The CCR5Δ32 allele is associated with reduced liver inflammation in hepatitis C virus infection

European Journal of Immunogenetics

Volumn 31, Issue 6, 2004, Pages 249-252

  Wald, O ^a   Pappo, O ^a   Ari, Z B ^b   Azzaria, E ^a   Wiess, I D ^a   Gafnovitch, I ^a   Wald, H ^a   Spengler, U ^c   Galun, E ^a   Peled, Amnon ^a  

^a HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^b RABIN MEDICAL CENTER   (Israel)

^c UNIVERSITY OF BONN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR CCR5;

ADULT; AGED; ALLELISM; ARTICLE; DELETION MUTANT; DISEASE COURSE; FEMALE; GENE MUTATION; HEPATITIS C; HUMAN; INFECTION SENSITIVITY; ISRAEL; JEW; MAJOR CLINICAL STUDY; MALE; OUTCOMES RESEARCH; PRIORITY JOURNAL; GENETICS; HEPATITIS C VIRUS; HETEROZYGOTE; INFLAMMATION; LIVER; METABOLISM; MIDDLE AGED; MUTATION; VIROLOGY;

HEPATITIS C VIRUS;

ADULT; AGED; AGED, 80 AND OVER; FEMALE; HEPACIVIRUS; HEPATITIS C; HETEROZYGOTE; HUMANS; INFLAMMATION; LIVER; MALE; MIDDLE AGED; MUTATION; RECEPTORS, CCR5;

EID: 9644267011     PISSN: 09607420     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2370.2004.00482.x     Document Type: Article

References (15)

1. Apolinario, A., Majano, P.L., Alvarez-Perez, E., Saez, A., Lozano, C., Vargas, J. & Garcia-Monzon, C. (2002) Increased expression of T cell chemokines and their receptors in chronic hepatitis C: relationship with the histological activity of liver disease. American Journal of Gastroenterology, 97, 2861.
2. Fischereder, M., Luckow, B., Hocher, B., Wuthrich, R.P., Rothenpieler, U., Schneeberger, H., Panzer, U., Stahl, R.A., Hauser, I.A., Budde, K. et al. (2001) CC chemokine receptor 5 and renal-transplant survival. Lancet, 357, 1758.
3. Hellier, S., Frodsham, A.J., Hennig, B.J., Klenerman, P., Knapp, S., Ramaley, R, Satsangi, J., Wright, M., Zhang, L., Thomas, H.C. et al. (2003) Association of genetic variants of the chemokine receptor CCR5 and its ligands, RANTES and MCP-2, with outcome of HCV infection. Hepatology, 38, 1468.
4. Kantor, R. & Gershoni, J.M. (1999) Distribution of the CCR5 gene 32-base pair deletion in Israeli ethnic groups. Journal of Acquired Immune Deficiency Syndrome and Human Retrovirology, 20, 81.
5. Knodell, R.G., Ishak, K.G., Black, W.C., Chen, T.S., Craig, R., Kaplowitz, N., Kiernan, T.W. & Wollman, J. (1981) Formulation and application of a numerical scoring system for assessing histological activity in asymptomatic chronic active hepatitis. Hepatology, 1, 431.
6. McKechnie, V.M., Mills, P.R. & McCruden, E.A. (2000) The NS5a gene of hepatitis C virus in patients treated with interferon-alpha. Journal of Medical Virology, 60, 367.
7. Promrat, K., McDermott, D.H., Gonzalez, C.M., Kleiner, D.E., Koziol, D.E., Lessie, M., Merrell, M., Soza, A., Heller, T., Ghany, M. et al. (2003) Associations of chemokine system polymorphisms with clinical outcomes and treatment responses of chronic hepatitis C. Gastroenterology, 124, 352.
8. Rossi, D. & Zlotnik, A. (2000) The biology of chemokines and their receptors. Annual Review of Immunology, 18, 217.
9. Salazar-Mather, T.P., Lewis, C.A. & Biron, C.A. (2002) Type I interferons regulate inflammatory cell trafficking and macrophage inflammatory protein 1alpha delivery to the liver. Journal of Clinical Investigations, 110, 321.
10. Seeff, L.B. (2002) Natural history of chronic hepatitis C. Hepatology, 36, S35.
11. Shields, P.L., Morland, C.M., Salmon, M., Qin, S., Hubscher, S.G. & Adams, D.H. (1999) Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver. Journal of Immunology, 163, 6236.
12. Venkatesan, S., Petrovic, A., Van Ryk, D.I., Locati, M., Weissman, D. & Murphy, P.M. (2002) Reduced cell surface expression of CCR5 in CCR5Delta 32 heterozygotes is mediated by gene dosage, rather than by receptor sequestration. Journal of Biological Chemistry, 277, 2287.
13. Woitas, R.P., Ahlenstiel, G., Iwan, A., Rockstroh, J.K., Brackmann, H.H., Kupfer, B., Matz, B., Offergeld, R., Sauerbruch, T. & Spengler, U. (2002) Frequency of the HIV-protective CC chemokine receptor 5-Delta32/Delta32 genotype is increased in hepatitis C. Gastroenterology, 122, 1721.
14. Wu, L., Paxton, W.A., Kassam, N., Ruffing, N., Rottman, J.B., Sullivan, N., Choe, H., Sodroski, J., Newman, W., Koup, R.A. et al. (1997) CCR5 levels and expression pattern correlate with infectability by macrophage-tropic HIV-1, in vitro. Journal of Experimental Medicine, 185, 1681.
15. Zhang, M., Goedert, J.J. & O'Brien, T.R. (2003) High frequency of CCR5-delta32 homozygosity in HCV-infected, HIV-1-uninfected hemophiliacs results from resistance to HIV-1. Gastroenterology, 124, 867.