Kato M, Takada S, Ogawara S, Takayama S: Effect of levofloxacin on glycosaminoglycan and DNA synthesis of cultured rabbit chondrocytes at concentrations inducing cartilage lesions in vivo. Antimicrob Agents Chemother 39:1979-1983, 1995
17. Linseman DA, Hampton LA, Branstetter DG: Quinolone-induced arthropathy in the neonatal mouse: morphological analysis of articular lesions produced by pipemidic acid and ciprofloxacin. Fundam Appl Toxicol 28:59-64, 1995
18. Prydz K, Dalen KT: Synthesis and sorting of proteoglycans. J Cell Sci 113:193-205, 2000
19. Shakibaei M, Kociok K, Forster C, Vormann J, Gunther T, Stahlmann R, Merker HJ: Comparative evaluation of ultrastructural changes in articular cartilage of ofloxacin-treated and magnesium-deficient immature rats. Toxicol Pathol 24:580-587, 1996
20. Stahlmann R, Forster C, Shakibaei M, Vormann J, Gunther T, Merker HJ: Magnesium deficiency induced joint cartilage lesions in juvenile rats which are identical to quinlone-induced arthropathy. Antimicrob Agents Chemother 39:2013-2018, 1995
21. Stahlmann R, Merker HJ, Hinz N, Chahoud I, Webb J, Heger W, Neubert D: Ofloxacin in juvenile non-human primates and rats. Arthropathia and drug plasma concentrations. Arch Toxicol 64:193-204, 1990
22. Tatsumi H, Senda H, Yatera S, Takemoto Y, Yamayoshi M, Ohnishi K: Toxicological studies on pipemidic acid. V. Effect on diarthrodial joints of experimental animals. J Toxicol Sci 3:357-367, 1978
23. Yabe K, Murakami Y, Nishida S, Sekiguchi M, Furuhama K, Goryo M, Okada K. A non-arthropathic dose and its disposition following repeated oral administration of ofloxacin, a new quinolone antimicrobial agent, to juvenile dogs. J Vet Med Sci 63:867-872, 2001
24. Yabe K, Yoshida K, Yamamoto N, Nishida S, Ohshima C, Sekiguchi M, Yamada K, Furuhama K. Diagnosis of quinolone-induced arthropathy in juvenile dogs by use of magnetic resonance (MR) imaging. J Vet Med Sci 59:597-599, 1997
25. Yoshida K, Yabe K, Nishida S, Yamamoto N, Ohshima C, Sekiguchi M, Yamada K, Furuhama K. Pharmacokinetic disposition and arthropathic potential of oral ofloxacin in dogs. J Vet Pharmacol Ther 21:128-132, 1998